Clinical trials: Tractography
Cervical Spine Herniation
Diffusion Tensor (Magnetic Resonance) Imaging and Tractography in Herniation of the Cervical Spine
This is an investigator-iniated pilot study to determine if MRI with diffusion tensor imaging (DTI) and tractography will yield useful information in patients suspected of having cervical spine disc herniation to provide imaging…
- Trial name
- NCT00599183
- Testing
- MRI-Diffusion Tensor Imaging and Tractrography
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Cedars-Sinai Medical Center
ACL Injury, MRI
Evaluation of Anterior Cruciate Ligament Tears Using Diffusion Tractography
Knees injuries commonly affect the ACL. French current methodology is based on MRI focused on the knee with morphological sequences (T1, DP fat sat) allowing the study of ACL as follows: No lesion / Partial tear / Complete tear.
- Conditions
- ACL Injury, MRI, Tractography
- Trial name
- TRACTOLCA (NCT05806034)
- Testing
- tractography MRI sequence protocol
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Treatment Resistant Depression, Undergoing Deep Brain Stimulation (DBS) Surgery
Tractography Guided Subcallosal Cingulate Deep Brain Stimulation for Treatment Resistant Depression
Treatment resistant depression remains a major problem for individuals and society. Surgical procedures may provide relief for some of these patients.
- Trial name
- NCT03952962
- Testing
- Abbott Laboratories Infinity™ implantable deep brain stimulation system
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Nader Pouratian
Brain Damage, Chronic, Cerebellar Cognitive Affective Syndrome
DTI & Tractography in Pediatric Tumor Surgery
The goal of this project will be to demonstrate that Synaptive Medical's Diffusion Tensor Imaging(DTI) product functionality used in pre-operative planning and intraoperative surgical navigation, improves clinical outcomes…
- Conditions
- Brain Damage, Chronic, Cerebellar Cognitive Affective Syndrome, Cerebellar Mutism
- Trial name
- NCT02810626
- Testing
- BrightMatter™ products
- Volunteers
- 24 people
- Sponsor
- London Health Sciences Centre
Cranial Nerve Palsy
Cranial Nerves Tractography
Introduction: The skull base tumors surgery remains a challenge since numerous cranial nerves or vessels closely surround them. Recently, diffusion tensor imaging has developed with the tractography following white fibers and…
- Trial name
- CN Tracto (NCT02978911)
- Testing
- preoperative cerebral MRI and operative findings
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Hospices Civils de Lyon
Diffusion Tensor Imaging, Tractography
Diffusion-tensor Imaging in Brain Tumors Evaluation
Primary and secondary brain tumors are challenging pathologies regarding diagnosis and treatment. MRI is widely used in the imaging evaluation and surgical planning, due to its spatial resolution and ability of tissular…
- Conditions
- Diffusion Tensor Imaging, Tractography, MRI
- Trial name
- NCT05261724
- Testing
- MRI
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures
Neurological Diseases
In Vivo and ex Vivo Validation of MR Tractography of Brain White Matter Tracts - FIBRATLAS II-III
White matter tracts connect cortical areas to other parts of the cortex, to basal ganglia and to the brain stem and spinal cord. These tracts form the internal part of the brain and transmit the nervous impulses.
- Trial name
- FIBRATLAS (NCT02455284)
- Testing
- MRI
- Where
- 7 sites in France
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Essential Tremor, Deep Brain Stimulation
Multicentre RCT of Awake Versus Asleep Tractography Based DBS for ET
Rationale: Deep brain stimulation (DBS) of the thalamus is an effective surgical treatment for patients with disabling essential tremor, despite optimal pharmacological treatment.
- Conditions
- Essential Tremor, Deep Brain Stimulation, Diffusion Tensor Imaging, Magnetic Resonance
- Trial name
- TREMBLE (NCT05968976)
- Testing
- Awake DBS, Asleep DBS
- Where
- Netherlands
- Volunteers
- 110 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Parotid Tumor
Intra-parotid Facial Nerve Tractography
The aim of the study is to evaluate concordance between the facial nerve's path in the parotid evaluated by radiologist in preoperatively and the facial nerve's path in the parotid evaluated by surgeon in peroperatively.
- Trial name
- R-PO19053 (NCT03950323)
- Testing
- MRI with Facial nerve tractography
- Where
- France
- Volunteers
- 40 people
- Sponsor
- CHU de Reims
Knee Osteoarthritis
Magnetic Resonance Imaging Diffusion Tensor Tractography for Early Osteoarthritis Assessment
The aim of this study is the evaluation of new MRI tractography maps for early knee osteoarthritis assessment.
