Clinical trials: Thermal Injury
Chronic Pain Following Thermal Burn Injury
Vitamin D and n-3 Polyunsaturated Fatty Acids (PUFAs) to Prevent Chronic Pain Following Major Thermal Burn Injury
The goal of this study is to develop a safe, effective, and readily available treatment that will prevent chronic pain following Major Thermal Burn Injury (MThBI).
- Trial name
- NCT03313076
- Testing
- Omega-3 fatty acids (fish oil), Vitamin D3 (cholecalciferol)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of North Carolina, Chapel Hill
Burns
Fluid Shifts During Resuscitation: Impacts on Macrocirculation and Microcirculation
Fluid resuscitation in burn patients is associated with major macrocirculatory and microcirculatory disturbances that have been poorly described.
- Trial name
- NCT00326729
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Montreal Burn Centre
Intraoperative Complications, Thermal Injury
Laparoscopic Cholecystectomy And Capacitive Coupling - Coag Versus Blend Mode Causing Thermal Injury at Port Site Skin
Monopolar radiofrequency energy is used to perform the laparoscopic cholecystectomy operation. The appearance of burns are common following laparoscopic cholecystectomy; particularly at the port site of the active electrode.
- Conditions
- Intraoperative Complications, Thermal Injury, Electrocoagulation
- Trial name
- NCT01664806
- Testing
- Covidien Triad monopolar generator
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Thermal Injury Pain
Study of the Safety and Efficacy of REGN475(SAR164877) in Patients With Pain Resulting From Thermal Injury
This is a randomized, double-blind, placebo-controlled, parallel-group, single-dose study of the efficacy of REGN475 in patients with pain due to thermal injury.
- Trial name
- NCT01053702
- Testing
- R475
- Where
- United States
- Sponsor
- Regeneron Pharmaceuticals
Burns, Thermal Burn
Evaluating MMPs in Burns
The objective of this study is to determine whether our chemical assay can be used to reliably predict graft take or failure in patients undergoing autologous skin grafting for treatment of acute burn injury.
- Conditions
- Burns, Thermal Burn, Thermal Injury
- Trial name
- NCT03148977
- Testing
- Graft
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- University of Florida
Atrial Fibrillation (AF), Atrial Fibrillation Ablation Procedure
Efficacy and Safety of a Voltage-Guided Stepwise Strategy for Pulmonary Vein Isolation
The goal of this clinical trial is to learn if a voltage-guided stepwise pulmonary vein isolation (PVI) strategy can achieve effective PVI while potentially reducing lesion delivery, compared with conventional circumferential…
- Conditions
- Atrial Fibrillation (AF), Atrial Fibrillation Ablation Procedure, Atrial Tachyarrhythmia Recurrence, Esophageal Thermal Injury
- Trial name
- VoS-PVI (NCT07354737)
- Testing
- Radiofrequency ablation catheter system
- Where
- South Korea
- Volunteers
- 130 people
- Sponsor
- Ajou University School of Medicine
Chronic Subdural Hematoma, Subdural Hematoma
Non-Thermal Plasma to Reduce Recurrence in Chronic Subdural Hematoma
The goal of this randomized controlled trial is to evaluate whether the adjuvant application of non-thermal plasma (NTP) during standard surgical drainage of chronic subdural hematoma (cSDH) can reduce the recurrence rate at 6…
- Conditions
- Chronic Subdural Hematoma, Subdural Hematoma, Recurrence, Postoperative Complications
- Trial name
- NCT07656818
- Testing
- Standard Surgery Protocol, Non-Thermal Plasma
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Benjamín Gonzalo Rodríguez Méndez
COPD, Aging
Heat Waves and the Elderly With COPD
The purpose of this study is to investigate thermoregulatory responses in older individuals with COPD.
- Conditions
- COPD, Aging, Hyperthermia
- Trial name
- NCT06295523
- Testing
- Water Spray, Control
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Texas Southwestern Medical Center
Burns
Effects of Therapy With Sulfamylon® 5% Topical Solution Compared to a Historical Control Group
The primary objective is to compare the effectiveness of treatment with Sulfamylon® solution as the initial topical moist dressing over meshed autografts following the initial graft procedure on preventing graft loss in a…
- Trial name
- NCT00634166
- Testing
- Sulfamylon® For 5 % Topical Solution, Topical Antimicrobial/Antifungal Medications
- Where
- 9 sites in United States
- Volunteers
- 220 people
- Sponsor
- Mylan Inc.
Thermal Burn, Amitriptyline
Pilot Studies Blocking Injury-Induced MVP Release in Skin Using Topical Amitriptyline
The purpose of this study is to determine the amount of substances contained in skin known as microvesicle particles (MVP). Studies suggest these MVP are involved in many conditions such as after the thermal burn injury.
