Clinical trials: Tolerance
Postprandial Glucose, GI Tolerance
A Crossover Study Evaluating the Postprandial Glycemic Response of Three Sweeteners in a Mixed Meal Setting
This study is using a double-blind, randomize crossover evaluating the impact of three different sweeteners on postprandial glycemic response in a mixed meal setting.
- Trial name
- NCT07895628
- Testing
- LOAM Fiber-based Sweetener, Sugar, Stevia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- LOAM Science
Kidney Failure Chronic, Stem Cell Transplant
Addition of Venetoclax to Combined Hematopoietic Stem Cell and Kidney Transplantation
The primary objective is to assess the safety of the addition of venetoclax to reduced intensity conditioning for HLA-matched and haploidentical combined HSC and kidney transplantation as measured by stable full donor…
- Conditions
- Kidney Failure Chronic, Stem Cell Transplant, Stem Cell Transplant Complications, Tolerance
- Trial name
- NCT07358195
- Testing
- Venetoclax, Hematopoietic Cell Transplantation Conditioning Regimen, Kidney Transplant
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Massachusetts General Hospital
Cardiovascular Diseases, Cardiac Rehabilitation
Effects of External Upper Limb Loading on Gait and Trunk Muscle Activity in Cardiac Rehabilitation Patients
This study examines how external loading applied to the upper limbs affects gait parameters and the activity of selected trunk- and pelvis-stabilizing muscles (erector spinae, gluteus medius, tensor fasciae latae, external…
- Conditions
- Cardiovascular Diseases, Cardiac Rehabilitation, Gait Abnormality, Muscle Contraction
- Trial name
- ND (NCT07803120)
- Testing
- External Upper Limb Loading During Treadmill Walking
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Pomeranian University in Slupsk
Type 2 Diabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Effects of Different Fish Oil Types on Type 2 Diabetes Risk Factors in High-Risk Adults
The purpose of this clinical trial is to find out whether one type of fish oil works better than another at improving metabolic health in people who are at high risk of developing type 2 diabetes.
- Conditions
- Type 2 Diabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Prediabetes / Type 2 Diabetes, Obesity & Overweight
- Trial name
- END-T2D (NCT07575438)
- Testing
- Fish Oil, Corn oil control
- Where
- Canada
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- May Faraj, PDt, PhD
PreDiabetes, Impaired Glucose Tolerance
Effect of Probiotics Versus Metformin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Prediabetes.
Pre diabetes (PD) is a term that refers to alterations in blood glucose levels, including impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or both, and increase in glycated hemoglobin (HbA1c), all this factors…
- Conditions
- PreDiabetes, Impaired Glucose Tolerance, Hyperglycemia, Resistance, Insulin
- Trial name
- NCT04341571
- Testing
- Probiotics, Metformin
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- University of Guadalajara
Aging, Frailty
Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults
This is a randomized, double-blind, placebo-controlled, two-arm crossover clinical trial evaluating the effects of nicotinamide mononucleotide (NMN) combined with trimethylglycine (TMG) supplementation, compared to NMN alone.
- Conditions
- Aging, Frailty, Exercise Tolerance, Healthy Male and Female Subjects
- Trial name
- NCT07144527
- Testing
- NMN and TMG (Euexia), Nicotinamide Mononucleotide (NMN)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Scott Silveira
Diabetes Mellitus, Type 2, Impaired Glucose Tolerance
Efficacy and Safety of Sanggua Tablets in the Treatment of Patients With Impaired Glucose Tolerance and Mild Type 2 Diabetes
Type 2 diabetes mellitus (T2DM) and impaired glucose tolerance (IGT) are growing public health challenges. Early intervention in mild T2DM and IGT is essential to prevent disease progression and severe complications.
- Trial name
- NCT06964620
- Testing
- Sanggua tablets
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Tongji Hospital
Preterm Infants, Orogastric Feeding
Effects of Different Positions During Skin-to-Skin Contact in Preterm Infants Receiving Orogastric Feeding
This study will be conducted as a randomized controlled crossover study to evaluate the effects of different positions during skin-to-skin contact on physiological parameters, comfort, and feeding tolerance in preterm infants…
- Conditions
- Preterm Infants, Orogastric Feeding, Feeding Tolerance, Skin to Skin Contact
- Trial name
- NCT07857512
- Testing
- Skin-to-Skin Contact in a Semi-Elevated Right Lateral Position, Skin-to-Skin Contact in an Upright Position, Control
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Multimodal Risk Factor Graph Mapping, Metabolic Subtyping, and Digital Intelligent Chronic Disease Management for Prediabetes: An Integrated Cohort and Case-Control Clinical Study
This observational study aims to understand the metabolic characteristics and long-term changes in adults with prediabetes and to identify risk and protective factors associated with progression to diabetes or return to normal…
- Conditions
- Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Impaired Fasting Glucose, Impaired Glucose Tolerance (Prediabetes)
- Trial name
- DM-PIONEER (NCT07854002)
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
Multiple Sclerosis, Heat Tolerance
Cooling During Inpatient Rehabilitation in Persons With MS
The goal of this clinical trial is to shed light on the use of cooling during intensive active training sessions during a three-week multidisciplinary inpatient rehabilitation stay in persons with Multiple Sclerosis.
