Total Knee ReplacementNCT07654309
In-Clinic Versus Tele-Rehabilitation in Women With Knee Osteoarthritis
A study testing In-Clinic Rehabilitation and Tele-Rehabilitaion in people with Total Knee Replacement, run by Riphah International University at 1 site in Pakistan.
Trial summary
To compare the effectiveness of in clinic rehabilitation versus tele rehabilitation in improving knee function in women diagnosed with knee OA. To assess the impact of both rehabilitation approaches on improving strength. Read more about this study
- Who is it for?
- Ages 40 to 60 years, women only
- Conditions the study is for
- Total Knee Replacement
- What is being tested?
- In-Clinic Rehabilitation and Tele-Rehabilitaion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 26 participants
- Where
- 1 sitePakistan
- Study dates
- 1 Apr 2026to 10 Jun 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 60 years
- Women only
- No healthy volunteers
- Adult
Who may be able to join
- Only female participant
- Age 40 to 60 years
- Radiographically confirmed OA (Grade II or III)
- Self-limitation in walking, climbing or ADLs
- Access to smartphone, tablet, or computer with internet
Who cannot join
- Advanced OA (G IV)
- Other joint disorder
- Recent surgeries
- Pregnancy
- Swelling and morning stiffness more than 30 min
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Comparison Between In-clinic Versus Tele-rehabilitation on Knee Function, Muscle, Muscle Strength, and Pain in Women With Knee Osteoarthritis
- To compare the effectiveness of in clinic rehabilitation versus tele rehabilitation in improving knee function in women diagnosed with knee OA.
- To assess the impact of both rehabilitation approaches on improving strength.
- To evaluate the effects of in-clinic and tele-rehabilitation on pain reduction in women with knee osteoarthritis.
Read the detailed description
Knee osteoarthritis (OA) is a chronic, progressive musculoskeletal disorder, which is marked by degeneration of articular cartilage, subchondral bone remodeling, inflammation of the synovium, and limitation of knee joint function. It is also among the primary causes of chronic pains, disability, and diminished physical functions in middle-aged and older adults across the world. Knee OA clinically appears with pain in the joints, stiffness, crepitus, reduced mobility, muscle weakness, and gradual impairment of activities of daily living, which eventually affects independence and quality of life.
- Conditions
- Total Knee Replacement
- Being tested
- In-Clinic Rehabilitation, Tele-Rehabilitaion
- Keywords
- Knee Function, Muscle Strength, Pain
- Medical subject headings
- Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
In-Clinic RehabilitationOther
Hot Pack \& Strengthening Exercises
Tele-RehabilitaionOther
Hot Pack \& Strengthening Exercises
| Study group | Role | What they receive |
|---|---|---|
| In-Clinic Rehabilitation | Experimental | Hot pack (for 15 minutes)
Strengthening Exercises
1. Quadriceps Sets - 3 Sets of 10 Reps
2. Straight Leg Raise (SLR) - 3 Set of 10 Reps
3. Mini Squats (Wall-Supported) - 3 Sets of 10 Reps
4. Hamstring Curls (Standing or Prone) - Reps: 3 sets of 10 Reps - Add resistance band if tolerated
5. Seated Knee Extension (With or Without Weight) - 3 sets of 10 Reps -18 sessions for six weeks. Receives: Other: In-Clinic Rehabilitation |
| Tele-Rehabilitation | Experimental | Hot pack (for 15 minutes)
Strengthening Exercises
1. Quadriceps Sets - 3 Sets of 10 Reps
2. Straight Leg Raise (SLR) - 3 Set of 10 Reps
3. Mini Squats (Wall-Supported) - 3 Sets of 10 Reps
4. Hamstring Curls (Standing or Prone) - Reps: 3 sets of 10 Reps - Add resistance band if tolerated
5. Seated Knee Extension (With or Without Weight) - 3 sets of 10 Reps -18 sessions for six weeks. Receives: Other: Tele-Rehabilitaion |
What is being measured
The primary outcome is the main question the study is designed to answer.
WOMAC to assess knee function
The WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) is a widely used, self-administered 24-item questionnaire designed to evaluate pain, joint stiffness, and physical function in patients with knee or hip osteoarthritis. It measures these three dimensions to assess disease severity and treatment outcomes.
Measured: 6 Weeks
MMT to assess knee muscle strength
Manual Muscle Testing (MMT) is a generally valid and reliable tool for assessing muscle strength in patients with neuromusculoskeletal dysfunction, demonstrating good consistency, particularly in clinical settings with trained examiners. It is widely used for grading muscle strength (0-5 scale), though it has limited sensitivity in detecting small strength changes and may have a ceiling effect for high-functioning individuals.
Measured: 6 Weeks
VAS to assess pain
The visual analog scale (VAS) is a validated, subjective measure for acute and chronic pain. Scores are recorded by making a handwritten mark on a 10-cm line that represents a continuum between "no pain" and "worst pain."
