Clinical trials: Tissue Preservation
Heart Failure With Normal Ejection Fraction
Neuromodulation to Treat Patients With Heart Failure With Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) is a leading cause of mortality in the elderly. Outcomes of patients with HFpEF are poor and so far, no treatment has been shown to decrease morbidity or mortality.
- Trial name
- NCT03327649
- Testing
- low level transcutaneous vagus nerve stimulation
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Oklahoma
Heart Failure With Normal Ejection Fraction
Interleukin-1 Blockade in HF With Preserved EF
Heart Failure with Preserved Ejection Fraction (HFpEF) is a common form of heart failure Standard treatment for heart failure, show less than ideal results in HFpEF Evidence of systemic inflammation is common in all forms of…
- Trial name
- D-HART2 (NCT02173548)
- Testing
- Anakinra
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Virginia Commonwealth University
Breast Cancer
Axillary Lymph Node Preservation Surgery in Reducing Lymphedema in Patients With Breast Cancer
This pilot phase I and randomized phase II trial studies the best way to perform axillary lymph node preservation surgery and to see how well it works in preventing lymphedema in patients with breast cancer.
- Trial name
- NCT00932035
- Testing
- axillary lymph node dissection, isosulfan blue based lymphatic mapping, quality-of-life assessment
- Where
- 3 sites in United States
- Volunteers
- 39 people
- Sponsor
- City of Hope Medical Center
Alveolar Bone Loss, Pathological Conditions, Anatomical
Comparison of Amnion Chorion Membrane vs. Dense Polytetrafluoroethylene Membrane in Ridge Preservation Procedures
The purpose of this study is to examine if a biologically active commercially available amnion chorion membrane (ACM) is as effective as the commercially available inert dense polytetrafluoroethylene membrane (D-PTFE) in…
- Trial name
- NCT02602223
- Testing
- Placing Amnion chorion membrane over grafted site, Placing d-PTFE membrane over grafted site
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Indiana University
Breast Cancer, Infertility
RCT of Fixed vs Titrated Letrozole in Breast Cancer Patient Undergoing IVF
The purpose of this study is to compare two different ways to administer Letrozole to determine their effectiveness in blocking estrogen production during ovarian stimulation in patients with breast cancer prior to…
- Trial name
- NCT01035099
- Testing
- Letrozole
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Weill Medical College of Cornell University
Diastolic Heart Failure, Hypertensive Heart Disease
Effects of the Dietary Approaches to Stop Hypertension(DASH) Sodium-restricted Diet in Diastolic Heart Failure
Heart failure with preserved systolic function (HF-PSF, or 'diastolic heart failure') accounts for half of hospitalizations for heart failure in patients over the age of 65.
- Trial name
- DASH-DHF (NCT00939640)
- Testing
- DASH/sodium-restricted diet (SRD)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Michigan
Hypertension Pulmonary Secondary Heart Failure, Right Sided Heart Failure With Normal Ejection Fraction
Open-Label Rollover Study of Levosimendan in PH-HFpEF Patients
PH-HFpEF patients will receive open-label doses of levosimendan and be periodically evaluated for safety in extended use.
- Conditions
- Hypertension Pulmonary Secondary Heart Failure, Right Sided Heart Failure With Normal Ejection Fraction, Heart Failure With Normal Ejection Fraction
- Trial name
- NCT03624010
- Testing
- Levosimendan
- Where
- 9 sites in United States
- Volunteers
- 35 people
- Sponsor
- Tenax Therapeutics, Inc.
Alveolar Bone Loss, Tooth Loss
Changes of Soft and Hard Tissues After Alveolar Ridge Preservation: Freeze-dried Bone Allograft vs. L-PRF Clot
A Clinical Trial to study the effectiveness between two, tooth socket grafting materials namely, Freeze Dried Bone Allograft (human derived bone particles) and Leukocytic-Platelet Rich Fibrin (the patient's own centrifuged…
- Trial name
- NCT03331185
- Testing
- Freeze Dried Bone Allograft, L-PRF clot
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Oligodendroglioma, Oligoastrocytoma
Safety and Efficacy of PD0332991 (Palbociclib), a Cyclin-dependent Kinase 4 and 6 Inhibitor, in Patients With Oligodendroglioma or Recurrent Oligoastrocytoma Anaplastic With the Activity of the Protein RB Preserved
This multicenter, open-label, phase II trial aims to assess the safety and efficacy of palbociclib in adult patients with Oligodendroglioma or recurrent oligoastrocytoma anaplastic with the activity of the protein RB preserved.
