Clinical trials: Transferrin
Iron-deficiency Anemia
IHAT Absorption Kinetics
At MRC Human Nutrition Research, the investigators have developed an engineered analogue of the ferritin-core for safe and effective iron supplementation.
- Trial name
- NCT02498886
- Testing
- IHAT, Ferrous sulphate
- Where
- The Gambia
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Medical Research Council
Anemia of Chronic Kidney Disease
Oral Liposomal Iron Versus Injectable Iron Sucrose for Anemia Treatment in Non-Dialysis Chronic Kidney Disease Patients
This study aims to assess the comparative effects of intravenous and liposomal oral iron on hemoglobin levels in non-dialysis CKD patients.
- Trial name
- NCT06556134
- Testing
- Intravenous Iron Sucrose, Oral Iron
- Where
- Morocco
- Volunteers
- 27 people
- Sponsor
- Centre Hospitalier Hassan II - Fès
Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF)
IRONICA: IRON Repletion In Heart Failure - A Comparison of Oral and IV Approaches
The goal of this clinical trial is to learn which iron treatment works better for adults with congestive heart failure and low iron levels: intravenous (IV) iron given through a vein or oral (PO) iron taken by mouth.
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF), Heart Failure With Preserved Ejection Fraction (HFPEF), Iron Deficiency
- Trial name
- IRONICA (NCT07053475)
- Testing
- Ferric Carboxymaltose, Ferrous Sulfate
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Syed Hamza Mufarrih
Hypoferritenemia Without Anemia (HWA), Iron Deficiency Without Anemia)
Hypoferritinemia Without Anemia Among Reproductive Age Females
The goal of this randomized controlled trial is to compare the treatment outcomes of oral iron supplementation (Group A) versus Intravenous (IV) iron supplementation (Group B) versus no treatment (Group C) on the serum ferritin…
- Trial name
- NCT06437080
- Testing
- Iron III Hydroxide Polymaltose Complex eq. to Elemental Iron, 100 mg, Ferric Carboxymaltose
- Where
- 4 sites in Pakistan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Akram Medical Complex
Inflammatory Bowel Disease, Anemia
FERINJECT for Correction of Anaemia in IBD Patients, FER-IBD-COR
The purpose of this study is to determine how safe, tolerable and effective the new standardised dosage regimen of FERINJECT® infusions is, compared with a well established intravenous iron treatment.
- Conditions
- Inflammatory Bowel Disease, Anemia, Iron Deficiency, Iron-Deficiency Anemia
- Trial name
- FER-IBD-COR (NCT00810030)
- Testing
- Ferric carboxymaltose, Iron Sucrose
- Where
- Austria
- Volunteers
- 484 people
- Sponsor
- Vifor Pharma
Intensive Care (ICU), Critical Illness
Intensive Care Outcome Prediction Using Admission Carbohydrate-deficient Transferrin
The goal of this observational study is to learn whether hazardous alcohol consumption, measured objectively by carbohydrate-deficient transferrin (CDT) levels at intensive care unit (ICU) admission, is associated with worse…
- Conditions
- Intensive Care (ICU), Critical Illness, Alcohol Misuse
- Trial name
- IMPACT (NCT07632716)
- Testing
- Carbohydrate-Deficient Transferrin (CDT) Measurement
- Where
- Austria
- Volunteers
- 800 people
- Sponsor
- Medical University of Vienna
Iron Deficiency Anemia, Iron Overload
Iron Supplementation and Side Effects
The objective of this study is to examine patient-reported gastrointestinal side effects, as well as iron status indicators, inflammatory markers and oxidative stress following administration of ferrous sulfate and iron-enriched…
- Trial name
- NCT04018300
- Testing
- Ferrous sulfate, Aspiron
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Iowa State University
Iron Deficiency
Absorption, Stable Isotope Appearance and Non-transferrin-bound Iron (NTBI) Profile From NaFeEDTA and Ferrous Sulphate
Several iron compounds are used for fortification, including ferrous sulphate and NaFeEDTA. The absorption profile of these may differ because of differences in their dissolution in the gastrointestinal tract and in their…
- Trial name
- SIA (NCT01053442)
- Testing
- Porridge fortified with either NaFeEDTA, FeSO4
- Where
- Switzerland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Thrombocytosis, Iron-Deficiency Anemia
Ferinject® in Patient With Thrombocytosis Secondary to Inflammatory Bowel Disease (IBD)
The aim of this study is to show the benefits for patients, with a high platelet count, iron deficiency and IBD, receiving intravenous iron therapy.
- Trial name
- NCT00882414
- Testing
- FERINJECT® (Ferric carboxymaltose)
- Where
- Austria
- Volunteers
- 26 people
- Sponsor
- Vifor Pharma
Iron Deficiency
Iron Interventions and Non-transferrin-bound Iron (NTBI) in Women
The overall goal of this research is to develop safe and effective iron interventions that can be administered without production of plasma non-transferrin-bound iron (NTBI: iron in the systemic circulation not bound to the…
- Trial name
- NTBIwomen (NCT01404533)
- Testing
- Ferrous sulfate
- Where
- Switzerland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Healthy
Effect of Red Meat Intake on Occurrence of Serum Non-transferrin Bound Iron (NTBI)
This study aims to evaluate the effect of red meat intake on occurrence of non-transferrin bound iron (NTBI)
- Trial name
- NCT03019393
- Testing
- Beef
- Where
- Singapore
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Thomas Walczyk
Iron, Blood Level Abnormal
Duration of Red Blood Cell Storage Prior to Transfusion
This study will determine the minimal duration of red blood cell (RBC) storage that leads to increases in circulating non-transferrin-bound iron in healthy human volunteers post-transfusion.
- Trial name
- NCT02087514
- Testing
- Blood Transfusion, Packed red blood cells
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Columbia University
Center Involved Diabetic Macular Edema, Diabetic Macular Edema
Phase I Study to Assess the Safety and Efficacy of OCU200 for Center-Involved Diabetic Macular Edema (DME)
A Phase 1 study to assess the safety and efficacy of OCU200 for center-involved diabetic macular edema
- Trial name
- DME (NCT05802329)
- Testing
- OCU200
- Where
- 5 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ocugen
Retinopathy of Prematurity
Iron and Retinopathy of Prematurity (ROP)
The purpose of this study is to determine whether increased transferrin saturation in plasma (that reflects iron overload and/or low transferrin) is an independent risk factor for ROP development and severity.
- Trial name
- Fer-ROP (NCT05133999)
- Testing
- Plasma determination of iron, transferrin and ferritin, Fundus Examination by wide field digital imaging camera (PanocamTM camera)
- Where
- 3 sites in France
- Volunteers
- 175 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Congenital Atransferrinemia
Apotransferrin in Atransferrinemia
Atransferrinemia is a very rare disorder, which is caused by a deficiency of the protein transferrin. No regular treatment is available for these patients.
- Trial name
- NCT01797055
- Testing
- Human apotransferrin
- Where
- 3 sites in Germany, Italy and 1 more
- Volunteers
- 5 people
- Sponsor
- Prothya Biosolutions
Alcohol Dependence, Bipolar Disorder
Treatment of Alcohol Dependence and Comorbid Bipolar Disorder
The study will determine if individuals with co-occurring bipolar disorder and alcohol dependence report reduced alcohol consumption, improvement in mood symptoms, and cognitive performance if treated with lamotrigine plus their…
- Conditions
- Alcohol Dependence, Bipolar Disorder, Depression, Mania
- Trial name
- NCT01015586
- Testing
- Lamotrigine
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Medical University of South Carolina
Pregnancy
Iron Supplementation During Pregnancy and Non-Transferrin-Bound Iron (NTBI)
Although the essential role of iron during pregnancy is well established, concerns have been raised that current iron supplements given routinely during pregnancy may also have harmful consequences, such as increased oxidative…
- Trial name
- NTBI_pw (NCT01264042)
- Testing
- Ferrous Sulfate
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Healthy Infants
Influence of Inflammation on Micronutrient Status Assessment
Inflammation can influence several biochemical measurements those commonly used to interpret micronutrient status in children. Our primary objective is to investigate the effects of inflammation on several biochemical…
- Trial name
- NCT03801161
- Testing
- Pentavalent vaccine. It is a combination of five different antigens (Hepatitis B (HBV)/ Haemophilus influenzae type b (HiB) / Tetanus-Diphtheria-whole cell Pertussis (TDwP)).
- Where
- 2 sites in Bangladesh
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Iron Deficiency
Malaria and the Safety of Iron Supplements and Iron Fortification
The primary study hypothesis of the investigators is that administration of an iron supplement between meals at a dose like that used in the Pemba trial (~1 mg Fe/kg) during P.
- Trial name
- MIA (NCT01156896)
- Testing
- Ferrous sulfate
- Where
- Thailand
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Columbia University
Iron Deficiency
Iron Replacement in Blood Donors
Blood donors who have a low fingerstick hemoglobin level are usually deferred from donating. A possible solution to the problem of repeated deferrals might be for Blood Banks to offer donors with low hemoglobin levels oral iron…
- Trial name
- NCT00327067
- Where
- United States
- Volunteers
- 1,820 people
- Sponsor
- National Institutes of Health Clinical Center (CC)