Clinical trials: Tissue Perfusion, open to volunteers
Uveal Melanoma, Metastatic Cutaneous Melanoma
Locoregional Administration of TIL and Lymphodepletion in Patients With Melanoma and Liver Metastases
Evaluate the safety and tolerability of treatment with autologous tumor infiltrating lymphocytes (TIL) administered via hepatic arterial infusion and preconditioning with percutaneous hepatic perfusion in patients with liver…
- Trial name
- HAITILS-PHP (NCT05903937)
- Testing
- Autologous Tumor Infiltrating Lymphocytes, Melphalan, Interleukin-2
- Volunteers
- 6 people
- Sponsor
- Vastra Gotaland Region
SEPSIS, Septic Patients
Peripheral Perfusion and Outcomes in ICU Patients With Sepsis
People with sepsis who are treated in the intensive care unit (ICU) often have impaired blood flow to the skin and other tissues.
- Trial name
- PERFUSE-ICU (NCT07391098)
- Testing
- PERIPHERAL PERFUSION EVALUATION
- Where
- Romania
- Volunteers
- 80 people
- Sponsor
- Alexandra Elena Lazăr
Reconstructive Surgery Using Pedicled Perforating or Free Perforating Flaps, Pelvic Eschar
Study and Modeling of Perforator Flap Vascularization
The aim of reconstructive surgery is to restore physical integrity altered by trauma, congenital malformations or cancerous pathologies.
- Conditions
- Reconstructive Surgery Using Pedicled Perforating or Free Perforating Flaps, Pelvic Eschar, Traumatic Pathology of the Lower and/or Upper Limb
- Trial name
- EMoVaLP (NCT07084740)
- Testing
- PeriCam and PeriFlux measurements
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
Uveal Melanoma
Immune Response to Percutaneous Hepatic Perfusion With Melphalan for Ocular Melanoma Metastatic to the Liver
This study seeks to better understand the liver's immune response to receiving chemotherapy agent melphalan through Percutaneous Hepatic Perfusion (PHP) alone or in combination with Ipilimumab and Nivolumab for patients with…
- Trial name
- NCT07364474
- Testing
- Melphalan through Percutaneous Hepatic Perfusion, Melphalan through Percutaneous Hepatic Perfusion in combination with Ipilimumab and Nivolumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Normal Pregnancy
Using Cotyledon Perfusion to Study Drugs Transfer Across the Placenta
Drug prescriptions are usual during pregnancy however women and their fetuses still remain an orphan population with regard to drugs efficacy and safety clinical studies.
- Trial name
- DRUGS-PTP (NCT04400084)
- Testing
- Placenta perfusion
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Capillary Refill Time, Peripheral Tissue Perfusion
Smartphone Application for Automated Measurement of Capillary Refill Time (CRT)
This prospective, monocenter observational study aims to validate a smartphone application (CRTApp) that automatically measures capillary refill time (CRT) from a short video of a standardized finger compression.
- Trial name
- CRTApp (NCT07473869)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Delirium - Postoperative, Postoperative Cognitive Dysfunction (POCD)
Value of the Time-Weighted Average (TWA) of Mean Arterial Pressure (MAP) and Cerebral Oximetry (rSO₂) as Predictors of Postoperative Tissue Perfusion Impairment in Patients Undergoing Cardiac Surgery
Neurological problems after heart surgery are common and include confusion, memory loss, and difficulty thinking clearly. These issues may appear hours or days after surgery and can negatively affect recovery.
- Conditions
- Delirium - Postoperative, Postoperative Cognitive Dysfunction (POCD), Postoperative Acute Kidney Injury, Postoperative Morbidity
- Trial name
- NCT07510711
- Testing
- Continuous intraoperative monitoring of MAP and rSO₂; observational study with no therapeutic intervention.
- Volunteers
- 120 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Bone Sarcoma, Soft Tissue Sarcoma
In Vivo Lung Perfusion for Pulmonary Metastases of Sarcoma
Sarcoma which has spread to the lungs is most often treated with surgery. Even with surgery, most patients will not be cured and will die from their disease, probably because of small cancer cells that are present in the lungs at…
- Conditions
- Bone Sarcoma, Soft Tissue Sarcoma, Pulmonary Metastases
- Trial name
- NCT02811523
- Testing
- Doxorubicin
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- University Health Network, Toronto
Septic Shock, Sepsis
Discordance Between Capillary Refill Time and Oxygen Extraction Ratio in Septic Shock
In septic shock, restoring large-vessel (macrocirculatory) perfusion-reflected by a normal capillary refill time (CRT)-does not always mean that oxygen use at the tissue level has recovered.
- Trial name
- DISCO-SHOCK (NCT07774962)
- Testing
- Capillary refill time (CRT), Oxygen extraction ratio (O₂ER) assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul University - Cerrahpasa
Metastatic Melanoma, Liver Metastases
Hepzato Kit and Opdualag for Metastatic Melanoma and Liver Metastasis
This study is being done to see if combining HEPZATO KIT™ with nivolumab and relatlimab (Opdualag™) in patients with metastatic melanoma with liver metastasis is safe, tolerable, and will have a synergistic effect leading to…
- Trial name
- NCT07281924
- Testing
- Nivolumab and Relatlimab, Melphalan
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Wisconsin, Madison
Septic Shock, Fluid Resuscitation
Evolution of Tissue Perfusion and Venous Congestion Markers in Fluid-Responsive Septic Shock Patients
Septic shock remains a leading cause of mortality in intensive care, and while fluid resuscitation (FR) is a cornerstone of early management, its benefit-risk balance is highly variable.
