Clinical trials: Tissue Preservation
Soft Tissue Atrophy
Using of Collagen Matrix for Maxillary Tuberosity Donor Area Preservation
An interventional prospective randomised clinical trial (RCT) in parallel groups is planned. The sample size was 30 patients who will be randomly divided into two groups based on the surgical procedure.
- Trial name
- NCT06039839
- Testing
- Closure of the donor area after CTG harvesting without the use of collagen matrix, Closure of the donor area after CTG harvesting with collagen matrix
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Heart Failure With Normal Ejection Fraction
Neuromodulation to Treat Patients With Heart Failure With Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) is a leading cause of mortality in the elderly. Outcomes of patients with HFpEF are poor and so far, no treatment has been shown to decrease morbidity or mortality.
- Trial name
- NCT03327649
- Testing
- low level transcutaneous vagus nerve stimulation
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Oklahoma
Fertility Preservation, Ovarian Tissue Cryopreservation
Preservation of Ovarian Cortex Tissue in Girls With Turner Syndrome
Rationale: Infertility due is a major concern for girls with Turner syndrome (TS) and their parents. Physicians are often asked about possible options to preserve their fertility.
- Conditions
- Fertility Preservation, Ovarian Tissue Cryopreservation, Turner Syndrome, Live Birth
- Trial name
- NCT03381300
- Testing
- Ovarian tissue cryopreservation
- Where
- Netherlands
- Volunteers
- 106 people
- Sponsor
- Radboud University Medical Center
Heart Failure With Preserved Ejection Fraction (HFPEF)
The Role of Epicardial Adiposity in Heart Failure With Preserved Ejection Fraction
In this study the investigators are aiming to recruit 130 patients with heart failure with preserved ejection fraction who are obese and non-obese to undergo CT and MRI scans, as well as some other investigations including blood…
- Trial name
- EAT HFpEF (NCT06768437)
- Where
- United Kingdom
- Volunteers
- 130 people
- Sponsor
- University of Leicester
Minimal Residual Disease, Fertility Preservation
Contamination of Ovarian Tissue by RT-PCR in Participants With Solid Tumors
For prepubertal patients, cryopreservation of ovarian tissue is the only option available to preserve their fertility before cancer treatment.
- Trial name
- OVAMAR (NCT02400827)
- Testing
- malignant cells
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Socket Preservation
Post Extraction Alterations Following Ridge Preservation In The Esthetic Zone Using Partially Demineralized Autogenous Dentine Graft Versus Xenograft
the aim of this study is to establish if there are clinical, radio-graphical and histomorphometrical differences between using Partially Demineralized Dentin graft versus Xenograft in the esthetic zone.
- Trial name
- NCT06552793
- Testing
- autogenous partially demineralized dentin graft, Xenograft
- Where
- Egypt
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Cairo University
Glioma
fMRI Reveal Functional Preservation in Glioma Peritumoral Edema
he goal of this observational study is to investigate the functional and biological characteristics of the brain tissue surrounding diffuse gliomas, known as peritumoral edema (PTE).
- Trial name
- NCT07343492
- Where
- China
- Volunteers
- 44 people
- Sponsor
- West China Hospital
Cancer, Cancer-Related Condition
Testicular Tissue Cryopreservation in Children
This protocol is being designed to offer testicular tissue cryopreservation to male pediatric patients (0-17 years of age) with fertility threatening medical diagnoses or facing surgery, chemotherapy or radiation therapy that may…
- Conditions
- Cancer, Cancer-Related Condition, Infertility
- Trial name
- NCT02872532
- Testing
- Testicular tissue cryopreservation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic
Breast Augmentation and Breast Reconstruction, Mammaplasty
Clinical Study on Tissue Preservation in Breast Augmentation and Reconstruction
This clinical study aims to evaluate the safety and effectiveness of advanced, minimally invasive techniques for breast augmentation and reconstruction.
- Conditions
- Breast Augmentation and Breast Reconstruction, Mammaplasty, Breast Augmentation, Tissue Preservation
- Trial name
- NCT07623564
- Testing
- Mia Harmonization, Mia Scarless Lift, Mia Reconstruction
- Where
- Costa Rica
- Volunteers
- 60 people
- Sponsor
- Establishment Labs
Breast Cancer
Increasing Access to Fertility Preservation for Women with Breast Cancer
The EVAPREF project aims to increase access to fertility preservation by developing an approach to improve and evaluate existing information and coordination tools developed by the Pays-de-la-Loire and Occitanie Regional Cancer…
- Trial name
- EVAPREF (NCT05989776)
- Testing
- Informational brochure for patients and brief training for oncologists
- Where
- 2 sites in France
- Volunteers
- 750 people
- Sponsor
- University Paul Sabatier of Toulouse
Reconstructive Surgical Procedure
Nonincised Papillae in the Treatment of Intrabony Defects.
