Clinical trials: Transcriptomic Profiling
Advanced / Metastic Solid Tumors, Glioblastoma
Profiling Program of Cancer Patients With Sequential Tumor and Liquid Biopsies (PLANET)
The proposal is to conduct a prospective, multi-cohort study aiming to decipher molecular profiles/biological characteristics of advanced cancer patients during the course of their disease with longitudinal and sequential…
- Conditions
- Advanced / Metastic Solid Tumors, Glioblastoma, Chronic Leukemia Lymphocytic
- Trial name
- PLANET (NCT05099068)
- Testing
- Blood and tumor samples
- Where
- 2 sites in France
- Volunteers
- 500 people
- Sponsor
- Centre Leon Berard
Melanoma
Profiling of Circulating Immune Cells to Uncover Response Signatures to Anti-PD1 Immunotherapy in Melanoma Patients
Despite being standard of care, there are still many medical requirements related to immune checkpoint blocker based therapies such as identify patients susceptible to respond with the less adverse events, evaluate the clinical…
- Trial name
- PHENOMENAL (NCT06154668)
- Where
- France
- Volunteers
- 707 people
- Sponsor
- University Hospital, Grenoble
Nephrotic Syndrome Steroid-Dependent, Nephrotic Syndrome Steroid-Resistant
Biomarkers and Outcome Predictors of Pediatric Nephrotic Syndrome: A Genetic, Transcriptomic, and Secretome Multiomics Study
Idiopathic Nephrotic Syndrome is a rare disease of the kidneys, which typically affects children. For most affected children there is the need of a prolonged treatment with drugs reducing the activity of the immune system, also…
- Conditions
- Nephrotic Syndrome Steroid-Dependent, Nephrotic Syndrome Steroid-Resistant, Nephrotic Syndrome in Children, Glomerulonephritis
- Trial name
- PRECISE (NCT06792448)
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Brest Cancer, Lung Cancer (NSCLC)
The CCANED-CIPHER Study: Early Cancer Detection and Treatment Response Monitoring Using AI-Based Platelet and Immune Cell Transcriptomic Profiling
The purpose of the CCANED-CIPHER study is to develop and validate an AI-based blood test for early cancer detection and to monitor treatment effectiveness in cancer patients.
- Conditions
- Brest Cancer, Lung Cancer (NSCLC), Pancreatic Cancer, Adult, Prostate Cancers
- Trial name
- CCANED-CIPHER (NCT06717295)
- Testing
- DiNanoQ: A multi-cancer early detection (MCED) blood test, DiNanoTrack: Therapeutic Response Monitoring Blood Test
- Where
- 4 sites in Argentina, Nigeria and 1 more
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Javier Toledo
Contact Dermatitis, Contact Dermatitis Irritant
Molecular Diagnosis of Allergic Contact Dermatitis
Allergic contact dermatitis (ACD) is a common inflammatory skin disease, affecting approximately 15-20% of the general population in industrialized countries and ranking first among occupational diseases in many European…
- Conditions
- Contact Dermatitis, Contact Dermatitis Irritant, Contact Dermatitis, Allergic
- Trial name
- MODAL (NCT06177314)
- Testing
- correlate the molecular signatures of active lesions of contact dermatitis with allergological results
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Hospices Civils de Lyon
Trauma, Inflammation
Transcriptomic Profiling in Severely Injured Patients
Discovery of differences in the host response in patients with systemic inflammation and sepsis, and identification of novel, specific markers by using a longitudinal clinico-transcriptomic approach.
- Conditions
- Trauma, Inflammation, Sepsis
- Trial name
- NCT02508272
- Where
- Switzerland
- Volunteers
- 115 people
- Sponsor
- University of Zurich
Alzheimer Disease, Early-Onset
Examining Neuroinflammation in AlzHeimer's
Alzheimer disease (AD) is a neurodegenerative disorder with a poorly understood pathology. It is an irreversible progressive brain disease that slowly deteriorates memory, thinking and behavior.
