Clinical trials: Transfemoral Amputation
Amputation, Transfemoral Amputation
Transfemoral Osseointegrated Prosthesis Limb-Load Symmetry Training
This randomized controlled trial (n=25 enrolled, n=15 expected to complete) will 1) determine the feasibility of a 40-week limb-load biofeedback training intervention, 2) determine if there is an intervention signal of efficacy…
- Conditions
- Amputation, Transfemoral Amputation, Osseointegration
- Trial name
- TOPLOAD (NCT05695911)
- Testing
- Limb Load Biofeedback Training Intervention, Attention Control
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Colorado, Denver
Unilateral Transfemoral Amputation in Prosthetic Users
Impact of Anterior Load Carriage on Gait in Individuals With Transfemoral Amputation
This monocentric prospective crossover study aims to evaluate the impact of anterior load carriage on gait performance in individuals with unilateral transfemoral amputation using a prosthesis.
- Trial name
- LOAD TF (NCT07875634)
- Testing
- Anterior Load Carriage During Walking
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Institut Robert Merle d'aubigné
Transfemoral Amputation, Limb Loss
Effect of a Microprocessor-controlled Prosthetic Knee Joint on K2 Level Ambulators
Microprocessor-controlled knees (MPKs) automatically adjust resistance or damping in the joint to improve swing- and/or stance-phase control as appropriate for the prosthesis user during gait.
- Conditions
- Transfemoral Amputation, Limb Loss, Limb Absence
- Trial name
- MPK-K2 (NCT07103798)
- Testing
- College Park ICON, Conventional NMPK
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Transfemoral Amputation
An Osseointegrated Transfemoral Prosthesis Offering Long-Term Bi-Directional Efferent-Afferent Neural Transmission
The purpose of the study is to investigate the clinical and functional outcomes of a transfemoral amputation with osseointegrated titanium implant, AMI muscle constructs, and implanted electrodes in the domain of gait, free space…
- Trial name
- NCT07615465
- Testing
- MIT Powered Knee Prosthesis
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Massachusetts Institute of Technology
Transfemoral Amputation, Limb Loss
A Biomechanical Evaluation of the Ossur Power Knee in Persons With Transfemoral Amputation
Microprocessor-controlled knees (MPKs) do not typically utilize motors to power joint rotation, but they automatically adjust resistance or damping in the joint to improve swing- and/or stance-phase control as appropriate for the…
- Conditions
- Transfemoral Amputation, Limb Loss, Limb Absence
- Trial name
- OPKTFA (NCT06218238)
- Testing
- Powered prosthetic knee joint, Conventional microprocessor-controlled prosthetic knee joint
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Transfemoral Amputation
Assessment of Strength, Balance, and Function in Above-Knee Amputees in Relation to Residual Limb Length
The goal of this observational study is to learn how muscle strength, balance, and functional ability are affected in people with above-knee (transfemoral) amputations.
- Trial name
- NCT07032233
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Ceren Kuzu
Unilateral Transfemoral Amputation
A Comparison Between Ischial-Containment and Sub-Ischial Prosthetic Sockets to Determine Their Effects on Secondary Health Conditions
Long-term above-knee prosthesis users are at an increased risk of developing secondary musculoskeletal conditions compared to the general able-bodied population.
- Trial name
- NCT07768072
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Transfemoral Amputation, Balance Impairment
Effect of Dual-Task Training on Balance and Fall Risk in Lower Limb Amputees Using Prosthesis
This prospective randomized controlled trial aims to investigate the effect of dual-task training on balance and fall risk in individuals with unilateral transfemoral amputation using a prosthesis.
- Conditions
- Transfemoral Amputation, Balance Impairment, Fall Risk
- Trial name
- DTBALANCE (NCT07731698)
- Testing
- Dual-task training, Conventional Physiotherapy
- Where
- Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- Kafrelsheikh University
Diabetes Mellitus, Transfemoral Amputation
Effectiveness of an Inpatient Rehabilitation and Prosthetic Training Model in Patients With Vascular and Metabolic Transfemoral Amputation
Patients with vascular and metabolic transfemoral amputations experience substantial functional limitations and high rates of prosthetic abandonment.
- Conditions
- Diabetes Mellitus, Transfemoral Amputation, Peripheral Arterial Disease, Vascular Thrombosis
- Trial name
- NCT07665775
- Where
- Mexico
- Volunteers
- 54 people
- Sponsor
- Instituto Nacional de Rehabilitacion
Transfemoral Amputation
Towards Efficient Personalization of Computerized Lower Limb Prostheses Via Reinforcement Learning in a Clinical Setup - Group 1
The goal of this clinical trial is to understand the feasibility and effectiveness of using reinforcement learning to personalize robotic prosthetic legs (an experimental prototype) for unilateral transfemoral amputees.
