Clinical trials: Total Knee Arthroplasty
Postoperative Pain Following Knee Arthroplasty, Total Knee Arthroplasty
Biceps Femoris Short Head (BiFeS) Block and Adductor Canal Block for Postoperative Analgesia Following Total Knee Arthroplasty
This prospective randomized controlled study aims to evaluate the effect of ultrasound-guided Biceps Femoris Short Head (BiFeS) block combined with adductor canal block on postoperative opioid consumption and pain control in…
- Trial name
- BiFeS Adductor (NCT07577869)
- Testing
- Procedure: Biceps Femoris Short Head Block, Procedure: Spinal Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ömer Kayar
Total Knee Arthroplasty
Continuous Adductor Canal Block in Fast Track Total Knee Arthroplasty
Total knee arthroplasty (TKA) is a frequent performed surgery. Many institutions are implementing fast track programs for this surgery and adequate pain management is an important feature.
- Trial name
- CACB (NCT05962970)
- Testing
- continuous adductor canal block (CACB) ropivacaine
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Total Knee Arthroplasty Recovery
Effects of Progressive Restricted Blood Flow Exercises in Post Total Knee Arthroplasty
Total knee arthroplasty (TKA) is a commonly performed procedure for advanced knee osteoarthritis. Despite successful surgery, many patients experience postoperative impairments including pain, reduced range of motion (ROM)…
- Trial name
- TKA PBFR (NCT07601906)
- Testing
- Blood Flow Restriction Exercises and Conventional Physical Therapy, Conventional Physical Therapy alone
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Sarcopenia, Total Knee Arthroplasty
Branched Chain Amino Acids for Sarcopenia in Patients Undergoing Total Knee Arthroplasty
This multicenter, prospective, randomized controlled trial evaluates whether postoperative administration of branched chain amino acids affects skeletal muscle mass index and sarcopenia related functional outcomes in patients…
- Trial name
- LIVACT IIT (NCT07634523)
- Testing
- Livact Granule
- Where
- 3 sites in South Korea
- Volunteers
- 140 people
- Sponsor
- Seoul National University Hospital
Total Knee Arthroplasty
IO Vancomycin Administration in TKA
This is a prospective, single-center, open-label study evaluating systemic vancomycin levels following preoperative intraosseous administration in patients undergoing primary unilateral total knee arthroplasty.
- Trial name
- IO Vanco (NCT07633418)
- Testing
- Intraosseous Vamcomycin Administration
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Gonarthrosis, Total Knee Arthroplasty
Infiltration or Nerve Blocks in Addition to Adductor Canal Block
The aim of this study is to evaluate the analgesic efficacy of this quadruple sensory block compared with the currently recommended procedure (adductor canal block + infiltration).
- Trial name
- INCA (NCT06920186)
- Testing
- Analgesia
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Osteoarthritis, Knee, Postoperative Pain
Cryotherapy Versus Standard Care in Reducing Opioid Consumption After Total Knee Arthroplasty
The goal of this clinical trial is to learn if compressive cryotherapy can reduce postoperative opioid consumption in patients undergoing primary total knee arthroplasty.
- Conditions
- Osteoarthritis, Knee, Postoperative Pain, Total Knee Arthroplasty
- Trial name
- NCT07630337
- Testing
- Game Ready® compressive cryotherapy device, Standard cryotherapy (ice packs)
- Where
- Argentina
- Volunteers
- 74 people
- Sponsor
- Hospital Italiano de Buenos Aires
Osteo Arthritis Knee, Knee Arthritis
Persona IQ Cohort Study
A prospective multicenter longitudinal cohort study of Zimmer Biomet (ZB) Persona IQ The Smart Knee which consists of the Persona Personalized Knee (PPK) System with mymobility® platform that is attempting to develop correlative…
- Conditions
- Osteo Arthritis Knee, Knee Arthritis, Monitoring Orthopedic Devices, Total Knee Arthroplasty
- Trial name
- NCT06089291
- Testing
- Persona IQ
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Zimmer Biomet
Total Knee Arthroplasty
NEUROCUPLE™ in TKA Patients to Enhance Pain Management
This is a randomized (1:1) placebo-controlled clinical trial to determine the feasibility and effectiveness of 30-day application of NEUROCUPLE™ patch for pain reduction and opioid consumption following TKA.
- Trial name
- NCT06460350
- Testing
- NEUROCUPLE™ Patch
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- nCap Medical
Total Knee Arthroplasty, Electrocardiographic Changes
Effect of Spinal and General Anesthesia on Frontal QRS Axis in Patients Undergoing Total Knee Arthroplasty
This prospective observational study aims to compare the effects of spinal and general anesthesia on frontal QRS axis in patients undergoing elective total knee arthroplasty.