- Trial name
- ENHANCE (NCT03548883)
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- AdventHealth
Malignant Tumor With Metastasis, CUP
Evaluating the Predictive Capability of Transcriptomic Profiling for Identifying the Primary Site of Metastatic Tumors
This study will enroll patients with metastatic malignancies. Tumor samples (fresh or formalin-fixed paraffin-embedded tissue specimens) will undergo RNA extraction and next-generation sequencing (RNA-seq).
- Trial name
- NCT07319949
- Volunteers
- 30 people
- Sponsor
- Fudan University
PCOS (Polycystic Ovary Syndrome), Cumulus Cell
Transcriptomic Profiling of Cumulus Cells From CAPA-IVM
Capacitation in vitro maturation (CAPA-IVM) has improved oocyte maturation and resulted in live births. Because cumulus cells (CCs) communicate bidirectionally with the oocyte, their transcriptomic profile may serve as a…
- Conditions
- PCOS (Polycystic Ovary Syndrome), Cumulus Cell, Capacitation IVM, Transcriptomic Profiling
- Trial name
- NCT07197255
- Where
- Vietnam
- Volunteers
- 10 people
- Sponsor
- Mỹ Đức Hospital
Breast Neoplasms
Development of a Multi-omics Prediction Model for Immunotherapy Response in Triple-Negative Breast Cancer Subtypes
This study aims to collect clinical samples from breast cancer patients who have undergone or are expected to undergo immunotherapy at our institution.
- Trial name
- NCT06833723
- Testing
- Retrospective Data Collection and Analysis
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences
Enteric Fever, Acute Febrile Illness
Transcriptomic Responses for the Identification of Pathogens
Acute undifferentiated febrile infection (AUFI) is a common presenting syndrome in low-resource settings and better diagnostics are urgently needed to improve patient management and guide disease prevention interventions.
- Conditions
- Enteric Fever, Acute Febrile Illness, Typhoid, Paratyphoid Fever
- Trial name
- TRiP (NCT04878549)
- Testing
- 5-gene transcription signature
- Where
- India
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Sheffield
Metastatic Pancreatic Cancer, Advanced Pancreatic Cancer
Profiling Program of Advanced/Metastatic Pancreatic Cancer Patients
The proposal is to implement a molecular screening program for advanced/metastatic pancreatic cancer patients before the initiation of 1st line treatment in order to allow a better selection of patients for rationale personalized…
- Trial name
- NCT05380414
- Testing
- Tumor samples (archival FFPE and optional de novo biopsy) and blood samples
- Where
- France
- Volunteers
- 750 people
- Sponsor
- Centre Leon Berard
MASLD, T2DM (Type 2 Diabetes Mellitus)
Non-Invasive MASLD Diagnosis & T2D Remission Biomarkers
The goal of this observational study is to prospectively develop and validate a non-invasive scoring system based on metabolic markers, proteomic, and transcriptomic profiles to accurately screen, diagnose, stage, and monitor…
- Conditions
- MASLD, T2DM (Type 2 Diabetes Mellitus), Non-alcoholic Fatty Liver Disease (NAFLD), Obesity
- Trial name
- ENSURE-MASLD (NCT07172997)
- Testing
- Bariatric Surgery
- Where
- 2 sites in Bahrain
- Volunteers
- 163 people
- Sponsor
- Royal College of Surgeons in Ireland - Medical University of Bahrain
Periodontis, Aggressive Periodontitis
Single-cell and Spatial Transcriptomic Profiling of Gingival Tissues in Aggressive and Chronic Periodontitis: Deciphering Cellular Heterogeneity and Inflammatory Microenvironment Features
The goal of this observational study is to investigate cellular heterogeneity and inflammatory microenvironment features in gingival tissues from patients with aggressive periodontitis compared to chronic periodontitis and…
- Trial name
- NCT07487272
- Where
- China
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine