Clinical trials: Testosterone Deficiency
Athletic Performance, Testosterone
Study of Testosterone and Athlete Response
Trial objectives and purpose: The primary aim is to study the effects of moderately increased testosterone concentration on aerobic performance (endurance running time to exhaustion), and secondary aims to investigate the effects…
- Conditions
- Athletic Performance, Testosterone, Women's Health: Female Athlete/Female Athlete Triad
- Trial name
- STAR (NCT03210558)
- Testing
- Testosterone cream 1% (Andro-Feme® )
- Where
- Sweden
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Spinal Cord Injury, Spinal Cord Injuries
Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury
This pilot study will determine the feasibility of implementing a combinatory rehabilitation strategy involving testosterone replacement therapy (TRT) with locomotor training (LT; walking on a treadmill with assistance and…
- Conditions
- Spinal Cord Injury, Spinal Cord Injuries, Trauma, Nervous System, Wounds and Injury
- Trial name
- NCT04460872
- Testing
- Testosterone Enanthate, Locomotor Training
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- North Florida Foundation for Research and Education
Hysterectomy, Ovariectomy
TDSM- Testosterone Dose Response in Surgically Menopausal Women
TDSM will study the physiology of testosterone in women ages 21-60 who have had surgical menopause (uterus and both ovaries removed).
- Conditions
- Hysterectomy, Ovariectomy, Menopause, Testosterone Deficiency
- Trial name
- NCT00494208
- Testing
- Testosterone
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Testosterone Deficiency
Diurnal Testosterone Concentration
In this case-controlled, observational study, 24 subjects will participate in a 12-hour blood collection with a single blood draw at +24 hours.
- Trial name
- NCT03091296
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Men's Health Boston
Metastatic Prostate Cancer
High Dose Testosterone for ATM, CDK12 or CHEK2 Altered Prostate Cancers
This study will determine whether the presence of DNA repair deficiency in the form of alterations in the genes ATM, CDK12 or CHEK2 predicts for a high likelihood of responding to the use of intermittent high dose testosterone.
- Trial name
- VA-BAT (NCT05011383)
- Testing
- High dose testosterone
- Where
- 17 sites in United States
- Volunteers
- 51 people
- Sponsor
- VA Office of Research and Development
Hypogonadism, Testosterone Deficiency
An Efficacy and Safety Study of ABT-SLV176 for the Treatment of Hypogonadal Men
This is an open-study with a 26 week open label treatment period followed by an optional 26 week open label extension. The total treatment period will be 52 weeks.
- Trial name
- NCT02082197
- Testing
- ABT-SLV176
- Where
- 42 sites in United States
- Sponsor
- AbbVie
HIV Infections
Use of a Test That Evaluates How the Body Handles Insulin and Glucose
The purpose of this study is to find out if testosterone gel affects how the body handles insulin and glucose. Specific anti-HIV treatments may increase a patient's risk of certain diseases by causing metabolic problems such as…
- Trial name
- NCT00027092
- Where
- 8 sites in United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hormone Deficiency
Hormone Treatment in Growth Hormone and Testosterone Deficient Patients
Growth hormone and gonadotropin deficiency after brain injury (traumatic brain injury, ischemic stroke, subarachnoidal hemorrhage): the effects of hormone replacement on cognition, quality of life and body composition Randomized…
- Trial name
- NCT01397500
- Testing
- Genotropin, Testosterone undecannoate
- Where
- Germany
- Volunteers
- 54 people
- Sponsor
- Max-Planck-Institute of Psychiatry
Gonadotropin Deficiency
ITT-5 Mechanisms of Spermatogenesis in Man
The purpose of this investigational drug study is to determine how much male hormone, testosterone, is needed to maintain sperm production in the testis.
- Trial name
- ITT-5 (NCT02147964)
- Testing
- Testosterone 1% Gel, Acyline, Dutasteride
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Washington
Castration-resistant Prostate Cancer, Homologous Recombination Deficiency
Bipolar Androgen Therapy + Carboplatin in mCRPC
The purpose of this study is to determine the efficacy of BAT and carboplatin in men with metastatic castrate-resistant prostate cancer (mCRPC).
