Clinical trials: TKA
Arthroplasty, Replacement
TKA Melatonin and Sleep Quality
This randomized controlled trial (RCT) will compare the effects of melatonin vs. placebo in patients undergoing primary total knee arthroplasty (TKA). This RCT aims to study the effects melatonin has on sleep quality after TKA.
- Conditions
- Arthroplasty, Replacement, Knee, Sleep Initiation and Maintenance Disorders
- Trial name
- NCT05332717
- Testing
- Melatonin 5 mg
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Unilateral Knee Arthroplasty
Intra-Venous Acetaminophen and Muscle Relaxants After Total Knee
This is a prospective, three-arm, randomized, open-label trial to determine if a new pain control protocol which includes regular dosing of intravenous acetaminophen and orphenadrine for 48 hours after total knee surgery reduces…
- Trial name
- IVAM (NCT02449369)
- Testing
- Preop acetaminophen IV, Preop orphenadrine IV, Postop oral oxycodone & acetaminophen
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- AdventHealth
Total Knee Arthroplasty
Comparison Between Brainlab Knee 3 Computer-assisted Navigation Systems and Conventional Instruments in TKA: a Prospective Cohort Study.
This is a a prospective cohort study. According to the inclusion criteria, volunteers were recruited from patients undergoing total knee arthroplasty.
- Trial name
- NCT04960345
- Testing
- Brainlab Knee 3
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Knee Arthroplasty, Total
Evaluation of Navigation-Assisted TKA Using Mechanical vs. Restricted Kinematic Alignment
The purpose of this study is to evaluate both clinical measures and PROMs in patients undergoing total knee arthroplasty (TKA) using restricted inverse kinematic alignment (iKA) compared to mechanical alignment (MA), both using…
- Trial name
- NCT05516381
- Testing
- Optetrak Logic CR Knee System
- Where
- Spain
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Exactech
Arthritis Knee, Blood Loss
Blood Loss Assessment in the Limited Application of Tourniquet During Primary Unilateral TKA
Tourniquet application in total knee arthroplasty has many benefits and might have a role in the incidence of peri-operative complications the aim of this research: is to look into the effectiveness of the limited application of…
- Conditions
- Arthritis Knee, Blood Loss, Arthroplasty Complications
- Trial name
- NCT05691751
- Testing
- primary unilateral total knee arthroplasty with limited application of tourniquet, primary unilateral total knee arthroplasty with full application of tourniquet
- Where
- Syria
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Damascus University
Knee Osteoarthritis
Outcome of TKA Using Customized Cutting Block Compared With Conventional Intramedullary Cutting Guide
Customized cutting block and conventional cutting guide are both effective in improving accuracy and function of OA knee patients.
- Trial name
- NCT02128464
- Testing
- Patient specific cutting guides, Standard knee cutting guides
- Where
- Thailand
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Thammasat University
Wound Surgical, Diabetes
Negative Pressure Wound Therapy Devices in Total Knee Arthroplasty
This study is a single-center, prospective, randomized, open-label clinical trial evaluating three commercially available closed-incision negative pressure wound therapy (ciNPWT) devices: NPseal, PICO, and Prevena, in adult…
- Conditions
- Wound Surgical, Diabetes, Obesity, Chronic Kidney Diseases
- Trial name
- NCT07770633
- Testing
- NP Seal, PICO, Prevena
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Total Knee Arthroplasty, Pain Management
Analgesic Efficacy of Preemptive Stepwise Infiltration Anesthesia for Perioperative Analgesia After TKA
This is a single-center prospective cohort study in which patients were evaluated by inclusion and exclusion criteria before total knee arthroplasty (TKA).
- Trial name
- NCT06600815
- Testing
- preemptive stepwise infiltration anaesthesia(PSIA), postoperative local infiltration analgesia(PLIA)
- Where
- China
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Knee Replacement
Total Knee Replacement With Tourniquet or Aquamantys
The purpose of this study is to compare quadriceps muscle strength, pain, opioid consumption and patient function during the first three months after short-stay total knee replacement between patients treated with short-duration…
- Trial name
- NCT04016285
- Testing
- Aquamantys, Tourniquet
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Stephen Duncan
Osteo Arthritis Knee, Insomnia
Improving Sleep After TKA Using Mirtazapine and Quetiapine
Use of mirtazapine and quetiapine for improvement of sleep quality after TKA
- Trial name
- NCT04728581
- Testing
- Mirtazapine, Quetiapine
- Where
- 2 sites in Netherlands
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- St. Anna Ziekenhuis, Geldrop, Netherlands
Arthroplasty Complications, Kinesiophobia
Effects of Music and Comedy Application on Pain and Kinesyophobia in Patients With TKA
Total knee arthroplasty (TKA) is a surgical procedure used to restore painless joint function and increase patients' activities of daily living in patients with progressive knee osteoarthrosis.
- Trial name
- NCT05471778
- Testing
- Watching comedy movie, listening to music
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Malatya Turgut Ozal University
Arthropathy of Knee, Pain, Joint
Assessing if Cryoneurolysis Improves Prehabilitation and Decreases Pain After Surgery With Less Opioid Use in TKA Patients
This is a prospective, randomized control trial to evaluate the impacts of preoperative cryoneurolysis treatment on opioid consumption with prehabilitation and resulting postoperative functional improvement in patients undergoing…
- Conditions
- Arthropathy of Knee, Pain, Joint, Arthritis Knee, Opioid Use
- Trial name
- NCT03836313
- Testing
- iovera°
- Volunteers
- healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Pain, Postoperative, Total Knee Arthroplasty (TKA)
Continuous Adductor Canal Blocks Vs. Low Dose Femoral Nerve Blocks For Early Rehabilitation After Total Knee Arthroplasty
Recently, several articles have suggested or reported that Adductor Canal Blocks (ACBs) offer adequate or equal analgesia and may promote better performance in early rehabilitation following Total Knee Arthroplasty (TKA) when…
- Trial name
- FemVsACB (NCT02453321)
- Testing
- Continuous Femoral Nerve Block, Nerve Block, Continuous Adductor Canal, Continuous Sciatic Nerve Block
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Kevin King, DO
Total Blood Loss
Reducing Blood Loss Using Tisseel in TKA
The purpose of this study is to conduct a prospective randomized controlled trial to investigate the blood-conservation effect of the topical hemostatic agents in patients receiving primary TKA procedures.
- Trial name
- NCT03310060
- Testing
- Tisseel, Tranexamic Acid
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Knee Replacement, Total Knee Arthroplasty
Trial of Liposomal Bupivacaine for TKA
Total knee arthroplasty (TKA), also known as a knee replacement, is a procedure performed to reduce severe pain and improve function of the joint.
- Conditions
- Knee Replacement, Total Knee Arthroplasty, Post-Operative Pain
- Trial name
- NCT05635916
- Testing
- Liposomal bupivacaine, Bupivacaine
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Northern Light Mercy Hospital
Osteoarthritis of Knee, Edema
Microcurrent Stimulation Reduces Post-Operative Swelling and Healing Time Following Knee Replacement Surgery
The purpose of this study is to determine if patients undergoing a total knee arthroplasty (TKA) experience a clinically significant reduction in healing time when treated post operatively with a specific form of micro and…
- Conditions
- Osteoarthritis of Knee, Edema, Wounds and Injuries
- Trial name
- NCT02623660
- Testing
- ODIN1, Standard Care, Diagnostic Device Testing
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bioelectric Research Corporation
Osteoarthritis Knees Both
Reparel Knee Sleeve vs. TED Hose for Post-op Swelling, Pain and Range of Motion After Total Knee Replacement
This prospective study will evaluate pain, swelling, ROM as well as narcotic use in post-operative total knee arthroplasty patients using novel Non-Compressive Bioactive Garment (NCBG) versus current standard of care gradient…
- Trial name
- NCT04751942
- Testing
- Non-compressive Bioactive Garment, thrombo-embolic deterrent
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Aseptic Loosening, Infection
Maxx Orthopedics' PCK Revision TKA Study of Component Survivorship
The objectives of this clinical investigation are to evaluate the safety and performance of the Freedom Total Knee® PCK System.
- Conditions
- Aseptic Loosening, Infection, Bone Loss, MCL - Medial Collateral Ligament Rupture of the Knee
- Trial name
- NCT03312088
- Testing
- Freedom Knee PCK Components
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Maxx Orthopedics Inc
Total Knee Arthroplasty (TKA)
VRAS (Velys Robot-Assisted Solution) Operational Excellence Study
The aim of this study is to investigate the differences in process set-up, efficiency, OR team workload, instrument trays and OR financial performance when using the VRAS (Velys Robotic Assisted Solution) of DePuy Synthes…
- Trial name
- NCT06563843
- Testing
- Robotic-assisted TKA, Conventional TKA
- Where
- 10 sites in Austria, Belgium and 6 more
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- DEO NV
Knee Arthropathy, Opioid Use
Opioid Requirements Post Discharge of Patients Having Total Knee Arthroplasty (TKA)
Total knee arthroplasty (TKA) may result in significant postoperative pain. The majority of these patients are prescribed opioids for the management of postoperative pain.
- Conditions
- Knee Arthropathy, Opioid Use, Pain, Rehabilitation
- Trial name
- NCT03106129
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre