Clinical trials: Transfusion Reactions
Vaccination Reaction, Hepatitis B Virus Infection
Hepatitis B Vaccination After Neonatal Surgery
At present, whether the hepatitis B vaccine (HBV) can be vaccinated on time after neonatal surgery has become a common problem for children's families, neonatal surgeons, and vaccination departments, but there are few relevant…
- Conditions
- Vaccination Reaction, Hepatitis B Virus Infection, Digestive System Disorders of Fetus and Newborn, Blood Transfusion Complication
- Trial name
- NCT06023056
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Chongqing Medical University
Multifocal Motor Neuropathy (MMN), Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Do IgG Level Variations in CIDP and MMN Patients Following Initial Intravenous IVIg Treatment Correlate With Ultimate Dosing
CIDP and MMN are part of a group of chronic inflammatory conditions that affect the peripheral nervous system. In CIDP, there is chronic inflammation of the peripheral nerves and nerve roots leading to demyelination.
- Trial name
- digG (NCT04356781)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Walton Centre NHS Foundation Trust
Spinal Metastases, Blood Transfusion Complication
The Safety and Efficacy of Autologous Transfusion in Spinal Surgery for Lung Cancer With Spinal Metastasis
The goal of this single-center prospective randomized controlled trial is to test and compare the safety and effectiveness of autologous blood transfusion in spinal surgery for lung cancer spinal metastases.
- Conditions
- Spinal Metastases, Blood Transfusion Complication, Lung Cancer, Surgery
- Trial name
- NCT06244264
- Testing
- Autoblood transfusion
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Guangdong Provincial People's Hospital
Idiopathic Scoliosis, Transfusion Reaction
Changes in Cerebral Oxygenation During the Administration of Cell Saver Blood and Allogeneic Blood
A prospective study designed to evaluate changes in tissue and cerebral oxygenation before and following administration of blood for patients undergoing spinal surgery.
- Trial name
- NCT02607150
- Testing
- Cerebral Oxygenation Changes
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Post Operative Hemorrhage, Transfusion Related Complication
Monitoring Noninvasively for Infusion and Transfusion Optimization
This is a multicenter, cluster randomized controlled trial to assess the effects of an optimized intraoperative fluid and blood management strategy on postoperative complications.
- Conditions
- Post Operative Hemorrhage, Transfusion Related Complication, Blood Transfusion Associated Adverse Reactions, Hypovolemia
- Trial name
- NCT04388722
- Testing
- Pulse CO-Oximeter Sensor
- Sponsor
- Masimo Corporation
Blood Transfusion Complication, Oxidative Stress
Study the Effect of Blood Transfusion on Oxidant-antioxidant Status in Term and Near-term Neonates
Primary aim is to evaluate the effect of blood transfusion on oxidant-antioxidant status in premature neonates. Secondary aim is to assess the effect of the age of transfused red blood cells on the biological markers of oxidative…
- Trial name
- NCT03767361
- Testing
- packed red blood cells transfusion
- Where
- Egypt
- Volunteers
- 65 people
- Sponsor
- Rania Ali El-Farrash
Blood Transfusion, Hip Fracture Surgeries
Hip Fracture Surgery Timing and Blood Transfusion Risk in Patients on DOACs
This study looks at patients with hip fractures who are taking direct oral anticoagulants (DOACs), a type of blood thinner. In many hospitals, surgery for these patients is delayed because of concerns about bleeding, but waiting…
- Conditions
- Blood Transfusion, Hip Fracture Surgeries, Geriatric, Bleeding Complications
- Trial name
- OPTIMIZEDOAC (NCT07309848)
- Where
- 7 sites in Netherlands
- Volunteers
- 374 people
- Sponsor
- St. Antonius Hospital
Transfusion Reaction, Anemia
POOLED Red Blood Cells Prepared From Pooling 5 Leukoreduced, Irradiated RBC Units
The purpose of the study is to determine the safety of pooled red blood cells (RBCs) compared to standard leukoreduced RBC products stored in additive solution.
- Trial name
- Pooled RBCs (NCT03056378)
- Testing
- Standard RBCs
- Where
- United States
- Sponsor
- New York Blood Center
Transfusion Reaction
Transfusion Associated Dyspnea Profiling
Transfusion reactions are defined as harms occurring during or after blood transfusion, with new heart/lung stress (eg. troubled breathing) regarded as cardiorespiratory transfusion reactions (CRTRs).
- Trial name
- TADPOL (NCT04267029)
- Testing
- TADPOL battery (deep clinicolaboratory profile)
- Where
- 4 sites in Canada
- Volunteers
- 151 people
- Sponsor
- Toronto Transfusion Medicine Collaborative
Transfusion-Transmitted Infection
Blood Transfusion in Patients With Lung Cancer
The main purpose of approaching the anemic patient is to provide and maintain hemoglobin levels that will allow oxygen to reach the tissue at an adequate level.
