Clinical trials: Telomere Shortening
Bladder Cancer, Telomere Shortening
Lifestyle Change for Better Health
The goal of the research is to provide a first critical test of the novel scientific idea that a combined diet and exercise intervention may ameliorate shortening of leukocyte telomere length (LTL) in individuals with histories…
- Conditions
- Bladder Cancer, Telomere Shortening, Colorectal Adenoma
- Trial name
- LCBH (NCT03286699)
- Testing
- Dietary Intervention, Physical Activity Intervention
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pittsburgh
Telomere Shortening, Telomere Length, Mean Leukocyte
Rosuvastatin Effect on Telomere-telomerase System in ACS
Coronary heart disease (CHD) is one of the diseases characterised by biological aging as one of the important risk factors in several epidemiological studies.
- Conditions
- Telomere Shortening, Telomere Length, Mean Leukocyte, 22q Telomere Deletion Syndrome
- Trial name
- NCT02299245
- Testing
- rosuvastatin
- Volunteers
- 400 people
- Sponsor
- Xiao-dong Zhuang
Schizophrenia, Physical Activity
Physical Exercise in Patients With Schizophrenia
Randomised clinical trial on a cohort of subjects with a diagnosis of schizophrenia of legal age, of both sexes, recruited in the mental health clinics of the Salamanca University Assistance Complex and who will be randomly…
- Conditions
- Schizophrenia, Physical Activity, Telomere Shortening, Premature Aging
- Trial name
- NCT05978921
- Testing
- Strength physical exercise programme, Normal life
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- University of Salamanca
Stress, Psychological, Telomere Shortening
Stress-Busting Program and QoL, Bio-markers of Immunity/Stress and Cellular Aging
The purpose of this study is to explore the differences in quality of life , inflammation, stress, telomere length, and mucosal immune function of Hispanic and non-Hispanic caregivers of persons with Alzheimer's disease and…
- Conditions
- Stress, Psychological, Telomere Shortening, Stress, Physiological
- Trial name
- NCT02844478
- Testing
- SBP English, SBP SPANISH
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Telomere Disease, Telomere Shortening
Nasal Brushing for the Diagnosis and Understanding of Telomeropathies
To date, the diagnosis of telomeropathies is based on telomere length measured in blood cells. However, this type of analysis is not always sufficient because some mutations underlying the development of telomeropathies are not…
- Trial name
- TELOSTIC (NCT05508321)
- Testing
- Nasal brushing, Sniffin' Sticks
- Where
- Belgium
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Pulmonary Fibrosis, Telomere Shortening
The TELO-SCOPE Study: Attenuating Telomere Attrition With Danazol. Is There Scope to Dramatically Improve Health Outcomes for Adults and Children With Pulmonary Fibrosis
TELO-SCOPE is a national, multi-centre, double-blind, placebo-controlled, randomised (2:1) trial which will test the hypothesis that, compared to placebo, the addition of danazol to standard of care in pulmonary fibrosis…
- Conditions
- Pulmonary Fibrosis, Telomere Shortening, Telomere Disease, Dyskeratosis Congenita
- Trial name
- NCT04638517
- Testing
- Danazol
- Where
- 9 sites in Australia
- Volunteers
- 29 people
- Sponsor
- The University of Queensland
Telomere Length in Healthy Controls
Telomeres and T-cell Receptor Excision Circles (TRECs) From Peripheral Blood in Normal Subjects Over Time
The Investigators have established a cohort of patients with recent-onset inflammatory arthritis called Early Undifferentiated PolyArthritis (EUPA). This cohort was established to define novel biomarkers of poor outcomes.
- Trial name
- NCT01982890
- Testing
- Control
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Menopause Syndrome, Inflammation
Genetic Evaluation and Modification of Lifestyles to Improve Female Life Expectancy
The GEMLIFE Study is a 12-month clinical trial for menopausal women. The purpose of this study is to promote an improved aging process for women in menopause through lifestyle changes.
- Conditions
- Menopause Syndrome, Inflammation, Inflammatory Response, Aging
- Trial name
- GEMLIFE (NCT05715372)
- Testing
- Mediterranean diet, AHA walking program, Mindfulness-based stress reduction
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Aging, Frailty
Effect of Infections and Global DNA Methylation on Frailty Trajectories in Hospitalized Older Patients (INFRAGEN)
This prospective multicenter study aims at exploring the impact of infections on intra-hospital and 3-month changes in the frailty profile of older inpatients.
- Conditions
- Aging, Frailty, Telomere Shortening, Inflammation
- Trial name
- INFRAGEN (NCT06430073)
- Volunteers
- 340 people
- Sponsor
- University Hospital of Ferrara
Stress, Psychological, Telomere Shortening
Biological and Behavioral Outcomes of Community Nature Walks
The investigators will test the efficacy of our proposed intervention to reduce embodied stress in four racial/ethnic groups (Black, Latinx, Pilipinx, and Pacific Islander) as a preventative intervention for health disparities…
- Conditions
- Stress, Psychological, Telomere Shortening, Stress Reaction
- Trial name
- NCT06056375
- Testing
- Reclaiming Nature Intervention
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Charlotte Tate
Type 2 Diabetes Mellitus, Telomere Shortening
Efficacy of Pythagorean Self-Awareness for Aging Biomarkers Improvement, in T2D Patients and Healthy Individuals.
The present study explored the effects of the implementation of the Pythagorean Self Awareness Intervention (PSAI) on the dynamics of stress-related aging factors of immune cells in healthy volunteers and a cohort patients with…
- Trial name
- NCT04763525
- Testing
- Pythagorean Self-Awareness Intervention(PSAI)
- Where
- Greece
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Aging, Obesity
Obesity and Aging: Impacts of Nutritional Counseling and Physical Exercise on Telomeres and Senescence Parameters
The study will involve 80 elderly women, 40 eutrophic and 40 obese, divided into four groups, each with n=20. 1) Eutrophic Group (EG) undergoing only nutritional counseling (NC), 2) Eutrophic Group with NC and combined training…
- Conditions
- Aging, Obesity, Nutrition, Exercise
- Trial name
- NCT07479940
- Testing
- Combined Training, Nutritional Counseling
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Acute Disease, Telomere Shortening
Telomere Length in Relation to Acute Stress Response in Critical Care Patients
the investigators studied the impact of severe stress (in this case any event or illness leading to a necessity of critical care) on telomere length.
- Trial name
- NCT03982589
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Rabin Medical Center
Psychological Stress, DNA Degradation, Apoptotic
CBART: The Reduction of Psychological and Physiological Stress in Women Undergoing IVF
The study is a randomized controlled trial of a cognitive behavioral interventions and an art-based stress reduction treatment protocol (CB-ART) with 100 women, identified with elevated perceived stress, before undergoing IVF…
- Conditions
- Psychological Stress, DNA Degradation, Apoptotic, Telomere Shortening, Fertility Disorders
- Trial name
- NCT03459053
- Testing
- CBART
- Where
- Israel
- Volunteers
- 88 people
- Sponsor
- University of Haifa
Telomere Shortening, Aging
TA-65 and Aging Associated Microvascular Dysfunction
The goal of this clinical trial is to test whether activation of telomerase with a dietary supplement (TA-65) improves microvascular function.
- Conditions
- Telomere Shortening, Aging, Vascular Diseases
- Trial name
- NCT05598359
- Testing
- TA-65
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Telomere Shortening, Telomere Length, Mean Leukocyte
Evaluating Efficacy and Safety of Danazol in Severe Hematologic or Pulmonary Disease Related to Telomeropathy
Constitutional mutations of genes involved in telomere repair and maintenance are responsible for "telomeropathy" (" Congenital Dyskeratosis "). Attrition of telomeres promotes cell senescence and genetic instability.
- Trial name
- ANDROTELO (NCT03710356)
- Testing
- Danazol 200 MG
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aplastic Anemia, Bone Marrow Failure Syndromes
Nandrolone Decanoate in the Treatment of Telomeropathies
Decrease in blood cell counts due to deficient bone marrow function, called bone marrow failure, as well as some lung diseases, called idiopathic pulmonary fibrosis, can be caused by genetic defects in telomere biology genes…
- Conditions
- Aplastic Anemia, Bone Marrow Failure Syndromes, Idiopathic Pulmonary Fibrosis, Telomere Shortening
- Trial name
- NCT02055456
- Testing
- Nandrolone Decanoate
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo
Telomere Shortening, Bone Marrow Failure
Study to Evaluate of EXG34217 in Patients With Telomere Biology Disorders With Bone Marrow Failure
This is a Phase I/II, open label, single center study to assess the safety and tolerability of EXG34217 in bone marrow failure patients with telomere biology disorders.
- Trial name
- NCT04211714
- Testing
- EXG34217
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Elixirgen Therapeutics, Inc.