Clinical trials: Transjugular Intrahepatic Portosystemic Shunt
Portal Hypertension, Liver Diseases
Achieving Portal Access With Scorpion Post-Approval Study (APASS)
Creation of the parenchymal tract between the portal vein and the hepatic vein is the most difficult and time consuming step in a TIPS procedure.
- Conditions
- Portal Hypertension, Liver Diseases, Ascites Hepatic, Hydrothorax
- Trial name
- NCT05765253
- Testing
- Scorpion Portal Vein Access Kit, Cook Transjugular Liver Access Set, Transjugular Intrahepatic Portosystemic Shunt (TIPS)
- Where
- 3 sites in United States
- Volunteers
- 3 people
- Sponsor
- Argon Medical Devices
Liver Cirrhosis
Long-term Efficacy and Safety of LSD Versus TIPS for Cirrhotic Portal Hypertension Bleeding and Hypersplenism
This study aims to compare two treatments for cirrhotic portal hypertension with acute esophagogastric variceal bleeding and hypersplenism: laparoscopic splenectomy and azygoportal disconnection (LSD) and transjugular…
- Trial name
- LSD、TIPS (NCT07490405)
- Testing
- LSD, TIPS
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Northern Jiangsu People's Hospital
Portal Hypertension, Bleeding Gastric Varices
TIPS in Fundal Variceal Bleeding (the TFB Study)
In the last years, important advances have been done in the treatment and prevention of fundal variceal bleeding in patients with cirrhosis.
- Trial name
- TFB (NCT02364297)
- Testing
- Early TIPS
- Where
- 5 sites in Spain
- Volunteers
- 60 people
- Sponsor
- Institut d'Investigacions Biomèdiques August Pi i Sunyer
Portal Hypertension, Liver Fibroses
Impact of Transjugular Intrahepatic Portosystemic Shunts on Liver Stiffness
Pilot study examining changes in liver stiffness measured by ultrasound before and after TIPS creation
- Trial name
- NCT03352882
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Pennsylvania
Cirrhosis, Liver, Hepatorenal Syndrome
HRS-AKI Treatment With TIPS in Patients With Cirrhosis
The study compares the effectiveness and safety of TIPS implantation in patients with HRS-AKI (stage1, 2 and 3) and liver cirrhosis with standard therapy (drug therapy with terlipressin + albumin).
- Conditions
- Cirrhosis, Liver, Hepatorenal Syndrome, Acute Kidney Injury, Ascites Hepatic
- Trial name
- Liver-HERO (NCT05346393)
- Testing
- TIPS, Standard of Care
- Where
- 14 sites in Germany
- Volunteers
- 124 people
- Sponsor
- Jena University Hospital
Ascites, Variceal Bleeding
VIATORR® TIPS Study Evaluating 6-10mm Diameters (VIATIPS)
This Registry will look at patients being treated with a transjugular intrahepatic portosystemic shunt (TIPS) procedure for portal hypertension.
- Conditions
- Ascites, Variceal Bleeding, Portal Hypertension Related to Cirrhosis
- Trial name
- VIATIPS (NCT07390344)
- Testing
- GORE® VIATORR® TIPS Endoprosthesis with Controlled Expansion (6-10mm)
- Where
- 3 sites in United States
- Volunteers
- 152 people
- Sponsor
- W.L.Gore & Associates
Portal Hypertension
Non-invasive Evaluation Program for TIPS and Follow Up Network 2 (NEPTUN2)
Evaluation of non-invasive prognostic parameters in patients receiving transjugular intrahepatic portosystemic shunt (TIPS) for complications of portal hypertension.
- Trial name
- NEPTUN2 (NCT04393519)
- Testing
- TIPS procedure
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Bonn
Thrombosis Portal Vein
TIPS or Anticoagulation in Portal Vein Thrombosis
The PROGRESS is an investigator-initiated, multicentre, randomized, trial comparing anticoagulation, which is the currently most frequently used treatment, alone, versus transjugular intrahepatic portosystemic shunt (TIPS)…
- Trial name
- PROGRESS (NCT03422419)
- Testing
- Heparin, TIPS
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cirrhosis, Liver
Microbiome Translocation in Different Circulatory Compartments in Decompensated Cirrhosis
Acquired dysfunctional immunity in cirrhosis predisposes patients to frequent bacterial infections contributing to disease progression and may lead to the development of acute-on-chronic liver failure (ACLF).
- Trial name
- NCT04195724
- Testing
- mNGS for pathogen detection
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Portal Hypertension Related to Cirrhosis
Small Diameter TIPS in Patients with Severe Liver Atrophy and Variceal Bleeding
Portal hypertension is the most common complication in patients with end-stage liver cirrhosis. Portal hypertension-related complications, such as variceal bleeding, often lead to a poor prognosis.
- Trial name
- NCT06589531
- Testing
- During TIPS operation, shunt diameter or diameter of covered stent
- Volunteers
- 120 people
- Sponsor
- Huang Mingsheng
Refractory Ascites
Evaluation of Hemodynamic Parameters Following Transjugular Intrahepatic Portosystemic Shunt (TIPS)
During a TIPS procedure, a shunt or stent (mesh tube) is passed down the jugular vein (the vein above the collarbone in the neck) using fluoroscopy (real time x-rays) guidance.