- Trial name
- NCT02530320
- Testing
- Palbociclib
- Where
- 11 sites in Spain
- Volunteers
- 34 people
- Sponsor
- Grupo Español de Investigación en Neurooncología
Heart Failure, Diastolic, Obesity
Exercise Intolerance in Elderly Patients With HFpEF(Heart Failure With Preserved Ejection Fraction)
The purpose of this study is to examine the effects of weight loss via hypocaloric diet (CR)and aerobic exercise (AT) compared to the effects of weight loss via hypocaloric diet (CR), aerobic training (AT)and resistance training…
- Trial name
- SECRET-II (NCT02636439)
- Testing
- dietary, aerobic and resistance training, dietary, and aerobic exercise
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Wake Forest University Health Sciences
Bone Loss, Vertical Alveolar Bone Loss
Bioactive Glass (Sol-gel) for Alveolar Bone Regeneration After Surgical Extraction
The purpose of the present research is to evaluate the effect of bioactive glass in bone regeneration immediately following extraction of mandibular and maxillary premolars.The hypothesis of the study assumes that this treatment…
- Conditions
- Bone Loss, Vertical Alveolar Bone Loss, Horizontal Alveolar Bone Loss
- Trial name
- NCT01878084
- Testing
- bioactive glass (sol-gel), empty extraction socket
- Where
- Egypt
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Breast Cancer, Hormone Changes
Triptorelin for Preserving Ovarian Function in Premenopausal Women Receiving Chemotherapy for Early-Stage Breast Cancer
RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Chemoprotective drugs, such as triptorelin, may protect normal ovarian cells from the side effects of…
- Conditions
- Breast Cancer, Hormone Changes, Drug Toxicity
- Trial name
- NCT00090844
- Testing
- triptorelin
- Where
- 9 sites in United States
- Volunteers
- 49 people
- Sponsor
- University of South Florida
Tooth Extraction
A Volumetric Analysis of Soft and Hard Tissue Healing for Ridge Preservation and Socket Seal After Tooth Extraction
This study will be a randomized clinical trial involving a total of 24 subjects. The investigators propose to recruit subjects into 2 groups: 1) Extraction treated with xenograft bone substitute (BioOss Collagen®) + collagen…
- Trial name
- NCT02844569
- Testing
- Xenograft bone substitute, Collagen dressing, 3D-collagen matrix
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Meniscus Tear, Knee Meniscus Injury
High-Purity Type I Collagen Augmentation in Meniscal Repair
This prospective, single-arm feasibility study evaluates the safety, procedural feasibility, and early clinical outcomes of High-Purity Type I Collagen used as an adjunct in arthroscopic meniscal repair.
- Conditions
- Meniscus Tear, Knee Meniscus Injury, Meniscal Repair, Knee Arthroscopy (for Diagnostic or Therapy)
- Trial name
- NCT07352410
- Testing
- High-Purity Type I Collagen
- Where
- India
- Volunteers
- 18 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Heart Failure With Preserved Ejection Fraction, Sleep Disordered Breathing
Heart Function in Patients Assessed for Sleep Apnoea
This study aims to determine the prevalence and prognosis of heart failure with preserved ejection function (HFpEF) among patients being assessed for sleep disordered breathing (SDB).
- Conditions
- Heart Failure With Preserved Ejection Fraction, Sleep Disordered Breathing, Heart Failure With Normal Ejection Fraction, Obstructive Sleep Apnea
- Trial name
- NCT03226652
- Where
- United Kingdom
- Volunteers
- 101 people
- Sponsor
- Imperial College London
Hypertension Pulmonary Secondary, Heart Failure, Right Sided
Hemodynamic Evaluation of Levosimendan in Patients With PH-HFpEF
Phase 2 study to evaluate the efficacy and safety of intermittent levosimendan compared with placebo in hemodynamic improvement with exercise in PH-HFpEF subjects
- Conditions
- Hypertension Pulmonary Secondary, Heart Failure, Right Sided, Heart Failure With Normal Ejection Fraction
- Trial name
- HELP (NCT03541603)
- Testing
- Levosimendan
- Where
- 16 sites in United States
- Volunteers
- 44 people
- Sponsor
- Tenax Therapeutics, Inc.
Breast Cancer
Goserelin Acetate Study for Ovarian Function in Patients With Primary Breast Cancer
Primary Objective: To determine the effectiveness of goserelin acetate (Zoladex) in preserving ovarian function in premenopausal women undergoing neoadjuvant and/or adjuvant chemotherapy for primary invasive breast cancer by…
- Trial name
- NCT00429403
- Testing
- Goserelin
- Where
- 2 sites in United States, Japan
- Volunteers
- 1 people
- Sponsor
- M.D. Anderson Cancer Center
Heart Failure With Normal Ejection Fraction, Sleep Apnea
Adherence to ASV Therapy in Heart Failure With Preserved Ejection Fraction Feasibility Study
This study is designed to demonstrate feasibility of study conduct and that acceptable adherence to adaptive servo-ventilation (ASV) therapy can be achieved in recently hospitalized HFpEF patients with moderate to severe sleep…
- Trial name
- CAT-PEF (NCT03195660)
- Testing
- ASV Therapy
- Where
- 4 sites in United States, Germany
- Volunteers
- 6 people
- Sponsor
- ResMed