Clinical trials: Transfusion Reactions
Safety Issues
INTERCEPT Safety Evaluation on Whole Blood
The pathogen reduction system for whole blood using amustaline (S-303) and glutathione (GSH) hast a potential to decrease transfusion-transmitted infection.
- Trial name
- POINT1africa (NCT04020224)
- Testing
- Amustaline/GSH pathogen reduction technology, Standard of Care
- Sponsor
- Swiss Transfusion SRC
Trauma, Blood Transfusion Complication
UltraMTP in Adult Trauma Patients Undergoing Surgery Within 24 Hours: Effects on Mortality and Clinical Outcomes
The purpose of this study is to determine the effects of ultraMTP (>/=30 units pRBC within 24 hours) in trauma patients on mortality and secondary outcomes.
- Conditions
- Trauma, Blood Transfusion Complication, Death
- Trial name
- NCT04866953
- Testing
- Blood transfusion
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- University of Southern California
Anastomotic Leak, Colorectal Neoplasms
Enhanced Recovery and Patient Blood Management in Colorectal Surgery
To prospectively study the effect of adherence to ERAS and PBM programs on early outcomes after colorectal surgery
- Conditions
- Anastomotic Leak, Colorectal Neoplasms, Blood Transfusion Complication, Colorectal Disorders
- Trial name
- iCral4 (NCT05227014)
- Testing
- Colorectal resection
- Where
- Italy
- Volunteers
- 5,000 people
- Sponsor
- Ospedale Sandro Pertini, Roma
Vaccination Reaction, Hepatitis B Virus Infection
Hepatitis B Vaccination After Neonatal Surgery
At present, whether the hepatitis B vaccine (HBV) can be vaccinated on time after neonatal surgery has become a common problem for children's families, neonatal surgeons, and vaccination departments, but there are few relevant…
- Conditions
- Vaccination Reaction, Hepatitis B Virus Infection, Digestive System Disorders of Fetus and Newborn, Blood Transfusion Complication
- Trial name
- NCT06023056
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Chongqing Medical University
Hematuria, Retention, Urinary
Anticoagulant/Antiaggregant Use and Postoperative Bleeding Risk in Patients With Bladder Tumor and Benign Prostatic Hyperplasia
Patients who were using anticoagulant or antiaggregant medications for any reason and underwent transurethral resection of bladder tumor (TUR-BT) or transurethral resection of the prostate (TURP) or open prostatectomy (OP) due to…
- Conditions
- Hematuria, Retention, Urinary, Operative Bleeding, Blood Transfusion Complication
- Trial name
- NCT05314582
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Bezmialem Vakif University
Acute Lung Injury, Transfusion Related
Role of Ascorbic Acid Infusion in Critically Ill Patients With Transfusion Related Acute Lung Injury
TRALI was defined as "acute noncardiogenic pulmonary edema typically occurs ≤ 6 hours following transfusion of plasma-containing blood products, such as packed red blood cells, fresh frozen plasma, platelets, or cryoprecipitate."…
- Trial name
- ASTRALI (NCT04153487)
- Testing
- Ascorbic Acid Injectable Product
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Damanhour University
Blood Transfusion Complication
Blood Transfusion Education Using Blended Virtual Reality and Simulation for Nursing Undergraduate Students
Nurse-administered blood transfusion (BT) is a common form of medical treatment, but nursing students are often excluded from participating in and observing BTs during clinical placements.
- Trial name
- NCT05922163
- Testing
- Evidence-based VR simulation
- Where
- Hong Kong
- Volunteers
- 151 people
- Sponsor
- The University of Hong Kong
Transfusion Reaction
Transfusion Associated Dyspnea Profiling
Transfusion reactions are defined as harms occurring during or after blood transfusion, with new heart/lung stress (eg. troubled breathing) regarded as cardiorespiratory transfusion reactions (CRTRs).
- Trial name
- TADPOL (NCT04267029)
- Testing
- TADPOL battery (deep clinicolaboratory profile)
- Where
- 4 sites in Canada
- Volunteers
- 151 people
- Sponsor
- Toronto Transfusion Medicine Collaborative
Blood Transfusion Complication
Can we Transfuse Blood Over Shorter Period ?
Blood transfusion is very lengthy procedure and consumes a substantial time from patients and health care providers. On average, it may take most if not all the working day which leads to significant constrains on hospital bed…
- Trial name
- NCT03444610
- Testing
- Blood transfusion escalation rate
- Sponsor
- King Faisal Specialist Hospital & Research Center
Transfusion-Transmitted Infection
Blood Transfusion in Patients With Lung Cancer
The main purpose of approaching the anemic patient is to provide and maintain hemoglobin levels that will allow oxygen to reach the tissue at an adequate level.
- Trial name
- NCT05590429
- Testing
- Blood transfusion
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Karadeniz Technical University
Acute Kidney Injury, Transfusion-Associated Circulatory Overload
Effects of Red Blood Cells Transfusion on Renal Blood Flow
The renal Doppler resistive index (RRI) is a noninvasive tool that has been used to assess renal perfusion in the intensive care unit (ICU) setting. It is associated with the occurrence of acute kidney injury (AKI).
- Conditions
- Acute Kidney Injury, Transfusion-Associated Circulatory Overload, Anemia, Fluid Overload
- Trial name
- NCT04194047
- Testing
- Transfusion, Crystalloids infusion
- Where
- Italy
- Volunteers
- 33 people
- Sponsor
- Università degli Studi di Ferrara
Surgery--Complications, Blood Transfusion Complication
Acute Normovolemic Hemodilution (ANH) in Patients Undergoing Cardiac Surgery
The purpose of this small randomized pilot study is to evaluate adherence to strict transfusion protocols in both the control and ANH group examining compliant and noncompliant transfusion rates and reasons for violation of the…
- Trial name
- NCT04127825
- Testing
- Acute Normovolemic Hemodilution (ANH)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Minnesota
Transfusion Reaction
ABTEST© Card Clinical Perfomance Study
The study confirms the performance equivalence of the in vitro Diagnostic reagent ABTEST card used with the new reformulated WS solution
- Trial name
- NCT05140395
- Testing
- ABTEST card
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Diagast
Bleeding, Cardiac Defect
ZEPLAST- PED: ZEro_PLASma Trial in Small Infants Undergoing Cardiac Surgery
In pediatric patients (newborns and infants weighing less than 10 kg) undergoing cardiac surgery with extracorporeal circulation postoperative bleeding represents a known complication with a significant impact on outcome.
- Conditions
- Bleeding, Cardiac Defect, Surgery--Complications, Fibrinogenopenia; Acquired
- Trial name
- ZEPLAST-PED (NCT04434001)
- Testing
- Fibrinogen Concentrate Human, Prothrombin Complex Concentrate, Fresh Frozen Plasma
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Policlinico S. Donato
Post-cardiac Surgery, Blood Transfusion Complication
Perioperative Risk Factors of Outcomes for Cardiac Surgery: A Retrospective Study
Based on a review of about 10,000 patients undergoing cardiac surgery under CPB in West China Hospital of Sichuan University and the Second Affiliated Hospital of Zhejiang University, we try to evalute the effect of blood…
- Conditions
- Post-cardiac Surgery, Blood Transfusion Complication, Prognosis
- Trial name
- NCT04980742
- Testing
- acute normovolemic hemodilution
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Post Operative Hemorrhage, Transfusion Related Complication
Monitoring Noninvasively for Infusion and Transfusion Optimization
This is a multicenter, cluster randomized controlled trial to assess the effects of an optimized intraoperative fluid and blood management strategy on postoperative complications.
- Conditions
- Post Operative Hemorrhage, Transfusion Related Complication, Blood Transfusion Associated Adverse Reactions, Hypovolemia
- Trial name
- NCT04388722
- Testing
- Pulse CO-Oximeter Sensor
- Sponsor
- Masimo Corporation
Allergy, Transfusion Reaction
Allergic Transfusion Reactions in Plasma Transfusion
Allergic transfusion reactions are a common complication of transfusion by blood components containing plasma. This study aims to investigate passive transfer of Immunoglobin E antibodies as a risk factor of allergic reactions to…
- Trial name
- NCT02200692
- Where
- Norway
- Volunteers
- 38 people
- Sponsor
- Haukeland University Hospital
Blood Transfusion Complications
Point-of-Care RBC Washing to Prevent Transfusion-Related Pulmonary Complications
This study is designed to determine if point-of-care washing of allogeneic Leukocyte-Reduced Red Blood Cells reduces pulmonary complications when compared to standard-of-care Leukocyte-Reduced Red Blood Cells in a cardiac…
- Trial name
- NCT02094118
- Testing
- Point-of-care washed red blood cell transfusion., Standard of care red blood cell transfusion.
- Where
- 2 sites in United States
- Volunteers
- 171 people
- Sponsor
- Mayo Clinic
Blood Transfusion Complication, Oxidative Stress
Study the Effect of Blood Transfusion on Oxidant-antioxidant Status in Term and Near-term Neonates
Primary aim is to evaluate the effect of blood transfusion on oxidant-antioxidant status in premature neonates. Secondary aim is to assess the effect of the age of transfused red blood cells on the biological markers of oxidative…
- Trial name
- NCT03767361
- Testing
- packed red blood cells transfusion
- Where
- Egypt
- Volunteers
- 65 people
- Sponsor
- Rania Ali El-Farrash
Transfusion-associated Circulatory Overload, Blood Transfusion Reaction
TACO Crossover TRIAL
This is an open-label, prospective crossover randomized controlled trial to investigate wether TACO is solely hydrostatic pressure overload or arises from a combination of hydrostatic pressure overload and capillary leakage, by…
- Trial name
- NCT03135457
- Testing
- Autologous RBC transfusion, Saline transfusion
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)