- Conditions
- Septic Shock, Fluid Resuscitation, Congestion, Venous
- Trial name
- FLUID-IMPACT (NCT06958809)
- Testing
- Echography
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hospital Ambroise Paré Paris
Kidney Failure, Chronic, Kidney Transplantation
Drone Transport of Deceased-Donor Kidney Grafts Between Two French Hospitals Before Transplantation: a Pilot Safety Study
Cold ischemia time, the period during which a donated kidney is kept cold outside the body between its removal from the donor and its transplantation into the recipient, is one of the main modifiable factors influencing how…
- Conditions
- Kidney Failure, Chronic, Kidney Transplantation, Delayed Graft Function, Cold Ischemia
- Trial name
- RAfALREIN (NCT07851571)
- Testing
- Kidney graft transport by autonomous unmanned aircraft (drone) between the procurement and transplantation centres
- Volunteers
- 5 people
- Sponsor
- Nantes University Hospital
Fetal Conditions, Maternal; Procedure
A Prospective Study on the Role of Karl Storz Curved and Straight Fetoscopes (11508AAK and 11506AAK) for Fetoscopic Intrauterine Procedures
In this research study, the investigators want to learn more about the role of new innovative surgical devices, the Karl Storz Curved and Straight Fetoscopes for in-utero surgery.
- Conditions
- Fetal Conditions, Maternal; Procedure, Pregnancy Related, Twin to Twin Transfusion Syndrome
- Trial name
- NCT06056635
- Testing
- Karl Storz Curved Scope, Karl Storz Straight Scope
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital
Urethral Perfusion Index, Tissue Perfusion
Urethral PeRfusion Index-Guided Hemodynamic ManagemenT in Patients Having Major Abdominal Surgery: the UPRIGHT Randomized Feasibility Trial
We will perform this single-center pilot trial to determine if the intraoperative urethral perfusion index is higher in patients assigned to maintaining postinduction baseline urethral perfusion index than in patients assigned to…
- Conditions
- Urethral Perfusion Index, Tissue Perfusion, Microcirculation
- Trial name
- UPRIGHT (NCT06799832)
- Testing
- urethal perfusion index monitoring
- Where
- 2 sites in Germany
- Volunteers
- 116 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Acute Ischemic Stroke
Recombinant Human Prourokinase for Acute Ischemic Stroke in the Extended Window Selected by CT-Based Artificial Intelligence
This multicenter, prospective, randomized, double-blind, placebo-controlled trial aims to evaluate the efficacy and safety of intravenous recombinant human prourokinase (rhPro-UK) in patients with acute ischemic stroke treated…
- Trial name
- RAISE-AI (NCT07901842)
- Testing
- Recombinant Human Prourokinase for Injection (rhPro-UK)
- Where
- China
- Volunteers
- 826 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
To Assess the Feasibility, Visualization Capability, and Optimal Dosing of ICG Fluorescence Imaging for Intraoperative Assessment of Knee Tissue Perfusion
ICG Fluorescence in Knee Arthroscopy Study
The purpose of this study is to first evaluate whether ICG fluorescence angiography can be used to evaluate blood flow of the anterior cruciate ligament (ACL), tendons, and knee structures during an arthroscopic surgery.
- Trial name
- NCT07793266
- Testing
- Intravenous administration of indocyanine green (SPY Agent Green) 2 mL of SPY Agent Green (5.0 mg dose), Intravenous administration of indocyanine green (SPY Agent Green) 3 mL of SPY Agent Green (7.5 mg dose), Intravenous administration of indocyanine green (SPY Agent Green) 4 mL of SPY Agent Green (10 mg dose)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Henry Ford Health System
Kidney Neoplasm, Renal Mass up to 7cm
Hyperspectral Imaging in Robot-Assisted Partial Nephrectomy
The goal of this prospective observational study is to learn about the use of a novel imaging technique called hyperspectral imaging in adult participants who are having surgery for removing a tumor from their kidney.
- Trial name
- HSI-Renal (NCT07803315)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Leipzig
Gingival Vascularization, Oral Soft Tissue Wound Healing
Analysis of the Reliability and Validity of Laser Speckle Contrast Imaging
This study is designed to validate laser speckle contrast imaging (LSCI) as a non-invasive method for measuring superficial gingival blood perfusion.
- Conditions
- Gingival Vascularization, Oral Soft Tissue Wound Healing, Laser Speckle Contrast Imaging, Periodontal Wound Healing
- Trial name
- LSCI (NCT07527351)
- Testing
- Laser Speckle Contrast Imaging
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Prostate Cancer, Surgery
Electric Cardiometry-Guided Standard Versus Restricted Fluid Therapy In Robotic Prostaectomy
Fluid therapy during surgery is an important factor that is related to long term mortality and morbidity and it's directly related to tissue perfusion as well.
- Conditions
- Prostate Cancer, Surgery, Fluid Overload, Lactate Blood Increase
- Trial name
- NCT07626151
- Testing
- Liberal Fluid Therapy, Restricted Fluid Therapy
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Nazmy Edward Seif
Kawasaki Disease, Cardiovascular Disease
Magnetic Resonance Myocardial Stress Perfusion in Pediatric Patients with Cardiovascular Disease
the goal of this observational study is to evaluate myocardial ischemia and myocardial microcirculation dysfunction in children with cardiovascular disease by myocardial stress perfusion imaging.
- Conditions
- Kawasaki Disease, Cardiovascular Disease, Anomalous Origin of Coronary Artery
- Trial name
- NCT06641843
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- West China Second University Hospital