Clinical trials: Tick Bites
Tick Bites, Immunity to Ticks
The Uninfected Ixodes Scapularis Human Tick Challenge Model
An innovative way to prevent multiple tick-borne diseases is an anti-tick vaccine, i.e. targeting the vector to prevent transmission of pathogens from the tick to the host.
- Trial name
- TICKME (NCT05965635)
- Testing
- Ixodus scapularis nymphs
- Where
- Netherlands
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Tick Bites
Evaluating the Impacts of Informal Tick and Tickborne Disease Educational Tools on Children
The purpose of this study is to evaluate the impacts of informal educational tools used by the Midwest Center of Excellence for Vector-Borne Disease in collaboration with the Wisconsin Department of Health Services.
- Trial name
- NCT07756606
- Testing
- Tick check mannequin, Ticks on bagel, LEGO Build-a-Tick
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Tick Bites
Determining the Complete Protection Time of an Insect Repellent With 30% Citriodiol® Against Three Species of Ticks.
This study evaluates the length of time an insect repellent product can protect against three species of ticks. Participants will have one arm treated with the repellent, and throughout the next 10 hours, ticks will be given the…
- Trial name
- NCT03708120
- Testing
- Citrepel (Insect Repellent) EPA Reg. No. 84878-2
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- ARCTEC
Tick-borne Encephalitis, France
Evaluation of Knowledge on Tick-borne Encephalitis Virus (TBEV) Infection Among General Practitioners in France
Tick-borne encephalitis is a relatively rare disease (approximately 35 cases diagnosed per year), but most cases (86%) are due to contamination in France via a tick bite.
- Trial name
- CoMTBEV (NCT07191223)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Tick Bites, Encephalitis
Evolving Diagnostic Approaches to Undocumented Lymphocytic Meningitis and Meningoencephalitis
Tick-borne encephalitis (TBE) is a viral infection transmitted by ticks. TBE is the third most common cause of encephalitis in France.
- Conditions
- Tick Bites, Encephalitis, Meningitis, Viral Encephalitis
- Trial name
- CHAN-MEE (NCT07186881)
- Testing
- Recommendation from the infectious diseases team
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Central Hospital, Nancy, France
Alpha-Gal Syndrome
The α-gal Syndrome - Investigating Immune Reactions to Tick Bites
Tick bites can transmit pathogens, but they can also induce a food allergy to mammalian meat. The goal of this clinical trial is to follow immune response and antibody build-up in individuals bitten by a tick.
- Trial name
- ImmunoGal (NCT07177729)
- Where
- 2 sites in Luxembourg
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Luxembourg Institute of Health
Tick Bites, Tick-borne Diseases
Tick-borne Illness and Clothing Study of Rhode Island
Lyme and other tick-borne diseases pose a significant health threat to outdoor workers. This study is a double-blind randomized controlled trial of outdoor workers in Rhode Island and the surrounding area that will address the…
- Trial name
- NCT02613585
- Testing
- Permethrin Impregnated Clothing
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Human Anaplasmosis
Epidemiological, Clinical and Biological Characteristics of Human Anaplasmosis Cases in Alsace
Anaplasmosis is a bacterial infection caused by the intracellular bacterium Anaplasma phagocytophilum and transmitted by ticks. This bacterium is present in approximately 1% of ticks in Alsace.
- Trial name
- ANARETRO (NCT07312474)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Tick-borne Diseases, Tick Resistance
Human Immune Response to Ixodes Scapularis Tick Bites
Background: Each year, the number of cases of tick-borne diseases increases. The deer tick (Ixodes scapularis) is the vector of at least 7 pathogens that cause human diseases, including Lyme disease.
- Conditions
- Tick-borne Diseases, Tick Resistance, Lyme Disease
- Trial name
- NCT05036707
- Testing
- Xenodiagnosis Ticks, skin biopsy, blood draw
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tick Bites, Tick-borne Illness
Tick-borne Illness and Clothing Study
The high risk of acquiring tick-borne diseases by outdoor workers is well documented. Workers most at risk include, foresters, park rangers, land surveyors and other outdoor workers have frequent exposure to tick-infested…
- Trial name
- TICS (NCT01454414)
- Testing
- Permethrin Impregnated Uniforms
- Where
- United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Tick Bites, Tick Resistance
Acquired Tick Resistance in Naturally Exposed Participants
Tick-borne diseases are increasing worldwide, and there are currently few effective ways to prevent them. One promising new strategy is to develop a vaccine that targets the tick itself ("anti-tick vaccine") to block the…
- Trial name
- TICK REACT (NCT07479537)
- Testing
- Tick challenge
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Febrile Syndrome
Study of Febrile Syndromes After Tick Bite
Febrile syndromes after tick bites can be caused by different microorganisms: bacteria (B. miyamotoi, A. phagocytophilum, R. helvetica…), parasites (Babesia spp) and viruses (TBE virus).
- Trial name
- FebriTick (NCT05090969)
- Where
- France
- Volunteers
- 940 people
- Sponsor
- University Hospital, Strasbourg, France
Post-tick Bite Illness, Mast Cell Stabilizer
Mast Cell Treatment in Post-tick Bite Illness (PTBI)
This is a Phase II double-blinded study to assess the safety, tolerability, and feasibility of the mast cell stabilizing medications ketotifen and cromolyn compared to participants receiving standard of care treatment with…
- Trial name
- NCT07526558
- Testing
- Ketotifen, fexofenadine, Cromolyn Sodium
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Tick Bites
The Tick App: Changing Behaviors With Educational Messaging
The goal of this work is to evaluate the use of ecological momentary assessments as a tool to assess risk and risk factors for tick encounters and tick-borne diseases.
- Trial name
- NCT06880692
- Testing
- Educational Materials delivered via the Tick App
- Where
- 4 sites in United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Lyme Disease
Xenodiagnosis After Antibiotic Treatment for Lyme Disease
Background: The most common tick-borne illness in the United States, Lyme disease is caused by Borrelia burgdorferi bacteria that are transmitted to people by Ixodes scapularis ticks.
- Trial name
- NCT02446626
- Testing
- Skin biopsy, Blood draw, Xenodiagnosis
- Where
- 5 sites in United States
- Volunteers
- 72 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tick-Bite; Fever, Tick Fever
Fever After Tick Bite Study
The proposed study is a collaboration between Microbiology, SU/Sahlgrenska and the Infectious Diseases clinic at SU/Östra as well as several Infectious Diseases clinics throughout Sweden aiming at improving microbiological…
- Conditions
- Tick-Bite; Fever, Tick Fever, Tick-Borne Diseases, Encephalitis, Tick-Borne
- Trial name
- FATB (NCT03932448)
- Testing
- The proposed study is not interventional.
- Where
- Sweden
- Sponsor
- Göteborg University