Clinical trials: Transcriptome
Heart Failure, Aortic Stenosis
Heart Failure and Aortic Stenosis Transcriptome
This study is aimed to investigate the global transcriptome in order to determine the expression profile of messenger RNAs (mRNAs), as well as long noncoding- (lncRNAs) and micro noncoding-RNAs (miRNAs) in heart failure (HF) and…
- Trial name
- RNA-HF-AS (NCT03268135)
- Testing
- measurement of RNAs
- Where
- 2 sites in Italy
- Volunteers
- 500 people
- Sponsor
- IRCCS Policlinico S. Donato
Sepsis, Acute Respiratory Distress Syndrome
A Validation Study on a Prognostic Prediction Model for Respiratory Tract Infections
This study adopted a prospective, single-center, open-label design, aiming to evaluate the efficacy of the RTI clinical outcome prediction model in predicting clinical outcomes in subjects with acute respiratory tract infections.
- Conditions
- Sepsis, Acute Respiratory Distress Syndrome, Community Acquired Pneumonia, Transcriptome
- Trial name
- NCT07109310
- Testing
- RTImodel001
- Volunteers
- 150 people
- Sponsor
- Peking Union Medical College Hospital
Lung Neoplasms, Lung Cancer, Nonsmall Cell
Therapeutic ResistAnce and Clonal Evolution Assessed With Liquid Biopsy in ICIs Treated NSCLC Patients
To evaluate the predictive value of ctDNA in response, relapse for patients treated with immune checkpoint inhibitors or targeted therapy for ALK, ROS1, MET ex14 skipping.
- Conditions
- Lung Neoplasms, Lung Cancer, Nonsmall Cell, Adenocarcinoma of Lung, Squamous Cell Lung Cancer
- Trial name
- NCT04566432
- Testing
- Observation
- Where
- China
- Volunteers
- 252 people
- Sponsor
- Geneplus-Beijing Co. Ltd.
Polymyositis, Dermatomyositis
myoARRAY and TcLandscape Analysis for the Diagnosis of Inflammatory Myopathies
The diagnosis of the different forms of inflammatory myopathies (polymyositis, dermatomyositis, inclusion-body myositis...) remains difficult which may lead to unappropriate patient care.
- Trial name
- MYOARRAY (NCT00213629)
- Testing
- transcriptome analysis, T cell repertoire analysis
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Rouen
Atopy, Atopic Dermatitis Eczema
Breast Milk: Influence of the Micro-transcriptome Profile on Atopy in Children Over Time
This is an observational cohort study of 221 breast-feeding mother-infant dyads delivered at term. The goal of the study is to investigate whether levels of immune-related microRNAs (miRNAs) in maternal breast milk (MBM)…
- Conditions
- Atopy, Atopic Dermatitis Eczema, Wheezing, Food Allergy in Infants
- Trial name
- IMPACT (NCT04017520)
- Where
- United States
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Malaria
Trajectories and Mechanisms of Recovery From Malaria: An Observational Study
This observational research study aims to answer the question: 'Which aspects of human biology play an important role in recovery from symptomatic malaria?' In particular, the researchers aim to identify human genes for which the…
- Trial name
- SCRIPT (NCT05149157)
- Testing
- Symptomatic malaria
- Where
- United Kingdom
- Volunteers
- 240 people
- Sponsor
- Imperial College London
Primary Liver Cancer, Hepatocellular Carcinoma
Therapeutic ResistAnce and Clonal Evolution Assessed With Liquid Biopsy in ICIs Treated Primary Liver Cancer
To evaluate the predictive value of ctDNA in response, relapse for liver cancer patients treated with immune checkpoint inhibitors
- Conditions
- Primary Liver Cancer, Hepatocellular Carcinoma, Intrahepatic Cholangiocarcinoma, Combined Hepatocellular-cholangiocarcinoma
- Trial name
- NCT05292443
- Testing
- Observation
- Where
- 5 sites in China
- Sponsor
- Geneplus-Beijing Co. Ltd.
Childhood Obesity, Morbid Obesity
Whole Transcriptome Profiling and Metabolic Phenotyping in Children With ROHHAD Syndrome
Rapid onset Obesity, Hypoventilation, Hypothalamic dysfunction and Autonomic Dysregulation (ROHHAD) is a syndrome named in 2007. The hallmark of the syndrome is the rapid onset obesity and dysregulation of central ventilation.
- Trial name
- NCT02602769
- Testing
- Transcriptome profiling
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Columbia University
Giant Cell Arteritis, Polymyalgia Rheumatica
Assessing Biomarker in Giant Cell Arteritis and Polymyalgia Rheumatic
The GCAIO study is an innovative, multimodal research initiative designed to enhance the understanding, diagnosis, and management of giant cell arteritis (GCA) and frequently associated polymyalgia rheumatica (PMR).