- Trial name
- NCT04050683
- Testing
- Study - Transjugular Intrahepatic Portosystemic Shunt (TIPS), Control - Transjugular Intrahepatic Portosystemic Shunt (TIPS)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Medical College of Wisconsin
Hepatocellular Carcinoma (HCC), TACE
DEB-TACE vs cTACE in HCC After TIPS
This is a Phase 3, open-label, multicenter, randomized controlled clinical trial designed to evaluate the efficacy and safety of Drug-Eluting Bead Transarterial Chemoembolization (DEB-TACE) compared with Conventional…
- Conditions
- Hepatocellular Carcinoma (HCC), TACE, TIPS, DEB-TACE
- Trial name
- UPGRADE (NCT07322848)
- Testing
- DEB-TACE, cTACE
- Where
- China
- Volunteers
- 206 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Hypertension, Portal, Liver Cirrhosis
Outcome After TIPS
This clinical trial is a retrospective single-centre study. Research data will be acquired via patient histories stored in the hospital data system.
- Conditions
- Hypertension, Portal, Liver Cirrhosis, Variceal Hemorrhage, Ascites Hepatic
- Trial name
- NCT03459378
- Testing
- no intervention - retrospective analyses
- Where
- Austria
- Volunteers
- 158 people
- Sponsor
- Medical University of Graz
Porto-Sinusoidal Vascular Disease, Cirrhosis Due to Hepatitis B
TIPS for Platinum-Related Porto-Sinusoidal Vascular Disease With Variceal Bleeding
Platinum-based compounds are associated with several adverse effects, including Porto-Sinusoidal Vascular Disease (PSVD). Therapeutic strategies for platinum-related PSVD are based on the management of complications seen in…
- Conditions
- Porto-Sinusoidal Vascular Disease, Cirrhosis Due to Hepatitis B, Esophageal Variceal Rebleeding, Gastric Variceal Bleeding
- Trial name
- NCT06635122
- Testing
- Transjugular intrahepatic portosystemic shunt, Endoscopic treatment
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Air Force Military Medical University, China
Cirrhosis
Feasibility of Critical Flicker Frequency Procedure for the Diagnosis of Minimal Encephalopathy
All patients eligible for TIPS (Transjugular intrahepatic portosystemic shunt) procedure will be considered for inclusion. After written inform consent, psychometric tests in order to calculate the psychometric hepatic…
- Trial name
- NCT01080144
- Testing
- Critical flicker frequency procedure
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Portal Hypertension
Austrian Registry on Transjugular Intrahepatic Portosystemic Shunts
Patients with TIPS will be recruited in this prospective registry study. The clinical course will be documented and biomarkers for prediction of complicatiosn will be assessed.
- Trial name
- AUTIPS (NCT03409263)
- Testing
- Observational study
- Where
- Austria
- Volunteers
- 400 people
- Sponsor
- Thomas Reiberger
Portal Hypertension
Clinical Study of PTFE Covered Stent for Treating Portal Hypertension
To validate the safety and efficacy of TIPS (Transjugular Intrahepatic Portosystemic Shunt) using PTFE covered stent in the treatment of portal hypertension.
- Trial name
- NCT06117735
- Testing
- Transjugular Intrahepatic Portosystemic shunt
- Where
- 4 sites in China
- Volunteers
- 177 people
- Sponsor
- Enlight Medical Technologies (Shanghai) Co., Ltd
MASLD, Liver Cirrhosis, Alcoholic
Acquisition of Cardiac Function Parameters in MRI and Echocardiography in Patients With Ethyltoxic Liver Cirrhosis and Transjugular Intrahepatic Portosystemic Shunt (TIPSS) Placement
The aim of this clinical trial is to investigate the development of cardiac decompensation following transjugular intrahepatic portosystemic shunt (TIPSS) implantation in order to draw conclusions for future treatment methods or…
- Conditions
- MASLD, Liver Cirrhosis, Alcoholic, Cirrhosis of Liver, Heart Decompensation
- Trial name
- EVALUATION (NCT06814990)
- Testing
- Cardiac MRI, Blood samples, Echocardiography
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Stephanie Gräger
Portal Hypertension
Ultrasound Elastography Assessment of Spleen and Liver Stiffness Before and After Transjugular Intrahepatic Portosystemic Shunt (TIPS) Procedure
The primary purpose of this project is to determine if acute monitoring of shunt patency via ultrasound elastography measurements of splenic stiffness before and after TIPS placement results in reduced morbidity and mortality…
- Trial name
- NCT03427164
- Testing
- Transjugular Intrahepatic Portosystemic Shunt
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Kansas Medical Center
Liver Cirrhosis
Embolization of Large Spontaneous Portosystemic Shunts for the Prevention of Post-TIPS Hepatic Encephalopathy
The purpose of this study is to determine whether transjugular intrahepatic portosystemic shunt (TIPS) combined with large spontaneous portosystemic shunts embolization are effective in the prevention of hepatic encephalopathy…
- Trial name
- NCT02156232
- Testing
- TIPS, SPSS embolization
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Air Force Military Medical University, China