Clinical trials: Thyroid Carcinoma
Thyroid Nodule, Thyroid Neoplasms
TRAIL Study: Feasibility and Pilot
This is a pilot study to compare two ways of managing newly identified thyroid nodules that are likely to be cancerous based on ultrasound result and which under usual care would undergo immediate biopsy.
- Conditions
- Thyroid Nodule, Thyroid Neoplasms, Thyroid Cancer
- Trial name
- NCT06220656
- Testing
- Biopsy, Active Monitoring
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Non-Medullary Thyroid Carcinoma
Digoxin for the Reinduction of Radioiodine Uptake in Metastatic or Locally Advanced Non-medullary Thyroid Carcinoma
Non-medullary thyroid carcinoma has a good prognosis in most patients. However, a small subset of patients nevertheless develop metastatic or locally advanced and unresectable disease which in some cases also becomes radioiodine…
- Trial name
- DIGUP-TC (NCT05507775)
- Testing
- Digoxin tablet
- Where
- Netherlands
- Volunteers
- 8 people
- Sponsor
- Radboud University Medical Center
Refractory Differentiated Thyroid Gland Carcinoma, Refractory Thyroid Gland Follicular Carcinoma
Cediranib Maleate With or Without Lenalidomide for the Treatment of Thyroid Cancer
This partially randomized phase I/II trial studies the side effects and best dose of cediranib maleate when given together with or without lenalidomide and to see how well they work in treating patients with thyroid cancer.
- Conditions
- Refractory Differentiated Thyroid Gland Carcinoma, Refractory Thyroid Gland Follicular Carcinoma, Refractory Thyroid Gland Hurthle Cell Carcinoma, Refractory Thyroid Gland Papillary Carcinoma
- Trial name
- NCT01208051
- Testing
- Cediranib, Cediranib Maleate, Laboratory Biomarker Analysis
- Where
- 33 sites in United States, Canada
- Volunteers
- 127 people
- Sponsor
- National Cancer Institute (NCI)
Differentiated Thyroid Gland Carcinoma, Follicular Variant Thyroid Gland Papillary Carcinoma
Testing the Combination of Cabozantinib, Nivolumab, and Ipilimumab (CaboNivoIpi) for Advanced Differentiated Thyroid Cancer
This phase II trial studies how well cabozantinib, nivolumab, and ipilimumab work in treating patients with differentiated thyroid cancer that does not respond to radioactive iodine and that worsened after treatment with a drug…
- Conditions
- Differentiated Thyroid Gland Carcinoma, Follicular Variant Thyroid Gland Papillary Carcinoma, Poorly Differentiated Thyroid Gland Carcinoma, Refractory Differentiated Thyroid Gland Carcinoma
- Trial name
- NCT03914300
- Testing
- Biospecimen Collection, Cabozantinib S-malate, Computed Tomography
- Where
- 33 sites in United States
- Volunteers
- 11 people
- Sponsor
- National Cancer Institute (NCI)
Papillary Thyroid Carcinoma, Thyroid Cancer
Pattern and Surgical Outcome of Papillary Thyroid Cancer at Sohag University Hospitals
The aim of this study is to evaluate the clinicopathological pattern and surgical outcome of papillary thyroid carcinoma (PTC) at Sohag University Hospitals.
- Trial name
- NCT07823439
- Volunteers
- 30 people
- Sponsor
- Sohag University
Advanced Cancer, Anal Carcinoma
Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158)
In this study, participants with multiple types of advanced (unresectable and/or metastatic) solid tumors who have progressed on standard of care therapy will be treated with pembrolizumab (MK-3475).
- Conditions
- Advanced Cancer, Anal Carcinoma, Anal Cancer, Biliary Cancer
- Trial name
- NCT02628067
- Testing
- pembrolizumab
- Volunteers
- 1,609 people
- Sponsor
- Merck Sharp & Dohme LLC
Thyroid Cancer
Vemurafenib Neoadjuvant Trial in Locally Advanced Thyroid Cancer
The goal of this clinical research study is to learn about how vemurafenib may affect certain biomarkers in patients with PTC. Biomarkers are in the blood/tissue and may be related to your reaction to the study drug.
- Trial name
- NCT01709292
- Testing
- Vemurafenib (All Groups), Vemurafenib (Post Surgery) - Group A + C, Post Surgery - Group B
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- M.D. Anderson Cancer Center
Thyroid Cancer
Surgery for Thyroid Cancer With or Without Autofluorescence to Prevent Hypoparathyroidism
The study aims to test if use of autofluorescence imaging (AF) reduces the risk of developing hypoparathyroidism (hypoPT) following surgery for thyroid cancer, either total thyroidectomy (TT) or completion hemithyroidectomy (cHT).
- Trial name
- NCT06222606
- Testing
- Surgery with autofluorescence
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Aarhus University Hospital
Helicobacter Pylori Infected Patients, Thyroid Cancer Patients
The Effect of Radioactive Iodine Administration for Thyroid Diseases on H.Pylori Eradication
Because of the high iodine uptake in the stomach, radioactive iodine treatment for thyroid diseases (cancer or hyperthyroidism) or radioactive iodine administered for thyroid scan may be able to eradicate H.pylori infection from…
- Conditions
- Helicobacter Pylori Infected Patients, Thyroid Cancer Patients, Hyperthyroidism
- Trial name
- NCT00822289
- Volunteers
- 120 people
- Sponsor
- Rabin Medical Center
Thyroid Nodule, Thyroid Cancer
Genomic Profiling of Nodular Thyroid Disease and Thyroid Cancer
The purpose of this registry is to collect uniform genomics-centered data on patients with nodular thyroid disease and cancer in a prospective fashion.