The primary objective of the present study is to clinically and radiographically evaluate nonincised papillae surgical approach and entire papilla preservation approach for the treatment of intrabony defects with GTR membrane and…
- Trial name
- NCT04376450
- Testing
- Experimental- Nonincised papillae surgical approach, Active comparator- Entire papilla preservation technique
- Where
- India
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences
Chronic Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF)
Precision Subtyping and Prognostic Study of Heart Failure Based on Multi-Omics Integration and Clinical Indicators: A Prospective Single-Center Cohort Study
This is a prospective single-center cohort study conducted at The First Affiliated Hospital of Xinjiang Medical University, aiming to enroll 400 patients with chronic heart failure (including HFrEF, HFmrEF, HFpEF) and 200 healthy…
- Conditions
- Chronic Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF), Heart Failure With Preserved Ejection Fraction (HFPEF), Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF)
- Trial name
- HF-MultiOmics (NCT07355088)
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Xinjiang Medical University
Coronary Artery Disease
A Study of Hemopure® to Enhance Tissue Preservation During Cardiopulmonary Bypass Surgery
The purpose of this study is to determine if Hemopure® will enhance tissue preservation during Cardiopulmonary Bypass surgery.
- Trial name
- NCT00301535
- Testing
- HBOC-201 (hemoglobin glutamer-250 bovine)
- Where
- 3 sites in Greece, South Africa and 1 more
- Volunteers
- 60 people
- Sponsor
- Biopure Corporation
Gonadotropin Releasing Hormone Agonists, Ovarian Function
Gonadotropin-Releasing Hormone Agonists Benefit in Preserving the Ovarian Function in Premenopausal Breast Cancer Patients During Chemotherapy
The purpose of this study is to investigate the benefits of gonadotropin-releasing hormone agonist administration during chemotherapy on preserving ovarian function and Fertility in Premenopausal breast cancer patients, as…
- Conditions
- Gonadotropin Releasing Hormone Agonists, Ovarian Function, Premenopausal, Breast Cancer
- Trial name
- NCT07127315
- Testing
- Gonadotropin-releasing hormone agonist, Chemotherapy
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Helwan University
Alveolar Ridge Preservation, Socket Preservation
Radiographic And Histomorphometric Assessment Following Alveolar Ridge Preservation Using Chitosan Gel Versus Normal Socket Healing In Posterior Maxillary and Mandibular Region
After tooth extraction, the alveolar bone, which supports the teeth, undergoes a natural resorption process. This bone loss can be significant, especially in the first few months post-extraction, leading to a reduction in both…
- Conditions
- Alveolar Ridge Preservation, Socket Preservation, Wound Healing
- Trial name
- NCT07571863
- Testing
- Chitosan gel Sigma-Aldrich® in socket preservation, Gelfoam® absorbable gelatin sponge in socket preservation post extraction
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Cairo University
Glioblastoma, Glioblastoma Multiforme
Improving Understanding of Glioblastoma Through Preservation of Biologically Active Brain Tissue
To collect and preserve glioblastoma tissue during standard of care tumor resection surgery and blood for future molecular and genetic testing.
- Conditions
- Glioblastoma, Glioblastoma Multiforme, Gliosarcoma
- Trial name
- NCT05756985
- Testing
- Specimen Collection
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Baptist Health South Florida
Alveolar Bone Loss
Clinical, Radiographical, Histological Evaluation and Blood Flow Analysis of Alveolar Ridge Preservation
With alveolar ridge preservation (ARP) ridge resorption following extraction may be reduced. Several materials and techniques have been advocated for ARP.
- Trial name
- NCT05674331
- Testing
- Extraction site development technique, autogenous tooth bone graft, Socket seal technique
- Where
- Hungary
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Atypical, Myoma
Transcervical Myoma Biopsy Video
To describe the fertility-sparing management of an atypical uterine myoma. Step-by-step video explanation of transcervical biopsy using transabdominal ultrasound guidance, highlighting tips and tricks.
- Trial name
- TMBV (NCT04983719)
- Where
- France
- Volunteers
- 1 people
- Sponsor
- University Hospital, Montpellier
Invasive Ductal Breast Carcinoma
Efficacy and Tolerance of an Ovarian Stimulation Protocol Combining Follicle Stimulating Hormone (FSH) and Degarelix Acetate in Female Candidates for Fertility Preservation Before Chemotherapy for Breast Cancer
The present investigation aims to evaluate the efficacy of an innovative protocol of controlled ovarian stimulation for breast cancer patients, who are candidates for fertility preservation.
- Trial name
- DEGASTIM (NCT03947151)
- Testing
- Degarelix injection(s)
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cancer, Toxicity Due to Chemotherapy
Co-treatment With GnRH Analogs on the Ovarian Reserve in Young Women Treated With Alkylating Agents for Cancer
The purpose of this study is to determine the efficacy of a temporary ovarian suppression obtained by administration of a gonadotropin releasing hormone agonist during alkylating agents containing chemotherapy on ovarian reserve…
- Conditions
- Cancer, Toxicity Due to Chemotherapy, Sarcoma, Osteosarcoma
- Trial name
- PRESOV (NCT02856048)
- Testing
- Triptorelin (GnRHa) + Chemotherapy
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris