Clinical trials: Total Knee Replacements
Total Knee Replacement
In-Clinic Versus Tele-Rehabilitation in Women With Knee Osteoarthritis
To compare the effectiveness of in clinic rehabilitation versus tele rehabilitation in improving knee function in women diagnosed with knee OA. To assess the impact of both rehabilitation approaches on improving strength.
- Trial name
- NCT07654309
- Testing
- In-Clinic Rehabilitation, Tele-Rehabilitaion
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Arthroplasty, Replacement, Knee, Total Knee Arthroplasty
Systemic Lidocaine Versus Ultrasound-guided Adductor Canal Block for Patients Undergoing Total Knee Arthroplasty
The investigators are evaluating the postoperative outcomes in patients undergoing total knee arthroplasty that receive either systemic lidocaine or ultrasound-guided adductor canal block as part of their anesthetic plan.
- Trial name
- ACBSL (NCT04828083)
- Testing
- Lidocaine IV, Saline IV
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Rhode Island Hospital
Post Operative Pain, Total Knee Replacement
Morphine Consumption in Joint Replacement Patients, With or Without Gabapentin Treatment
Total knee arthroplasty is amongst the most painful procedures postoperatively, and pain management can be a challenge. Different measures have been introduced to manage severe postoperative pain int hese patients.
- Trial name
- TKR (NCT01307202)
- Testing
- Gabapentin
- Where
- Canada
- Volunteers
- 101 people
- Sponsor
- McMaster University
Osteo Arthritis Knee, Knee Arthritis
Persona IQ Cohort Study
A prospective multicenter longitudinal cohort study of Zimmer Biomet (ZB) Persona IQ The Smart Knee which consists of the Persona Personalized Knee (PPK) System with mymobility® platform that is attempting to develop correlative…
- Conditions
- Osteo Arthritis Knee, Knee Arthritis, Monitoring Orthopedic Devices, Total Knee Arthroplasty
- Trial name
- NCT06089291
- Testing
- Persona IQ
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Zimmer Biomet
Knee Arthroplasty, Total, Knee Replacement Arthroplasty
Remote Monitoring After Knee Replacement Surgery
The goal of this clinical trial is to evaluate the effect, cost-effectiveness, safety and satisfaction with replacing standardized, pre-scheduled face-to-face visits with remote monitoring and video consultations or face-to-face…
- Trial name
- OA-AID TKR (NCT07003932)
- Testing
- Remote monitoring, Usual Care
- Where
- Norway
- Volunteers
- 140 people
- Sponsor
- Diakonhjemmet Hospital
Knee Osteoarthritis, Total Knee Replacement
Effect of Physical Therapy Rehabilitation on Gait and Plantar Pressure in Patients After Total Knee Replacement
This study aims to investigate the effects of a structured physical therapy and rehabilitation program on gait temporospatial parameters and plantar pressure distribution in patients who have undergone total knee replacement…
- Trial name
- NCT07556003
- Testing
- Physical Therapy Rehabilitation
- Where
- Saudi Arabia
- Volunteers
- 30 people
- Sponsor
- Jouf University
Total Knee Replacement Surgery, Post-operative Pain
Suzetrigine for Treatment and Reduction of Intense Discomfort After knEe Replacement PAIN
This is a prospective, randomized study. The purpose of this study is to evaluate if the addition of Suzetrigine, a new pain medication, to well established peri-operative pain regimen used for total knee replacement surgery will…
- Trial name
- STRIDE-PAIN (NCT07548385)
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 235 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Osteoarthritis, Total Knee Replacement
Adductor Canal Block
The investigators aim to investigate whether the addition of a surgeon-administered adductor canal blockade to a multimodal periarticular injection cocktail provides additional pain relief for patients undergoing total knee…
- Trial name
- NCT04513145
- Testing
- Ropivacaine injection, Saline Injection, Total Knee Arthroplasty
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- OrthoCarolina Research Institute, Inc.
Primary Osteoarthritis Patients Scheduled for Total Knee Replacement Surgery
Cold and Compression Post TKA
The purpose of this study is to compare pain score (Patient-Reported Outcomes Measurement Information System: PROMIS NRS Pain Subscale) between the control and cold/compression groups pre-surgically, daily after surgery for 14…
- Trial name
- NCT07023185
- Testing
- Cold and Compression, SOC (Standard of care)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Ochsner Health System
Pain (Visceral, Somatic, or Neuropathic), Hip Arthroplasty Replacement
Characteristics of Persistent Pain Composition Following Total Hip or Knee Arthroplasty: a Descriptive Study
Despite high success rates of hip and knee arthroplasty, up to 20% of patients report moderate-to-severe pain (NRS > 3) persisting beyond the expected healing period.