- Trial name
- NCT07716722
- Testing
- Amitriptyline
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Wright State University
Burn Wound
Safety Study of a Novel Wearable Phototherapy System for the Management of Acute Burn Wounds
The primary purpose of this first-in-human, early feasibility study is to assess safety and feasibility of the Low-Irradiance Monochromatic Biostimulation (LIMB) System as a phototherapeutic intervention for the management of…
- Trial name
- NCT03948360
- Testing
- Low-Irradiance Monochromatic Biostimulation (LIMB) Device, Standard of Care
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Rogers Sciences Inc.
Gait Disorder, Sensorimotor
The Effects of Gait Performance and Brain Activity After Robot-assisted Gait Training (RAGT) On Patients With Lower Extremity Thermal Injury
Gait enables individuals to move forward and is considered a natural skill. Gait disturbances are very common in patients with burn injury. Major causes of gait disturbances are pain and joint contractures.
- Trial name
- NCT05988905
- Testing
- robot assited gati training, conventional traiing
- Volunteers
- 40 people
- Sponsor
- Hangang Sacred Heart Hospital
Carpal Tunnel Syndrome, Median Neuropathy, Carpal Tunnel
Thermal and Pulsed Ultrasound for Carpal Tunnel Syndrome
This study will be a Randomized controlled trial with a sample size of at least 100 individuals with carpal tunnel syndrome. Participants will be randomized to receive either thermal ultrasound, pulsed ultrasound, a combination…
- Trial name
- NCT05838807
- Testing
- Thermal Ultrasound, Pulsed Ultrasound, Combined Ultrasound
- Where
- Egypt
- Volunteers
- 92 people
- Sponsor
- Ahram Canadian University
Aging
Identification of Critical Thermal Environments for Aged Adults
This study evaluates critical environmental limits (temperature and humidity) above which older adults are unable to effectively thermoregulate.
- Trial name
- NCT04284397
- Testing
- Low dose ASA, Control
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Penn State University
Esophagus Injury, Atrial Fibrillation
Prevalence and Predictors of Esophageal Thermal Lesions in High-power-Short-duration Ablation of Atrial Fibrillation
Patients with documented atrial fibrillation who were referred to our clinic for catheter ablation will undergo standard HPSD ablation and subsequent esophagoscopy.
- Trial name
- VISUAL-AF (NCT05709756)
- Where
- 2 sites in Germany
- Volunteers
- 263 people
- Sponsor
- Helios Health Institute GmbH
Burns
Lipopolysaccharide Adsorption (Efferon LPS) in Patients With Thermal Burns
This observational pilot study aims to establish criteria for evaluating the effectiveness of hemoadsorption with the Efferon LPS device in adult patients with burn injury.
- Trial name
- NCT07259668
- Testing
- Efferon LPS
- Where
- Russia
- Sponsor
- Efferon JSC
Heat Stress, Heat Strain
Effects of Solar Radiation on Human Function and Cognition
Solar radiation is a physical phenomenon which interacts with any human being throughout its life on earth. This interaction is associated with numerous physiological functions, as well as a broad spectrum of deleterious effects…
- Trial name
- NCT04160741
- Testing
- Radiation and warm environment, Warm environment, Neutral environment with radiation
- Where
- Greece
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Petros Dinas
Atrial Fibrillation
Esophageal Cooling for AF Ablation
The purpose of this study is to determine if esophageal cooling using the Attune Medical Esophageal Heat Transfer Device (EnsoETM) limits the number or seriousness of injury to the esophagus during atrial fibrillation ablation…
- Trial name
- eCoolAF (NCT03691571)
- Testing
- Esophageal Cooling, Control
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Pennsylvania
Burn
Oral Care Study on Burn Patients
There have been multiple articles done regarding oral hygiene on patients in burn and intensive care patients. All articles agree the need for good oral hygiene in these special needs patients.
- Trial name
- NCT01302457
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Saint Elizabeth Regional Medical Center
Heat Stress, Temperature Change, Body
Identifying the Limits of Survivability in Heat-exposed Older Females
Climate change increases extreme heat events, elevating global heat-illness risk. Females have reduced heat loss capacity (~5%) compared to males, driven by differences in skin blood flow and sweating responses.
- Conditions
- Heat Stress, Temperature Change, Body, Aging, Thermoregulation
- Trial name
- NCT07032493
- Testing
- Humidity-Ramp Protocol, Above-inflection fixed-condition exposure (5%), Below-inflection fixed-condition exposure (5%)
- Where
- 2 sites in Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Ottawa