Clinical trials: Total Blood Loss
Blood Loss
Tranexamic Acid for Unilateral Total Knee Arthroplasty
Total knee arthroplasty is often associated with excessive postoperative bleeding due to increased fibrinolysis. Hence, the objective of the proposed of this multicentre study is to determine the peri-operative bleeding comparing…
- Trial name
- TRANEXTOP (NCT01594671)
- Testing
- Tranexamic Acid, haemostasia
- Where
- 2 sites in Spain
- Volunteers
- 150 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Infection of Total Knee Joint Prosthesis, Aseptic Loosening of Prosthetic Joint
Surgical / Economic Effect of the Aquamantys System in Blood Management for Aseptic and Septic Revision TKA
To assess the surgical and economic effectiveness of the Aquamantys System in managing intra- and post-operative blood loss, and reducing transfusion needs in patients undergoing both aseptic and septic revision total knee…
- Trial name
- NCT02266407
- Testing
- Aquamantys System
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medtronic Surgical Technologies
Esmarch Bandages, Simple Leg Elevation
Adequacy of Exsanguination Between Esmarch Bandages and Simple Leg Elevation in Total Knee Arthroplasty
To compare the adequacy of exsanguination in the surgical field between the use of the Esmarch bandages elevation and the simple leg elevation.
- Trial name
- NCT03989648
- Testing
- Esmarch bandages, simple leg elevation
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Navamindradhiraj University
Hemorrhage, Vascular Injury
A Transparent Elasticized Adhesive Occlusive Compression Bandage for Use as an Arterial Tourniquet
This cross-over study of twenty five (anticipated) healthy human subjects will utilize two active control devices, and two different widths of the investigational device.
- Trial name
- NCT02592655
- Testing
- Pneumatic Tourniquet, One Windlass Tourniquet, Two Windlass Tourniquets
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Marcus Migura
Orthopaedic Surgery
The Influence of Perioperative Strategies on the Extent of in Orthopaedic Prosthetic Surgery
To assess the extent of blood loss in prosthetic surgery, considering whether possible variables may influence, either positively or negatively, the extent of such loss.
- Trial name
- IPECO (NCT07500350)
- Where
- Italy
- Volunteers
- 1,683 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Arthropathy of Hip, Arthropathy of Knee
Tranexamic Acid Dosing for Total Joint Arthroplasty
The purpose of this study is to determine the effect of increasing doses of tranexamic acid (TXA) on limiting blood loss during total knee and total hip arthroplasty as defined by a change in hemoglobin from pre-operative…
- Trial name
- NCT02584725
- Testing
- Tranexamic Acid
- Volunteers
- 84 people
- Sponsor
- Columbia University
Surgical Blood Loss, Total Knee Arthroplasty
Topical Tranexamic Acid for Total Knee Arthroplasty
Total knee arthroplasty (TKA), the definitive treatment of osteoarthritis, is often associated with excessive postoperative bleeding due to increased fibrinolysis.
- Trial name
- NCT00985920
- Testing
- tranexamic acid
- Where
- Canada
- Volunteers
- 125 people
- Sponsor
- University Health Network, Toronto
Total Knee Arthroplasty
Study of Local Administration of DepoTXA for Reduced Postsurgical Bleeding in Subjects Undergoing TKA
This is a Phase 2, randomized, single-blind, active-controlled dose-ranging study in subjects scheduled to undergo total knee arthroplasty (TKA).
- Trial name
- NCT02922582
- Testing
- DepoTXA, Tranexamic Acid
- Where
- 5 sites in United States
- Volunteers
- 16 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Perioperative Bleeding, Coagulopathy During Cardiac Surgery
Flow-Based Platelet Function Assessment Using Total Thrombus-Formation Analysis System (T-TAS) and Early Bleeding After Cardiac Surgery With Cardiopulmonary Bypass (CPB)
The goal of this observational study is to learn how flow-based platelet function measured with the Total Thrombus-formation Analysis System (T-TAS) relates to early postoperative bleeding in adults undergoing cardiac surgery…
- Conditions
- Perioperative Bleeding, Coagulopathy During Cardiac Surgery, Platelet Dysfunction, Cardiac Surgery
- Trial name
- TTAS-CPB (NCT07619261)
- Testing
- Total Thrombus-formation Analysis System (T-TAS)
- Volunteers
- 30 people
- Sponsor
- Hospital de la Santa creu i Sant Pau - Barcelona
Hemorrhage Postoperative, Total Blood Loss
Noninferiority Oral Tranexamic Acid vs Intravenous Administration in Total Hip Arthroplasty
To find noninferiority relationship between oral and intravenous administration of tranexamic acid on peroperative and postoperative blood loss and serum concentration during primary total hip arthroplasty.
- Conditions
- Hemorrhage Postoperative, Total Blood Loss, Arthroplasty Complications
- Trial name
- NCT04691362
- Testing
- Tranexamic Acid Oral Product, Tranexamic acid injection
- Where
- Belgium
- Volunteers
- 230 people
- Sponsor
- University of Liege
Intraoperative Blood Loss
The Effect of Administration of Low Dose Adrenaline During Surgery on Bleeding During Hip Surgery
The purpose of this study is to evaluate the effect of intraoperative administration of low-dose adrenaline on intraoperative blood loss in patients undergoing hip surgery.
- Trial name
- NCT01708642
- Testing
- Adrenaline
- Where
- 3 sites in Denmark
- Volunteers
- 106 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Total Hip Arthroplasty (THA)
Comparison of Blood Loss Between Cemented and Uncemented Femoral Stems in Anterior Total Hip Arthroplasty
Total hip arthroplasty (THA) yields excellent results. To perform the procedure, the surgeon must make certain decisions, including the choice of fixation method for the femoral implant.
- Trial name
- FEMFIX (NCT07492212)
- Testing
- Total hip replacement with cemented fixation, Total hip replacement with non-cemented fixation
- Where
- 2 sites in France
- Volunteers
- 86 people
- Sponsor
- Clinique du Pré
Osteoarthritis, Blood Loss, Surgical
Non-inferiority Trial of Oral Tranexamic Acid vs. Intravenous Tranexamic Acid in Joint Replacement Surgery
The purpose of this research is to determine if the oral form of a medication (tranexamic acid) to reduce bleeding can be used in place of an intravenous (IV) form, to learn the best way to give tranexamic acid: either a pill by…
- Conditions
- Osteoarthritis, Blood Loss, Surgical, Blood Loss, Postoperative
- Trial name
- NCT02438566
- Testing
- Tranexamic Acid (Oral), Tranexamic Acid (Intravenous)
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- The New England Baptist Hospital
Osteoarthritis, Knee
Comparison of Topical and Infusion Tranexamic Acid After Total Knee Arthroplasty
The purpose of the study, therefore, is to conduct a prospective randomized controlled trial to investigate the blood-conservation effect of TXA in different TKA patients groups with rivaroxaban for VTE prophylaxis, first group…
- Trial name
- NCT02453802
- Testing
- Tranexamic Acid 5%,5ml/amp, rivaroxaban (10mg), 0.9% Normal Saline
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Chang Gung Memorial Hospital
Osteoarthritis, Hip, Blood Loss
Bipolar Sealer for Reduction of Blood Loss in Anterior Total Hip Arthroplasties
The overall objectives and purpose of this study is to show that the Smith and Nephew Werewolf Fastseal 6.0 Bipolar Sealer is an effective tool to aide the surgical team in providing significant hemostasis during anterior total…
- Trial name
- NCT05356637
- Testing
- Werewolf Fastseal 6.0
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- North Texas Medical Research Institute, PLLC
Arthroplasty, Replacement, Hip
Tranexamic Acid Study
The purpose of this study is to determine if tranexamic acid significantly reduces blood loss and blood transfusion in revision total hip replacement. Tranexamic acid is a drug that helps to reduce blood loss during surgery.
- Trial name
- NCT00375440
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Knee Osteoarthritis, Total Knee Arthroplasty
Effect of Preoperative Cold Therapy on Early Postoperative Outcomes in Total Knee Arthroplasty
This prospective, single-center, randomized controlled trial investigates the effects of preoperative cold therapy on early postoperative outcomes in patients undergoing unilateral primary total knee arthroplasty (TKA).
- Conditions
- Knee Osteoarthritis, Total Knee Arthroplasty, Cryotherapy, Postoperative Pain Management
- Trial name
- NCT07134283
- Testing
- Preoperative and Postoperative Cold Therapy with Gel Cold Pack, Postoperative Cold Therapy with Gel Cold Pack
- Where
- Turkey (Türkiye)
- Volunteers
- 208 people
- Sponsor
- Ankara City Hospital Bilkent
Primary Total Hip and Knee Arthroplasty
Pilot Study Evaluating Alterations in Thrombogenicity and Platelet Reactivity Following Lower Extremity Arthroplasty
This is a prospective, randomized study from pre-surgery to 6 weeks post-surgery designed to detect changes in coagulability following elective total knee and hip arthroplasty.
- Trial name
- NCT01809054
- Testing
- Arixtra, Pneumatic compression stockings, Aspirin
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- LifeBridge Health
To Calculate Total Blood Loss Immediately Postoperative
Efficacy of Topical Versus Intravenous Tranexamic Acid in Controlling Blood Loss
Total laryngectomy with bilateral block neck dissection is considered one of the major head and neck surgeries. Intraoperative bleeding is considered a risk factor for this operation specially that the population of this…
- Trial name
- NCT06188052
- Testing
- Tranexamic acid
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Kasr El Aini Hospital
Arthritis Knee, Blood Loss
Blood Loss Assessment in the Limited Application of Tourniquet During Primary Unilateral TKA
Tourniquet application in total knee arthroplasty has many benefits and might have a role in the incidence of peri-operative complications the aim of this research: is to look into the effectiveness of the limited application of…
- Conditions
- Arthritis Knee, Blood Loss, Arthroplasty Complications
- Trial name
- NCT05691751
- Testing
- primary unilateral total knee arthroplasty with limited application of tourniquet, primary unilateral total knee arthroplasty with full application of tourniquet
- Where
- Syria
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Damascus University