Clinical trials: Tooth Erosion
Tooth Erosion
In Situ Erosion Study to Investigate the Effectiveness of an Experimental Toothpaste
This will be a randomized, controlled, single center, single- blind, 3 period, 3 treatment, cross-over, in situ design which consists of placing pre-eroded bovine enamel specimens intra orally using a palatal appliance and…
- Trial name
- NCT03296072
- Testing
- 0.254% w/w sodium fluoride and 5% KNO3, 0.454% w/w stannous fluoride, 5% KNO3
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Erosion, Acid Wear
Evaluation of Efficacy of Experimental Gel to Foam Dentifrices in Dental Erosion
The purpose of this study is to compare and evaluate the ability of two European Union (EU) regulated gel to foam toothpaste formulations versus a non-fluoride toothpaste using a modified in-situ model of dental erosion and…
- Trial name
- NCT01657903
- Testing
- Sodium Fluoride, Potassium nitrate
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tooth Erosion
In Vivo Investigation of Initial Stages of Enamel Erosion
This exploratory study is designed to help develop a clinical model to measure the earlier stages of dietary acid medicated enamel loss. The study will use fluoride as positive control to explore the validity of this design.
- Trial name
- NCT02533466
- Testing
- Sodium fluoride + potassium nitrate, Potassium nitrate
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tooth Wear
Timing of Dietary Acid Intake, Brushing Teeth and Acid Erosion.
This is a questionnaire based study investigating the relationship between the timing of dietary acid intake toothbrushing and erosive tooth wear.
- Trial name
- NCT02449434
- Where
- United Kingdom
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- King's College London
Tooth Erosion
An Erosion Study to Investigate the Efficacy of an Experimental Dentifrice to Remineralize Enamel
The purpose of this study is to investigate the ability of an experimental dentifrice containing 1150 parts per million (ppm) fluoride to remineralize acid-softened dental enamel and help prevent further demineralization compared…
- Trial name
- NCT06242444
- Testing
- Experimental Dentifrice, Reference Dentifrice
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- HALEON
Tooth Erosion
Evaluation of a Test Mouthwash and Dentifrice Regimen in an In-situ Model of Dental Erosion
An in situ model will be used to evaluate and compare enamel remineralization of bovine enamel specimens.
- Trial name
- NCT01128972
- Testing
- Sodium fluoride, Sodium monoflurophosphate, Sterile water
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tooth Erosion
Intra Oral Kinetics of Fluoride Containing Dentifrices
The aim of this study is to assess the impact of formulation differences on fluoride retention clearance with US levels of fluoride (1150 ppm of fluoride) by evaluating and comparing between treatments the concentrations of…
- Trial name
- NCT02548156
- Testing
- Test Dentifrice, Reference Dentifrice, Comparator Dentifrice
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Erosion
Experimental Dentifrice Remineralization/Fluoride Uptake in an in Situ Model
The purpose of this study is to determine whether an experimental fluoridated dentifrice is effective in the treatment of dental caries
- Trial name
- NCT00752089
- Testing
- NaF/ KNO3/isopentane Dentifrice, NaF/KNO3 Dentifrice, NaF Dentifrice
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline