Clinical trials: Tibia Fracture
Tibial Stress Fracture
Effects of Footstrike Transition on Tibial Stress Fracture Risk
Biomechanical literature suggests that runners who utilize a mid or forefoot strike pattern may suffer from a reduced incidence of chronic injuries compared to a rearfoot strike.
- Trial name
- NCT05786079
- Testing
- Footstrike modification, Control
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Central Lancashire
Tibial Fractures
Safety Study of Treatment of Leg Fractures
This study evaluates the safety of the EVOS SMALL Plating system in patients who have a fracture of the tibia requiring surgery.
- Trial name
- EVOS SMALL (NCT03881241)
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Smith & Nephew, Inc.
Acute Compartment Syndrome, Tibia Fracture
Biomarkers in the Diagnosis of Acute Compartment Syndrome
This prospective multinational, multicentre cohort study aims to investigate the hypothesis that biomarkers of muscle cell damage can predict acute compartment syndrome in patients with tibial fractures.
- Trial name
- BioFACTS (NCT04674592)
- Testing
- Blood samples and biopsies
- Where
- Sweden
- Volunteers
- 250 people
- Sponsor
- University Hospital, Linkoeping
Tibial Fractures
Immobilization Versus Observation in Children With Toddler's Fractures: a Prospective Randomized Controlled Trial
Toddler's fractures of the tibia are by definition non-displaced and of a stable pattern. Children have thickened periosteum compared with adults, which therefore may impart stability to the fracture without the need for…
- Trial name
- NCT01926795
- Testing
- Short leg cast, No Immobilization
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Prisma Health-Upstate
Proximal Tibia Fracture
The Efficacy and Cost Effectiveness of Preoperative and Postoperative Cryotherapy in Proximal Tibia Fractures
Consenting patients with proximal tibia fractures will be randomized to 10 degree or 21 degree cryotherapy sleeves. Time to discharge and complications will be monitored.
- Trial name
- ARCTIC CAT (NCT01104831)
- Testing
- Cryotherapy, Room temperature cuff
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Manitoba
Tibial Fractures, Malleolar Fractures
Intramedullary Nailing of Tibia Fractures
Currently, the treatment of choice for tibial fracture is intramedullary nailing. This procedure has been shown to have low rates of infection, high rates of bone healing, and a faster return to weight bearing and activity in…
- Trial name
- NCT01797640
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Utah
Tibial Fractures
Mobile Monitoring of Fracture Healing
The objective of this study is to develop methods for using forces measured on circular external fixators to predict the state of individual patient's healing of severe tibial fractures and defects.
- Trial name
- NCT02534259
- Testing
- Force monitoring of external fixator struts
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Milton S. Hershey Medical Center
Tibial Fractures
Multiregion BHA in Open Tibia Fractures
This clinical study is being conducted to demonstrate the safety and effectiveness of the Bone Healing Accelerant (BHA) product when applied to tibia (leg bone) fractures with an external wound or skin break (also called open…
- Trial name
- NCT04056429
- Testing
- BHA
- Sponsor
- Carmell Therapeutics Corporation
Broken Leg
Suprapatellar Nailing of Tibial Shaft Fractures
To investigate the functional outcomes and prevalence and severity of knee pain for patients undergoing suprapatellar nailing of tibial shaft fractures.
- Trial name
- NCT02728362
- Volunteers
- 38 people
- Sponsor
- Corewell Health West
Non-union Diaphysary Tibial Fractures
A Prospective Randomized Controlled Trial on the Use of Bone Morphogenetic 7 (BMP-7) (OP-1®) and Demineralized Bone Matrix in Tibial Non-union
The researchers propose a prospective, randomised partially-blinded study to investigate the clinical and radiological outcome, effect on quality of life and socio-economic impact of non-union of diaphysary tibial fractures…
- Trial name
- NCT00551941
- Testing
- BMP-7 in adjunct to fresh frozen allograft, allograft together with DBM
- Where
- 2 sites in Belgium
- Volunteers
- 2 people
- Sponsor
- University Hospital, Ghent
Tibial Fracture
Doppler Ultrasonography Evaluation of Tibial Fracture Site Vascularity
The purpose of this study is to evaluate the blood supply to patients that are suffering from fracture in the tibia by UltraSound Doppler.
