Clinical trials: Toxicity Due to Chemotherapy
Gastrointestinal Cancers, Frailty
Longitudinal Geriatric Vulnerability, Chemotherapy Toxicity, and Functional Outcomes in Older Adults With Gastrointestinal Cancer
Older adults with gastrointestinal cancers may be more likely to experience side effects from chemotherapy and difficulties with everyday activities. These problems are not always explained by age alone.
- Conditions
- Gastrointestinal Cancers, Frailty, Sarcopenia in Elderly, Malnutrition Elderly
- Trial name
- VITAL-GI (NCT07184047)
- Testing
- Standard-of-Care Systemic Chemotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 132 people
- Sponsor
- Ankara Etlik City Hospital
Cancer, Fertility Issues
Impact of Gonadotoxic Therapies on Fertility
The goal of this observational study is to learn how gonadotoxic treatments (chemotherapies, radiotherapies or immunotherapies) affect the fertility status of participants with cancer.
- Conditions
- Cancer, Fertility Issues, Fertility Preservation, Toxicity Due to Chemotherapy
- Trial name
- FertiTOX (NCT05885048)
- Testing
- Blood samples for analysis, Sperm samples for analysis, Satisfaction evaluation
- Where
- Switzerland
- Volunteers
- 7,000 people
- Sponsor
- Michael von Wolff
Cancer, Toxicity Due to Chemotherapy
Co-treatment With GnRH Analogs on the Ovarian Reserve in Young Women Treated With Alkylating Agents for Cancer
The purpose of this study is to determine the efficacy of a temporary ovarian suppression obtained by administration of a gonadotropin releasing hormone agonist during alkylating agents containing chemotherapy on ovarian reserve…
- Conditions
- Cancer, Toxicity Due to Chemotherapy, Sarcoma, Osteosarcoma
- Trial name
- PRESOV (NCT02856048)
- Testing
- Triptorelin (GnRHa) + Chemotherapy
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Colorectal Adenocarcinoma, Oesogastric
Cardiovascular Events From Trifluridine/Tipiracil +/- Oxaliplatin in Colorectal/Oesogastric Adenocarcinoma Patients
The purpose of this study is to assess the incidence of cardiovascular events in patients with esophageal/stomach or colorectal cancer treated by trifluridine/tipiracil +/- oxaliplatin after an episode of cardiac angina-related…
- Trial name
- NCT04894123
- Testing
- Trifluridine/Tipiracil, Oxaliplatin
- Where
- 11 sites in France
- Volunteers
- 1 people
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Breast Neoplasms, Colorectal Neoplasms
Limiting Chemotherapy Side Effects by Using Moxa
This study investigates whether it is feasible to teach cancer patients undergoing chemotherapy to self-administer daily moxibustion to reduce chemotherapy side effects.
- Conditions
- Breast Neoplasms, Colorectal Neoplasms, Genital Neoplasms, Female, Toxicity Due to Chemotherapy
- Trial name
- NCT02781155
- Testing
- Moxibustion
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- East and North Hertfordshire NHS Trust
Cervical Cancer, Toxicity Due to Radiotherapy
Evaluation of Postoperative Radiotherapy and Concurrent Chemotherapy Effectiveness in Cervical Cancer
The present study is a randomized, control, phase II/III study of early stage (FIGO Ia2-IIb) cervical cancer after radical hysterectomy in Northwest China treated with radiotherapy or concurrent chemoradiotherapy based on the…
- Trial name
- NCT01999933
- Testing
- Radiation, cisplatin（DDP） weekly, docetaxel plus cisplatin
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Mei Shi
Peripheral Neuropathy, Toxicity Due to Chemotherapy
Acupuncture for Chemotherapy-induced Peripheral Neuropathy
The purpose of this study is to evaluate whether acupuncture can be effective for chemotherapy-induced peripheral neuropathy in lymphoma or multiple myeloma patients.
