Clinical trials: Thin Endometrium
Thin Endometrium, Female Infertility
Intrauterine G-CSF Infusion for Thin Endometrium
Thin endometrium is a condition in which the lining of the uterus is too thin during preparation for embryo transfer. This may reduce the chance of pregnancy and live birth in patients undergoing frozen-thawed embryo transfer.
- Trial name
- GIFT (NCT07692672)
- Testing
- Granulocyte Colony-Stimulating Factor(G-CSF), Normal Saline
- Volunteers
- 620 people
- Sponsor
- Nanjing University
Infertility, Infertility, Female
Concentrate of Autologous Rich Plasma in Growth Factors in the Treatment of the Thin Endometrium
This study evaluate the percentage of women with thin endometrium who achieve an endometrial thickness equal to or greater than 7 mm after administration of PRGF (plasma rich in growth factors)
- Trial name
- APTE (NCT03387501)
- Testing
- Plasma rich in growth factors (PRGF-Endoret)
- Where
- Spain
- Volunteers
- 13 people
- Sponsor
- Sara Rafael Fernandez
IVF, Endometrial Receptivity
Endometrial Effects of Sildenafil in Frozen-Thawed Cycles in Women With Thin Endometrium
Management of Thin endometrium in IVF is challenging. Thin endometrium is often defined as <7 mm or < 8 mm on the day of Human Gonadotropin administration(Bu and Sun, 2015; Wu et al., 2014).
- Trial name
- NCT04283435
- Testing
- Sildenafil Citrate, Estradiol Valerate
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Thin Endometrium, Intrauterine Adhesion
Clinical Study of Umbilical Cord Mesenchymal Stem Cells Combined With Collagen Scaffold in the Treatment of Thin Endometrium
This is a non-blind self-control trial. We mainly compare the changes of endometrial thickness，changes in menstrual flow, and improvement in pregnancy before and after stem cell treatment in patients with thin endometrium.
- Trial name
- NCT03724617
- Testing
- umbilical cord mesenchymal stem cells combined with collagen scaffold
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Sir Run Run Shaw Hospital
Infertility, Female, Endometrium
The Efficacy and Safety of Collagen Scaffold Loaded With Umbilical Cord Derived Mesenchymal Stem Cells in Infertile Women With Thin Endometrium or Endometrial Scarring
The purpose of the study is to evaluate the safety and effectiveness of the collagen scaffold loaded with umbilical cord derived mesenchymal stem cells (UC-MSCs) in infetile women with thin endometrium or endometrial scarring.
- Trial name
- NCT03592849
- Testing
- UC-MSCs therapy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Fertility Disorders
Use of Gcsf in Patients With Recurrent Ivf/Icsi Failure
Evaluate the effectiveness of granulocyte colony-stimulating factor (GCSF) in the treatment of thin endometrium or in women with recurrent implantation failure in ICSI cycles
- Trial name
- NCT03023774
- Testing
- Neupogen
- Volunteers
- 20 people
- Sponsor
- Ain Shams Maternity Hospital
Asherman Syndrome, Endometrial Atrophy
Umbilical Cord Plasma for Treating Endometrial Pathologies (Thin Endometrium / Asherman's Syndrome/ Endometria Atrophy)
In the last years, platelet-rich plasma (PRP) has emerged as a promising alternative to treat endometrial pathologies affecting the endometrial lining.
- Trial name
- hSCU-PRP (NCT05095597)
- Testing
- Injection of hUC-PRP by hysteroscopy, Oestraclin, Umbilical cord blood collection
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Fundación IVI
Infertility
Tamoxifen Compared With Clomiphene Citrate for Women Who Had Thin Endometrium Women Under Clomiphene in a Previous Cycle
About 10-15% of all couples attempting to conceive will not become pregnant within one year. Among those, the majority will have ovulatory dysfunction, mild male infertility or unexplained infertility.
- Trial name
- NCT00449514
- Testing
- tamoxifen, clomiphene citrate
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Shaare Zedek Medical Center
Thin Endometrium
The Effect of the GM-CSF Gel on the Endometrial Thickness in Infertile Women With Thin Endometrium
The purpose of this study is to investigate the efficacy of the granulocyte-macrophage colony stimulating factor(GM-CSF) gel on the endometrial thickness in infertile women with thin endometrium.
- Trial name
- NCT04100655
- Testing
- GM-CSF, 17-ß estradiol
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Sir Run Run Shaw Hospital
Recurrent Implantation Failure, Endometrial Receptivity Disorders
Experimental Study on the Use of Intrauterine Infusion of Autologous Platelet-rich Plasma (PRGF-IUI) in Patients With Recurrent Implantation Failure and/or Refractory Thin Endometrium
Endometrial receptivity is a key determinant of success in assisted reproductive technology (ART). A significant proportion of patients experience repeated implantation failure despite euploid embryos and adequate laboratory…
- Conditions
- Recurrent Implantation Failure, Endometrial Receptivity Disorders, Embryo Implantation, Platelet-Rich Plasma
- Trial name
- PMA_PREPAIRE (NCT07455773)
- Testing
- Intrauterine Platelet-Rich Plasma (PRP) Infusion, Hormone Replacement Therapy (HRT)
- Volunteers
- 80 people
- Sponsor
- Azienda Sanitaria Locale di Asti
Endometrium, Laser
Intravenous Laser Irradiation Effect on Treatment Resistant Thin Endometrium
We will recruit 30 poor ovarian responders and thin endometrium patients, aged 35-45 year old, and treat with intravascular laser irradiation of blood (ILIB) via an intravenous catheter for irradiation of the blood under a period…
- Trial name
- NCT03081130
- Testing
- Intravenous laser irradiation treatment
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Veterans General Hospital.
