Clinical trials: Tranexamic Acid Use
Knee Osteoarthritis
Safety of Use and Efficacy of Pandora for Patients Suffering From Gonarthrosis (PANDORA2)
The knee osteoarthritis is a frequent degenerative condition that mainly affects subjects over 60, population often weakened by numerous comorbidities and concomitant treatments, justifying the development of new therapies.
- Trial name
- PANDORA2 (NCT05978180)
- Testing
- Medical Device : HO-1, Medical Device : HS-3, Medical Device : SINOVIAL® ONE
- Where
- 35 sites in France, Monaco
- Volunteers
- 252 people
- Sponsor
- Labrha
Bariatric Surgery, Bariatric Patients
BAR-TAX - Tranexamic Acid in Bariatric Surgery.
Perioperative bleeding is a relevant complication in bariatric surgery and may lead to hemoglobin decrease, blood transfusions, reinterventions, prolonged hospital stay, and increased healthcare costs.
- Conditions
- Bariatric Surgery, Bariatric Patients, Bariatric Surgery Complications, Bleeding
- Trial name
- BAR-TAX (NCT07401394)
- Testing
- Tranexamic Acid (TXA)
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Santa Maria Hospital - GVM Care & Research
Abortion, Dilation and Evacuation
Tranexamic Acid for Second Trimester Dilation and Evacuation and Bleeding Outcomes
Although procedural abortion in the second trimester is extremely safe, hemorrhage is one of the leading causes of morbidity and mortality.
- Conditions
- Abortion, Dilation and Evacuation, Hemorrhage, Prophylactic Tranexamic Acid Use
- Trial name
- NCT06820177
- Testing
- Tranexamic Acid
- Where
- 3 sites in United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Hip Fracture, Anemia
IV Iron in Association With Tranexamic Acid for Hip Fracture
It is a prospective randomized controlled study aiming to test if tranexamic acid combined to intravenous iron before and after surgery for hip fracture in elderly can decrease peri-operative red cell transfusion.
- Trial name
- NCT02428868
- Testing
- tranexamic acid (Exacyl®), intravenous iron (Ferroven®), Saline
- Where
- Tunisia
- Volunteers
- 150 people
- Sponsor
- Institut Kassab d'Orthopédie
Spinal Stenosis, Intervertebral Disc Displacement
Tranexamic Acid in Reducing Gross Hemorrhage and Transfusions of Spine Surgeries
Multilevel decompression and bone graft fusion is a most effective measure for treating degenerative lumbar spinal diseases. Yet, the surgery is commonly associated with large amount of perioperative blood loss and high demand…
- Trial name
- TARGETS (NCT03011866)
- Testing
- Wound topically irrigated with 500mg TXA, 1mg/kg/hr TXA intravenous infusion till the last suture
- Volunteers
- 176 people
- Sponsor
- Peking Union Medical College Hospital
Subconjunctival Hemorrhage
Topical Tranexamic Acid After Intravitreal Injections
We aim to investigate whether topical administration of Tranexamic acid can reduce the occurence of subconjunctival hemorrahge after routine intravitreal injections for retinal conditions.
- Trial name
- NCT04400916
- Testing
- Tranexamic acid, Balanced Salt Solution
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Knee Osteoarthritis, Blood Loss
Extended Postoperative Oral Tranexamic Acid in Knee Replacement
A comparison of outcomes between use of oral tranexamic acid as compared to oral placebo in the first days after total knee replacement will be made to determine impact on clinical indications and patient reported outcomes.
- Conditions
- Knee Osteoarthritis, Blood Loss, Pain, Postoperative
- Trial name
- NCT05099276
- Testing
- Tranexamic Acid Pill
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Campbell Clinic
Arteriovenous Fistula
Use of Topical Tranexamic Acid and Bacitracin in Dialysis Patients
This study will investigate how the use of Tranexamic acid and Bacitracin applied to the bleeding site after the hemodialysis fistula needle is removed will affect Time to Clot and Infection Rate
- Trial name
- NCT02106962
- Testing
- Topical Tranexamic Acid 5% with bacitracin, Topical Tranexamic Acid 25% with bacitracin
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- California Institute of Renal Research
Tranexamic Acid, Blood Loss, Surgical
Do Anesthesiologists Follow Guidelines on Perioperative Use of Tranexamic Acid?
Tranexamic acid has been used to reduce bleeding and transfusion for years. Randomized studies showed its efficacity in orthopedic surgery, trauma and post-partum hemorrhage.
- Conditions
- Tranexamic Acid, Blood Loss, Surgical, Blood Transfusion
- Trial name
- Periop_TXA (NCT05783648)
- Testing
- Use of tranexamic acid
- Where
- Belgium
- Volunteers
- 1,726 people
- Sponsor
- Erasme University Hospital
Uterine Fibroid, Myoma;Uterus
INTERVENTION WITH TRANEXAMIC ACID TO REDUCE HAEMORRHAGE DURING LAPAROSCOPIC MYOMECTOMY
This research is planned as a randomised double-blind controlled trial. interventions to reduce haemorrhage during laparoscopic myomectomy for fiboids is important.
- Conditions
- Uterine Fibroid, Myoma;Uterus, Tranexamic Acid Adverse Reaction
- Trial name
- NCT04192643
- Testing
- Tranexamic Acid 100 MG/ML
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alkü Alanya Education and Research Hospital
Drug Use
A Randomized Comparison of Two Doses of Tranexamic Acid in Open-Heart Surgery
Perioperative bleeding during cardiac surgery is associated with a higher incidence of reoperation and blood transfusion leading to an increase in morbidity and mortality. Coagulopathy is a major cause of excessive bleeding.
- Trial name
- NCT04996368
- Testing
- Tranexamic acid injection
- Where
- Nepal
- Volunteers
- 120 people
- Sponsor
- Shahid Gangalal National Heart Centre
Bleeding, Transfusion Related Complication
Use of Transexamic Acid in Hip Replacement
Studies have shown that tranexamic acid reduces blood loss and transfusion need in patients undergoing total hip arthroplasty. However, no to date, no study has been large enough to determine definitively whether the drug is safe…
- Trial name
- NCT02587845
- Testing
- Tranexamic Acid (IV), Tranexamic Acid (Topical)
- Where
- South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Breast Cancer, Blood Loss, Surgical
Role of TXA in Patients Undergoing Breast Free Flap Reconstruction
Tranexamic acid (TXA) is a synthetic, competitive lysine receptor inhibitor on plasminogen. It ultimately stabilizes the fibrin matrix, therefore used as a hemostatic agent for various indications.
- Trial name
- NCT06428682
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Virginia
Colon Neoplasm
Tranexamic Acid During Colonic Endoscopic Resection Procedures
Colonoscopy with polypectomy reduces the incidence and mortality associated with colon cancer. However, polypectomy is associated with adverse events such as bleeding.
- Trial name
- NCT05345613
- Testing
- Tranexamic acid, Standard
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Assaf-Harofeh Medical Center
Injection Site Bruising
Use of Tranexamic Acid in Facial Fillers
The overall purpose of this study is to evaluate the safety and efficacy of co-administration of tranexamic acid (TXA) with hyaluronic acid (HA) in reducing swelling, bruising and pain after facial injection.
- Trial name
- NCT04373603
- Testing
- Tranexamic acid, Saline, Hyaluronic acid
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Pain, Postoperative, Bruising
Use of Tranexamic Acid in Blepharoplasties
The goal of this investigation is to assess whether or not there is a significant difference in the presence and/or degree of post-operative ecchymosis, pain, and edema between groups of patients undergoing upper lid…
- Trial name
- NCT04724772
- Testing
- Tranexamic acid injection
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwestern University
Seroma Complicating A Procedure, Hematoma Postoperative
SEroma Reduction pOst MAstectomy "SEROMA Study"
This is a pilot study to evaluate the feasibility of conducting a larger trial to determine if the use of intraoperative topical tranexamic acid (TXA) decreases the rate of post-operative hematomas and seromas in breast cancer…
- Conditions
- Seroma Complicating A Procedure, Hematoma Postoperative, Breast Cancer
- Trial name
- SEROMA (NCT03738527)
- Testing
- Tranexamic Acid 100mg/mL, 20mL topical, Normal Saline Flush, 0.9%, 20mL topical
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Hamilton Health Sciences Corporation
Postpartum Hemorrhage, Vaginal Delivery
Prophylactic Tranexamic Acid Use After Vaginal Delivery
In this study, our aim was to evaluate the effectiveness of prophylactic tranexamic acid use after vaginal delivery in pregnant women aged 18-45 years and 34-42 weeks according to the risk of postpartum hemorrhage.
- Conditions
- Postpartum Hemorrhage, Vaginal Delivery, Prophylactic Tranexamic Acid Use
- Trial name
- NCT05429580
- Testing
- Tranexamic acid, 5% Dextrose
- Where
- Turkey (Türkiye)
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Femur Surgery
The Use of Tranexamic Acid (TXA) Intravenously, to Reduce Blood Loss in Proximal Femur Surgery
The use of Tranexamic Acid (TXA) intravenously, to Reduce Blood Loss in proximal femur surgery.
- Trial name
- NCT02164565
- Testing
- Tranexamic Acid (TXA) treatment, control grup: without Tranexamic Acid (TXA) treatment.
- Where
- Israel
- Sponsor
- HaEmek Medical Center, Israel
Intracerebral Haemorrhage, Stroke
STOP-AUST: The Spot Sign and Tranexamic Acid On Preventing ICH Growth - AUStralasia Trial
The aim of the study is to test if intracerebral haemorrhage (ICH) patients who have contrast extravasation on computed tomography angiography, the "spot sign", have lower rates of haematoma growth when treated with tranexamic…
- Trial name
- STOP-AUST (NCT01702636)
- Testing
- Tranexamic Acid
- Where
- 11 sites in Australia, Finland
- Volunteers
- 100 people
- Sponsor
- Neuroscience Trials Australia