- Trial name
- TRACTILAGE (NCT03181425)
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Grenoble
Malignant Brain Tumor
Evaluation of the Contribution of NODDI Protocol Tractography in Brain Tumor Surgery
The objective of this study is to evaluate to what extent the capacity of the NODDI model can allow, in case of Malignant brain tumor patients with vasogenic edema, the elaboration of a reliable cerebral functional mapping in…
- Trial name
- NODDI-TRACT (NCT05669326)
- Testing
- NODDI TRACT
- Where
- France
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Parkinson Disease
Advancing Pre-operative Targeting for Deep Brain Stimulation in the Globus Pallidus Internus
In the proposed pilot project, MRI data will be prospectively collected to show the feasibility of the segmentation algorithm and the potential relation to final lead positioning.
- Trial name
- NCT03600740
- Testing
- DBS Programming
- Where
- 3 sites in United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Neuralgia Arnold
Cryoneurolysis of Arnold's Nerve and Follow-up by Tractography: Feasibility Study
According to the World Health Organization (WHO), headaches are one of the most common nervous system disorders. The therapeutic strategy is well established for certain subcategories of headache.
- Trial name
- CRYOARNOLD (NCT03735914)
- Testing
- MRI
- Where
- France
- Volunteers
- 1 people
- Sponsor
- University Hospital, Grenoble
Head and Neck Neoplasms, Congenital Abnormalities
3D Modeling of the Cervico-facial Region and Cranial Nerve Tractography: IMAG 2 ORL Project
3D modeling associated with the tracking of nerve fibers meets the needs of preoperative planning for tumors and cervico-facial congenital malformations.
- Trial name
- IMAG 2 ORL (NCT05763615)
- Testing
- Tractography MRI
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Brain (Nervous System) Cancers, Glioma
Connectome-guided Onco-functional Resection With Tractography-Extended Neuronavigation in Brain Tumor Surgery
Brain tumor surgery in so-called "eloquent" brain areas aims to remove as much tumor as possible while preserving neurological functions.
- Conditions
- Brain (Nervous System) Cancers, Glioma, Brain Metastasases, Brain Connectivity
- Trial name
- CORTEx (NCT07717827)
- Testing
- Connectome-guided network-based neuronavigation, Advanced diffusion MRI tractography and connectome pipeline
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- ARNAS Civico Di Cristina Benfratelli Hospital
Brain Tumor, Brain Pathology
Can we Use Resting-state fMRI and CSD Fiber Tractography for Presurgical Mapping?
This prospective study aims to investigate and validate the use of resting-state functional MRI (rs-fMRI) and high angular resolution diffusion imaging (HARDI), specifically constrained spherical deconvolution (CSD) tractography…
- Conditions
- Brain Tumor, Brain Pathology, Epilepsy, Vascular Malformations, Brain
- Trial name
- NCT06040580
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Spinal Cord Injury
The Effects of Anti-oxidants on Clinical Outcomes and Radiological Features of Chronic Spinal Cord Injury: A Pilot Study
This study will enroll 10 adults with a chronic spinal cord injury. The investigators will image their damaged motor tracts using MRI tractography scanning, and the investigators will formally assess their ASIA motor level at the…
- Trial name
- NCT01904591
- Testing
- Selenium, Vitamin E
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- McMaster University
Obsessive-Compulsive Disorder
Deep-brain Stimulation in Obsessive-compulsive Disorder: Randomized, Double-blinded Clinical Trial
A prospective, randomized, double-blinded study was conducted in 7 OCD patients during which 4 electrode contacts along a striatal axis were stimulated bilaterally.
- Trial name
- 10/131 (NCT03217123)
- Testing
- Deep Brain stimulation
- Volunteers
- 7 people
- Sponsor
- Hospital San Carlos, Madrid
Essential Tremor
3-D Tractography FUS Ablation for Essential Tremor
The investigators propose to advance Vim-FUSA (Ventral Intermediate Nucleus - Focused Ultrasound Ablation) with the support of 3-D tractography, a neuroimaging technique to visually represent nerve tracts within the brain.
- Trial name
- NCT06331052
- Testing
- MR-guided Focused Ultrasound Ablation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of North Carolina, Chapel Hill
Temporal Lobe Epilepsy
Application of Diffusion Tensor Imaging and Tractography in Epilepsy Surgery
Using Synaptive Medical's BrightMatter™ products to better visualize and plan epilepsy surgeries by considering white matter tracts, and considering whether the technology results in improved clinical outcomes.
- Trial name
- NCT02590419
- Testing
- BrightMatter™ products
- Volunteers
- 40 people
- Sponsor
- Andrew Parrent