Measured: 6 Weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Jun 2026
- Study start1 Apr 2026
- Primary completion10 Jun 2026
- Study completion10 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Total Knee ReplacementStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 26 participants (actual)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Ayesha Sadiq, MSPT (OMPT), Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07654309
- Sponsor's protocol ID
- REC-01026 Hajra
- Status last verified
- Feb 2026
- First submitted
- 13 Jun 2026
- Last updated
- 17 Jun 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 17 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison Between In-clinic Versus Tele-rehabilitation on Knee Function, Muscle, Muscle Strength, and Pain in Women With Knee Osteoarthritis
- ClinicalTrials.gov ID
- NCT07654309
- Acronym / sponsor ID
- REC-01026 Hajra
- Conditions
- Total Knee Replacement
- Keywords
- Knee Function, Muscle Strength, Pain
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 26 participants (actual)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 1 Apr 2026 (actual)
- Primary completion
- 10 Jun 2026 (actual)
- Study completion
- 10 Jun 2026 (actual)
- First posted
- 17 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
- To compare the effectiveness of in clinic rehabilitation versus tele rehabilitation in improving knee function in women diagnosed with knee OA.
- To assess the impact of both rehabilitation approaches on improving strength.
- To evaluate the effects of in-clinic and tele-rehabilitation on pain reduction in women with knee osteoarthritis.
Detailed description
Knee osteoarthritis (OA) is a chronic, progressive musculoskeletal disorder, which is marked by degeneration of articular cartilage, subchondral bone remodeling, inflammation of the synovium, and limitation of knee joint function. It is also among the primary causes of chronic pains, disability, and diminished physical functions in middle-aged and older adults across the world. Knee OA clinically appears with pain in the joints, stiffness, crepitus, reduced mobility, muscle weakness, and gradual impairment of activities of daily living, which eventually affects independence and quality of life.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| In-Clinic Rehabilitation | Experimental | Other: In-Clinic RehabilitationHot pack (for 15 minutes) Strengthening Exercises 1. Quadriceps Sets - 3 Sets of 10 Reps 2. Straight Leg Raise (SLR) - 3 Set of 10 Reps 3. Mini Squats (Wall-Supported) - 3 Sets of 10 Reps 4. Hamstring Curls (Standing or Prone) - Reps: 3 sets of 10 Reps - Add resistance band if tolerated 5. Seated Knee Extension (With or Without Weight) - 3 sets of 10 Reps -18 sessions for six weeks. |
| Tele-Rehabilitation | Experimental | Other: Tele-RehabilitaionHot pack (for 15 minutes) Strengthening Exercises 1. Quadriceps Sets - 3 Sets of 10 Reps 2. Straight Leg Raise (SLR) - 3 Set of 10 Reps 3. Mini Squats (Wall-Supported) - 3 Sets of 10 Reps 4. Hamstring Curls (Standing or Prone) - Reps: 3 sets of 10 Reps - Add resistance band if tolerated 5. Seated Knee Extension (With or Without Weight) - 3 sets of 10 Reps -18 sessions for six weeks. |
Who may qualify
- Ages
- 40 to 60 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Only female participant
- Age 40 to 60 years
- Radiographically confirmed OA (Grade II or III)
- Self-limitation in walking, climbing or ADLs
- Access to smartphone, tablet, or computer with internet
Key exclusion criteria (5 listed)
- Advanced OA (G IV)
- Other joint disorder
- Recent surgeries
- Pregnancy
- Swelling and morning stiffness more than 30 min
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| In-Clinic RehabilitationHot Pack \& Strengthening Exercises | Other | In-Clinic Rehabilitation |
| Tele-RehabilitaionHot Pack \& Strengthening Exercises | Other | Tele-Rehabilitation |
Primary outcome
WOMAC to assess knee function
Time frame: 6 Weeks
The WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) is a widely used, self-administered 24-item questionnaire designed to evaluate pain, joint stiffness, and physical function in patients with knee or hip osteoarthritis. It measures these three dimensions to assess disease severity and treatment outcomes.
MMT to assess knee muscle strength
Time frame: 6 Weeks
Manual Muscle Testing (MMT) is a generally valid and reliable tool for assessing muscle strength in patients with neuromusculoskeletal dysfunction, demonstrating good consistency, particularly in clinical settings with trained examiners. It is widely used for grading muscle strength (0-5 scale), though it has limited sensitivity in detecting small strength changes and may have a ceiling effect for high-functioning individuals.
VAS to assess pain
Time frame: 6 Weeks
The visual analog scale (VAS) is a validated, subjective measure for acute and chronic pain. Scores are recorded by making a handwritten mark on a 10-cm line that represents a continuum between "no pain" and "worst pain."
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Jun 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Ayesha Sadiq, MSPT (OMPT) principal investigator
Riphah International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing In-Clinic Rehabilitation and Tele-Rehabilitaion in people with Total Knee Replacement, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 17 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
WOMAC to assess knee function (time frame: 6 Weeks). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Jun 2026.