- Trial name
- HiTeCH (NCT03522064)
- Testing
- Testosterone Enanthate 100 MG/ML Injectable Solution, Testosterone Enanthate 100 MG/ML Injectable Solution / Carboplatin AUC 5
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- St Vincent's Hospital, Sydney
Hypogonadism, Benign Prostatic Hyperplasia
TRADE-Testosterone Replacement and Dutasteride Effectiveness
The purpose of this research study is to determine whether the combination of the male hormone testosterone [T] in gel form and the oral drug dutasteride [D], used to shrink large prostate glands can safely reduce the size of the…
- Trial name
- TRADE (NCT00194675)
- Testing
- Dutasteride, Testosterone gel
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Washington
Hypogonadism
Open-Label Study of ARD-0403 in Testosterone Deficient Men
Male hypogonadism, a disorder associated with testosterone deficiency, is frequently seen in clinical practice and has significant effects on patient wellbeing.
- Trial name
- NCT00448955
- Testing
- ARD-0403
- Where
- 12 sites in United States
- Volunteers
- 150 people
- Sponsor
- Ardana Bioscience Ltd
Multiple Sclerosis, Erectile Dysfunction
Testosterone Treatment for Erectile Dysfunction and Multiple Sclerosis
The purpose of the study is to determine the effects of testosterone treatment on erectile function, fatigue, depression, cognitive function, quality of life, urinary incontinence, pain, and damage to neurons in male Multiple…
- Conditions
- Multiple Sclerosis, Erectile Dysfunction, Testosterone Deficiency
- Trial name
- NCT04601233
- Testing
- XYOSTED 75 milligram (mg) in 0.5 ML Auto-Injector
- Where
- United States
- Sponsor
- Tulane University
Gonadal Dysfunction, Gonadal Failure
Fertility Enhancement Through Regenerative Treatment in Ovaries and Testes
This study investigates the safety and efficacy of stem cell or stem cell-derived exosome therapy for gonadal failure, including testicular failure, hypogonadism, ovarian insufficiency, and premature ovarian failure (POF).
- Conditions
- Gonadal Dysfunction, Gonadal Failure, Azoospermia, Testosterone Deficiency
- Trial name
- FERTILE (NCT06841328)
- Testing
- Stem cells
- Where
- United Arab Emirates
- Volunteers
- 60 people
- Sponsor
- Jumeirah American Clinic
Panhypopituitarism
Baseline Sexual Function, Cognitive Function, Body Composition and Muscle Parameters and Pharmacokinetics of Transdermal Testosterone Gel in Women With Hypopituitarism
The purpose of this study is to determine the blood levels of testosterone gel administered for a week to women with hypopituitarism and determine if this leads to testosterone replacement in a normal range for women.
- Trial name
- NCT00144404
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Charles Drew University of Medicine and Science
Heart Failure
Benefit of the Treatment With Testosterone in Chronic Heart Failure Testosterone Deficiency Subjects
The purpose of this clinical trial is to determine whether intermittent administration of testosterone against placebo is associated with a reduction of mortality and heart failure hospitalizations at 1 year, in male patients…
- Trial name
- TIC (NCT01813201)
- Testing
- Testosterone undecanoate, Saline isotonic solution
- Where
- Spain
- Volunteers
- 14 people
- Sponsor
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
Arthroplasty, Replacement, Hip
Does Testosterone Therapy Improve Patient-Reported Outcomes in Age-Related Testosterone Deficient Patients Undergoing Total Hip Replacement: A Randomized-Controlled Trial
This randomized-controlled trial will study on the effect of testosterone therapy on patients undergoing total hip replacement. Subjects will be male patients > 50 years with testosterone deficiency undergoing total hip…
- Trial name
- NCT05722301
- Testing
- Testosterone Therapy, No Testosterone Therapy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- American Hip Institute
Menopause, Testosterone Deficiency
Estradiol and Testosterone Subdermal Implants for Menopause Treatment (ESTIME)
Estrogen and androgen deficiencies negatively impact the quality of life of women at different stages of life, especially after menopause. New modalities and new therapeutic alternatives have been researched.
- Conditions
- Menopause, Testosterone Deficiency, Estrogen Deficiency
- Trial name
- ESTIME (NCT06343870)
- Testing
- testosterone pellet (100 mg)
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- University of Sao Paulo General Hospital
Infertility, Male, Testosterone Deficiency
Determining the Reproductive Health of Men Post-COVID-19 Infection
Study rationale 1. An increasing proportion of the worldwide population is being infected with COVID-19. 2. There are ongoing and currently unanswered safety concerns about the effects of COVID-19 on reproductive health. 3.
- Trial name
- NCT04414904
- Testing
- Exposure: Covid-19 infection
- Where
- United Kingdom
- Sponsor
- Imperial College London
Testosterone Deficiency
Metabolomics During Testosterone Therapy
One promising but understudied area in the field of testosterone (T) therapy is its effect on metabolism and the development of type II diabetes.
- Trial name
- NCT01963390
- Testing
- Testosterone Therapy
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Men's Health Boston