Clinical trials: Tobacco Dependence Treatment
Tobacco Use Cessation, Alcohol-related Disorders
Concurrent Alcohol and Smoking Treatment: Effects on Alcohol Relapse Risk
The majority of individuals with alcohol problems remain current smokers, and the negative health consequences of smoking among these individuals are substantial.
- Trial name
- NCT00861146
- Testing
- behavioral counseling plus contingency management
- Where
- 2 sites in United States
- Volunteers
- 151 people
- Sponsor
- Yale University
Tobacco Dependence, Alcohol Dependence
Effect of Varenicline on Reactivity to Smoking and Drinking Cues
Alcohol and nicotine dependence are often co-morbid, with 85% of alcoholics also smoking. However, very little research has been conducted into the nature of this co-occurrence.
- Trial name
- NCT00873535
- Testing
- Varenicline
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Smoking Cessation; Tobacco Dependence, E-Cig Use
BREATHE Free Curriculum
The purpose of this study is to evaluate whether BREATHE Free, an in-person faith-based smoking cessation program, can help people quit using tobacco products, including cigarettes, cigars, cigarillos, and e-cigarettes/vapes.
- Conditions
- Smoking Cessation; Tobacco Dependence, E-Cig Use, Nicotine Dependence, Other Tobacco Product
- Trial name
- NCT06862050
- Testing
- BREATHE Free Curriculum
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Augusta University
Nicotine Dependence, Nicotine Addiction
A Smartphone Application (ACT on Vaping) for Vaping Cessation in Young Adults
Almost one in ten young adults report current e-cigarette use, putting them at risk of developing nicotine addiction and long-term health effects of exposure to inhaled toxicants.
- Conditions
- Nicotine Dependence, Nicotine Addiction, Nicotine Use Disorder, Nicotine Vaping
- Trial name
- NCT05897242
- Testing
- Smartphone app, Text Message, Survey Administration
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Tobacco Use Disorder, Nicotine Dependence
The MATCH (Medication Aids for Tobacco Cessation and Health) Study
Clinically proven medications such as nicotine replacement therapy, bupropion and varenicline are available to help smokers quit but there are not widely used.
- Trial name
- MATCH (NCT02146911)
- Testing
- Bupropion, Varenicline, Weekly Motivational Emails
- Where
- Canada
- Volunteers
- 968 people
- Sponsor
- Centre for Addiction and Mental Health
Nicotine Dependence
Smoking While on Transdermal Nicotine Replacement Therapy: Effects on Craving and Cessation
Smoking while on nicotine patches will help subjects to reduce their expired carbon monoxide levels from the levels they were before they started using the patch. Subjects will also decrease their daily consumption of cigarettes.
- Trial name
- NCT00289653
- Testing
- Nicoderm
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Centre for Addiction and Mental Health
Tobacco Smoking, Harm Reduction
Smoking Harm Reduction Using E-cigarettes and Cytisine
Smoking remains the leading cause of preventable death globally, with high prevalence in disadvantaged populations despite access to free nicotine replacement therapy (NRT) and counseling through Ontario's STOP Program.
- Conditions
- Tobacco Smoking, Harm Reduction, Nicotine
- Trial name
- SHRECC (NCT07274475)
- Testing
- E-cigarette e-liquid, Cytisine
- Volunteers
- 6,000 people
- Sponsor
- Centre for Addiction and Mental Health
Nicotine Dependence
Transcranial Direct Current Stimulation in a Smoking Cessation Trial
The purpose of this study is to determine the effectiveness of transcranial direct current stimulation (tDCS) plus nicotine patch as a viable smoking cessation program for nicotine dependent smokers.
- Trial name
- tDCS (NCT01710410)
- Testing
- active transcranial Direct Current Stimulation
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Nicotine Dependence
Testing a Full Substitution Therapy Approach As Treatment of Tobacco Dependence
This study will test a new medication strategy designed to help smokers quit. It will combine selegiline, a drug currently approved and available for the treatment of Parkinson's disease, with a nicotine skin patch.
- Trial name
- NCT00390923
- Testing
- Selegiline + nicotine replacement therapy
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre for Addiction and Mental Health
Tobacco Dependence
Smoking Cessation With Smokeless Tobacco, Nicotine Tablets and Nicotine Patches
To test if smokeless tobacco is more effective than nicotine buccal tablets in smoking cessation compared with a control group with low dose nicotine patches.
- Trial name
- NCT00313105
- Testing
- Smokeless tobacco (Oliver Twist pellets), smoking cessation counseling
- Where
- Denmark
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Insomnia, Nicotine Dependence
Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and Zyban
Objectives: The primary objective of this study is to determine the efficacy of eszopiclone at treating sleep problems related to withdrawal from nicotine in healthy smokers attempting smoking cessation.