- Conditions
- Pain (Visceral, Somatic, or Neuropathic), Hip Arthroplasty Replacement, Knee Arthroplasty, Total, Survey and Questionnaire
- Trial name
- PAIN-COMPO (NCT07110324)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Total Knee Replacement, Optic Nerve Sheath Diameter Measurement
The Effect of Epidural Anesthesia on Optic Nerve Sheath Diameter Measurements in Total Knee Prosthesis Surgery
This study investigates the effects of epidural anesthesia on intracranial pressure (ICP) by using ultrasonographic optic nerve sheath diameter (ONSD) measurements as a non-invasive indicator.
- Conditions
- Total Knee Replacement, Optic Nerve Sheath Diameter Measurement, Intracranial Pressure Change
- Trial name
- NCT07458321
- Testing
- Bupivacaine %0.25 (isobaric), Bupivacaine %0.5 (hyperbaric)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bursa City Hospital
Knee Osteoarthristis, Knee Replacement Arthroplasty
Comparing Articular Noise and Its Perception Between Two Different Types of Total Knee Arthroplasty
Some patients complain of articular noise (such as clicking, snapping, cracking or popping) after a total knee replacement. Controversy remains about whether there is a correlation between articular noise and worse outcomes…
- Conditions
- Knee Osteoarthristis, Knee Replacement Arthroplasty, Knee Replacement, Total
- Trial name
- NATKA (NCT06880497)
- Testing
- total knee arthroplasty
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Elsan
Total Knee Replacement
Postural Correctors & Activity Trackers in Total Knee Replacement Rehab
To assess the impact of postural corrector on post-operative knee function and activity To evaluate the role of activity tracker in monitoring and enhancing post-operative rehabilitation To assess the effects of postural…
- Trial name
- NCT06877845
- Testing
- Activity Tracker & Postural Corrector, Conventional Therapy
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- Riphah International University
Total Knee Replacement, Total Knee Replacement Surgery
Mako Cementless TKA vs Mako Cemented TKA
The overall aims of this prospective, randomised, single-blinded controlled trial are to compare functional, radiological and clinical outcomes in Mako robotic-arm assisted cementless Total Knee Arthroplasty (TKA) versus Mako…
- Conditions
- Total Knee Replacement, Total Knee Replacement Surgery, Total Knee Arthroplasty, Osteoarthritis (OA) of the Knee
- Trial name
- NCT06929871
- Testing
- Mako cementless TKA, Mako cemented TKA
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University College, London
Arthroplasty, Replacement Material
Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)
Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when…
- Conditions
- Arthroplasty, Replacement Material, Knee Arthritis Osteoarthritis, Knee Arthroplasty, Total
- Trial name
- CRYO-TKA (NCT07425457)
- Testing
- CT-guided Cryoneurolysis of the Genicular Nerves
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Attikon Hospital
Pain, Total Knee Replacement
Analysis of Postoperative Analgesic of Different Nerve Blocks for Total Knee Replacement Surgery
This study is a retrospective analysis using the accumulated clinical database from 2017/09-2023/12 to analyze patients who underwent total knee arthroplasty and received nerve blocks.
- Conditions
- Pain, Total Knee Replacement, Motor Function
- Trial name
- NCT06521619
- Testing
- Femoral and sciatic nerve blocks
- Where
- Taiwan
- Volunteers
- 126 people
- Sponsor
- Fu Jen Catholic University Hospital
Total Knee Arthroplasty, Total Knee Replacement
Comparing Temperature in Burr vs Saw Cutting for Knee Arthroplasty
We will assess the temperatures achieved during bone cutting in total knee replacements, comparing burr and saw techniques. Our study involves recruiting 20 patients from East Suffolk and North Essex NHS Foundation Trust…
- Trial name
- NCT07010809
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- East Suffolk and North Essex NHS Foundation Trust
Pain After Total Knee Arthroplasty, Pain, Postoperative
Comparison of BiFeS + ACB and IPACK + ACB Block Combinations for Postoperative Pain After Total Knee Arthroplasty
This prospective observational study will compare the postoperative analgesic efficacy of two multimodal regional anesthesia combinations routinely used after total knee arthroplasty (TKA) performed under spinal anesthesia.
- Conditions
- Pain After Total Knee Arthroplasty, Pain, Postoperative, Arthroplasty, Replacement, Knee
- Trial name
- NCT07231692
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Total Knee Replacement, Mediation
Mindfulness Meditation Intervention Study
The goal of this pilot study is to develop a randomized control trial study with sufficient power to definitely address if a preop mindfulness meditation intervention can improve post-total knee arthroplasty mental well-being or…
- Conditions
- Total Knee Replacement, Mediation, Feasibility
- Trial name
- NCT06180486
- Testing
- Mindfulness Meditation Intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Hospital for Special Surgery, New York
Total Knee Replacement
Comparative Effect of Instrument Assisted Soft Tissue Mobilization and Cross Fiber Massage in Patients With Total Knee Replacement.
Comparative effect of Instrument Assisted Soft Tissue Mobilization and Cross Fiber Massage in patients with Total Knee Replacement
- Trial name
- NCT07361770
- Testing
- Instrument-assisted soft tissue mobilization, Cross Fibre Massage
- Where
- Pakistan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rashid Latif Medical College