Clinical trials: Trauma, Multiple
Multiple Trauma, Coagulation Disorder
Estimation of Coagulation Factor XIII Activity Based on the Initial Plasma Fibrinogen Level in Trauma
Coagulation factor XIII (FXIII), a plasma transglutaminase, is known as the final enzyme of the coagulation cascade, responsible for a cross-linking of fibrin to strengthen blood clot.
- Conditions
- Multiple Trauma, Coagulation Disorder, Coagulation Factor Deficiency, Coagulation Defect; Acquired
- Trial name
- NCT03634215
- Testing
- fibrinogen plasma concentration, coagulation factor XIII activity
- Where
- 3 sites in Czechia
- Volunteers
- 357 people
- Sponsor
- Masaryk Hospital Krajská zdravotní a.s.
Compartment Syndromes, Polytrauma
Non-invasive Limb Compartment Pressure Measurement
Compartment syndrome (CS) is a serious complication of soft-tissue injuries in patients with fractures of the musculoskeletal apparatus.
- Conditions
- Compartment Syndromes, Polytrauma, Burn Injury
- Trial name
- FNO-TRAUMA-CPM (NCT03730688)
- Testing
- Conventional compartment pressure measurement, Experimental compartment pressure measurement
- Where
- 2 sites in Czechia
- Volunteers
- 70 people
- Sponsor
- University Hospital Ostrava
Rib Fractures, Polytrauma
Blunt Thoracic Trauma: Definition of a Standard Operating Procedure
Rib fractures are the most frequent injury after blunt thoracic trauma. It is very important to choose the most appropriate interventions to prevent complications.
- Conditions
- Rib Fractures, Polytrauma, Thoracic Injury, Respiratory Failure
- Trial name
- NCT05617404
- Testing
- CT scan
- Where
- Spain
- Volunteers
- 553 people
- Sponsor
- Corporacion Parc Tauli
Polytrauma
Comparing Trauma Severity Scores Injury Severity Score "ISS", Rapid Emergency Medicine Score "REMS" and Kampala Trauma Score "KTS"
Trauma is defined as a physical injury from an external source of sudden onset and severity, which require immediate medical attention.Despite improvements in trauma systems worldwide, trauma continues to be one of the leading…
- Trial name
- NCT05544773
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Assiut University
Trauma, Sepsis
Prediction Study of Complications After Severe Trauma
The purpose of this study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of post-traumatic complications in a multicenter sample of severe trauma patients.
- Conditions
- Trauma, Sepsis, Multiple Organ Dysfunction Syndrome
- Trial name
- PSCAT (NCT01713205)
- Where
- 6 sites in China
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- Jiang Jianxin
Multiple Sclerosis, Stroke
An Assistive Powered Wheelchair: Stage 2 Trial
Preliminary evaluation of an obstacle alerting system to enhance the user's independent mobility by improving their confidence to drive and their safety in driving a powered wheelchair.
- Conditions
- Multiple Sclerosis, Stroke, Cystic Fibrosis, Motor Neurone Disease
- Trial name
- EDUCAT (NCT05292690)
- Testing
- Powered Wheelchair Obstacle Alerting System
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- East Kent Hospitals University NHS Foundation Trust
Chronic Pain, Chronic Pain Syndrome
Outcomes Mandate National Integration With Cannabis as Medicine
This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pain Due to Injury, Chronic Pain Due to Trauma
- Trial name
- OMNI-Can (NCT03944447)
- Testing
- Cannabis, Medical, RYAH-Medtech Inhaler
- Where
- 17 sites in United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- OMNI Medical Services, LLC
Sepsis, Septic Shock
The Role of Serotonin in Intensive Care Patients
Sepsis, cardiac arrest and multiple trauma are potentially life-threatening conditions and common reasons for intensive care unit (ICU) admission.
- Conditions
- Sepsis, Septic Shock, Cardiac Arrest With Successful Resuscitation, Multiple Trauma
- Trial name
- SERO-22 (NCT05386199)
- Where
- Norway
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Sepsis Syndrome, MODS
Nafamostat Mesilate for Anticoagulation During CRRT in Critically Ill Patients
Continuous renal replacement therapy is widely used in intensive care medicine, which is known as an alternative therapy to save injured kidney . Anticoagulation is an important part of this therapy.
- Conditions
- Sepsis Syndrome, MODS, AKI, Hemorrhage
- Trial name
- NMFADCICIP (NCT05382078)
- Where
- China
- Volunteers
- 188 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Multiple Trauma
Proteomics in Multiple Trauma to Identify Organ Failure
To analyse differences in protein expression in multiple trauma patients for identification of potential biomarkers to predict organ dysfunction.