- Trial name
- NCT00365573
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Hadassah Medical Organization
Tibial Fracture
SPRINT - Randomized Trial of Tibial Fracture Fixation
The purpose of this study is to determine if there is a difference in the rate of healing of a tibia fracture treated with an intramedullary nail based on whether or not the bone was reamed prior to nail insertion.
- Trial name
- NCT00038129
- Testing
- Intramedullary nail implant
- Where
- 16 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- University of Minnesota
Closed Proximal Tibial Fracture Schatzker I - VI, Closed Proximal Tibial Fracture AO-OTA 41
chronOS Inject in Proximal Tibial Fractures
The primary objective of this study is to observe the safety, the radiological and clinical outcomes of chronOS Inject after having been used as bone void filler in internal fixation of proximal tibial fractures.
- Conditions
- Closed Proximal Tibial Fracture Schatzker I - VI, Closed Proximal Tibial Fracture AO-OTA 41, Closed Proximal Tibial Fracture AO-OTA 42
- Trial name
- NCT02056834
- Testing
- chronOS Inject
- Where
- 2 sites in South Korea
- Volunteers
- 36 people
- Sponsor
- Synthes GmbH
Tibial Fracture
Blood Flow Restriction Therapy to Optimize Muscle Size and Strength in Recovery From Lower Limb Fractures
This study will assess the feasibility and effectiveness of blood flow restriction therapy in patients with tibia fractures (or lower leg bone).
- Trial name
- BOOST (NCT07103252)
- Testing
- Blood Flow Restriction Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Tibia Plateau Fractures
Safety and Efficacy of I 0401 in the Treatment of Tibial Plateau Fractures Requiring Grafting
For certain tibial plateau fractures the bone is compressed due to the force acting on the tibia during the accident. The void provoked by the compression of the bone is filled with an appropriate filling material and the…
- Trial name
- NCT00409799
- Testing
- I-0401 (a new bone graft substitute)
- Where
- 45 sites in Australia, France and 7 more
- Volunteers
- 208 people
- Sponsor
- Kuros Biosurgery AG
Tibial Fractures
Results of Cross-leg Free Vascularized Fibular Graft
This study aims to evaluate the new technique of cross-leg vascularized fibular graft for reconstruction of post-traumatic long tibial bone defects in terms of restoring normal anatomy and function of the traumatized limb in a…
- Trial name
- NCT06491316
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Assiut University
Femur Fracture, Tibial Fractures
Postoperative Pain Management in Patients Undergoing Intramedullary Nail Fixation After Tibia and Femoral Fractures
The purpose of this trial is to determine whether oral acetaminophen and intravenous ketorolac are viable alternatives to opioid medication regimens for the pain management of patients with tibial and femoral shaft fractures…
- Trial name
- NCT04761302
- Testing
- Intravenous ketorolac and oral acetaminophen, Intravenous morphine and oral oxycodone
- Where
- Puerto Rico
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- University of Puerto Rico
Calcaneus Fracture
Posterior Tibial Nerve PRF for Painful Calcaneal Fracture
Patients who underwent pulsed radiofrequency (PRF) treatment of the posterior tibial nerve under ultrasound guidance, which is routinely performed in our clinic for severe heel pain following a calcaneal fracture, were evaluated…
- Trial name
- NCT06888804
- Testing
- ultrasound-guided posterior tibial nerve pulsed radiofrequency, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Diskapi Teaching and Research Hospital
Tibial Fractures
Trial to Evaluate UltraSound in the Treatment of Tibial Fractures
The purpose of this study is to determine the effect of low-intensity, pulsed ultrasound on tibial fractures treated with intramedullary nailing.
- Trial name
- TRUST (NCT00667849)
- Testing
- Exogen 4000+
- Where
- 16 sites in United States, Canada
- Volunteers
- 501 people
- Sponsor
- Bioventus LLC
Tibial Fracture
Criteria-Based Rehabilitation After Tibial Fracture Fixation: A Randomized Controlled Trial
This randomized controlled trial will evaluate the effectiveness of a criteria-based progressive loading and functional rehabilitation program compared with usual physiotherapy in adults following surgical fixation of traumatic…
- Trial name
- NCT07810478
- Testing
- Criteria-Based Progressive Loading and Functional Rehabilitation Program
- Where
- Palestinian Territories
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University