Clinical trials: Thromboelastography
Burn, Coagulation, Blood
Thromboelastography to Study Burn Coagulopathy
This pilot study examines the use of thromboelastography (TEG), a specialized blood test, to evaluate clotting abnormalities in burn patients.
- Trial name
- NCT06879509
- Testing
- Thromboelastography
- Where
- United States
- Sponsor
- Francesco Egro
Hematological Malignancies Treated With Intensive Chemotherapy
Evolution of Thromboelastography During Tranexamic Acid Treatment
Patients with hematological malignancies are at increased risk of bleeding, especially during intensive chemotherapy. The aim of this study is to compare by thromboelastography changes during the intensive chemotherapy in…
- Trial name
- TTRAP-Bleeding (NCT03801122)
- Testing
- Tranexamic acid
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Hemophilia A
Individualizing Hemophilia Prophylaxis Using Thromboelastography
Currently dosing for prophylaxis is not individualized, and the general approach is to use a dose of 25-40 units/kg given 3 times per week or every other day.
- Trial name
- NCT02582060
- Testing
- Thromboelastography/Thromboelastometry-Guided Treatment Regimen
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Children's Hospital Los Angeles
Postpartum Haemorrhage
Fibrinogen Concentrate as Initial Treatment for Postpartum Haemorrhage: A Randomised Clinically Controlled Trial
Severe maternal bleeding is a serious complication of birth and causes 125.000 deaths worldwide each year. The investigators aim to investigate if early treatment with fibrinogen concentrate versus saline can reduce the incidence…
- Trial name
- FIB-PPH (NCT01359878)
- Testing
- Fibrinogen Concentrate, Isotonic Saline
- Where
- 4 sites in Denmark
- Volunteers
- 249 people
- Sponsor
- Copenhagen University Hospital at Herlev
Extracorporeal Circulation of Blood; Thrombocytopenia
Thrombo-Elastography Guided Management of ECMO
Anticoagulation and coagulation management during ECMO is a challenge. Bleeding and clotting are major sources of morbidity and mortality. The currently used strategies are of poor evidence.
- Trial name
- TEGMO (NCT04268940)
- Testing
- Thromboelastography
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- Damian Ratano
Traumatic Intracranial Hemorrhage
Platelet Transfusion and Repeat TEG-PM in Patients With Severe TBI on Antiplatelet Therapy (Repeat TEG-PM)
The aim of this study is to see if administering platelets (cells in our blood that stop or prevent bleeding) results in improved platelet function and slows/stops the progression of a head bleed for patients who have a traumatic…
- Trial name
- NCT06433622
- Testing
- Repeat Thromboelastography with Platelet Mapping
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Lancaster General Hospital
Surgery
Effect of Prostacyclin on Haemostasis in Abdominal Surgery
The purpose of this study is to investigate the effect of continuous perioperative infusion of prostacyclin on haemostasis and endothelial functionality in patients undergoing major abdominal surgery.
- Trial name
- NCT01528943
- Testing
- Prostacycline, Isotonic saline
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Liver Cirrhosis
Rotational Thromboelastometry [ROTEM] vs Thromboelastography [TEG] Guided Blood Component Use in Patients With Cirrhosis of Liver With Non-variceal Bleeding.
This study is aim to compare ROTEM and TEG guided coagulopathy correction in cirrhosis with non- variceal bleed.There are no other study in literature to compare this two group in cirrhosis with non-variceal bleed.This study will…
- Trial name
- NCT06153082
- Testing
- ROTEM, Thromboelastography
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Bone Marrow Diseases, Lymphoma
Thromboelastography, Platelet Function and Platelet Recovery in Haemato-oncologic Patients With Thrombocytopenia
This is a prospective observational clinical study to characterise abnormalities of thromboelastography (TEG) parameters in patients with chemotherapy-induced thrombocytopenia.
- Trial name
- NCT01928017
- Where
- Norway
- Volunteers
- 13 people
- Sponsor
- University of Bergen
Blood Platelet Disorders, Cardiac Surgery
Observational Study of Platelet Dysfunction Assessed by Thromboelastography in Cardiovascular Surgery (DISPLATEG)
Perioperative bleeding requiring blood transfusion is common during cardiovascular surgery, especially in procedures requiring cardiopulmonary bypass. Adenosine diphosphate (ADP) plays a fundamental role in platelet function.
