Clinical trials: Topical Anesthesia
Anesthesia of Mucous Membrane
Comparison of Topical and Nebulized Anesthesia in Patients Undergoing Esophago-Gastro-Duodenoscopy
This study compares the effect of nebulized lidocaine and lidocaine spray in patients undergoing esophago-gastro-duodenoscopy. The investigators evaluate the success rate of the procedure between two methods.
- Trial name
- NCT02317770
- Testing
- Lidocaine Spray, Nebulized Lidocaine
- Where
- Thailand
- Volunteers
- 110 people
- Sponsor
- Mahidol University
Pain, Acute, Laceration
Prospective Evaluation of Topical Analgesia for Laceration Repair in the Emergency Department
The purpose of this study is to determine if topical analgesia using a lidocaine and prilocaine cream improves pain scores compared to the usual local anesthesia using subcutaneous 1% lidocaine and adrenalin injected near the…
- Trial name
- NCT03071601
- Testing
- Lidocaine-Prilocaine Cream 2.5-2.5%, Lidocaine 1% Epinephrine 0.005mg/mL solution
- Where
- 2 sites in France
- Volunteers
- 132 people
- Sponsor
- Centre Hospitalier le Mans
Intratympanic Steroid Injection, Idiopathic Sudden Sensorineural Hearing Loss
Comparing Topical Tetracaine Drops to Topical Focal Phenol for Local Anesthesia During Intratympanic Steroid Injection
Intratympanic steroid injections are an accepted treatment for Meniere's disease and idiopathic sudden sensorineural hearing loss. This treatment is typically performed using local topical anesthesia.
- Conditions
- Intratympanic Steroid Injection, Idiopathic Sudden Sensorineural Hearing Loss, Meniere Disease
- Trial name
- NCT04794842
- Testing
- Tetracaine 5% drops, Phenol 90% concentration
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Our Lady of the Lake Hospital
Cataract
Comfort Operative Ocular Light Study
Digital 3D microscopes require less light and may be more comfortable for patients requiring cataract surgery under topical anesthesia compared to conventional microscopes.
- Trial name
- COOL (NCT05085314)
- Testing
- Ngenuity digital 3D microscope, Conventional microscope
- Where
- 2 sites in France
- Volunteers
- 134 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Perioperative Pain Experiences
Comparison the Topical Anesthesia and Retrobulbar Anesthesia for 27-gauge Vitrectomy for Vitreous Floaters
Routine anesthesia methods for vitrectomy surgery include retrobulbar and peribulbar anesthesia. However, both methods have potential complications that can vary from minor to severe.
- Trial name
- NCT03049163
- Testing
- vitrectomy under topical anesthesia [Proparacaine HCL (Alcaine®)]
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Lin Zhong
Pain
Topical Amethocaine Gel for Intramuscular Injection in Term Neonates
This study will examine the efficacy of topical amethocaine gel (Ametop) in decreasing the pain response in term neonates subjected to intramuscular injection for administration of vitamin K.
- Trial name
- NCT00267111
- Testing
- Eucerin plus, Amethocaine gel 4%
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- Mount Sinai Hospital, Canada
Procedural Pain
Comparison of Virtual Reality, EMLA Cream, and Standard Care for Pain During Blood Draws in Children
This randomized controlled trial evaluates methods to reduce pain during venipuncture in children aged 3 to 15 years. The study compares three approaches: virtual reality distraction using a VR headset, topical anesthesia with…
- Trial name
- NCT07763132
- Testing
- Virtual Reality Distraction, Lidocaine-Prilocaine Cream
- Where
- Czechia
- Volunteers
- 450 people
- Sponsor
- Marie Lulková
Pain Management
Pain Reduction Using Vibration and Topical Anesthesia
The goal of this clinical trial is to study if a powered toothbrush providing vibrations compared with 20% benzocaine topical gel is more effective in reducing pain before local anesthetic injections in children aged 6-12 years…
- Trial name
- TG-EB-Eff (NCT06804616)
- Testing
- 20% benzocaine Gel, Powered Toothbrush
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- University of Lahore
Arterial Catheterization
Rapydan Topical Anaesthesia for Arterial Cannulation
Arterial catheterization is painful and is associated with patient stress and anxiety. Analgesia is usually provided by subcutaneous injection of local anesthetic.