- Conditions
- Thyroid Nodule, Thyroid Cancer, Thyroid Diseases, Thymic Carcinoma
- Trial name
- NCT03170804
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Aventura Hospital and Medical Center
Thyroid Nodules
Improved Preoperative Selection of Cold Thyroid Nodules
Molecular gene profiling of fine-needle aspiration samples in addition to fine-needle aspiration cytology can improve the selection of patients with benign versus malignant thyroid nodules with improved sensitivity.
- Trial name
- NCT00297297
- Testing
- No intervention. Applying gene profiling on needle aspirates
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Herlev Hospital
Extensive Stage Small Cell Lung Cancer, Hereditary Paraganglioma
Temsirolimus and Vinorelbine Ditartrate in Treating Patients With Unresectable or Metastatic Solid Tumors
RATIONALE: Temsirolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as vinorelbine ditartrate, work in different ways to stop the growth of tumor…
- Conditions
- Extensive Stage Small Cell Lung Cancer, Hereditary Paraganglioma, Male Breast Cancer, Malignant Paraganglioma
- Trial name
- NCT01155258
- Testing
- temsirolimus, vinorelbine ditartrate
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Southern California
DTC - Differentiated Thyroid Cancer
Study on the Treatment of Differentiated Thyroid Carcinoma with Anlotinib
The purpose of this study is to evaluate the efficacy of anlotinib in patients with locally advanced or metastatic differentiated thyroid cancer resistant to iodine therapy.
- Trial name
- NCT05007093
- Testing
- Anlotinib hydrochloride
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Yansong Lin
Thyroid Cancer, Thyroid Nodule
Surgical Competency for Robot-Assisted Thyroidectomy: Construction and Validation of a Robotic Thyroidectomy Assessment Score (RTAS)
To develop and validate a structured scoring tool (robotic thyroidectomy assessment score, RTAS) for assessing and quantifying surgical performance in robotic thyroidectomy (RT).
- Conditions
- Thyroid Cancer, Thyroid Nodule, Thyroid Diseases, Thyroid Cancer, Papillary
- Trial name
- NCT06730321
- Testing
- Observations on clinicopathological factors influencing the assessment score of surgery
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai 6th People's Hospital
Thyroid Tumor
Effect of Early Postoperative Drinking Water on Postoperative Recovery Quality of Patients With Thyroid Surgery
This study is a single-center, prospective and randomized controlled study to investigate the effects of early recovery of oral intake (E) and late recovery of oral intake (L) on postoperative recovery quality and satisfaction of…
- Trial name
- NCT05532384
- Testing
- Early resumption of oral intake, Late resumption of oral intake
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Peking Union Medical College Hospital
Ovarian Insufficiency, Radiation Exposure
Effect of Radioiodine Therapy on Ovarian Reserve in Female Patients With Differentiated Thyroid Cancer
Thyroid carcinoma is the most common endocrine malignancy. Surgery is the standard therapeutic approach for patients with differentiated thyroid carcinoma (DTC), followed by radioiodine (RAI) therapy if indicated.
- Trial name
- NCT04396158
- Testing
- radioactive iodine
- Volunteers
- 38 people
- Sponsor
- Assiut University
PET / CT, FDG PET/CT
18F-FDG PET/TC in TIR3A e TIR3B
The primary objective of this study is to evaluate the diagnostic performance of 18F-FDG PET/CT performed by normal care pathway in the identification of malignancy of undetermined resulting thyroid lesions at cytology (TIR3A and…
- Conditions
- PET / CT, FDG PET/CT, Cytology, Thyroid Nodules
- Trial name
- PET-TIR3-2021 (NCT06829043)
- Testing
- clinical practice drug treatment
- Where
- Italy
- Volunteers
- 216 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Melanoma, Non-Small-Cell Lung Cancer
A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07799933) administered as a single agent and in combination with other study medicines in people with solid tumors.
- Conditions
- Melanoma, Non-Small-Cell Lung Cancer, Thyroid Cancer, Glioma
- Trial name
- NCT05355701
- Testing
- PF-07799933, binimetinib, cetuximab
- Where
- 40 sites in United States, Canada and 1 more
- Volunteers
- 103 people
- Sponsor
- Pfizer
Nasopharyngeal Carcinoma, Nasopharyngeal Cancer
The Protection of Thyroid Function in IMRT for Nasopharyngeal Carcinoma
This study aimed to reduce radiation-induced thyroid injury without compromising control of the cervical region by optimizing the delineation of the cervical lymph node drainage area.
- Conditions
- Nasopharyngeal Carcinoma, Nasopharyngeal Cancer, Hypothyroidism
- Trial name
- NCT06268600
- Testing
- Modified neck target volume delineation
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Jiangxi Provincial Cancer Hospital
Thyroid Cancer
RW Study of Adjuvant Radiotherapy in Locally Advanced Thyroid Cancer
This study is a real-world study to observe the role of adjuvant radiotherapy in locally advanced recurrent high-risk thyroid cancer.
- Trial name
- NCT06524167
- Testing
- adjuvant radiotherapy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Fudan University
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