Clinical trials: Total Joint Replacement Surgery
Hip Replacement Surgery
Efficacy and Safety of Fibrin Sealant Vapor Heated Solvent/Detergent Treated (FS VH S/D) for Hemostasis in Subjects Undergoing Total Hip Replacement
The purpose of the study is to monitor the safety of FS VH S/D and evaluate whether FS VH S/D is superior to standard treatment in reducing blood loss in subjects undergoing total hip replacement with cement-free hip prostheses.
- Trial name
- NCT00161902
- Testing
- Fibrin Sealant Vapor-Heated Solvent/Detergent-treated
- Where
- 7 sites in Austria, Germany and 1 more
- Sponsor
- Baxter Healthcare Corporation
Osteoarthritis
Study of AQUACEL™ Ag Surgical Cover Dressing Following Total Knee Replacement
The aim of the study is to determine whether the AQUACEL™ Ag SURGICAL cover dressing is successful in reducing the incidence of wound infection in high risk patients following total knee replacement.
- Trial name
- NCT02217202
- Testing
- Aquacel Ag dressing
- Sponsor
- Golden Jubilee National Hospital
Degenerative Joint Disease, Osteoarthritis
PEAK PlasmaBlade 4.0 Versus Traditional Electrosurgery in Total Knee Replacement.
The objective of this clinical study is to evaluate the operative performance of the PEAK PlasmaBlade 4.0 during total knee replacement; to monitor and record post-operative pain, activity level, narcotic consumption, adverse…
- Trial name
- PRECISE (NCT01081886)
- Testing
- PEAK PlasmaBlade 4.0, Traditional Electrosurgery with scalpel
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Medtronic Surgical Technologies
Feasibility Studies
The Aim of This Study is to Assess the Feasibility of the Study Protocol and the Acceptability of the Mobile Application-Based Intervention. The Results Will Guide the Design and Evaluation of a Definitive, Larger-scale Study to Further Examine the Efficacy of the Refined Intervention.
This study is a pilot study for a larger future research project aimed at examining the effects of patient education delivered via a mobile application on patients' self-reported receipt of information in relation to their…
- Trial name
- NCT07589803
- Testing
- Digital patient education mobile application., Standard Care (in control arm)
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Coxa, Hospital for Joint Replacement
Osteoarthritis
Pain Expectations in Subjects With Osteoarthritis
The purpose of this research study is to test whether or not researchers can alter or change expectations on pain. The researchers will test whether there is an effect on the size of the pupil and responses to thermal heat…
- Trial name
- NCT02155257
- Testing
- Modafinil, Gabapentin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Joint Contracture
Joint Stiffness Following Knee Replacement Surgery
Our primary research question is to find out whether there is a genetic component to the development of joint contractures following knee surgery, through the application of lab techniques.
- Trial name
- NCT00664651
- Where
- Canada
- Sponsor
- Ottawa Hospital Research Institute
Tranexamic Acid, Arthroplasty, Replacement, Knee
Prevention of Bleeding in Total Joint Replacement: Combined Route Administration of Tranexamic Acid
The investigators aimed to compare two doses of intravenous (IV) tranexamic acid (TXA) with a combined single dose of topical and IV TXA on haemoglobin decline 24 hours after total joint arthroplasties.
- Conditions
- Tranexamic Acid, Arthroplasty, Replacement, Knee, Blood Transfusion, Arthroplasty, Replacement, Hip
- Trial name
- NCT05874583
- Testing
- Combined route administration of Tranexamic acid, Intravenous route Tranexamic acid injection
- Where
- Tunisia
- Volunteers
- 100 people
- Sponsor
- Mongi Slim Hospital
Excessive Amount of Blood / Fluid Transfusion
Iron and Vitamin Adminstration Prior to Joint Replacement to Prevent Transfusion
To establish the efficacy of screening for anemia and treatment of mild anemia with iron and vitamins prior to THR and TKR as a means of increasing hemoglobin and reducing perioperative allogeneic blood transfusion.
- Trial name
- NCT01676740
- Testing
- Iron Supplement,
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Meir Medical Center
Knee Replacement, Total
Knee Replacement Rehabilitation Care Pathways
Previous research has shown that use of rehabilitation (including physical therapy) and the recovery of function after knee replacement surgery may differ depending on patients' race, sex, income or insurance, and geographic…
- Trial name
- NCT07598539
- Testing
- TKA Journey - patient education, Optimized Rehab Scheduling, Usual Rehab
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Arthroplasty, Replacement, Knee, Anesthesia, Conduction
Adductor Canal Vs Adductor Canal Plus SPANK Block for Postoperative Pain in Knee Arthroplasty Surgery
This study will prospectively investigate the efficacy of Adductor canal block with periarticular infiltration Vs Adductor canal block, Periarticluar infiltration and Sensory posterior articular nerve of the knee block in…
- Conditions
- Arthroplasty, Replacement, Knee, Anesthesia, Conduction, Acute Pain
- Trial name
- NCT04290442
- Testing
- adductor canal block, SPANK, Ropivacaine
- Where
- United States
- Sponsor
- Bruce Ben-David
Osteoarthritis
A Randomized Controlled Trial of Long Versus Short Wait For Primary Total Hip and Knee Arthroplasty
The primary research question is: Does expedited hip and knee replacement result in improved lower-extremity function at 36 months post randomization as measured by the Western Ontario McMaster Universities Osteoarthritis Index…
- Trial name
- NCT00138892
- Testing
- Waiting time (access time to Total joint replacement)
- Where
- Canada
- Volunteers
- 236 people
- Sponsor
- University of British Columbia
Knee Osteoarthritis
Comparing Femoral Nerve Catheters to Single Shot Femoral Nerve Blocks for Total Knee Replacement Surgery
The purpose of this study is to compare two methods of pain control used during total knee joint replacement surgery. The pain medication that will be used for this study is not experimental.