- Trial name
- NCT01494311
- Testing
- Lidocaine/tetracaine patch, Subcutaneous injection of 0.5 ml Lidocain 1%, Subcutaneous injection of saline
- Where
- 3 sites in United States, Austria and 1 more
- Volunteers
- 90 people
- Sponsor
- Medical University of Vienna
Anesthesia, Local
A Study of Safety and the Local Anesthetic Effect of AG-920 Ophthalmic Solution in a Pediatric Population
A Phase 3, randomized, active-controlled, study in pediatric subjects. It is designed to evaluate the safety and anesthetic efficacy of one dose of AG-920 ophthalmic solution compared to Proparacaine Hydrochloride Ophthalmic…
- Trial name
- NCT05325853
- Testing
- AG-920, Proparacaine Ophthalmic
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- American Genomics, LLC
Local Anesthesia of the Skin
Fractional Laser Assisted Delivery of Anesthetics III
The purpose of this study is to compare the effect of pretreatment with two different ablative laser modalities, a CO2 laser and an Er:YAG laser, and to assess the role of laser density in fractional laser assisted topical…
- Trial name
- NCT02938286
- Testing
- Fractional CO2 laser, 2.5 mJ, 5% density, Fractional CO2 laser, 2.5 mJ, 15% density, Fractional Er:YAG laser, 9 mJ, 5% density
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Netherlands Institute for Pigment Disorders
Skin Lacerations
Prospective Evaluation of Topical Anesthesia in Children
This study is designed to assess efficacy and comfort of LET solution vs. EMLA cream and topical infiltration of lidocaine.
- Trial name
- LET (NCT04378283)
- Testing
- LET gel (lidocaine 4%, epinephrine 0.1%, and tetracaine 0.5%), EMLA plus infiltration as anesthetic for wound repair.
- Where
- Germany
- Volunteers
- 99 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Wound, Anesthesia, Local
To Evaluate Reduction of Pain in Wounds Treatment Previously Applying Lidocaine Topical Solution vs Placebo.
The purpose of this study is to evaluate if applying a lidocaine topical solution before wounds treatment decreases the pain of the procedure in comparison with placebo solution.
- Trial name
- NCT03676556
- Testing
- Lidocaine, Saline Solution
- Where
- 2 sites in Spain
- Volunteers
- 46 people
- Sponsor
- Hospital Universitari de Bellvitge
Anesthesia
Effects of Benzocaine 20% Topical Anesthetic and no Topical Agent on Pain Perception During Intra-oral Injections
The aim of this randomized controlled trial. is to test the efficacy of topical anesthesia against the use of no topical agent during buccal infiltration in maxillary anterior teeth.
- Trial name
- NCT03261115
- Testing
- No topical anesthesia
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nurain Rehman
Analgesia
Effectiveness of Pre-administered Natural Sweet-tasting Solution (Honey) for Decreasing Pain of Needle Insertion
This study aims to assess Effectiveness of Pre-administered Natural Sweet-tasting Solution (honey) for Decreasing Pain Associated with Dental Injections (infiltration) prior to dental extraction in 6-8 years old healthy Children…
- Trial name
- NCT06393777
- Testing
- honey
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Cairo University
Macular Holes, Intraocular Lens Opacification
Oral Sedation in Vitreoretinal Surgery
The purpose of this study is to compare the efficacy of oral sedation to intravenous sedation with anesthesiology support and monitoring.
- Conditions
- Macular Holes, Intraocular Lens Opacification, Vitrectomy, Vitreous Hemorrhage
- Trial name
- NCT04346095
- Testing
- Oral Sedatives with or Without Analgesia, Intravenous Sedatives with or Without Analgesia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Rocky Vista University, LLC
Bronchopulmonary Disease
Nebulized Lignocaine for Topical Airway Anesthesia During Flexible Bronchoscopy: A Randomized Controlled Trial
Flexible bronchoscopy is one of the most widely performed procedures for diagnosis of various bronchopulmonary diseases. Most patients tolerate the procedure well although cough is often reported as a distressing symptom.
- Trial name
- NEBULA (NCT03040193)
- Testing
- Lignocaine Nebulization, Saline Nebulization
- Where
- India
- Volunteers
- 200 people
- Sponsor
- All India Institute of Medical Sciences
Pain
Comparison Between the Analgesic Effectiveness of Virtual Reality and Topical Anesthesia: A Clinical Study
A split-mouth, controlled trial aimed to clinically compare and evaluate the effectiveness of virtual reality versus topical anesthesia gel prior to administration of dental anesthesia injection in reducing the perceived pain and…
- Trial name
- NCT04919421
- Testing
- Dental injection and topical gel application, Dental injection and virtual reality device
- Where
- Saudi Arabia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Riyadh Elm University
Retinal Disease, Diabetic Retinopathy
Pain During Pars Plana Vitrectomy With Sub-tenon Anesthesia
Vitreoretinal surgery has evolved to less invasive procedures, and it is used to treat a wide range of diseases. So anesthesia for vitreoretinal procedures has evolved, promoting adequate analgesia while reducing risks to the…
- Conditions
- Retinal Disease, Diabetic Retinopathy, Maculopathy
- Trial name
- NCT03902925
- Testing
- Topical lidocaine 2% jelly plus sub-tenon ropivacaine 10% injection, Peribulbar injection
- Where
- Brazil
- Volunteers
- 56 people
- Sponsor
- University of Sao Paulo
Pain, Infant, Newborn
Intravenous and Topical Analgesics for Procedural Pain in Neonates
This study will test which type of pain medication is best for the management of pain in newborn preterm and full-term infants having a deep intravenous cannula inserted.
- Trial name
- NCT00213200
- Testing
- morphine, amethocaine
- Where
- 2 sites in Canada
- Volunteers
- 108 people
- Sponsor
- The Hospital for Sick Children