- Trial name
- NCT05590429
- Testing
- Blood transfusion
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Karadeniz Technical University
Acute Kidney Injury, Transfusion-Associated Circulatory Overload
Effects of Red Blood Cells Transfusion on Renal Blood Flow
The renal Doppler resistive index (RRI) is a noninvasive tool that has been used to assess renal perfusion in the intensive care unit (ICU) setting. It is associated with the occurrence of acute kidney injury (AKI).
- Conditions
- Acute Kidney Injury, Transfusion-Associated Circulatory Overload, Anemia, Fluid Overload
- Trial name
- NCT04194047
- Testing
- Transfusion, Crystalloids infusion
- Where
- Italy
- Volunteers
- 33 people
- Sponsor
- Università degli Studi di Ferrara
Transfusion Reaction, Transfusion Related Complication
Transfusion Surveillance in Anaesthesia
the aim of this register is to collect exhaustively the different data available surrounding a transfusion act in the context of an active haemorrhage.
- Conditions
- Transfusion Reaction, Transfusion Related Complication, Anesthesia, Anesthesia; Shock
- Trial name
- STAR (NCT06403163)
- Testing
- Transfusion
- Where
- Belgium
- Volunteers
- 50,000 people
- Sponsor
- Erasme University Hospital
Safety Issues
INTERCEPT Safety Evaluation on Whole Blood
The pathogen reduction system for whole blood using amustaline (S-303) and glutathione (GSH) hast a potential to decrease transfusion-transmitted infection.
- Trial name
- POINT1africa (NCT04020224)
- Testing
- Amustaline/GSH pathogen reduction technology, Standard of Care
- Sponsor
- Swiss Transfusion SRC
Orthopedic Disorder
Transfusion Reaction by Washed Red Blood Cell (RBC)
The hypothesis is that transfusion of washed red blood cell can decrease the complication by transfusion.
- Trial name
- NCT01934907
- Testing
- Washing of packed RBC by normal saline
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- Seoul National University Bundang Hospital
Acute Lung Injury
Transfusion-related Acute Lung Injury: a Prospective Cohort Study in Critically Ill Children
Transfusions cause more adverse events in children than in adults. Patients in pediatric intensive care units (PICU) are particularly exposed to transfusions of plasma-rich blood products (red blood cell (RBC), plasma and…
- Trial name
- TRALI (NCT02613377)
- Testing
- Blood transfusion
- Where
- 4 sites in Canada
- Volunteers
- 717 people
- Sponsor
- St. Justine's Hospital
Transfusion-associated Circulatory Overload, Blood Transfusion Reaction
TACO Crossover TRIAL
This is an open-label, prospective crossover randomized controlled trial to investigate wether TACO is solely hydrostatic pressure overload or arises from a combination of hydrostatic pressure overload and capillary leakage, by…
- Trial name
- NCT03135457
- Testing
- Autologous RBC transfusion, Saline transfusion
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Transfusion Related Acute Lung Injury
A Open Label, Post Marketing Surveillance Study Following Transfusion of INTERCEPT Platelet Components
This study is a prospective, non-randomized sequential cohort, open label, multi-center, non-inferiority, Phase IV surveillance study following transfusion of INTERCEPT PCs.
- Trial name
- PIPER (NCT02549222)
- Testing
- Standard of Care
- Where
- 15 sites in United States
- Volunteers
- 2,291 people
- Sponsor
- Cerus Corporation
Respiratory Distress Syndrome, Adult, Gastrointestinal Hemorrhage
INR-Triggered Transfusion In GI Bleeders From ER
Transfusion-related acute lung injury (TRALI) is the most common cause of transfusion-related morbidity and mortality in the United States.
- Conditions
- Respiratory Distress Syndrome, Adult, Gastrointestinal Hemorrhage, Liver Diseases, Transfusion Related Lung Injury
- Trial name
- I-TRIGER (NCT01461889)
- Testing
- Transfuse plasma to High INR target, Transfuse plasma to Low INR target
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Transfusion Reactions, Post Cardiac Surgery
Blood Conservation in Cardiac Surgery
The objective of the study is to examine the safety of two different hemoglobin (Hgb)-based transfusion triggers in patients post cardiac surgery.
- Trial name
- NCT01463345
- Testing
- Blood transfusion
- Where
- United States
- Sponsor
- Hackensack Meridian Health
Transfusion-Related Acute Lung Injury, ARDS, Human
Comparison of the Proteome in ICU Patients in Search for TRALI Biomarkers: A Case-control Study Using Both Retrospective and Prospective Samples
Transfusion-related acute lung injury (TRALI) is a severe complication of blood transfusions. After a transfusion, TRALI develops in 0.08-15% of cases depending on the characteristics of the studied population.
- Trial name
- CURIE (NCT06444750)
- Testing
- Blood sample collection
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)