- Conditions
- Peripheral Neuropathy, Toxicity Due to Chemotherapy, Lymphoma, Multiple Myeloma
- Trial name
- NCT01892852
- Testing
- Acupuncture
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Pusan National University Hospital
Gastric Cancer, Gastric Adenocarcinoma
Perioperative Leucovorin, Oxaliplatin, Docetaxel and S-1 (LOTS) For Locally Advanced Gastric or Gastroesophageal Junction Cancer
The aim of the trial is to investigate the clinical efficacy and toxicity of perioperative chemotherapy with leucovorin, oxaliplatin, docetaxel and S-1 (LOTS) in patients with locally advanced gastric or gastroesophageal junction…
- Conditions
- Gastric Cancer, Gastric Adenocarcinoma, Effects of Chemotherapy, Toxicity Due to Chemotherapy
- Trial name
- LOTS (NCT04999332)
- Testing
- leucovorin, oxaliplatin, docetaxel, S-1
- Where
- 4 sites in Taiwan
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Nasopharyngeal Squamous Cell Carcinoma, Toxicity Due to Radiotherapy
GP VS TP in the Treatment of Advanced Nasopharyngeal Carcinoma in Northwest China
The present study is a randomized, control, phase II study of locally advanced nasopharyngeal carcinoma (NPC) in Northwest China treated with Gemcitabine plus cisplatin regimen (GP) or Docetaxel plus cisplatin regimen (TP)…
- Trial name
- NCT01596868
- Testing
- gemcitabine and cisplatin, docetaxel and cisplatin
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Air Force Military Medical University, China
Toxicity Due to Chemotherapy
Uridine Triacetate as Antidote for Patients at Excess Risk of 5-FU Toxicity Due to Overdosage or Impaired Elimination
The purpose of this study is to provide emergency treatment of adult and pediatric patients: Following a fluorouracil or capecitabine overdose regardless of the presence of symptoms or Who exhibit early-onset, severe or…
- Trial name
- NCT01432301
- Testing
- uridine triacetate
- Sponsor
- Wellstat Therapeutics
Toxicity Due to Chemotherapy, Cancer Cachexia
Chemotherapy-related Toxicity, Nutritional Status and Quality of Life
Determine whether nutritional support with high protein ONS in adult oncologic patients in the first step of cancer cachexia - asymptomatic precachexia, influence on the toxicity of systemic therapy.
- Conditions
- Toxicity Due to Chemotherapy, Cancer Cachexia, Metastatic Colorectal Cancer, Quality of Life
- Trial name
- NCT02848807
- Testing
- NUTRIDRINK Compact Protein
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- University Clinical Centre, Gdansk
Cancer, Systemic Treatment
Systemic Treatment Related Toxicity Identified With a Smartphone APPlication Measuring Step Count
The goal of this observational study is to investigate whether daily physical activities measured with a smartphone are related to the possible side effects or other physical complaints that arise as a result of cancer treatment.
- Conditions
- Cancer, Systemic Treatment, Physical Activity, Toxicity Due to Chemotherapy
- Trial name
- STAPPS (NCT05927636)
- Where
- 3 sites in Netherlands
- Volunteers
- 411 people
- Sponsor
- Radboud University Medical Center
Toxicity Due to Chemotherapy
Optimized Multi-modality Machine Learning Approach During Cardio-toxic Chemotherapy to Predict Arising Heart Failure
The present project will develop an automated machine learning approach using multi-modality data (imaging, laboratory, electrocardiography and questionnaire) to increase the understanding and prediction of arising heart failure…
- Trial name
- MERMAID (NCT02934971)
- Where
- Germany
- Volunteers
- 470 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Toxicity Due to Chemotherapy, Cardiovascular Morbidity
Investigating Cardiovascular Adverse Events Related to Cancer Treatment
Cisplatin, anthracyclines, bleomycin and trastuzumab can cause severe cardiovascular or pulmonary toxicity. Why some patients are susceptible to extreme toxicity of cancer treatment is largely unknown.
- Conditions
- Toxicity Due to Chemotherapy, Cardiovascular Morbidity, Cancer, Treatment-Related
- Trial name
- InvestiCAT (NCT03199300)
- Testing
- Anthracyclines, Trastuzumab, Cisplatin
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Cardiotoxicity, Risk Factor, Cardiovascular
Risk-Guided Cardioprotection With Carvedilol in Breast Cancer Patients Treated With Doxorubicin and/or Trastuzumab
Investigators will evaluate the safety, tolerability, and feasibility of a risk-guided cardioprotective treatment strategy with carvedilol, as compared to usual care, in breast cancer patients undergoing treatment with…
- Conditions
- Cardiotoxicity, Risk Factor, Cardiovascular, Toxicity Due to Chemotherapy, Breast Cancer
- Trial name
- CCTGuide Pilot (NCT04023110)
- Testing
- Carvedilol
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Non-small Cell Lung Cancer Stage IIIB, Toxicity Due to Chemotherapy
Chemotherapy Combined With Whole-body Hyperthermia to Treat Stage IIIB/IV Non Small Cell Lung Cancer
Millions of patients die of non-small cell lung cancer (NSCLC) every year. There are several methods to treat NSCLC, including surgery, chemotherapy, radiotherapy and bioimmuotherapy.
- Trial name
- WBH&NSCLC (NCT01493011)
- Testing
- chemotherapy & WBH
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xijing Hospital
Cancer, Toxicity Due to Chemotherapy
Dose Optimization and Efficacy Assessment of a Fluoropyrimidine Antidote
Fluoropyrimidines (FLU) are drugs widely used in chemotherapy for various tumors, such as breast, colon, rectal, and gastric cancers.
- Trial name
- ARCTURUS (NCT07032142)
- Testing
- I-01/23
- Where
- 5 sites in Brazil
- Volunteers
- 66 people
- Sponsor
- D'Or Institute for Research and Education
Breast Cancer, Chemotherapeutic Agent Toxicity
G-CSF in Preventing Neutropenia in Women Receiving Chemotherapy for Breast Cancer
RATIONALE: G-CSF may prevent or reduce febrile neutropenia in women receiving chemotherapy for breast cancer. It is not yet known which G-CSF regimen is more effective in preventing neutropenia.
- Conditions
- Breast Cancer, Chemotherapeutic Agent Toxicity, Neutropenia
- Trial name
- NCT00771433
- Testing
- filgrastim
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Francois Baclesse
Sarcopenia, Oncology
Effect of Sarcopenia on the Occurrence of Toxicity Related to Anti-cancer Treatments
The goal of this clinical trial is to learn about the effect of sarcopenic status on the occurrence of treatment-related toxicity during the first course of anti-cancer treatment in several types of cancers.
- Conditions
- Sarcopenia, Oncology, Physical Inactivity, Toxicity Due to Chemotherapy
- Trial name
- SARC-ONCO (NCT06274268)
- Testing
- Sarcopenia diagnostic test
- Where
- France
- Volunteers
- 700 people
- Sponsor
- Centre Hospitalier Metropole Savoie
Cardiotoxicity, Toxicity Due to Chemotherapy
Pilot Study of an NTproBNP Guided Strategy of Cardioprotection
Investigators will evaluate the safety and feasibility of a biomarker-guided cardioprotection strategy using NTproBNP, as compared to usual care, in breast cancer and lymphoma patients treated with anthracyclines.
- Conditions
- Cardiotoxicity, Toxicity Due to Chemotherapy, Breast Cancer, Lymphoma
- Trial name
- NTproBNP-Guide (NCT04737265)
- Testing
- Biomarker Guided Intervention
- Where
- 3 sites in United States
- Volunteers
- 108 people
- Sponsor
- Abramson Cancer Center at Penn Medicine