Clinical trials: Toxicity Due to Radiotherapy
Toxicity Due to Radiotherapy
Supplementation With Dietary Anthocyanins and Side Effects of Radiotherapy for Breast Cancer
Attention has been focused recently on the development of modalities that can protect healthy organs from the harmful effects of radiation applied during different cancer treatment schedules.
- Trial name
- ATHENA (NCT02195960)
- Testing
- intake anthocyanin-rich corn extract
- Where
- Italy
- Volunteers
- 242 people
- Sponsor
- Neuromed IRCCS
Cancer, Radiotherapy Side Effect
Attribution of Toxicities Due to Radiotherapy and Immuno-Biological Therapies
Every year, new molecular agents enter the market with more and more patients receiving these treatments, especially in the metastatic setting.
- Trial name
- AtTRIBut (NCT04115267)
- Testing
- Radiotherapy
- Where
- Canada
- Volunteers
- 3,600 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cancer Induced Bone Pain, Secondary Malignant Neoplasm of Bone
Thermal Testing in Bone Pain (TiBoP)
If cancer spreads to bones it can be very painful, especially when trying to move around. One of the best treatments is radiotherapy, which has to be given in a cancer centre.
- Conditions
- Cancer Induced Bone Pain, Secondary Malignant Neoplasm of Bone, Toxicity Due to Radiotherapy, Pain
- Trial name
- TiBoP (NCT02887833)
- Testing
- Clinical biomarker (thermal sensory testing)
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- University of Edinburgh
Cancer, Fertility Issues
Impact of Gonadotoxic Therapies on Fertility
The goal of this observational study is to learn how gonadotoxic treatments (chemotherapies, radiotherapies or immunotherapies) affect the fertility status of participants with cancer.
- Conditions
- Cancer, Fertility Issues, Fertility Preservation, Toxicity Due to Chemotherapy
- Trial name
- FertiTOX (NCT05885048)
- Testing
- Blood samples for analysis, Sperm samples for analysis, Satisfaction evaluation
- Where
- Switzerland
- Volunteers
- 7,000 people
- Sponsor
- Michael von Wolff
Post-surgery Radiotherapy
Mepitel Film Treatment for the Prevention and Cutaneous Toxicity Due to Radiotherapy
This is a randomized study, mepitel vs standard of care for the prevention and skin toxicity due to radiotherapy in patients with post-surgery breast cancer.
- Trial name
- NCT02741258
- Testing
- Mepitel Film, skin cream
- Where
- 2 sites in Switzerland
- Volunteers
- 164 people
- Sponsor
- Dario Valcarenghi
Radiation Toxicity, Xerostomia Due to Radiotherapy
Mesenchymal Stem Cells for Radiation-induced Xerostomia
A prospective study for long-term follow-up (LTFU) to evaluate safety and efficacy in subjects who participated in the Phase 1/2 randomized placebo-controlled trial MESRIX.
- Conditions
- Radiation Toxicity, Xerostomia Due to Radiotherapy, Dry Mouth, Hyposalivation
- Trial name
- NCT03876197
- Testing
- Autologous adipose-derived mesenchymal stem/stromal cells
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Colorectal Adenocarcinoma, Oesogastric
Cardiovascular Events From Trifluridine/Tipiracil +/- Oxaliplatin in Colorectal/Oesogastric Adenocarcinoma Patients
The purpose of this study is to assess the incidence of cardiovascular events in patients with esophageal/stomach or colorectal cancer treated by trifluridine/tipiracil +/- oxaliplatin after an episode of cardiac angina-related…
- Trial name
- NCT04894123
- Testing
- Trifluridine/Tipiracil, Oxaliplatin
- Where
- 11 sites in France
- Volunteers
- 1 people
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
NSCLC, NSCLC, Stage I
A Study of BIO 300 and Thoracic Radiation Therapy in People With Non-Small Cell Lung Cancer and Interstitial Lung Disease
The purpose of this study to find out whether giving BIO 300 in combination with thoracic radiation therapy is effective in preventing pneumonitis in people with non-small cell lung cancer (NSCLC) and interstitial lung disease…
- Conditions
- NSCLC, NSCLC, Stage I, NSCLC Stage II, Non Small Cell Lung Cancer
- Trial name
- NCT07323732
- Testing
- BIO 300
- Where
- 7 sites in United States
- Volunteers
- 25 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Oral Mucositis Due to Radiation
A Sequential Cohort Study Exploring GELCLAIR in the Management of Oral Mucositis in Patients Receiving Radical Radiation for Head and Neck Cancer
The goal of this clinical trial is to learn if Gelclair lubricant gel can help manage Oral Mucositis (OM) among Oropharyngeal and Oral cavity cancer patients receiving radiation treatment.
- Trial name
- GOMS (NCT06897215)
- Testing
- Hyaluronic acid hydrogel
- Volunteers
- 48 people
- Sponsor
- Nova Scotia Health Authority
Prostate Neoplasms, Toxicity Due to Radiotherapy
Prostate Cancer Stereotactic Radiotherapy
Primary purpose of the study is to develop a stereotactic radiation treatment (RT) to prostate cancer which minimizes treatment related toxicity.
- Trial name
- ESKO (NCT02319239)
- Testing
- Fractionation, hypofractionated, stereotactic fractionation
- Where
- Finland
- Volunteers
- 80 people
- Sponsor
- Tampere University Hospital
Rectal Cancer, Radiotherapy
IMRT Versus 3DCRT for Locally Advanced Rectal Cancer, Prospective Phase II Study.
