Clinical trials: Thyroidectomy, open to volunteers
Thyroid Diseases, Wound Healing
Safety and Efficacy of NTP in Thyroid Surgery: Pilot Study on Morbidity Prevention and Adjuvant Oncological Control
The goal of this clinical trial is to evaluate the therapeutic efficacy and safety of non-thermal plasma (NTP) as an adjuvant treatment for surgical bed decontamination and accelerated tissue repair in patients undergoing total…
- Conditions
- Thyroid Diseases, Wound Healing, Thyroidectomy, Surgical Wound Infection
- Trial name
- NCT07382973
- Testing
- Atmospheric Pressure Non-Thermal Plasma, Standard Surgical Wound Care Protocol
- Where
- Mexico
- Volunteers
- 26 people
- Sponsor
- National Institute of Nuclear Research - Mexico
Swallowing Difficulties, Thirst
Effect of Cold Water Spray on Swallowing Difficulty, Pain, and Thirst After Thyroid Surgery
Dysphagia and thirst are common in the early period after thyroidectomy and negatively affect patient comfort. This study aims to evaluate the effect of cold water spray on dysphagia, pain during swallowing, and thirst after…
- Conditions
- Swallowing Difficulties, Thirst, Thyroidectomy
- Trial name
- CWS-THY (NCT07879404)
- Testing
- Cold water spray
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Saglik Bilimleri Universitesi Gulhane Tip Fakultesi
Thyroidectomy, Oxidative Stress
Opioid-Free Versus Opioid-Based Anesthesia in Thyroid Surgery
This study will compare opioid-free anesthesia and opioid-based anesthesia in adult euthyroid patients undergoing elective thyroidectomy.
- Conditions
- Thyroidectomy, Oxidative Stress, Anesthesia
- Trial name
- OFA-OBA (NCT07864155)
- Testing
- Fentanyl (IV), Dexmedetomidine and lidocaine
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Malatya Egitim Ve Arastirma Hastanesi
Total Thyroidectomy, Hyperthyroidism
Evaluation of Levothyroxine Replacement Therapy After Total Thyroidectomy Using a Smart Wristband
The goal of this observational study is to determine whether nighttime heart rate and heart rhythm data collected by a smart wristband can identify under- or over-replacement with levothyroxine before the routine 1-month thyroid…
- Conditions
- Total Thyroidectomy, Hyperthyroidism, Hypothyroidism
- Trial name
- SMART-THY (NCT07733375)
- Testing
- Xiomi Smart Band 10
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Yeditepe University Hospital
Post-Thyroidectomy Dysphonia
Effects of Therapeutic Exercise With and Without Nerve Stimulation on Dysphonia in Post Thyroidectomy Patients
This clinical trial evaluates rehabilitation strategies for post-thyroidectomy dysphonia. Voice impairment is a frequent complication following thyroid surgery. It often occurs even without direct laryngeal nerve transection.
- Trial name
- NCT07811154
- Testing
- therapeutic exercise, therapeutic exercise + transcutaneous nerve stimulation
- Volunteers
- 60 people
- Sponsor
- University of Lahore
Post Operative Pain Relief After Thyroidectomy
Comparison Low-volume Versus Standard-volume Ultrasound-guided Bilateral Intermediate Cervical Plexus Block
Thyroidectomy is commonly associated with mild-to-moderate postoperative pain that may affect respiratory function and recovery.
- Trial name
- ICPB (NCT07789548)
- Testing
- Bupivacain only
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Thyroidectomy
Comparing Medial and Lateral Dissection Approaches to the Recurrent Laryngeal Nerve During a Thyroidectomy
The goal of this interventional study is to compare the effectiveness of two surgical approaches in identifying the recurrent laryngeal nerve (RLN) during thyroidectomy.