- Trial name
- NCT07204925
- Testing
- RISE guided personalization of prosthetic legs by tuning experts, RISE guided personalization of prosthetic legs by prosthetists, Manual personalization of the prosthetic leg by tuning experts
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- North Carolina State University
Transtibial Amputation, Transfemoral Amputation
Improving Socket Fit in Female and Male Veterans With Transtibial and Transfemoral Amputation
The investigators do not yet know how a prosthetic socket with adjustable panels affects the performance of people with a lower limb amputation compared to a conventional prosthetic socket.
- Trial name
- SocketFit (NCT05989243)
- Testing
- Conventional prosthetic socket, Adjustable Quatro socket
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Traumatic Transfemoral Amputation, Painful Bone Spur
Efficacy of Extracorporeal Shockwave Therapy on Painful Bone Spur in Traumatic Transfemoral Amputees
Painful bone spur is one of the causes of residual limb pain in individuals with traumatic lower extremity amputation and can be a significant problem in rehabilitation clinics.
- Trial name
- NCT07440550
- Testing
- Extracorporeal shockwave therapy (ESWT), Therapeutic exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Transfemoral Amputation
Metabolic Cost of Walking With Passive vs. Powered Prosthetic Knees Among Persons With Limb Loss
The purpose of this industry-initiated research study is to test that a powered microprocessor controlled knee improves metabolic function during walking in level and sloped conditions as compared to the subject's physician…
- Trial name
- NCT05831696
- Testing
- Powered Microprocessor-controlled Knee (PMPK)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Loma Linda University
Amputation, Transfemoral Amputation
Investigation on a New Power Knee Firmware Update on Gait and Daily Life Activities for Transfemoral Amputees
The goal of this interventional study is to investigate a new firmware in development for Power Knee on gait and daily life activities in unilateral transfemoral amputees.
- Trial name
- NCT06620861
- Testing
- Power Knee Firmware Update, Power Knee Current Marketed Firmware
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Össur Iceland ehf
Transfemoral Amputation
Sub-Ischial Socket for Transfemoral Amputation and Lower Mobility
The objective of this trial is to assess use and benefits of the subischial socket for persons with transfemoral amputation and lower mobility levels.
- Trial name
- NCT05662982
- Testing
- Northwestern University Flexible Subischial Suction Socket (NU-FlexSIS)
- Where
- 3 sites in United States
- Volunteers
- 84 people
- Sponsor
- University of Washington
Transfemoral Amputation
Active Knee Prosthesis Study
The purpose of the study is to investigate the clinical and functional outcomes of a powered knee prosthesis for people with a transfemoral amputation in the domain of gait, free space control, and embodiment
- Trial name
- NCT06700668
- Testing
- MIT Powered Knee
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts Institute of Technology
Transfemoral Amputation
Evaluation of a Neural-Controlled Powered Prosthesis Across Diverse Real-World Tasks
The purpose of this study is to evaluate the performance and adaptability of a neural-controlled powered knee or ankle prosthesis across diverse real-world mobility tasks.
- Trial name
- NCT07204912
- Testing
- MIT Powered Leg
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts Institute of Technology
Unilateral Transfemoral Amputation, Unilateral Knee Disarticulation
Real-time Motion Capture and Visual Feedback for Amputation Gait Training
People with transfemoral amputation face challenges such as gait asymmetry, instability, and increased energy consumption due to loss of the knee joint.
- Trial name
- NCT07049198
- Testing
- Real-time 2D motion capture and visual feedback system gait training, Conventional physical therapy group
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Yang Ming Chiao Tung University
Transfemoral Amputation
Personalizing MPK Prescription
In current clinical prosthetic practice, there is no evidence based method for selecting a microprocessor knee (MPK) joint for a patient with an above the knee amputation.
- Trial name
- NCT06399471
- Testing
- Microprocessor prosthetic knee
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Georgia Institute of Technology
Transfemoral Amputation, Amputation
Aerofit Post Market Investigation
The goal of this clinical investigation is to evaluate the clinical benefits of a ventilating suspension interface for individuals with transfemoral amputation.
- Conditions
- Transfemoral Amputation, Amputation, Skin Health
- Trial name
- NCT05925712
- Testing
- AeroFit Seal-In Liner / Socket, Seal-In Silicone Liner
- Where
- 7 sites in United States
- Volunteers
- 56 people
- Sponsor
- Össur Iceland ehf