Clinical trials: Total Weight Loss
Arthroplasty, Overweight and Obesity
Healthy Living After Knee Replacement
The purpose of this study is to examine if a weight loss program designed for adults after knee replacement improves weight loss, physical activity, pain, and function, as well as if the program is cost effective, as compared to…
- Trial name
- NCT05190666
- Testing
- PACE Weight Loss program, Chronic Disease Self-Management
- Where
- United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Arthroplasties, Replacement, Weight Loss
Weight Loss Before Total Joint Arthroplasty Using A Remote Dietitian and Mobile App
The purpose of this trial is to assess the impact of a 12-week remote dietitian supervised dietary and physical activity weight loss intervention and mobile app for patients with morbid obesity prior to undergoing total joint…
- Conditions
- Arthroplasties, Replacement, Weight Loss, Nutrition
- Trial name
- NCT04330391
- Testing
- Remote dietitian supervised weight loss intervention and mobile app
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Obesity
Efficacy and Safety of the Gastric Bypass Stent System on Body Weight and Metabolic Parameters in Obese Patients
In this study, the investigators use a novel endoscopic duodenal-jejunal bypass liner-the Gastric Bypass Stent System (Hangzhou Tangji Medical Technology Co., Ltd., China) for the treatment of obesity.
- Trial name
- NCT05864911
- Testing
- the Gastric Bypass Stent System
- Where
- China
- Volunteers
- 14 people
- Sponsor
- Beijing Friendship Hospital
Gastroesophageal Reflux Disease, Excessive Weight Loss
Sleeve Gastrectomy With Reestablishment of the Acute Angle of His (SG-REACH) in Obese Patients
Gastroesophageal reflux disease (GERD) is one of the most common chronic conditions that can affect one's quality of life. Laparoscopic sleeve gastrectomy (LSG) has become a popular technique and currently is the most frequently…
- Conditions
- Gastroesophageal Reflux Disease, Excessive Weight Loss, Total Weight Loss, Sleeve Gastrectomy
- Trial name
- SG-REACH (NCT05452980)
- Testing
- reestablishment of the acute angle of His, sleeve gastrectomy
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Zhen Jun Wang
Change in Total Body Fat Mass Percentage Loss Versus Body Weight
Evaluation of Sinetrol® Xpur in Fat Mass Reduction on Overweight and Obese Subjects
This study aims to evaluate effects of a 16-week supplementation with a polyphenol rich extract, Sinetrol® Xpur, on fat mass accumulation and body weight management improvement.Subjects were overweight or obese and received…
- Trial name
- NCT04149158
- Testing
- Sinetrol® Xpur
- Where
- Spain
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Fytexia
Obesity
The USGI Medical ESSENTIAL Study for Weight Loss
This is a multicenter, randomized, evaluator and subject blinded, parallel-group, controlled study intended to evaluate the safety and efficacy of treating obese patients with the placement of g-Cath EZ suture anchors followed by…
- Trial name
- NCT01958385
- Testing
- placement of g-Cath EZ suture anchors, Diet and Exercise
- Where
- 11 sites in United States
- Volunteers
- 377 people
- Sponsor
- USGI Medical
Obesity
Increased Dietary Protein and Meal Frequency Reduces Total and Abdominal Body Fat During Weight Maintenance and Weight Loss
The purpose of the current study was to examine the impact of macronutrient intake (PRO, 15% vs. 35%) and meal frequency (3 vs. 6 meals/day) on body composition, postprandial thermogenesis and plasma adipokines before and after…
- Trial name
- 3v6 (NCT01749449)
- Testing
- protein and meal frequency
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Skidmore College
Obesity, Weight Loss
Total Lifestyle Coaching Pilot Study (TLC)
The investigators aim to develop, pilot and evaluate a new "Total Lifestyle Coaching" (TLC) program, that will address both information and behavior-change aspects of nutrition education for patients whose body mass index (BMI)…
- Conditions
- Obesity, Weight Loss, Telemedicine
- Trial name
- TLC (NCT03025217)
- Testing
- Total Lifestyle Coaching (TLC)
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Bariatric Surgery Candidate, Obesity, Morbid
The Role of Extended Antral Resection on Weight Loss and Metabolic Response After Sleeve Gastrectomy
Aim: The impact of extended antral resection (AR) after laparoscopic sleeve gastrectomy (LSG) on weight loss changes and metabolic response is still not clearly elucidated with conflicting results.
- Trial name
- NCT04109664
- Testing
- laparoscopic sleeve gastrectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 111 people
- Sponsor
- Kocaeli Derince Education and Research Hospital
Knee Osteoarthritis
The Arthritis, Diet, and Activity Promotion Trial
The primary purpose of this study was to determine the effect of dietary weight-loss, exercise training, or a combination of both on physical function in overweight and obese adults with knee osteoarthritis (OA).
- Trial name
- ADAPT (NCT00979043)
- Testing
- Dietary Weight-loss, Exercise
- Where
- United States
- Volunteers
- 318 people
- Sponsor
- Wake Forest University Health Sciences
Weight Change, Body
Digital Lifestyle Management for Weight Loss Control After Thyroidectomy in Thyroid Cancer Patients
Thyroid hormones play an important role in the regulation of the body's metabolism. But the relationship between thyroid hormone status and the basal metabolism rate is not absolute.
- Trial name
- NCT05126706
- Testing
- Digital lifestyle management
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Hospital
Obesity, Osteoarthritis
Surgical Weight-Loss to Improve Functional Status Trajectories Following Total Knee Arthroplasty (SWIFT Trial)
The purpose of the SWIFT Trial is to answer two research questions. 1. Does bariatric surgery before total knee arthroplasty (TKA) improve both perioperative and long-term outcomes of TKA in extreme obesity? 2.
- Trial name
- SWIFT (NCT02598531)
- Where
- United States
- Volunteers
- 289 people
- Sponsor
- Geisinger Clinic
Sleeve Gastrectomy, Pre-cardial Fat Pad
Preserving the Pre-cardial Fat Pad During Sleeve Gastrectomy on Postoperative Gastroesophageal Reflux
Gastroesophageal reflux disease (GERD) is one of the most common chronic conditions that can affect one's quality of life. Laparoscopic sleeve gastrectomy (LSG) has become a popular technique and currently is the most frequently…
- Conditions
- Sleeve Gastrectomy, Pre-cardial Fat Pad, Excessive Weight Loss, Total Weight Loss
- Trial name
- Pad and SG (NCT06732661)
- Testing
- Preserve pre-cardial fat pad, Dissect pre-cardial fat pad
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Beijing Chao Yang Hospital
Arthropathy, Obesity
Postoperative BMI Changes and Functional Outcomes in Knee and Hip Arthroplasty
PURPOSE Obesity poses challenges to preoperative mobility and functional recovery for arthroplasty patients, yet postoperative weight loss remains elusive.
- Trial name
- NCT06440863
- Testing
- Total Knee Arthroplasty, Total Hip arthroplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 459 people
- Sponsor
- Istanbul University - Cerrahpasa
Type2diabetes, Disordered Eating
ARIADNE: A Study of Weight Loss for Diabetes Treatment and Wellbeing
The NHS has started a trial-run of a weight loss programme replacing food with 800-calorie shakes and soups for 3 months, offered to people with newly diagnosed type 2 diabetes (T2D) to lose weight and put their diabetes into…
- Conditions
- Type2diabetes, Disordered Eating, Obesity, Overweight and Obesity
- Trial name
- NCT05744232
- Testing
- Low calorie total diet replacement, Usual care
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Excessive Weight Loss, Total Weight Loss
Sleeve Gastrectomy With Uncut Jejunal Bypass (SG-uncut JJB) Verus Sleeve Gastrectomy in Obese Patients
Among various bariatric procedures, sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) are the most frequently performed procedures worldwide.
- Conditions
- Excessive Weight Loss, Total Weight Loss, Sleeve Gastrectomy, Jejunojejunal Bypass
- Trial name
- NCT04534504
- Testing
- SG-JJB
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhen Jun Wang
Overweight and Obesity, Men
High-Intensity Interval Training and Fat Mass Losses
The aims of this study was to compare two isoenergetic HIIT (High-intensity Interval training) programs (cycling vs. running) on body composition, substrate oxidation at rest and during a moderate exercise, muscle functionality…
- Trial name
- RIESLING (NCT05311800)
- Testing
- Physical activity
- Where
- France
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques
Diabetes Mellitus, Type 2
DiaMester Pilot RCT: E-health Lifestyle Program for Type 2 Diabetes
This registration covers a pilot for a 3-armed parallel-group randomized controlled trial (RCT) that will evaluate the efficacy of DiaMester, a Norwegian e-health programme designed to improve self-management and induce…
- Trial name
- DiaMester (NCT07361640)
- Testing
- e-health lifestyle program, Low calorie diet
- Where
- Norway
- Volunteers
- 99 people
- Sponsor
- Oslo University Hospital
Arthropathy of Knee, Obesity
A Multi-Component Weight Loss Intervention to Improve Outcomes of Total Knee Replacement
Obesity, specifically BMIs ≥35 or 40 kg/m2, are associated with an increased probability of poor outcomes of Total Knee Arthroplasty (TKA) including increased pain, risk for infection, poor joint function, and increased rates of…
- Trial name
- NCT05853497
- Testing
- Multi-Component Weight Loss Intervention
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Kansas Medical Center
Obesity & Overweight, Mobility Disability
Proof-of-Concept Study Evaluating Total Body Weight, Physical Function & Safety of Enobosarm in Patients Treated With GLP-1 Receptor Agonist, for Weight Loss
The primary objective of this study is to assess the effect of enobosarm on total body weight
- Conditions
- Obesity & Overweight, Mobility Disability, HOMA-IR
- Trial name
- PLATEAU (NCT07446998)
- Testing
- Enobosarm, Semaglutide (Wegovy) weekly injection
- Where
- 13 sites in United States
- Volunteers
- 239 people
- Sponsor
- Veru Inc.