- Conditions
- Blood Platelet Disorders, Cardiac Surgery, Postoperative Bleeding
- Trial name
- DISPLATEG (NCT06961175)
- Where
- Spain
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Stroke
Interest of Thromboelastography (ROTEM) as a Biomarker of Revascularisation in Stroke
Revascularisation using recombinant tPA is the reference treatment of stroke. However, the efficacy of fibrinolysis is about 50%.
- Trial name
- ROTEMPredict (NCT02902393)
- Testing
- Thromboelastography
- Where
- France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Caen
Coronary Heart Disease
Clopidogrel Response Evaluation and AnTi-Platelet InterVEntion in High Thrombotic Risk PCI Patients
To identify the high-risk patients who might have in-stent thrombosis after PCI with thromboelastography and to head-to-head compare two intensified antiplatelet therapeutic strategies of double-dosage Clopidogrel and triple…
- Trial name
- CREATIVE (NCT01779401)
- Testing
- Clopidogrel 75mg, Clopidogrel 150mg, Aspirin 100mg
- Where
- 2 sites in China
- Volunteers
- 1,078 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Heart Failure
Influence of Edoxaban on Coagulability and Thrombin Generation: An in Vitro Study Focusing on Thrombelastography
The influence of different doses of edoxaban on physical characteristics of the clot and thrombin generation kinetics in blood samples will be studied by in vitro spiking of blood samples collected from patients treated for heart…
- Trial name
- NCT02448901
- Testing
- Edoxaban
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- LifeBridge Health
Fertilization in Vitro and Blood Coagulation Factors
The Effect of In Vitro Fertilization on Coagulation Parameters as Measured by Thromboelastogram
Since its introduction in 1978, over 3.75 million babies have been born using in vitro fertilization (IVF). Maturing ovarian follicles lead to a large rise in estrogen to supra-physiological levels .
- Trial name
- NCT02503371
- Testing
- Blood coagulation anyalsis by Thromboelastogram
- Where
- Israel
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Focus of Study, Coagulation Status of Cardiac Surgery Patient
Thromboelastography-derived Functional Fibrinogen Levels
This study hopes to determine if thromboelastography-derived functional fibrinogen (TEG-FF or FLEV) levels obtained during the rewarming phase of cardiopulmonary bypass can provide information on coagulation status sooner…
- Conditions
- Focus of Study, Coagulation Status of Cardiac Surgery Patient, Reducing Excess Blood Transfusion
- Trial name
- TEG-FF (NCT01992757)
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Pennsylvania
Haematological Abnormality
Coagulation Profile of Patients Undergoing CRS(Cytoreductive Surgery) and Hyperthermic Intraperitoneal Chemotherapy
To study the changes in coagulation profile in patients undergoing cytoreductive surgery and Hyperthermic intraperitoneal chemotherapy.
- Trial name
- NCT03137745
- Testing
- thromboelastography
- Volunteers
- 60 people
- Sponsor
- Rajiv Gandhi Cancer Institute & Research Center, India
Sepsis, Disseminated Intravascular Coagulation
Thrombin Generation and Thromboelastography in Non-overt DIC
Sepsis is the 13th most common cause of death in the United States, causing approximately 210,000 deaths per year. Once DIC has developed, irreversible organ injury has already occurred and the mortality rate is 70%.
- Trial name
- NCT00299949
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- The University of Texas Health Science Center, Houston
Non Variceal Bleed
TEG (Thromboelastography) Based Versus Conventional Coagulation Parameters Based Correction of Coagulopathy in Non Variceal Bleed.
All patients with non variceal bleed who are admitted under the Department of Hepatology at Institute of Liver and Biliary Sciences, who meet the inclusion criteria and who provide informed consent.
- Trial name
- NCT02689232
- Testing
- Fresh Frozen Plasma, Platelets Concentrate, Cryo Precitipitate
- Where
- 2 sites in India
- Volunteers
- 96 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Cirrhosis, Coagulation Disorder
Thromboelastographic Guide for Blood Products in Cirrhotics
Blood products are commonly used before invasive procedures in patients with end-stage liver diseases despite cirrhosis being a thrombophylic state.
- Trial name
- NCT02362178
- Testing
- Thromboelastography to guide blood products infusion, Standard of care coagulation tests to guide blood products infusion
- Volunteers
- 60 people
- Sponsor
- University of Modena and Reggio Emilia
Liver Cirrhosis
A Comparative Evaluation of TEG Versus ROTEM for Coagulopathy Correction
Studies comparing Thromboelastography or Rotational thromboelastometry versus standard coagulation tests are abundant. Data comparing the two exclusively in a liver intensive care set up is limited.
- Trial name
- NCT05333510
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India