Clinical trials: Total Mesorectal Excision
Rectal Cancer, Ileostomy; Functional Disturbance
Trial Evaluating the Tailored Versus the Systematic Use of Defunctioning Stoma After Total Mesorectal Excision for Rectal Cancer (GRECCAR17)
GRECCAR 17 will be the first prospective and randomized trial to assess a tailored policy in the use of defunctioning stoma after TME according to the personalized risk of anastomotic leakage.
- Trial name
- GRECCAR17 (NCT05233787)
- Testing
- Tailored use of defunctioning stoma after TME, Systematic use of defunctioning stoma
- Where
- 28 sites in France
- Volunteers
- 212 people
- Sponsor
- University Hospital, Bordeaux
Rectal Cancer Stage II, Rectal Cancer Stage III
Optimal Surgery and MRI Based Radiochemotherapy in Rectal Carcinoma
The objective of the study is to provide proof that a MRI based preoperative radiochemotherapy in patients with locally advanced rectal carcinoma allows limiting RCT to high risk patients without increase of locoregional…
- Trial name
- OCUM (NCT01325649)
- Testing
- total mesorectal excision / long course radiochemotherapy, long course 5-FU bases radiochemotherapy
- Where
- Germany
- Volunteers
- 1,051 people
- Sponsor
- Johannes Gutenberg University Mainz
Rectal Cancer
The Evaluation of the Safety and the Efficacy of Transanal Total Mesorectal Excision
The purpose of this study is evaluation of the safety and the efficacy of transanal total mesorectal excision.
- Trial name
- NCT01938027
- Testing
- Transanal total mesorectal excision
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- National Cancer Center, Korea
Rectum Cancer
Bacteriological Differences Between Transanal and Laparoscopic Total Mesorectal Excision for Rectal Cancer.
The primary purpose of this study is to compare the differences of bacteriological in rectal cancer patients undergoing laparoscopic or transanal endoscopy radical resection.
- Trial name
- NCT05201872
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Yanhong Deng
Locally Advanced Rectal Cancer
Neoadjuvant Bevacizumab, Capecitabine and Radiation Therapy With or Without Oxaliplatin Locally Advanced Rectal Cancer
Phase II clinical trial, open-label, randomized, two arms, multicentre (possibly multinational). Academic, investigator initiated.
- Trial name
- AXEBEAM (NCT00828672)
- Testing
- Oxaliplatin, Bevacizumab, Capecitabine
- Where
- 9 sites in Belgium
- Volunteers
- 84 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ileostomy - Stoma, Rectal Cancer
Alterations of Gut Microbiome, Function, and Its Intervention After Defunctioning Ileostomy
This study focused on the alterations of gut microbiome and function during defunctioning ileostomy, and observed the effects of probiotic intervention on intestinal microbiome and function.
- Conditions
- Ileostomy - Stoma, Rectal Cancer, Microbial Disease, Intestinal Functional Disorder
- Trial name
- NCT05759741
- Testing
- MIYAIRI 588
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Huashan Hospital
Rectal Cancer, Surgery
Multicenter Phase II Study of Transanal TME (taTME)
Radical rectal cancer resection, namely total mesorectal excision (TME), is the cornerstone of the treatment of resectable rectal cancer.
- Trial name
- NCT03144765
- Testing
- Transanal Total Mesorectal Excision (taTME)
- Where
- 12 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Rectum Cancer
Machine Learning-based Surgical Guidance System for Robot-assisted Rectal Surgery
The aim of the study is to evaluate the technical feasibility and applicability of a surgical assistance system based on image recognition algorithms in a first-in-human pilot study.
- Trial name
- CoBot2 (NCT05652361)
- Testing
- Additional visualisation of surgical assistance during surgery
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- Technische Universität Dresden
Rectal Cancer
Transanal Versus Laparoscopic Total Mesorectal Excision: a Cohort
The purpose of this study was to compare the long-term oncology outcomes and specimen quality of taTME and laTME in the treatment of middle and low rectal cancer by a large sample cohort.
- Trial name
- NCT05682794
- Testing
- transanal total mesorectal excision
- Volunteers
- 2,502 people
- Sponsor
- Sun Yat-sen University
Rectal Cancer
Total Meso-rectal Excision Versus Transanal Local Excision Followed by Radiotherapy for T2N0M0 Distal Rectal Cancer
A randomized controlled clinical trial to compare the short and long term outcomes of transanal endoscopic microsurgery following radiotherapy or total mesorectal excision for the treatment of Rectal Cancer
- Trial name
- NCT04098471
- Testing
- transanal local excision following radiotherapy, TME
- Where
- China
- Volunteers
- 168 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Colorectal Surgery
Duration of Urinary Catheterization
This study is being conducted to determine the length of time a urinary catheter is needed to drain urine from the bladder after colorectal surgery.