- Trial name
- GCAIO (NCT06460142)
- Testing
- Aortic/ cardiac magnetic resonance imaging, Vascular ultrasound, Transorbital Ultrasound
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Rare Cancer
Treatment Guided by Comprehensive Genome and Transcriptome Analysis Versus Standard of Care in Advanced Rare Cancers
Rare cancers, defined by an incidence of fewer than 6 cases per 100,000 persons per year, constitute nearly 25% of adult malignancies.
- Trial name
- RATIONALE (NCT06855134)
- Where
- 16 sites in Germany
- Volunteers
- 946 people
- Sponsor
- German Cancer Research Center
Colo-rectal Cancer
Total Neoadjuvant Treatment Without Surgery For Locally Advanced Rectal Cancer
NO-CUT is a one-stage phase II trial seeking to establish whether an oxaliplatin-based chemotherapy preceding standard neo-adjuvant fluoropyrimidines-based chemo radiotherapy, can safely spare demolitive surgical intervention in…
- Trial name
- NO-CUT (NCT03565029)
- Testing
- XELOX, Radiotherapy
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Niguarda Hospital
Non Hodgkin Lymphoma
A Single-cell Transcriptome Study in Patients With Non-Hodgkin's Lymphoma
Using single-cell RNA sequencing, this study will explore the heterogeneity of lymphoma inside and outside the lymph node, identify tumor specific molecular markers and cell subgroups, explore the differences in tumor…
- Trial name
- NCT04434833
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Ruijin Hospital
Central Nervous System Lymphoma
Study of Tissue Samples From Patients With Glioma or Other Brain Tumors
RATIONALE: Studying the genes expressed in samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00967200
- Testing
- laboratory biomarker analysis, pharmacogenomic studies
- Where
- 2 sites in France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Montpellier
Neuroendocrine Tumors, Pancreatic Neuroendocrine Tumors
Prospective Comprehensive Molecular Profiling In Neuroendocrine Tumors
Prospective study to obtain fresh tumor biopsies and three blood samples from patients with a confirmed histological or cytological diagnosis of well-differentiated neuroendocrine tumors (NETs) or well-differentiated pancreatic…
- Trial name
- NET-SEQ (NCT02586844)
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- University Health Network, Toronto
Tumor Tissues and Non-tumor Tissues From PDAC Patients Were Used for Genomic and Transcriptome Sequencing Analysis and Proteomics and Phosphorylated Proteomics
Integrative Proteomic Characterization of Pancreatic Ductal Adenocarcinoma
A large-scale, high-throughput, multi-dimensional comprehensive study of PDAC multiomics will be carried out. In this study, clinical specimens of resected PDAC collected by our research group from 2017 to 2019 will be selected…
- Trial name
- NCT04525209
- Testing
- No intervention
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Ruijin Hospital
Basal Cell Carcinomas
Transcriptomic Analysis and Optical Coherence Tomography Combined for Patients With Basal Cell Carcinoma
The goal of this observational study is to learn if tape strip for transcriptomic (RNA) analysis and optical coherence tomography (OCT) combined can optimize noninvasive management of basal cell carcinoma (BCC) patients.
- Trial name
- RNA-OCT-BCC (NCT06813833)
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Bispebjerg Hospital
MASH - Metabolic Dysfunction-Associated Steatohepatitis
High-Risk Transcriptome Molecular Prediction Study of MASH-Associated Colorectal Polyps
The goal of this observational study is to learn about the molecular characteristics of colorectal polyps in patients with metabolic dysfunction-associated steatohepatitis (MASH) compared to individuals without fatty liver, and…
- Trial name
- NCT07463287
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai East Hospital
Systemic Lupus Erythematosus
Transcriptional and Immune Parameters of Response to Belimumab
The investigators propose to perform RNA-sequencing of the whole blood initially, in a cohort of 80 SLE patients who will receive belimumab as part of standard clinical practice, in order to assess intra-patient longitudinal…
- Trial name
- NCT04570306
- Testing
- Belimumab
- Where
- Greece
- Volunteers
- 85 people
- Sponsor
- Biomedical Research Foundation, Academy of Athens
Erythema Migrans
Inflammatory Mediators in Erythema Migrans
The main objective of this study is to characterize the inflammatory proteins, gene polymorphisms, and transcriptome profiles in patients with erythema migrans to gain better insight into pathogenesis of early Lyme borreliosis…
- Trial name
- NCT03956212
- Testing
- Doxycycline 7 days, Doxycycline 14 days
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Ljubljana
Lung Cancer
Salivary Biomarkers for Non-small Cell Lung Cancer Detection
The investigators plan to recruit patients for a prospective study in patients in need of evaluation for lung lesions suspicious for cancer.
- Trial name
- NCT02294578
- Where
- 2 sites in United States
- Volunteers
- 166 people
- Sponsor
- PeriRx