Clinical trials: TKA
Anatomic Stage IV Breast Cancer AJCC v8, Metastatic HER2-Negative Breast Carcinoma
Tka Assay for CDK4/6i
This clinical trial assesses whether using a test developed by DiviTum can identify optimal levels of CDK 4/6 inhibitor medications in the blood and whether assessing medical compliance and drug-drug interactions can optimize…
- Trial name
- NCT06572800
- Testing
- DiviTum-TKa
- Where
- 18 sites in United States
- Volunteers
- 34 people
- Sponsor
- Yale University
Infection of Total Knee Joint Prosthesis, Aseptic Loosening of Prosthetic Joint
Surgical / Economic Effect of the Aquamantys System in Blood Management for Aseptic and Septic Revision TKA
To assess the surgical and economic effectiveness of the Aquamantys System in managing intra- and post-operative blood loss, and reducing transfusion needs in patients undergoing both aseptic and septic revision total knee…
- Trial name
- NCT02266407
- Testing
- Aquamantys System
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medtronic Surgical Technologies
Wear of Articular Bearing Surface of Prosthetic Joint, Migration of Implant
Migration of CS vs CR Insert in TKA Using RSA
Background: The choice whether or not to preserve the posterior cruciate ligament (PCL) in total knee arthroplasty (TKA) is coupled to the us of a PCL-retaining (CR) or a condylar (CS) insert.
- Trial name
- CS vs CR RSA (NCT05936593)
- Testing
- Condylar Stabilizing (CS) insert, Cruciate Retaining (CR) insert
- Where
- Netherlands
- Volunteers
- 44 people
- Sponsor
- Reinier Haga Orthopedisch Centrum
Total Knee Arthroplasty
Intraoperative VR for Older Patients Undergoing TKA
The objective of this study is to investigate whether the use of virtual reality (VR) during total knee arthroplasty (TKA) can facilitate reductions in intraoperative sedative requirements while maintaining high levels of patient…
- Trial name
- NCT04748549
- Testing
- Virtual Reality Immersive Relaxation, Immersive Audio Experience
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Beth Israel Deaconess Medical Center
Knee Osteoarthritis, Total Knee Arthroplasty
Prediction of Postoperative Outcomes After TKA Using Instrumented Insoles and DNN
This multicenter prospective observational study aims to evaluate whether preoperative clinical variables and wearable sensor-derived gait features can predict postoperative improvement after total knee arthroplasty (TKA).
- Trial name
- NCT07367789
- Testing
- Instrumented Insole Gait Assessment
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Knee Arthritis Osteoarthritis, Knee Replacement Arthroplasty
Is BMI Outdated in TKA Patient Selection? Assessment of the Impact of Pre-tubercular Subcutaneous Tissue Thickness and the Risk of Postoperative Infection Following Total Knee Arthroplasty
While Body Mass Index (BMI) is currently used as a primary tool for risk stratification in patients undergoing Total Knee Athroplasty(TKA), its limitations raise concerns regarding its accuracy and fairness in guiding surgical…
- Conditions
- Knee Arthritis Osteoarthritis, Knee Replacement Arthroplasty, BMI, Regional Body Composition
- Trial name
- BEYOND-BMI (NCT07763535)
- Volunteers
- 400 people
- Sponsor
- East Lancashire Hospitals NHS Trust
Osteo Arthritis of the Knee, Total Knee Anthroplasty
Dinalbuphine Sebacate in Postoperative Pain Control After TKA
To evaluate the effectiveness of Dinalbuphine Sebacate for controlling subacute pain after total knee arthroplasty
- Trial name
- Naldebain (NCT07140510)
- Testing
- Dinalbuphine Sebacate, Normal Saline
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Thammasat University
Osteoarthritis of Knee
The Recovery Time of Quadriceps Strength After Total Knee Arthroplasty (TKA): The Effect of Quadriceps Incision Length
Minimally invasive total knee arthroplasty (MIS-TKA) became the popular technique. It had the less postoperative pain and shorter recovery time compared to the conventional technique.
- Trial name
- NCT01450904
- Testing
- Quadriceps incision < 2 cm, Quadriceps incision 2-4 cm, Quadriceps incision > 4 cm
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Knee Osteoarthritis, Pain Management
Phase 3 Adductor Canal Block With EXPAREL in Subjects Undergoing Primary Unilateral Total Knee Arthroplasty
The purpose of the study is to compare magnitude of postsurgical analgesic effect in different groups following a single dose of study drug when administered via adductor canal block in subjects undergoing primary unilateral…
- Trial name
- NCT05139030
- Testing
- bupivacaine liposome injectable suspension, Bupivacaine Hydrochloride
- Where
- 6 sites in United States
- Volunteers
- 167 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Pain, Postoperative, Total Knee Arthroplasty
Duloxetine RCT on Postop TKA Outcomes
The aim of this study is to determine if duloxetine is associated with differences in post-operative pain, patient-reported outcome measures, and opioid consumption in patients undergoing primary total knee arthroplasty compared…
- Trial name
- NCT05086393
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Osteoarthritis, Metal Ion Levels
Serum Metal Ion Concentration After Total Knee Arthroplasty (TKA)
All metal implants release metal ions because of corrosion. Total knee arthroplasty implants have large metal surface areas and therefore substantial potential for corrosion.
