Clinical trials: Tracheobronchitis
Ventilator Associated Pneumonia, Respiratory Infection
Aerosolized Antibiotics and Respiratory Tract Infection in Patients on Mechanical Ventilation
The purpose of this study was to determine the effect of aerosolized antibiotics on respiratory infection in mechanically ventilated patients.We hypothesize that aerosolized antibiotics , which achieve high drug concentrations in…
- Conditions
- Ventilator Associated Pneumonia, Respiratory Infection, Tracheobronchitis
- Trial name
- NCT00396578
- Testing
- aerosolized vancomycin or gentamicin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Stony Brook University
Incidence of VAT
International Multicenter Study of Ventilator Associated Tracheobronchitis.
Justification and background Ventilator-associated complications (VACs) are those complications that develop during a period of intubation of a patient .
- Trial name
- TAVeM (NCT01791530)
- Where
- 8 sites in Argentina, Bolivia and 6 more
- Volunteers
- 3,000 people
- Sponsor
- Corporacion Parc Tauli
Multi-drug Resistant Gram-negative Bacilli Colonization
Multidrug Resistant Gram-negative Bacilli Colonization and Infection in Burn
This is a prospective observational study to determine the role of colonization and identify the timing of development of drug resistance in multidrug resistant Gram-negative bacilli (MDR-GNB) causing infection among critically…
- Trial name
- NCT02653157
- Testing
- MDR-GNB
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of North Carolina, Chapel Hill
Pneumonia, Blood Stream Infection
Optimizing Clinical Use of Polymyxin B
Polymyxin B is already being used extensively in the USA and other parts of the world; its use is likely to rapidly increase due to the greater burden of infections caused by MDR Gram-negative bacteria and the growing awareness…
- Conditions
- Pneumonia, Blood Stream Infection, Urinary Tract Infections, Respiratory Tract Infection (Including Tracheobronchitis)
- Trial name
- NCT02682355
- Where
- 6 sites in United States, Brazil and 1 more
- Volunteers
- 155 people
- Sponsor
- Rutgers, The State University of New Jersey
Airway Colonization, Tracheobronchitis and Pneumonia Associated With Ventilator
Ventilator Associated Tracheobronchitis in the First 14 Days in ICU
To investigate the clinical course and risk factors for VAT and the impact of VAT on Intensive Care Unit (ICU) morbidity and mortality.
- Trial name
- NCT01802827
- Volunteers
- 236 people
- Sponsor
- University of Thessaly
Respiratory Tract Infections
Evaluation of the Treatment With Klacid SR in Patients With Acute Tracheitis, Tracheobronchitis and Bronchitis, Acute Exacerbation of Chronic Bronchitis and Mild Community-acquired Pneumonia in Common Clinical Practice in Ukraine
To describe the relief of symptoms, tolerability, and compliance of treatment with Klacid® sustained release (SR) at a dose of 1000 mg once daily in patients with acute tracheitis, acute tracheobronchitis, acute bronchitis, or in…
- Trial name
- KLARAINE (NCT01095978)
- Testing
- Clarithromycin (Klacid SR)
- Where
- 126 sites in Ukraine
- Volunteers
- 2,822 people
- Sponsor
- Abbott
Invasive Pulmonary Aspergillosis, Morality
Clinical and Prognostic Comparisons Between Invasive Pulmonary Aspergillosis With or Without Invasive Tracheobronchitis During Severe Influenza: a Retrospective Multicenter Cohort Study.
Invasive tracheobronchial aspergillosis (ITBA) is an uncommon, but severe clinical form of Invasive Pulmonary Aspergillosis (IPA) in which the fungal infection is entirely or predominantly confined to the tracheobronchial tree.
- Trial name
- ITBA (NCT04077697)
- Testing
- RT-PCR for influenza
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Mechanical Ventilation Complication, Critical Illness
Antimicrobial Treatment in Patients With Ventilator-associated Tracheobronchitis
Antimicrobial treatment could be beneficial in patients with ventilator-associated tracheobronchitis (VAT). The hypothesis of this study is that antibiotic treatment for VAT (3 or 7 days), compared with no antibiotic treatment…
- Trial name
- TAVeM2 (NCT03012360)
- Testing
- ceftriaxone, ciprofloxacin, imipenem
- Where
- France
- Volunteers
- 103 people
- Sponsor
- University Hospital, Lille
Severe COVID-19
COVID-19 and VA-LRTI: Second Versus First Wave of the Pandemic
Multicenter observational retrospective cohort study aiming at comparing the incidence of ventilator-associated lower respiratory tract infections between COVID-19 patients from the first and the second wave of the pandemic.