- Trial name
- NCT07532889
- Testing
- Approach to RLN during Thyroidectomy
- Volunteers
- 430 people
- Sponsor
- Oleksandr Butskiy
Thyroidectomy, Cervical Plexus Block
The Effect of Bilateral Intermediate Cervical Plexus Block on the Surgical Stress Response Following Total Thyroidectomy
Total thyroidectomy triggers a systemic surgical stress response involving neuroendocrine and inflammatory pathways. Ultrasound-guided bilateral intermediate cervical plexus block (BICPB) is commonly utilized for postoperative…
- Conditions
- Thyroidectomy, Cervical Plexus Block, Surgical Stress Response
- Trial name
- NCT07740460
- Testing
- Ultrasound-Guided Bilateral Intermediate Cervical Plexus Block Using 0,25% Levobupivacaine
- Volunteers
- 48 people
- Sponsor
- University Hospital Dubrava
Surgical Stress Response, Total Thyroidectomy
The Association Between Bilateral Intermediate Cervical Plexus Block and Salivary Biomarkers of Surgical Stress Response Following Total Thyroidectomy
The aim of this study is to evaluate how an ultrasound-guided bilateral intermediate cervical plexus block affects the surgical stress response in individuals undergoing total thyroidectomy.
- Conditions
- Surgical Stress Response, Total Thyroidectomy, Saliva Collection, Cervical Plexus Block
- Trial name
- NCT07721818
- Testing
- Ultrasound guided bilateral intermediate cervical plexus block
- Volunteers
- 48 people
- Sponsor
- University Hospital Dubrava
Hernia, Inguinal, Hernia, Femoral
Recover@Home Postoperative Follow-up Study
This proposal describes a human subjects research study evaluating mHealth Ambulatory Surgery with Follow-up Nurse (Recovery@Home), as an alternative postoperative care pathway for selected low-acuity surgical procedures in…
- Conditions
- Hernia, Inguinal, Hernia, Femoral, Hernia, Umbilical, Hernia, Ventral
- Trial name
- NCT07714343
- Testing
- Recovery@home
- Where
- 4 sites in Uganda
- Volunteers
- 194 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Discharge Education, Patient Satisfaction
QR Code-Based Discharge Education and Readiness for Hospital Discharge
Effective discharge education is essential for patients undergoing thyroidectomy due to potential postoperative complications and the need for adequate self-care after discharge.
- Conditions
- Discharge Education, Patient Satisfaction, Thyroidectomy
- Trial name
- NCT07669701
- Testing
- QR Code-Based Discharge Education
- Where
- Turkey (Türkiye)
- Volunteers
- 192 people
- Sponsor
- Ankara Yildirim Beyazıt University
Total Thyroidectomy
Impact of Manual Therapy on Laryngeal Function Following Total Thyroidectomy
In this clinical trial, the investigators are seeking to learn if a course of voice therapy, including neck massage, stretches and pain science education in addition to voice exercise and scar massage will effectively treatment…
- Trial name
- Man Total Thy (NCT06383091)
- Testing
- Anterior Neck Manual Therapy, Pain Neuroscience Education, Neck Stretches
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Thyroidectomy, Coughing Reflex
The Effect of Esketamine on Cough Reflex During Tracheal Extubation in Patients Undergoing Non-inflatable Transoral Endoscopic Thyroid Surgery
This study intends to implement esketamine-assisted anesthesia in patients undergoing non-inflatable transoral endoscopic thyroidectomy through a prospective randomized controlled trial, in order to observe the effect of…
- Trial name
- NCT07641673
- Testing
- Esketamine（iv）, ESK spray, Normal Saline
- Where
- China
- Volunteers
- 186 people
- Sponsor
- The Second Hospital of Anhui Medical University
Thyroidectomy, Coughing Reflex
The Effect of Esketamine on Cough Reflex During Tracheal Extubation in Patients Undergoing Open Thyroid Surgery
This study intends to conduct a prospective randomized controlled trial to implement esketamine-assisted anesthesia in patients undergoing open thyroidectomy, in order to observe the effect of esketamine on coughing during…