- Conditions
- Multiple Sclerosis, Heat Tolerance, Fatigue Symptom
- Trial name
- CoolEx (NCT07852156)
- Testing
- Wearing a cooling vest during intensive, active training sessions, Control
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- Klinik Valens
Insulin Resistance, Glucose Tolerance
Effect of Daily Erythritol Versus Sucrose Intake Over 5 Weeks on Glucose Tolerance in Adolescents
This trial is divided into different parts: Part A the EryAdo trial and Part B the EryClot trial. Part A EryAdo Trial: Childhood and adolescence are crucial periods for prevention of obesity, as obese children are five times more…
- Conditions
- Insulin Resistance, Glucose Tolerance, Body Composition, Gastrointestinal Tolerance
- Trial name
- EryAdo (NCT04966299)
- Testing
- Erythritol, Sucrose, Glucose
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Kidney Failure, Transplant Recipient (Kidney)
Tolerance Through Mixed Chimerism (Sip-Tego)
This is an open-label, single-institution study to assess the safety and the efficacy of the Sip-Tego regimen for the induction of donor-specific immunologic unresponsiveness to a renal allograft.
- Conditions
- Kidney Failure, Transplant Recipient (Kidney), Transplant Tolerance, Immunosuppresion
- Trial name
- NCT06972069
- Testing
- Combined Kidney/Bone Marrow Transplant, Donation of Kidney / Bone Marrow, Conditioning Regimen (Rituxan, Siplizumab (or ATGAM), Cyclophosphamide, Tegoprubart)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Tatsuo Kawai, MD, PhD
Cannabis, Pain
Impact of Repeatedly-Administered THC-cannabis on Experimental Pain and Abuse Liability in Humans
Chronic pain is a significant public health concern in the U.S., for which prescription opioids have historically been the standard treatment. This has resulted in striking rates of opioid use disorders and fatal overdoses.
- Conditions
- Cannabis, Pain, Tolerance, Hyperalgesia
- Trial name
- NCT04596644
- Testing
- Active Cannabis
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Continuous Glucose Monitoring, Oral Glucose Tolerance
Non-Nutritive Sweetener Consumption and Glucose Homeostasis in Older Adults With Prediabetes
Animal and observational research in humans suggest that specific types of non-nutritive sweeteners (NNS) may impair glycemic control.
- Conditions
- Continuous Glucose Monitoring, Oral Glucose Tolerance, Insulin Sensitivity, Inflammatory Markers
- Trial name
- NCT05337098
- Testing
- Non-Nutritive Sweetener Intake and impact on glucose homeostasis
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Virginia Polytechnic Institute and State University
Body Weight, Oxidative Stress
The Effect of a Meatless,Keto Restrictive Diet on Body Composition,Strength Capacity,Oxidative Stress,Immune Response
The subject of doctoral dissertation: Assessment of the effects of a meatless, ketogenic restrictive diet on body composition, strength capacity, oxidative stress and immune response During planning of research and topic of the…
- Conditions
- Body Weight, Oxidative Stress, Trimethylamine N-oxide, Immunologic Factors
- Trial name
- NCT05558488
- Testing
- Meatless, restrictive ketogenic diet
- Where
- Poland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Katarzyna Siedzik
Diabetes Mellitus, Type 2, Impaired Glucose Tolerance (IGT)
Pre-diabetes in Subject With Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT)
HYPOTHESIS: Impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) have distinct pathophysiologic etiologies. Therefore, therapeutic interventions designed to correct the specific underlying pathogenic abnormalities…
- Conditions
- Diabetes Mellitus, Type 2, Impaired Glucose Tolerance (IGT), Impaired Fasting Glucose (IFG)
- Trial name
- NCT02969798
- Testing
- Dapagliflozin, Saxagliptin, Pioglitazone
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Moringa Leaf Powder for Prediabetes
The goal of this clinical trial was to learn whether Moringa oleifera leaf powder could lower fasting blood glucose in adults aged 25 to 55 years with prediabetes. It also assessed unwanted health effects during the intervention.
- Trial name
- NCT07833397
- Testing
- Moringa Oleifera Leaf Powder
- Where
- Indonesia
- Volunteers
- 114 people
- Sponsor
- Maranatha Christian University
Impaired Glucose Regulation, Impaired Glucose Tolerance (Prediabetes)
Probiotic Impact on Cognitive Performance, and Metabolic Outcomes in Overweight Young Adults With Impaired Glucose Regulation
This 12-week, double-blind, placebo-controlled trial will examine whether daily supplementation with the Lab4P probiotic can improve cognitive performance and metabolic health in overweight adults aged 18 to 40 with impaired…
- Conditions
- Impaired Glucose Regulation, Impaired Glucose Tolerance (Prediabetes), Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Overweight (BMI > 25)
- Trial name
- ProCog (NCT07073781)
- Testing
- Lab4p Probiotic Consortium
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Leeds Beckett University
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Efficacy and Safety of Oral Controlled-release Nicotinic Acid (CIR-NA) for the Remission of Prediabetes. (CONCEPT)
The goal of this clinical trial is to prevent the change from prediabetes (a pre-stage of type 2 diabetes mellitus (T2DM)) to T2DM in participants with prediabetes using oral CIR-NA (a nicotinic acid formulation that is designed…
- Trial name
- CONCEPT (NCT07286747)
- Testing
- controlled-ileal-release nicotinic acid as multiple dose 100 mg/day, controlled-ileal-release nicotinic acid as multiple dose 200 mg/day
- Where
- 6 sites in Germany
- Volunteers
- 390 people
- Sponsor
- University Hospital Schleswig-Holstein
Tolerance, Ureteral Double-J Stent
Risk Factors for Poor Tolerance of Ureteral Double-J Stent
The placement of a Ureteral Double-J Stent as an emergency treatment or preparation for endoscopy after Colic nephritis is very frequent. It is often poorly supported, most often by young patients.
- Conditions
- Tolerance, Ureteral Double-J Stent, Urinary Symptoms
- Trial name
- ToleJJ (NCT06815107)
- Testing
- questionnary, USSQ survey
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens