Clinical trials: Systolic Dysfunction
AV Block
Left Septal Pacing or Left Bundle Branch Pacing to Avoid Left Ventricle Systolic Dysfunction
Right ventricular apical pacing (RVAP) can produce left ventricular dysfunction (LVD). Conduction system pacing (CSP) has been used successfully to reverse LVD in patients with left bundle branch block.
- Trial name
- STAY II (NCT06707662)
- Testing
- Pacemaker and defibrillator
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Parc de Salut Mar
Modified Release Oral Formulation, Left Ventricular Systolic Dysfunction
COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure
The primary objectives of this study are (i) to select an oral modified release (MR) formulation and dose of omecamtiv mecarbil for chronic twice daily (BID) dosing in adults with heart failure and left ventricular systolic…
- Conditions
- Modified Release Oral Formulation, Left Ventricular Systolic Dysfunction, Chronic Heart Failure, History of Chronic Heart Failure
- Trial name
- COSMIC-HF (NCT01786512)
- Testing
- Omecamtiv Mecarbil Matrix F1 Formulation, Omecamtiv Mecarbil Matrix F2 Formulation, Omecamtiv Mecarbil Swellable Core Technology F2
- Where
- 101 sites in United States, Australia and 11 more
- Volunteers
- 544 people
- Sponsor
- Cytokinetics
Persistent Atrial Fibrillation, Atrial Fibrillation, Persistent
Hybrid Ablation of Atrial Fibrillation in Heart Failure
A randomised controlled trial to assess the efficacy of staged hybrid ablation when compared with standard catheter ablation in patients with non-paroxysmal atrial fibrillation (AF) and Heart Failure
- Conditions
- Persistent Atrial Fibrillation, Atrial Fibrillation, Persistent, Atrial Arrhythmia, Atrial Fibrillation
- Trial name
- HALT AF (NCT05411614)
- Testing
- AtriCure EPi-Sense-AF Guided Coagulation System +/- Atriclip, Endocardial Catheter Ablation
- Where
- 7 sites in United Kingdom
- Volunteers
- 120 people
- Sponsor
- St. George's Hospital, London
Left Ventricular Systolic Dysfunction
The SMART-LV Pilot Study
The goal of this pilot study is to evaluate the prospective performance of an image-based, smartphone-adaptable artificial intelligence electrocardiogram (AI-ECG) strategy to predict and detect left ventricular systolic…
- Trial name
- NCT05630170
- Testing
- AI-ECG
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Asymptomatic Left Ventricular Systolic Dysfunction (Disorder), Heart Failure
ECG AI-Guided Screening for Low Ejection Fraction
This is a randomized controlled trial (RCT) to test a novel artificial intelligence (AI)-enabled electrocardiogram (ECG)-based screening tool for improving the diagnosis and management of left ventricular systolic dysfunction.
- Trial name
- EAGLE (NCT04000087)
- Testing
- AI-enabled ECG-based Screening Tool
- Where
- United States
- Volunteers
- 358 people
- Sponsor
- Mayo Clinic
Diastolic Dysfunction
Effects of Remifentanil on Cardiac Function in Patients With Diastolic Dysfunction
In this study ASA 1, 2 individuals with grade 1 or 2 diastolic dysfunction will be recruited to assess the effects of Remifentanil infusion on left ventricular function evaluated with transthoracic echocardiagraphy.
- Trial name
- NCT04117009
- Testing
- Remifentanil 2 MG, Echocardiographic evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Yeditepe University
ST Elevation Myocardial Infarction
NP202 for Treatment of Post -STEMI Left Ventricular Systolic Dysfunction
NP202 is an experimental drug being developed by Armaron Bio Pty Ltd for potential use as a treatment for people after they have had a heart attack (MI).
- Trial name
- NCT02557217
- Testing
- NP202
- Where
- Australia
- Volunteers
- 120 people
- Sponsor
- Armaron Bio Pty Ltd
Diastolic Dysfunction
Effect of Exercise on Heart Function in Healthy Elderly People
The purpose of this study is to determine the effect of aerobic interval training on left- and right ventricular diastolic- and systolic function on healthy, sedate people over 70 years.
- Trial name
- NCT00804518
- Testing
- Aerobic interval training
- Where
- Norway
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Cardiomyopathies, Chemotherapy Effect
Bisoprolol Administration to Prevent Anthracycline-induced Cardiotoxicity
Anthracyclines are one of the most well-known and effective drugs used to treat malignancies.The most important limiting factor in the use of this drug is its cardiac toxicity which includes cardiomyopathy and congestive heart…
- Conditions
- Cardiomyopathies, Chemotherapy Effect, Diastolic Dysfunction, Systolic Dysfunction
- Trial name
- NCT05175066
- Testing
- Bisoprolol
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Heart Failure
The Product Surveillance Registry REVERSE Post Approval Study
The purpose of the REVERSE Post Approval Study (PAS) is to confirm the benefit observed in the REVERSE and RAFT pivotal studies in "real-world" clinical practice.
- Trial name
- PSR-REVERSE (NCT01660035)
- Where
- 123 sites in United States, Belgium and 8 more
- Volunteers
- 155 people
- Sponsor
- Medtronic
HF - Heart Failure
AI ECG Algorithm for Detecting LV Systolic Dysfunction
This prospective observational cohort study aims to evaluate the clinical performance of a deep learning-based electrocardiography (ECG) algorithm (DeepECG LVSD) for detecting left ventricular systolic dysfunction (LVSD), defined…
- Trial name
- NCT07636759
- Where
- South Korea
- Volunteers
- 1,500 people
- Sponsor
- Ajou University School of Medicine
Chagas Cardiomyopathy, Cardiac Arrhythmia
The Signal-averaged ElectrocArdiogram in Long Term Follow-up of Chronic CHagas Disease - RIO de Janeiro Cohort
The study investigated 100 subjects, both genders, with chronic Chagas disease, confirmed by at least two distinct serological tests, and classified according to Los Andes classification in a long term follow-up aiming at…
- Conditions
- Chagas Cardiomyopathy, Cardiac Arrhythmia, Stroke, Left Ventricular Function Systolic Dysfunction
- Trial name
- SEARCH-Rio (NCT01340963)
- Where
- 4 sites in United States, Brazil
- Volunteers
- 100 people
- Sponsor
- Universidade Gama Filho
Chronic Systolic Heart Failure (Dilated Cardiomyopathy)
NORDIC: Nitric Oxide-Derived Oxidants and Regional Endothelial and Diastolic Dysfunction in Dilated Cardiomyopathy
The principal aim is to investigate the safety and efficacy of rosiglitazone in patients with chronic systolic heart (Dilated cardiomyopathy).
- Trial name
- NORDIC (NCT00293137)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Cleveland Clinic
Ischemic Left Ventricle Systolic Dysfunction, Multivessel Coronary Artery Disease
STICH3C Cardiac Magnetic Resonance Observational Study
STICOS will test the hypothesis that residual jeopardized myocardium, late gadolinium enhancement, and non-ischemic substrate after revascularization is associated with postoperative adverse cardiovascular events such as heart…
- Trial name
- STICOS (NCT07133984)
- Testing
- Cardiac Magnetic Resonance Imaging
- Where
- 10 sites in United States, Austria and 4 more
- Volunteers
- 230 people
- Sponsor
- Weill Medical College of Cornell University
Coronary Microvascular Dysfunction, Obstructive Coronary Heart Disease
The Evaluation of Left Ventricular Systolic Function in Different Types of Ischemic Heart Disease
The study was designed to evaluate the left ventricular longitudinal strain and strain rate assessed by 2D-STI in patients with coronary microvascular dysfunction (CMD) or obstructive coronary artery disease (CAD) , to…
- Trial name
- NCT04959357
- Testing
- Two dimensional speckle tracking imaging
- Where
- China
- Volunteers
- 242 people
- Sponsor
- Peking University Third Hospital
Blood Pressure, Endothelial Dysfunction
Novel Time-efficient Inspiratory Muscle Strength Training for Lowering Systolic Blood Pressure
Above-normal systolic blood pressure (SBP), defined as SBP >/= 120 mmHg, is the major modifiable risk factor for cardiovascular disease, stroke, cognitive decline/dementia, and other chronic health problems.
- Conditions
- Blood Pressure, Endothelial Dysfunction, Hypertension
- Trial name
- NCT04848675
- Testing
- Inspiratory muscle strength training, Brisk walking
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Ventricular Dysfunction, Right, Lung Diseases
Evaluation of the Right Ventricular Systolic Function Using Real-time Three-dimensional Echocardiography in Intensive Care Unit Patients
Right ventricular failure (RVF) is an independent factor of mortality for many pulmonary diseases. Currently, RVF is defined as the incapacity of the RV to maintain the flow without dilating to use the Frank-Starling law (i.e.…
- Conditions
- Ventricular Dysfunction, Right, Lung Diseases, Intensive Care Units
- Trial name
- REA-3D-VD (NCT04222764)
- Testing
- Real-time three-dimensional echocardiography
- Where
- 2 sites in France
- Volunteers
- 341 people
- Sponsor
- University Hospital, Limoges
Psoriatic Arthritis (PsA), Subclinical Right Ventricular Systolic Dysfunction
Right Ventricular Strain in Detecting Subclinical Right Ventricular Systolic Dysfunction in Psoriatic Arthritis Patients: Relation to Serum Endostatin Level
The aim is to assess early right ventricular systolic dysfunction in psoriatic arthritis patients using RV strain echocardiography
- Trial name
- NCT07046312
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Congestive Heart Failure, Left Ventricular (LV) Systolic Dysfunction
A Pivotal Trial to Establish the Efficacy and Long-term Safety of the Parachute Implant System
Treatment of ischemic heart failure.
- Trial name
- PARACHUTE IV (NCT01614652)
- Testing
- CardioKinetix Parachute Implant and All Appropriate Medical Therapy (AAMT)
- Where
- 68 sites in United States, Canada
- Volunteers
- 331 people
- Sponsor
- CardioKinetix, Inc
Left Ventricular Systolic Dysfunction, Heart Failure (Pediatric)
A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction
Researchers are looking for a better way to treat children and young adults who have heart failure with left ventricular systolic dysfunction (LVSD).
- Trial name
- FIORELLO (NCT07192952)
- Testing
- Finerenone (Kerendia, BAY94-8862)
- Where
- 132 sites in United States, Argentina and 21 more
- Volunteers
- 117 people
- Sponsor
- Bayer