- Trial name
- NCT02106481
- Testing
- Femoral Nerve Catheters, Single Shot Femoral Nerve Blocks
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Eastern Maine Medical Center
Knee Osteoarthritis, Replacement, Knee
Exploration of Appropriate BIS Range and Propofol Effect-site Concentration During Total Intravenous Anesthesia With Concomitant Adjuvants.
The goal of this clinical trial is to determine the appropriate Bispectral Index (BIS) range and propofol effect-site concentration required to maintain adequate anesthesia depth during total intravenous anesthesia (TIVA)…
- Conditions
- Knee Osteoarthritis, Replacement, Knee, Elective Surgical Patients, ASA Class I/II Patients
- Trial name
- NCT07736352
- Testing
- Propofol + Remifentanil +Midazolam, Propofol + Remifentanil + Dexmedetomidine, Propofol + Remifentanil + Esketamine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China-Japan Friendship Hospital
Innate Inflammatory Response, Osteoarthritis, Hip
The Immunomodulatory Effect of Sugammadex After Total Hip Replacement Surgery Under Neuraxial Anaesthesia: a Pilot Study
Monocenter randomized controlled proof of principle study to investigate the effect of sugammadex at the end of total hip replacement surgery on the postoperative innate immune function
- Trial name
- MAGIC (NCT05723406)
- Testing
- Sugammadex 100 MG/ML [Bridion]
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Osteoarthritis
Comparison of a Minimally Invasive Technique for Total Knee Replacement to a Standard Technique
Comparison of a minimally invasive technique for total knee replacement to a standard technique
- Trial name
- NCT00175474
- Testing
- knee surgery
- Where
- Canada
- Volunteers
- 102 people
- Sponsor
- University of British Columbia
Osteoarthritis
Improving Services and Outcomes for Joint Replacement Patients
Primary total knee or total hip replacement surgeries are costly high volume procedures \& outcomes may be affected by surgical \& care processes \& individual patient characteristics.
- Trial name
- NCT01899443
- Testing
- Observation
- Where
- 18 sites in Australia
- Volunteers
- 1,900 people
- Sponsor
- South West Sydney Local Health District
Postoperative Pain, Total Hip Replacement
Morphine COnsumption in Joint Replacement Patients, With and Without GaBapentin Treatment, a RandomIzed ControlLEd Study
Total hip arthroplasty is amongst the most painful procedures postoperatively, and pain management can be a challenge. Different measures have been introduced to manage severe postoperative pain in these patients.
- Trial name
- MOBILE (NCT00889148)
- Testing
- Gabapentin
- Where
- Canada
- Volunteers
- 103 people
- Sponsor
- McMaster University
Adverse Reactions to Metal Debris, Infection of Total Hip Joint Prosthesis
Imaging of Joint Replacement Complications by PET/CT
Total hip replacement is the well-established surgical method for treatment of hip osteoarthritis and related diseases. The outcome of the procedure is commonly satisfactory and most patients will not need any revision surgery.
- Conditions
- Adverse Reactions to Metal Debris, Infection of Total Hip Joint Prosthesis, Mechanical Loosening of Prosthetic Joint
- Trial name
- Propeli (NCT01970228)
- Testing
- 68Ga-citrate and 18F-FDG PET/CT imaging
- Where
- Finland
- Volunteers
- 12 people
- Sponsor
- Turku University Hospital
Knee Replacement Arthroplasty
Effect of Adductor Canal Block vs. Placebo on Muscle Strength, Mobilisation and Pain After Total Knee Arthroplasty
The purpose of this study is to evaluate the effect of adductor canal block (ACB) vs. placebo on muscle strength, mobility and pain on the first postoperative day after total knee alloplastic (TKA).
- Trial name
- NCT02242591
- Testing
- Ropivacaine 7,5 mg/ml, Saline
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- Ulrik Grevstad
Osteoarthritis, Arthritis
Bipolar Sealer Aquamantys Use in Total Knee Replacement
This study will compare the clinical outcomes for patients undergoing a total knee replacement using a bipolar sealer, the Aquamantys® System, as compared to standard electrocautery.
- Conditions
- Osteoarthritis, Arthritis, Surgery, Infection
- Trial name
- NCT01736644
- Testing
- Electrocautery, Bipolar sealer Aquamantys
- Where
- 2 sites in United Kingdom
- Volunteers
- 97 people
- Sponsor
- Medtronic Surgical Technologies