Clinical trials: Total Knee Arthroplasty
Knee Osteoarthritis, Total Knee Arthroplasty
Adherence to Home-Based Physiotherapy and Music-Assisted Relaxation After Total Knee Arthroplasty
This randomized controlled study evaluated adherence to two home-based programs after total knee arthroplasty. All participants received a structured home-based physiotherapy program for 6 weeks.
- Trial name
- NCT07705971
- Testing
- Home-Based Physiotherapy, Music-Assisted Progressive Muscle Relaxation
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Pamukkale University
Perioperative Hypothermia, Total Knee Arthroplasty
Forced-Air Warming for Preventing Perioperative Hypot
Perioperative hypothermia is a common complication during total knee arthroplasty (TKA) and may increase the risk of shivering, delayed anesthetic recovery, and postoperative complications.
- Trial name
- NCT07613203
- Testing
- Forced-Air Warming, Routine Passive Warming
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Shanghai 6th People's Hospital
Arthroplasty, Replacement, Knee, Total Knee Replacement
Metal Ion Concentrations After Total Knee Arthroplasty
The purpose of this study is to analyze the metal ion concentrations in the patients blood following robotic-assisted total knee arthroplasty (TKA) compared to conventional total knee arthroplasty using cutting guides.
- Conditions
- Arthroplasty, Replacement, Knee, Total Knee Replacement, Blood Metal Ion Concentration
- Trial name
- NCT06447922
- Testing
- Metal ion level testing
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Total Knee Arthroplasty
Medrol Dosepak for Outpatient Total Knee Arthroplasty
The purpose of this study is to evaluate the efficacy of an oral methylprednisolone taper on acute postoperative pain, function, opioid consumption, nausea, and complications following outpatient total knee arthroplasty (TKA).
- Trial name
- NCT05097976
- Testing
- Methylprednisolone
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Total Knee Arthroplasty
Intraoperative VR for Older Patients Undergoing TKA
The objective of this study is to investigate whether the use of virtual reality (VR) during total knee arthroplasty (TKA) can facilitate reductions in intraoperative sedative requirements while maintaining high levels of patient…
- Trial name
- NCT04748549
- Testing
- Virtual Reality Immersive Relaxation, Immersive Audio Experience
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Beth Israel Deaconess Medical Center
Total Knee Anthroplasty, Total Knee Arthroplasty Recovery
The Effects of Mir Shakeel Teleintegrated Therapy Plan in Patients Undergoing Total Knee Arthroplasty
This randomized controlled trial aims to evaluate the effectiveness of a newly developed Modified Structured Telerehabilitation Intervention Protocol (MSTITP) compared with conventional in-person physical therapy in patients…
- Trial name
- RCT (NCT07239258)
- Testing
- Mir Shakeel Teleintegrated Therapy plan, Conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 150 people
- Sponsor
- Lincoln University College Malaysia
Periarticular Block, Osteoarthritis (OA)
Post-Operative Pain Relief: Zynrelef or Periarticular Injections in RATKA
Prospective Cohort of patients who are scheduled for a Robot Assisted Total Knee Arthroplasty (RATKA). A prospective survey of patient reported outcome measures (Numeric Rating Scale) will be obtained postoperatively of 72 hours…
- Conditions
- Periarticular Block, Osteoarthritis (OA), Osteoarthritis (OA) of the Knee, Pain After Surgery
- Trial name
- NCT07430085
- Testing
- bupivacaine-meloxicam (extended release), Bupivacaine, Ketorolac
- Volunteers
- 150 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Total Knee Arthroplasty Postoperative Pain, Opioid Reduction After TKA
NEUROCUPLE™ as an Opioid Alternative Following Total Knee Arthroplasty
The goal of this clinical trial is to learn if the NEUROCUPLE device can reduce pain and opioid use after primary unilateral total knee arthroplasty (TKA) in adults.
- Trial name
- NCT07439666
- Testing
- NEUROCUPLE™ Patch, Enhanced Recovery After Surgery (ERAS) Standard of Care
- Where
- 3 sites in United States
- Volunteers
- 274 people
- Sponsor
- Jacques E. Chelly
Postoperative Pain Management in Total Knee Arthroplasty
Efficacy of an AFCN Proxy Block in Post-TKA Multimodal Pain Management
This randomized controlled trial evaluates the additive effect of Supra-Sartorial Subcutaneous Infiltration (SSSI) when performed in combination with intermittent adductor canal block (iACB) and posterior capsule local…
- Trial name
- NCT07191964
- Testing
- Supra-Sartorial Subcutaneous Infiltration (SSSI), intermittent adductor canal block (iACB), posterior capsule local infiltration analgesia (PC-LIA)
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Taipei Medical University WanFang Hospital
Arthroplasty Replacement, Knee, Arthroplasty Total Hip Replacement
A Prospective, Single-arm, Trial to Determine Contamination Rates When Using an Antibacterial Incise Drape During Orthopedic Surgery
The goal of this clinical study is to generate data on the intended use of a chlorhexidine gluconate (CHG)-impregnated antimicrobial incise drape.