- Trial name
- TDP-QRS (NCT07551648)
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Total Knee Arthroplasty
Vancomycin in TKAs
Periprosthetic joint infection (PJI) is a national health crisis and leads to very poor outcomes for patients undergoing elective joint replacement.
- Trial name
- NCT07282782
- Testing
- Vancomycin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Knee Stiffness After Total Knee Arthroplasty
Flex Appeal: Evaluating the Efficacy of Anesthetic Techniques for Manipulation of Knees Under Anesthesia
The purpose of this study is to determine if changing the type of anesthesia improves the outcomes of manipulation and pain control after the procedure.
- Trial name
- NCT07348614
- Testing
- Spinal Anesthesia, General Anesthesia, Propofol
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Duke University
Knee Flexion Contracture, Total Knee Arthroplasty (TKA)
Anterior Heel Wedge to Treat Flexion Contracture After Total Knee Arthroplasty
Total knee arthroplasty (TKA) remains the only treatment for end-stage knee osteoarthritis, whereby the diseased ends of the bones comprising the knee joint are removed and replaced with prosthetic joint components.
- Trial name
- NCT07620145
- Testing
- Anterior heel wedge
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of North Carolina, Charlotte
Total Knee Arthroplasty
Persona MC vs PS RCT With ROSA
A randomized, controlled study comparing two total knee implant devices, Persona medial congruent (MC) vs posterior stabilized (PS). These surgeries will be performed using the ROSA robotic system.
- Trial name
- NCT05391828
- Testing
- Zimmer-Biomet Persona Medial Congruent (MC) Bearing Design, Zimmer-Biomet Persona Posterior-Stabilized (PS) Bearing Design
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- NYU Langone Health
Knee Arthroplasty, Total, Knee Replacement Arthroplasty
Remote Monitoring After Knee Replacement Surgery
The goal of this clinical trial is to evaluate the effect, cost-effectiveness, safety and satisfaction with replacing standardized, pre-scheduled face-to-face visits with remote monitoring and video consultations or face-to-face…
- Trial name
- OA-AID TKR (NCT07003932)
- Testing
- Remote monitoring, Usual Care
- Where
- Norway
- Volunteers
- 140 people
- Sponsor
- Diakonhjemmet Hospital
Postoperative Pain After Total Knee Arthroplasty
Genicular Nerve Versus Adductor Canal Block for Postoperative Analgesia
Severe postoperative pain following total knee arthroplasty (TKA ) has been shown to negatively affect early mobilization, physical rehabilitation, time to discharge, and overall post-operative recovery.Therefore, reducing…
- Trial name
- NCT07588958
- Testing
- Spinal Anesthesia with Bupivacaine and Fentanyl, Genicular nerve block with bupivacaine, Adductor Canal Block (ACB) Only
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Zagazig University
Postoperative Pain After a Total Knee Arthroplasty
Post-operative Analgesic Effect of Oral Nefopam
Primary knee arthroplasty by total prosthesis is a painful surgery, performed on patients with advanced gonarthrosis (stage III), thus already presenting hyperalgesia and hyperalgesia and allodynia.
- Trial name
- NefPO (NCT04576078)
- Testing
- Oral nefopam
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Knee Arthroplasty, Total
Comparison of the Analgesic Efficacy of Adductor Canal Block and Combined Adductor Canal Block Plus IPACK Block in Knee Surgery
To evaluate the effectiveness of Adductor Canal Block and combined Adductor Canal plus IPACK block in reducing postoperative pain and analgesic requirements in patients undergoing knee surgery.
- Trial name
- NCT07526831
- Testing
- Adductor Canal Block Group (Group I), Adductor Canal + iPACK Block Group (Group II)"
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Total Knee Arthroplasty, Total Knee Arthroplasty Recovery
Effects of Stress Ball Use and Breathing Exercises on Pain and Vital Signs During Drain Removal After Total Knee Arthroplasty
This randomized controlled trial aims to evaluate the effects of stress ball use and breathing exercises on procedural pain and vital signs during drain removal in patients undergoing total knee arthroplasty.
- Conditions
- Total Knee Arthroplasty, Total Knee Arthroplasty Recovery, Pain After Knee Arthroscop
- Trial name
- TDP (NCT07586436)
- Testing
- 3. Control Group Description, 1. Stress Ball Intervention Description, 2. Breathing Exercise Intervention Description
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Knee Arthroplasty, Total, Anesthesia, Regional
Continuous Adductor Canal Block in Outpatient Total Knee Arthroplasty
Total knee arthroplasty (TKA) is a frequent performed surgery. Many institutions are implementing outpatient programs for this surgery and adequate pain management is an important feature.
- Conditions
- Knee Arthroplasty, Total, Anesthesia, Regional, Acute Pain
- Trial name
- NCT05100706
- Testing
- Continuous adductor canal block (CACB)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Toronto