- Trial name
- CoVAPid2 (NCT05256511)
- Where
- France
- Sponsor
- University Hospital, Lille
Tracheitis, Tracheobronchitis
Evaluation of the Treatment With Klacid®SR in Patients With Lower Respiratory Tract Infection
The aim of this post-marketing observational study (PMOS) is to describe the relief of symptoms, tolerability and compliance of treatment with Klacid®SR in a dose 1000 mg once daily in patients with lower respiratory tract…
- Conditions
- Tracheitis, Tracheobronchitis, Bronchitis, Chronic Bronchitis
- Trial name
- NCT01108185
- Where
- 158 sites in Slovakia
- Volunteers
- 3,181 people
- Sponsor
- Abbott
Respiratory Infection, Bacterial Resistance
Reduction of Bacterial Resistance With Inhaled Antibiotics in the Intensive Care Unit
The purpose of this study was : to determine the effect of inhaled antibiotics on airway bacteria in ventilated patients to determine the effect of inhaled antibiotics on respiratory infection
- Conditions
- Respiratory Infection, Bacterial Resistance, Respiratory Failure
- Trial name
- NCT01878643
- Testing
- vancomycin or gentamicin
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Stony Brook University
Ventilator Associated Tracheobronchitis, Tracheobronchitis
Ventilator-associated Tracheobronchitis Initiative to Conduct Antibiotic Evaluation
The Ventilator Associated tracheobronchitis Initiative to Conduct Antibiotic evaluation (VATICAN) trial is a national, multicenter, non-inferiority trial in ICU patients comparing antibiotic treatment for 7 days versus clinical…
- Trial name
- VATICAN (NCT05266066)
- Testing
- Clinical observation without antibiotic therapy for VAT, 7 day antibiotic course for VAT
- Where
- 16 sites in Brazil
- Volunteers
- 590 people
- Sponsor
- Hospital Sirio-Libanes
Tracheobronchitis
Antibiotic Treatment in Ventilator Associated Tracheobronchitis (VAT)
Mechanically Ventilated patients in the intensive care unit (ICU) often present with fever, and purulent sputum, but without radiological evidence of pneumonia. These patients may have tracheobronchitis.
- Trial name
- NCT01027832
- Testing
- Piperacillin/Tazobactam for 7 days
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center
Ventilator Associated Pneumonia
Efficacy Study of Colistimethate Sodium Inhalation in Patients With Ventilator-associated Pneumonia
There might be additional benefit on clinical outcomes from adjunctive colistimethate sodium inhalation as therapy for multidrug resistant Gram-negative ventilator-associated pneumonia.
- Trial name
- NCT01975350
- Where
- Taiwan
- Volunteers
- 49 people
- Sponsor
- National Taiwan University Hospital
Ventilator-Associated Pneumonia, Tracheobronchitis
CT Scan and Lung Ultrasonography to Improve Diagnostic of Ventilation Acquired Pneumonia in ICU
We aim to show that systematic ultrasonography performed in ventilated patients suspected of ventilation-acquired pneumonia could improve the accuracy of diagnostic of pneumonia, and helps defining the diagnostic of…
- Trial name
- ECTOPICUS (NCT03018431)
- Testing
- CT Scan
- Where
- 2 sites in France
- Volunteers
- 160 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Upper Respiratory Tract Infection, Acute Tracheobronchitis
A Registry Study of 100 Thousand Cases of Pediatric Patients on Reduning Injection（a Chinese Medicine Injection）Used in Hospitals in China
This study was advocated by Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences in February 2018.
- Trial name
- NCT03461692
- Testing
- patients under 14 years of age using Reduning injeciton
- Volunteers
- 100,000 people
- Sponsor
- China Academy of Chinese Medical Sciences
Nosocomial Infection, Nosocomial Pneumonia
Mechanical Insufflation-exsufflation and Hypertonic Saline in Nosocomial Bacterial Respiratory Tract Infection
Multicenter, randomized open label clinical trial to evaluate IEM and HS as concomitant therapy for respiratory tract infection in patients under artificial ventilation in the ICU.
- Conditions
- Nosocomial Infection, Nosocomial Pneumonia, Tracheobronchitis, Mechanical Ventilation Complication
- Trial name
- ABSENTA (NCT06310941)
- Testing
- Mechanical insufflation-exsufflation, Standard of Care, Hypertonic saline with hyaluronic acid
- Where
- 8 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Hospital San Carlos, Madrid
Tracheobronchitis, Herpes Simplex Infection
Bronchoscopic Score for Prediction of Herpes Simplex-virus Type 1 (HSV-1) Reactivation
Tracheobronchial reactivation of HSV-1 is a common finding in critically ill patients and is associated with longer intensive care unit (ICU) stay and mechanical ventilation.
- Trial name
- NCT05331417
- Testing
- Patients with herpes-simplex infection requiring bronchoscopy
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University Hospital Muenster
Ventilator Associated Pneumonia, Tracheobronchitis
A Multi-Center Diagnostic Stewardship Program to Improve Respiratory Culture Utilization in Critically Ill Children
The objective of this study is to evaluate implementation of diagnostic stewardship programs as a strategy to safely reduce antibiotic use, and to generate evidence and tools to support dissemination of diagnostic stewardship…
- Trial name
- BrighT STAR (NCT04987840)
- Where
- 8 sites in United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Ventilator Associated Pneumonia, Prevention
Nebulized Aztreonam for Prevention of Gram Negative Ventilator-associated Pneumonia
Aerosol antibiotic administration offers the theoretical advantages of achieving high drug concentration at the infection site and low systemic absorption, thereby avoiding toxicity.
- Conditions
- Ventilator Associated Pneumonia, Prevention, Respiratory Infection Other
- Trial name
- AZLIS (NCT03749226)
- Testing
- Aztreonam lysine, Aerogen Solo, CombiHaler
- Where
- Spain
- Volunteers
- 9 people
- Sponsor
- Hospital Universitari Joan XXIII de Tarragona.