- Trial name
- NCT00511134
- Testing
- Eszopiclone, Bupropion
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Yale University
Smoking Cessation
Treatment of Smoking Lapses and Relapses
Many smokers who try to stop smoking with nicotine medications (NM) such as gum, lozenge and patch, go back to smoking (i.e., a slip or lapse).
- Trial name
- NCT01807871
- Testing
- nicotine patch, experimental use, nicotine patch, labeled use
- Where
- United States
- Volunteers
- 701 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Use; Tobacco, Harmful, Alcohol Abuse
Dental and Medical Office iMET to Reduce Teen Tobacco, Alcohol, and Drug Use
The purpose of the project is to improve adolescent behavioral counseling services in healthcare settings with a new Internet/Intranet-based Motivational Enhancement Therapy (iMET) intervention that targets the use of tobacco…
- Conditions
- Use; Tobacco, Harmful, Alcohol Abuse, Drug Abuse
- Trial name
- NCT00907309
- Testing
- iMET, iMET/TE
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Boston Children's Hospital
Tobacco Dependence, Smoking Cessation
Using Non-invasive Brain Stimulation (tDCS) With Varenicline for Treating Tobacco Dependence
The addition of tDCS as an adjunct to pharmacotherapy is a novel approach but one that is grounded in a growing evidence-base.The primary objective of this research is to provide preliminary evidence of the effectiveness of tDCS…
- Conditions
- Tobacco Dependence, Smoking Cessation, Tobacco Smoking, Tobacco Use Disorder
- Trial name
- NCT03841292
- Testing
- Varenicline, Active tDCS
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- Centre for Addiction and Mental Health
Nicotine Dependence
Mechanistic Evaluations of Pre-Cessation Therapies for Smoking Cessation
The purpose of this study is to look at brain function in order to understand how different treatments work to help people quit smoking.
- Trial name
- ConNicBrain (NCT01406223)
- Testing
- Varenicline, Bupropion, Nicotine patches
- Where
- 2 sites in United States
- Volunteers
- 282 people
- Sponsor
- Duke University
Tobacco Use Disorder
Smoking Cessation Treatment With Transdermal Nicotine Replacement Therapy - 1
The purpose of this study is to look at how feasible it is to incorporate a state-of-the-art smoking cessation treatment program into community substance abuse treatment programs and its impact on substance abuse and cigarette…
- Trial name
- NCT00067158
- Testing
- nicotine transdermal system
- Where
- 13 sites in United States
- Volunteers
- 585 people
- Sponsor
- New York University
Nicotine Dependence, E-Cig Use
Research and Innovation to Stop E-cigarette/Vaping in Young Adults
The aim of this study is to test intervention components to help young adults quit vaping. A 2x2 factorial design will be used where all participants receive quitline-delivered behavioral phone counseling, and components to be…
- Trial name
- (RISE) (NCT04974580)
- Testing
- Nicotine patch, Phone Counseling, Digital Coaching
- Where
- United States
- Volunteers
- 508 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Nicotine Dependence
Psilocybin-facilitated Smoking Cessation Treatment: A Pilot Study
One of the most promising lines of investigation for the therapeutic use of hallucinogens in the 1960s and 1970s was in the treatment of drug dependence.
- Trial name
- NCT01943994
- Testing
- Psilocybin-assisted treatment, Nicotine Replacement Therapy (NRT)
- Where
- 2 sites in United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
E Cigarette Use, Cessation, Tobacco
Evaluation of Dependence and Nicotine Replacement Therapy-Supported Cessation Efforts Among Regular Electronic Cigarette Use
This study aims to improve understanding of how people who use electronic cigarettes (ECIGs or e-cigarettes) respond when they try to stop using them and whether nicotine replacement therapy (NRT) can make that process easier.
- Conditions
- E Cigarette Use, Cessation, Tobacco, Cessation, Nicotine
- Trial name
- NCT07786896
- Testing
- Nicotine Replacement Therapies, Brief Behavioral Counseling
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- West Virginia University
Tobacco Use Cessation, Tobacco Use Disorder
Treating Nicotine Dependence in Schizophrenic Individuals: Effectiveness of Bupropion - 1
Schizophrenic individuals are typically nicotine dependent smokers who find it difficult to quit smoking. The purpose of this study is to determine the effectiveness of bupropion SR (commonly known as Zyban) in combination with a…
- Conditions
- Tobacco Use Cessation, Tobacco Use Disorder, Schizophrenia
- Trial name
- NCT00124683
- Testing
- Bupropion, nicotine transdermal patch
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)