- Trial name
- NCT07625826
- Testing
- Esketamine, Normal Saline
- Where
- China
- Volunteers
- 136 people
- Sponsor
- The Second Hospital of Anhui Medical University
Hypocalcemia, Hypoparathyroidism
NIRAF-Guided Parathyroid Identification During Thyroidectomy
This is a single-site, two-component prospective study evaluating whether near-infrared autofluorescence (NIRAF) imaging can improve intraoperative identification of parathyroid glands during thyroidectomy and reduce…
- Conditions
- Hypocalcemia, Hypoparathyroidism, Thyroid Diseases, Goiter, Nodular
- Trial name
- NCT07617584
- Testing
- Wearable Near-Infrared Autofluorescence Imaging System
- Where
- North Macedonia
- Volunteers
- 280 people
- Sponsor
- Ss. Cyril and Methodius University of Skopje
Postoperative Symptomatic Hypocalcemia Following Total Thyroidectomy
COMPARISON OF THE EFFICACY BETWEEN PREOPERATIVE CALCIUM & VITAMIN D3 VERSUS CALCIUM SUPPLEMENTATION ALONE TO PREVENT POST OPERATIVE SYMPTOMATIC HYPOCALCEMIA AFTER TOTAL THYROIDECTOMY IN EUTHYROID PATIENTS
Total thyroidectomy is a commonly performed surgery for thyroid diseases such as multinodular goiter. One of the most frequent complications after this procedure is hypocalcemia (low blood calcium levels), which may cause…
- Trial name
- NCT07597096
- Testing
- Calcium carbonate plus vitamin D3 (cholecalciferol)
- Where
- Pakistan
- Volunteers
- 124 people
- Sponsor
- King Edward Medical University
Post-Thyroidectomy Hypoparathyroidism Treatment
Calcium Replacement Therapy in Postoperative Hypoparathyroidism
The goal of this clinical trial is to evaluate whether a lower-dose calcium replacement therapy is non-inferior to a higher-dose regimen in preventing symptomatic hypoparathyroidism in patients following thyroidectomy.
- Trial name
- NCT07577570
- Testing
- Calcium carbonate 1250 mg (500 mg elemental calcium) twice a day, Calcium carbonate 1250 mg (500 mg elemental calcium) 4 times a day
- Where
- 2 sites in Estonia
- Volunteers
- 50 people
- Sponsor
- Tartu University Hospital
Papillary Thyroid Carcinoma, Central Compartment Neck Dissction
The Role of Prophylactic Central Compartment Neck Dissection in the Management of 2 to 4 cm Papillary Thyroid Carcinoma
Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy and is frequently associated with microscopic central neck lymph node metastases, even in the absence of preoperative clinical evidence of nodal…
- Conditions
- Papillary Thyroid Carcinoma, Central Compartment Neck Dissction, Thyroidectomy, Thyroid Lobectomy
- Trial name
- PRO-COMAND (NCT06899347)
- Testing
- Total Thyroidectomy + Central Compartment Neck Dissection, Thyroid Lobectomy + ipCCND
- Volunteers
- 392 people
- Sponsor
- Leonardo Rossi
Thyroidectomy, Sore Throat
Effects of Flurbiprofen Spray and Ice Cream for Pain and Voice Outcomes After Thyroidectomy
Researchers will compare oral flurbiprofen (%0.25) spray and ice cream to a placebo (a look-alike substance that contains no drug) to see if oral flurbiprofen (%0.25) spray and ice cream works to effect post-thyroidectomy throat…
- Conditions
- Thyroidectomy, Sore Throat, Voice Quality
- Trial name
- NCT07531147
- Testing
- Flurbiprofen, Food Effect cohort
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Izmir Katip Celebi University
Hypocalcemia, Parathyroid
Comparing PTeye-assisted Versus Conventional Total Thyroidectomy
This is a prospective, single-blinded, randomized controlled trial to evaluate whether PTeye™ can reduce post-operative hypoparathyroidism (PH).
- Conditions
- Hypocalcemia, Parathyroid, Hypoparathyroidism Post-surgical, Total Thyroidectomy
- Trial name
- NCT07416149
- Testing
- PTeye™ parathyroid detection system
- Where
- Hong Kong
- Volunteers
- 210 people
- Sponsor
- The University of Hong Kong