Anovulation
Sildenafil Vaginal Gel Co-treatment With Clomiphene Citrate in Infertile Women With Thin Endometrium
This is a prospective self controlled clinical trial. Women with clomiphene Citrate failure, and thin endometrium were recruited (N = 42).
- Trial name
- NCT02710981
- Testing
- clomiphene citrate, Sildenafil vaginal gel
- Volunteers
- 42 people
- Sponsor
- Assiut University
Infertility, Female, of Uterine Origin, Endometrial Fibrosis
Clinical Study of in Situ Regeneration of Endometrium
Thin endometrium will lead to hypomenorrhea，infertility and recurrent pregnancy loss and there are few effective methods to increase the endometrial thickness and improve the fertility outcomes.
- Trial name
- NCT04233892
- Testing
- CBD-bFGF, Collagen/BMMNCs, Estrogen
- Where
- China
- Volunteers
- 345 people
- Sponsor
- Yali Hu
Thin Endometrium, Infertility Female
Effectiveness of Intrauterine Growth Hormone Administration as an add-on Therapy to Conventional Hormone Therapy Compared to Placebo in Patients With Thin Endometrium Undergoing Frozen Thawed Embryo Transfer
The purpose of this clinical trial is to see if intrauterine growth hormone infusions can help subjects reach a suitable endometrial thickness in patients who are resistant to routine hormonal therapy for embryo transfer in the…
- Conditions
- Thin Endometrium, Infertility Female, Infertility
- Trial name
- NCT06379659
- Testing
- Growh hormone
- Where
- Iran
- Volunteers
- 54 people
- Sponsor
- Isfahan University of Medical Sciences
Thin Endometrium, Endometrial Disorder
Autologous Platelet-Rich Plasma (PRP) and Endometrial Thickness
The goal of this interventional study is to evaluate the increasing in endometrial thickening after the intrauterine infusion of 0,5-1 ml of autologous Platelet-Rich Plasma (PRP) and the implantation rate in women with thin…
- Conditions
- Thin Endometrium, Endometrial Disorder, Endometrial Thickness Not Growing Under Estrogen Stimulation
- Trial name
- NCT03067623
- Testing
- PRP, Tomcat catheter
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University Magna Graecia
Poor Endometrium
Use of Platelet Rich Plasma (PRP) for Improving Thin Endometrium
Platelets rich plasma is simple source of growth factors and cytokines that can regulate endometrial growth for subgroup of thin endometrium women.
- Trial name
- PRPITM (NCT03166345)
- Testing
- Treatment of Thin Endometrium
- Where
- 2 sites in Egypt
- Volunteers
- 150 people
- Sponsor
- Ibn Sina Hospital
Infertility
Platelet-Rich Protein and the Endometrium
Platelet-rich plasma (PRP) may promote the endometrial growth and improve pregnancy outcome of patients with thin endometrium undergoing ART treatments.
- Trial name
- NCT02973555
- Testing
- PRP injection
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hadassah Medical Organization
Endometrial Thickness, Pregnancy Outcome
HCG (Human Chorionic Gonadotropin) Priming for Thin Endometrium in IVF (in Vitro Fertilization)
A thin endometrium is one of the most difficult problems encountered in assisted reproduction every day practice Regarding the proliferative phase, several ways of treatment have been undertaken to circumvent thin endometrium…
- Trial name
- NCT01768247
- Testing
- HCG (human chorionic gonadotropin)
- Where
- Greece
- Volunteers
- 15 people
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility, Asherman's Syndrome
Platelet-rich Plasma (PRP) for Endometrial Regeneration and Repair
Patients with intrauterine adhesions (Asherman's Syndrome) and persistent thin endometrial lining in in vitro fertilization (IVF) treatment programs, particularly those resistant to standard therapies, present a significant…
- Trial name
- PRP-E (NCT02825849)
- Testing
- Intrauterine infusion of platelet rich plasma
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cell- and Tissue-Based Therapy
Amnion Bilayer and Stem Cell Combination Therapy on Thin Endometrium Infertile Patients
Severe infections or trauma to the endometrial lining causes permanent scars that disrupt the menstrual cycle and lead to conceive failure.
- Trial name
- NCT04676269
- Testing
- Amnion only, Amnion - endometrium cells, Amnion - amnion epithelial cells
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Indonesia