- Trial name
- NCT00862511
- Testing
- Coated Total Knee Arthroplasty, Standard Total Knee Arthroplasty
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Technische Universität Dresden
Knee Injuries
Evaluation of Patient Reported Outcomes (PRO) After Total Knee Arthroplasty (TKA) Under Spinal Anesthesia
The purpose of this study will be to evaluate and compare patients undergoing total knee arthroplasty (TKA) with sensor guidance versus that of a standard technique.
- Trial name
- NCT03053453
- Testing
- Spinal Surgery, Verasense Knee System device
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- NYU Langone Health
Osteoarthritis of the Knee
Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty
Total knee arthroplasty (TKA) is associated with moderate to severe postoperative pain, causing patient discomfort, mobilisation and hospital discharge. The aim of this study is to: 1.
- Trial name
- NCT00562627
- Testing
- ropivacaine, adrenaline, ketorolac
- Where
- Norway
- Volunteers
- 102 people
- Sponsor
- Asker & Baerum Hospital
Total Knee Replacement
Mepivacaine Vs. Bupivacaine Spinal for TKA
This study will enroll patients 18-75 years of age who are undergoing elective primary total knee replacement. The patients will be randomized to receive one of two spinal blocks: 1) mepivacaine or 2) bupivacaine.
- Trial name
- NCT05765682
- Testing
- Mepivacaine Spinal, Bupivacaine Spinal
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Medical University of South Carolina
Knee Arthroscopy
Outpatient Total Knee Arthroscopy (TKA): Comparison of Postoperative Recovery Versus a Conventional Hospitalization
Outpatient TKA is a controversial topic due to concerns about its safety as an outpatient procedure, and remains a marginal procedure.
- Trial name
- PTG (NCT07276061)
- Where
- France
- Volunteers
- 440 people
- Sponsor
- University Hospital, Strasbourg, France
Knee Osteoarthritis
The Effect of Perioperative Neuromuscular Training on the Outcome of Total Knee Arthroplasty
Introduction: Total knee arthroplasty (TKA) is a consensus treatment for end-stage knee osteoarthritis. The peri-operative rehabilitation is an important part of the outcome of such procedure.
- Trial name
- NCT00492674
- Testing
- APOS biomechanical gait system, Physical Therapy
- Sponsor
- Assaf-Harofeh Medical Center
Total Knee Arthroplasty
Study of Local Administration of DepoTXA for Reduced Postsurgical Bleeding in Subjects Undergoing TKA
This is a Phase 2, randomized, single-blind, active-controlled dose-ranging study in subjects scheduled to undergo total knee arthroplasty (TKA).
- Trial name
- NCT02922582
- Testing
- DepoTXA, Tranexamic Acid
- Where
- 5 sites in United States
- Volunteers
- 16 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Total Knee Arthroplasty
Inpatient Versus Outpatient Rehabilitation After TKA
The purpose of this study is to compare the effectiveness of inpatient and outpatient rehabilitation following total knee arthroplasty.
- Trial name
- NCT02120313
- Testing
- inpatient rehabilitation, outpatient rehabilitation
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- University of Rostock
Perioperative Pain
Effect of Dexamethasone Shortly Before Surgery on the Intraoperative Dose of Remifentanil
This explorative post hoc analysis included patients randomized in the DEX-2-TKA trial (NCT03506789) who were operated under general anesthesia with remifentanil and propofol.
- Trial name
- NCT05002361
- Testing
- Dexamethasone, Isotonic saline
- Where
- 5 sites in Denmark
- Volunteers
- 94 people
- Sponsor
- Naestved Hospital
Osteoarthritis (OA) of the Knee
Postoperative Pain and Analgesic Requirements After Preoperative Methadone for Primary TKA
The goal of this prospective, randomized study is to compare the outcomes of two cohorts of patients undergoing primary Total Knee Arthroplasty (TKA) and to determine whether a single dose of methadone administered preoperatively…
- Trial name
- NCT06691633
- Testing
- Preoperative Methadone, Preoperative Oxycodone
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Louisville