- Trial name
- NCT04359069
- Testing
- Urinary catheter removal on postoperative day 1, Urinary catheter removal on postoperative day 3
- Where
- 2 sites in United States
- Volunteers
- 176 people
- Sponsor
- University of Southern California
Locally Advanced Rectal Cancer
Rectal Cancer, Adjuvant Chemotherapy, FOLFOX(5-fluorouracil/Leucovorin/Oxaliplatin), Total Mesorectal Excision
The introduction of total mesorectal excision (TME) and the progress of neoadjuvant chemoradiotherapy has significantly reduced the risk of local recurrence in locally advanced rectal cancer.
- Trial name
- NCT02167321
- Testing
- Arm A : standard neoadjuvant chemoradiotherapy group, Arm B : adjuvant FOLFOX group
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Yonsei University
Rectal Cancer
Short-term Outcomes of Transanal Total Mesorectal Excision With Structured Training Curriculums in China
Transanal total mesorectal excision (TaTME) is an alternative for mid-low rectal cancer. In China, this procedure has been performed in high-volume centers with structured training curriculums.
- Trial name
- NCT05108753
- Testing
- Procedure/Surgery
- Where
- 2 sites in China
- Volunteers
- 175 people
- Sponsor
- Shanghai Minimally Invasive Surgery Center
Rectal Cancer
Quality of Life in Patients With Rectal Cancer Receiving Total Mesorectal Excision With or Without Stoma
The goal is to evaluate whether the renunciation of a diverting stoma in patients with adjuvant chemotherapy after low anterior resection with total mesorectal excision (TME) and neoadjuvant chemoradiotherapy leads to a better…
- Trial name
- NCT03487484
- Testing
- Quality of Life Questionnaire for gastrointestinal tract, Quality of Life Questionnaire, Faecal Incontinence Score
- Where
- Switzerland
- Volunteers
- 5 people
- Sponsor
- University Hospital, Basel, Switzerland
Rectal Cancer
Laparoscopic Assisted Transanal Resection of Rectal Cancer With Total Mesorectal Excision
Rectal cancer is one of the frequent malignant neoplasms ,Total mesorectal excision (TME) has become the gold standard treatment for middle and lower rectal cancers.
- Trial name
- NCT03171298
- Testing
- Laparoscopic Assisted Transanal Total Mesorectal Excision
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Rectum, Cancer
Long-term Cohort Study of Mesorectal Excision for Rectal Cancer
The aim of this cohort study is to record, evaluate and compare the surgical, oncological as well as the functional outcome and Quality of life after mesorectal excision for rectal cancer
- Trial name
- TME-KSW (NCT05112016)
- Testing
- Total mesorectal excision for rectal cancer
- Where
- Switzerland
- Volunteers
- 250 people
- Sponsor
- Kantonsspital Winterthur KSW
Rectal Cancer
Intraoperative Monitoring of the Pelvic Autonomic Nerves
One of the major problems of rectal cancer surgery is pelvic autonomic nerve damage, which is the main cause of urogenital dysfunction influencing postoperative quality of life.
- Trial name
- NEUROS (NCT01585727)
- Testing
- TME, Neuromonitoring
- Where
- Germany
- Volunteers
- 188 people
- Sponsor
- Johannes Gutenberg University Mainz
Rectal Cancer, Surgery
Local Excision Versus Total Mesorectal Excision In Pathological Complete Response (ypT0-1cN0) Mid- Or Low-Rectal Cancer After Neoadjuvant Therapy
Patients with cT2-4aN0-2M0 mid- or low-rectal cancer received neoadjuvant chemotherapy or combined chemoradiotherapy. Good responders (cT0-1N0) patients received local excision 4-8 weeks after treatment.
- Trial name
- NCT03548844
- Testing
- local excision, total mesorectal excision
- Where
- China
- Volunteers
- 326 people
- Sponsor
- Yanhong Deng
Rectal Cancer
Flexible Colonoscope Assisted Hybrid Transanal Total Mesorectal Resection (taTME)
The investigators propose to use flexible endoscopy combined with transanal total mesorectal resection to further reduce anal injury.
- Trial name
- NCT06380855
- Testing
- Flexible colonoscope assisted hybrid transanal total mesorectal resection
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Sun Yat-sen University
Rectal Neoplasms
Local Excision in Downstaged Rectal Cancer
Patients with T2T3 low rectal cancer (size =< 4 cm) received neoadjuvant treatment (50Gy in 5 weeks with concomitant chemotherapy.
- Trial name
- GRECCAR 2 (NCT00427375)
- Testing
- local rectal excision, total mesorectal excision
- Where
- 40 sites in France
- Volunteers
- 148 people
- Sponsor
- University Hospital, Bordeaux