- Trial name
- NCT07356323
- Testing
- 3M™ Ioban™ CHG Chlorhexidine Gluconate Incise Drape (2% w/w CHG)
- Where
- 2 sites in United States
- Volunteers
- 179 people
- Sponsor
- Solventum US LLC
Osteopenia, Total Knee Arthroplasty
Vibration Applications After Total Knee Arthroplasty in Osteopenic Women
Osteoarthritis (OA) is a chronic degenerative disease characterized by the destruction of articular cartilage, leading to functional impairment of surrounding bone and soft tissues.
- Trial name
- NCT06988033
- Testing
- Whole Body Vibration Therapy, Whole Body Vibration with Exercise, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Istinye University
Total Knee Arthroplasty (TKA)
Total Intravenous Anesthesia vs Spinal Anesthesia in Patients Undergoing Unilateral Primary Total Knee Arthroplasty
The purpose of this study is to compare same-day discharge rates and recovery outcomes across an adult patient population undergoing elective Total Knee Arthroplasty (TKA), and randomized to receive either spinal block anesthesia…
- Trial name
- NCT07672301
- Testing
- Total IntraVenous Anesthesia (TIVA), Spinal-Block, Electroencephalogram (EEG)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Chicago
Total Knee Arthroplasty
Journey 2 Multi Center Kinematic Study
The objective of this study is to determine and compare the in vivo kinematics and vibroarthrography (VAG) signals for subjects implanted with Journey II Bi-Cruciate Stabilized (BCS), CR (Cruciate Retaining), and Bi-Cruciate…
- Trial name
- NCT05107414
- Testing
- Total Knee Arthroplasty
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- The University of Tennessee, Knoxville
Dual Subsartorial Block, Adductor Canal Block
Dual Subsartorial Versus Adductor Canal Block Versus Femoral Nerve Block for Postoperative Analgesia in Patients Undergoing Total Knee Arthroplasty
This study aims to compare the effect of dual subsartorial block (DSB), adductor canal block (ACB), and femoral nerve block (FNB) for postoperative analgesia in patients undergoing total knee arthroplasty (TKA).
- Conditions
- Dual Subsartorial Block, Adductor Canal Block, Femoral Nerve Block, Postoperative Analgesia
- Trial name
- NCT07082374
- Testing
- Dual subsartorial block, Adductor canal block, Femoral nerve block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Total Knee Arthroplasty
Methadone in the Management of Post-Operative Pain in Total Knee Replacement
The goal of this study is to determine whether one dose of IV methadone given right before surgery will help patients' pain management after a total knee replacement and reduce the amount of pain medications taken in the weeks…
- Trial name
- NCT07485803
- Testing
- Methadone
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- AdventHealth
Postoperative Cognitive Dysfunction (POCD), Cognitive Change
Early Cognitive Changes After Same-day Discharge Hip and Knee Arthroplasty
The goal of this observational study is to explore early cognitive changes in patients aged 70 years or older undergoing same-day discharge after hip or knee replacement surgery.
- Conditions
- Postoperative Cognitive Dysfunction (POCD), Cognitive Change, Total Knee Arthroplasty, Unicompartmental Knee Arthroplasty
- Trial name
- NCT07598552
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Odense University Hospital
Anterior Cruciate Ligament Reconstruction, Total Hip Arthroplasty (THA)
Brain-Computer Interface Visualization Training to Optimize Muscle Activation Following Orthopaedic Surgery
After orthopedic surgeries like knee or hip replacement, some patients struggle to fully activate their muscles due to a condition called Arthrogenic Muscle Inhibition (AMI).
- Conditions
- Anterior Cruciate Ligament Reconstruction, Total Hip Arthroplasty (THA), Total Knee Arthroplasty, Hip Arthroscopy
- Trial name
- iBrainTechRCT (NCT07020312)
- Testing
- Visualization training with neurofeedback, Standard post-surgical rehabilitation therapy
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Rush University Medical Center
Arthroplasty, Replacement, Knee, Total Knee Arthroplasty
Systemic Lidocaine Versus Ultrasound-guided Adductor Canal Block for Patients Undergoing Total Knee Arthroplasty
The investigators are evaluating the postoperative outcomes in patients undergoing total knee arthroplasty that receive either systemic lidocaine or ultrasound-guided adductor canal block as part of their anesthetic plan.
- Trial name
- ACBSL (NCT04828083)
- Testing
- Lidocaine IV, Saline IV
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Rhode Island Hospital
Total Knee Arthroplasty
Multimodal Biopsychosocial Teleprehabilitation for Total Knee Arthroplasty
Knee replacement surgeries are one of the most frequently performed elective surgeries, with approximately 29,000 such procedures carried out annually in Belgium.
- Trial name
- MULTIPREP (NCT06565377)
- Testing
- Multimodal biopsychosocial teleprehabilitation, Best-evidence prehabilitation advice
- Where
- 2 sites in Belgium
- Volunteers
- 40 people
- Sponsor
- Universitair Ziekenhuis Brussel
Postoperative Pain Following Knee Arthroplasty, Total Knee Arthroplasty
Biceps Femoris Short Head (BiFeS) Block and Adductor Canal Block for Postoperative Analgesia Following Total Knee Arthroplasty
This prospective randomized controlled study aims to evaluate the effect of ultrasound-guided Biceps Femoris Short Head (BiFeS) block combined with adductor canal block on postoperative opioid consumption and pain control in…
- Trial name
- BiFeS Adductor (NCT07577869)
- Testing
- Procedure: Biceps Femoris Short Head Block, Procedure: Spinal Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ömer Kayar