The goal of this prospective phase II study was to determine whether personalized planning-based nCRT for LARC would indeed decrease small bowel dose, and whether selected plans, specifically prioritizing lower dose to small…
- Conditions
- Rectal Cancer, Radiotherapy, Toxicity Due to Radiotherapy
- Trial name
- NCT06160570
- Testing
- Intensive Modulated Radiation Therapy, 3-Dimension Conformal Radiation Therapy
- Where
- Israel
- Volunteers
- 75 people
- Sponsor
- Rabin Medical Center
Cervical Cancer, Toxicity Due to Radiotherapy
Evaluation of Postoperative Radiotherapy and Concurrent Chemotherapy Effectiveness in Cervical Cancer
The present study is a randomized, control, phase II/III study of early stage (FIGO Ia2-IIb) cervical cancer after radical hysterectomy in Northwest China treated with radiotherapy or concurrent chemoradiotherapy based on the…
- Trial name
- NCT01999933
- Testing
- Radiation, cisplatin（DDP） weekly, docetaxel plus cisplatin
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Mei Shi
Prostate Cancer, Metastasis
Targeted Radiotherapy in Androgen-suppressed Prostate Cancer Patients.
This multi-center, phase II trial will be conducted in men with castration resistant prostate cancer. The aim of the TRAP trial is to test whether a new precise radiotherapy technique called stereotactic body radiotherapy (SBRT)…
- Conditions
- Prostate Cancer, Metastasis, Toxicity Due to Radiotherapy, Circulating Tumour DNA
- Trial name
- TRAP (NCT03644303)
- Testing
- SBRT + ADT
- Where
- 7 sites in United Kingdom
- Volunteers
- 86 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Nasopharyngeal Carcinoma, Head and Neck Cancer
The Association of hsCRP and Radiotherapy-Induced Toxicity in Patients With Nasopharyngeal Carcinoma
The primary purpose of this study is to explore the association of high sensitivity C-reactive protein (hsCRP) and radiotherapy(RT)-induced toxicity in patients with nasopharyngeal carcinoma.
- Conditions
- Nasopharyngeal Carcinoma, Head and Neck Cancer, Toxicity Due to Radiotherapy
- Trial name
- NCT04303975
- Testing
- clinical measurements
- Volunteers
- 300 people
- Sponsor
- Jiarong Chen, MD
Nasopharyngeal Squamous Cell Carcinoma, Toxicity Due to Radiotherapy
GP VS TP in the Treatment of Advanced Nasopharyngeal Carcinoma in Northwest China
The present study is a randomized, control, phase II study of locally advanced nasopharyngeal carcinoma (NPC) in Northwest China treated with Gemcitabine plus cisplatin regimen (GP) or Docetaxel plus cisplatin regimen (TP)…
- Trial name
- NCT01596868
- Testing
- gemcitabine and cisplatin, docetaxel and cisplatin
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Air Force Military Medical University, China
Head and Neck Cancer (H&N), Oral Mucositis (Ulcerative) Due to Radiation
Oral Care Program for Mouth Side Effects During Head and Neck Radiation Therapy
People having radiation therapy to the head and neck often develop painful mouth problems - mouth sores, dry mouth, mouth pain, trouble eating and drinking, and changes in taste.
- Conditions
- Head and Neck Cancer (H&N), Oral Mucositis (Ulcerative) Due to Radiation, Stomatitis (Oral Mucositis), Xerostomia Due to Radiotherapy
- Trial name
- OSEM (NCT07885033)
- Testing
- ORAL CARE PRODUCT KIT
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- UNCANCER LLC
Cardiotoxicity, Risk Factor, Cardiovascular
Risk-Guided Cardioprotection With Carvedilol in Breast Cancer Patients Treated With Doxorubicin and/or Trastuzumab
Investigators will evaluate the safety, tolerability, and feasibility of a risk-guided cardioprotective treatment strategy with carvedilol, as compared to usual care, in breast cancer patients undergoing treatment with…
- Conditions
- Cardiotoxicity, Risk Factor, Cardiovascular, Toxicity Due to Chemotherapy, Breast Cancer
- Trial name
- CCTGuide Pilot (NCT04023110)
- Testing
- Carvedilol
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Prostate Cancer
Cross-linked Hyaluronan Gel Reduces Rectal Toxicity Due to Radiation Therapy for Prostate Cancer
The primary purpose of this study is to determine if cross-linked hyaluronan gel reduces the dose of radiation delivered to the rectum and the rectal toxicity of radiotherapy for localized prostate cancer.
- Trial name
- NCT00882232
- Testing
- Cross-linked hyaluronan gel
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Cancer Center of Irvine
Toxicity Due to Radiotherapy, Nasopharyngeal Carcinoma
Clincal Study of Reduced Target Radiotherapy in Nasopharyngeal Carcinoma
To determine whether subtractive radiotherapy can significantly reduce the acute side effects of radiotherapy and improve the quality of life of patients on the basis of ensuring the existing curative effect.
- Trial name
- NCT05741008
- Testing
- Target range
- Where
- China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Toxicity Due to Radiotherapy, Breast Cancer
REBECCA Study (RadiothErapy for BrEast Cancer and CArdiotoxicity)
The purpose of this study is to determine whether a new technique of radiotherapy for breast cancer (helical tomotherapy) can induce cardiac toxicity that would be detected in the first two years after treatment.
- Conditions
- Toxicity Due to Radiotherapy, Breast Cancer, Lesion; Cardiac
- Trial name
- REBECCA (NCT02079272)
- Testing
- Helical tomotherapy for breast cancer
- Where
- France
- Sponsor
- Sophie JACOB