Clinical trials: Systemic Inflammatory Response Syndrome (SIRS)
Fluid and Electrolyte Imbalance
Volume Kinetics of Fluid Resuscitation in Early Sepsis
The recommended volume resuscitation for patients with early sepsis-induced hypoperfusion is at least 30 ml/kg of crystalloid administered within the first three hours.
- Trial name
- NCT06499701
- Testing
- Ringer's Lactate
- Where
- 2 sites in Romania
- Volunteers
- 13 people
- Sponsor
- Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu
Sepsis
A Study on How the Immune System Responds to Sepsis and Its Long-term Effects
Sepsis occurs when an infection, caused by bacteria, a virus, or a fungus, enters the body and throws the immune system out of balance.
- Trial name
- HEAL-SEPSIS (NCT07273344)
- Testing
- blood sampling
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Radboud University Medical Center
Systemic Inflammatory Response Syndrome, Sepsis
Impact of Vitamin D Supplementation on Hepcidin Levels and Transfusion Requirements in Surgical and Septic Patients
Acute inflammation induced by surgery and sepsis is complicated by the development of iron-restricted anemia due to the up-regulation of hepcidin.
- Conditions
- Systemic Inflammatory Response Syndrome, Sepsis, Surgical Injuries
- Trial name
- DEHEPTRA (NCT03001687)
- Testing
- enteral supplementation with vitamin D, blood collection 3mL
- Where
- Romania
- Volunteers
- 40 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Sepsis
Methylene Blue and Ozone in Early Sepsis
effects of methylene blue and ozone O3 therapy effects in early sepsis management , and their implications upon outcome
- Trial name
- NCT02910765
- Testing
- methylene blue, ozone, saline infusion
- Volunteers
- 40 people
- Sponsor
- Assiut University
COVID-19
INB03 for the Treatment of Pulmonary Complications From COVID-19
The purpose of this study is to determine whether XPro1595 can prevent the progression of respiratory complications in COVID19 patients.
- Trial name
- NCT04370236
- Testing
- INB03
- Where
- 9 sites in United States
- Volunteers
- 79 people
- Sponsor
- Inmune Bio, Inc.
Acute Respiratory Distress Syndrome
Clinical, Biological and Histological Pulmonary and Renal Damage Associated With the SARS-CoV-2 Syndrome in Patients Admitted in ICU
Renal damage in patients hospitalized for ARDS in the ICU can also be related to multiple causes including, but not limited to, the consequences of hemodynamic fluctuations in these patients or the use of nephrotoxic drugs…
- Trial name
- PR-Covid-19 (NCT04385004)
- Where
- France
- Volunteers
- 320 people
- Sponsor
- University Hospital, Strasbourg, France
Candidemia
Safety and Efficacy of Interferon-Gamma 1b in Patients With Candidemia
A multi-center open label adaptive randomized interventional phase 2 study to evaluate safety and efficacy of rIFN-y treatment in patiens with candidemia.
- Trial name
- HDM-FUN Cand (NCT04979052)
- Testing
- Interferon Gamma-1B
- Where
- 6 sites in United States, Germany and 4 more
- Volunteers
- 65 people
- Sponsor
- Radboud University Medical Center
Sepsis, Infection
Meropenem and Piperacillin Plasma Concentrations During CRRT
This observational study reports meropenem and piperacillin plasma concentrations in patients treated with either antibiotic and simultaneous continuous renal replacement therapy (CRRT).
- Conditions
- Sepsis, Infection, Antibiotic, Renal Replacement Therapy
- Trial name
- ABC2 (NCT04203784)
- Testing
- Plasma concentration measurements
- Where
- Sweden
- Volunteers
- 135 people
- Sponsor
- Karolinska University Hospital
Intestinal Inflammation
Prospective Study Evaluating the Prevalence of Intestinal Dysfunction
The intestinal tract has multiple functions within the body beyond its primary function of nutrient absorption. It acts as a true barrier protecting the body from living microorganisms and antigens in the intestinal lumen.