- Trial name
- NCT02030327
- Where
- Germany
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Köln
Emergencies, Trauma Injury
Pre-Hospital Zone 1 Partial Resuscitative Endovascular Balloon Occlusion of the Aorta for Injured Patients With Exsanguinating Sub-diaphragmatic Haemorrhage
It is unknown whether this evolved strategy (Pre-Hospital Zone I P-REBOA) is feasible and with an acceptable safety profile. This study will address this question, therefore informing the design of a prospective multicentre…
- Conditions
- Emergencies, Trauma Injury, Trauma, Multiple
- Trial name
- P-PRO (NCT04145271)
- Testing
- Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA)
- Where
- 4 sites in United Kingdom
- Volunteers
- 10 people
- Sponsor
- Barts & The London NHS Trust
Head Trauma, Polytrauma
Comparative Study for the Validity of Various Severity Scoring System
Scoring systems for use in intensive care unit (ICU) patients have been introduced and developed over the last 30 years. They allow an assessment of the severity of disease and provide an estimate of in-hospital mortality
- Conditions
- Head Trauma, Polytrauma, Pre-Eclampsia, Sepsis
- Trial name
- NCT04683094
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Aswan University Hospital
Occult Bleeding, Hemorrhage
A 48 Subject Study Using Non-invasive Multi-Technology Measurements for Early Detection of Ongoing Hemorrhage
Early detection of ongoing hemorrhage (OH) before onset of hemorrhagic shock is a universally acknowledged great unmet need, and particularly important after traumatic injury.
- Conditions
- Occult Bleeding, Hemorrhage, Hemorrhagic Shock
- Trial name
- NCT04814810
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Trauma, Multiple, Trauma Injury
Factors Affecting Mortality and Morbidity in Trauma Patients Followed in Intensive Care Unit
In this study, the demographic and clinical characteristics of trauma patients followed up in the Intensive Care Unit of the Anesthesiology and Reanimation Clinic of the Health Sciences University Okmeydanı Training and Research…
- Trial name
- trauma (NCT05175872)
- Where
- Turkey (Türkiye)
- Volunteers
- 194 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Polytrauma
Analysis of Urogenital Injuries in Polytraumatized Patients
Urogenital injuries occur in approximately 5-10 % of all severly injured patients. The literature lacks a thorough investigation into the mechanisms of trauma, the analysis of the whole urogenital tract and especially the…
- Trial name
- NCT05074095
- Testing
- retrospective analysis
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Field Physician Care, Analgesics
Analgesia in ÖAMTC Helicopter Emergency Service in Austria
A sufficient analgesia in injured or sick people is the main goal of physicians treating a patient. In emergency medicine potent analgesia like ketamine or opioids are routinely used.
- Conditions
- Field Physician Care, Analgesics, Hypnotics, Emergencies
- Trial name
- NCT03760302
- Testing
- analgesics, hypnotics
- Where
- Austria
- Volunteers
- 35,000 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Rib Fracture Multiple, Trauma Chest
Lidocaine Infusions for Rib Fractures
Patients with traumatic rib fractures not receiving regional anesthesia through a epidural or nerve block catheter will be recruited for the study.
- Conditions
- Rib Fracture Multiple, Trauma Chest, Pain, Acute
- Trial name
- Lidocare (NCT03571919)
- Testing
- Lidocaine infusion, Saline infusion
- Where
- United States
- Sponsor
- Stanford University
Trauma, Multiple, Gun Shot Wound
A Snapshot Study of Patients Affected by Gunshot Related Injuries in Trauma in South Africa
Introduction- Gun violence represents an important cause of disability to the working age population in South Africa. It has unrecognised, but undoubtedly significant implications for the health service and patients affected by…
- Trial name
- GRIT (NCT03854591)
- Testing
- No intervention
- Where
- South Africa
- Volunteers
- 138 people
- Sponsor
- University of Cape Town
Trauma, Multiple, Coagulopathy
Use of Viscoelastic Tests in the Treatment of Traumatic Induced Coagulopathy: a Pragmatic Randomized Clinical Trial.
Trauma is the leading cause of death in young people. Trauma-induced coagulopathy (TIC) encompasses several aspects of traumatic bleeding.
- Conditions
- Trauma, Multiple, Coagulopathy, Massive Hemorrhage
- Trial name
- VISCOTRAUMA (NCT03380767)
- Testing
- Trauma-induced coagulopathy treatment
- Where
- Italy
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Critical Illness, ARDS
Replacing Protein Via Enteral Nutrition in a Stepwise Approach in Critically Ill Patients
In this study, we will explore the feasibility of a randomized controlled trial that will compare high protein dose from ICU day 6 to 14 with moderate protein intake.
- Conditions
- Critical Illness, ARDS, Septic Shock, Multiple Trauma
- Trial name
- Replenish (NCT03480555)
- Testing
- Replenish Protein, Standard protein
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- King Abdullah International Medical Research Center