- Trial name
- DIR-H (NCT07022548)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Rouen
Sepsis, Severe Sepsis
Unsupervised Machine Learning for Clustering of Septic Patients to Determine Optimal Treatment
The focus of this study will be to conduct a prospective, randomized controlled trial (RCT) at Cape Regional Medical Center (CRMC), Oroville Hospital (OH), and UCSF Medical Center (UCSF) in which a fluid treatment-specific…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT03752489
- Testing
- Treatment-specific InSight, InSight
- Volunteers
- 51,645 people, healthy volunteers welcome
- Sponsor
- Dascena
Sepsis
Efficacy & Safety of Resatorvid in Adults With Severe Sepsis
The purpose of this study is to determine the optimal dose of Resatorvid for reducing 28-day all-cause mortality in subjects with severe sepsis.
- Trial name
- NCT00143611
- Testing
- Resatorvid
- Where
- 144 sites in United States, Australia and 15 more
- Volunteers
- 277 people
- Sponsor
- Takeda
Sepsis
A Clinical Trial of Procalcitonin-guided Antimicrobial Therapy in Sepsis
The aim of the study is to demonstrate if using one procalcitonin (PCT)-guided rule of stop of antimicrobials, the incidence of infections by C.difficile and by Multi-Drug-Resistant (MDR) bacteria during the next six months may…
- Trial name
- PROGRESS (NCT03333304)
- Testing
- Procalcitonin measurement
- Where
- 7 sites in Greece
- Volunteers
- 266 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Sepsis, Trauma Related Injuries
Stratifying Critically Ill Patients for Novel Ferroptosis or Pyroptosis Intervention Strategies
In order to better determine which therapy is best for patiënts which present with organ falure during the course of their stay in the intesive care unit (ICU) , one has to determine which underlying mechanism is causing this…
- Conditions
- Sepsis, Trauma Related Injuries, Subarachnoid Haemorrhage (SAH)
- Trial name
- ICU-FERRO (NCT06928649)
- Testing
- Blood sampling
- Where
- Belgium
- Volunteers
- 600 people
- Sponsor
- University Hospital, Antwerp
Neonatal Sepsis, Necrotizing Enterocolitis
Bovine Lactoferrin and Neonatal Survival in Low Birth Weight Babies.
Pakistan has the third highest number of neonatal deaths worldwide. During the last two decades (1990-2013), neonatal mortality rate in the country has declined by only 1.0% per year.
- Trial name
- NCT03431558
- Testing
- bLF (Bovine lactoferrin)
- Where
- Pakistan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Pneumonia, Blood Stream Infection
Optimizing Clinical Use of Polymyxin B
Polymyxin B is already being used extensively in the USA and other parts of the world; its use is likely to rapidly increase due to the greater burden of infections caused by MDR Gram-negative bacteria and the growing awareness…
- Conditions
- Pneumonia, Blood Stream Infection, Urinary Tract Infections, Respiratory Tract Infection (Including Tracheobronchitis)
- Trial name
- NCT02682355
- Where
- 6 sites in United States, Brazil and 1 more
- Volunteers
- 155 people
- Sponsor
- Rutgers, The State University of New Jersey
Central Line-associated Bloodstream Infections
Impact of Disinfectant Caps on Nosocomial CLABSI
In a worldwide, one-day, prospective point-prevalence study, a prevalence of 15.1% for hospital-acquired central line-associated bloodstream infections (HA-CLABSI) was determined in 13,796 patients across 1,265 intensive care…
- Trial name
- NCT07430215
- Testing
- use of desinfection caps, sterile catheter cap
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- BDH-Klinik Hessisch Oldendorf
Neonatal Sepsis, Late-Onset
Population Pharmacokinetics of Amikacin in Neonates
Aminoglycosides such as Amikacin are routinely used in newborns for the treatment of neonatal sepsis due to gram-negative bacilli.
- Trial name
- NCT04867135
- Testing
- Amikacin Sulfate Injection
- Where
- Chile
- Volunteers
- 138 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Acute Respiratory Distress Syndrome, Critical Illness
Acetaminophen and Ascorbate in Sepsis: Targeted Therapy to Enhance Recovery
Prospective multi-center phase 2b randomized placebo-controlled double-blinded interventional platform trial of two different pharmacologic therapies (intravenous Vitamin C or intravenous Acetaminophen) for patients with…
- Conditions
- Acute Respiratory Distress Syndrome, Critical Illness, Respiratory Failure, Sepsis
- Trial name
- ASTER (NCT04291508)
- Testing
- Intravenous Acetaminophen (room temperature), Intravenous Vitamin C (refrigerated), 5% Dextrose (room temperature)
- Where
- 41 sites in United States
- Volunteers
- 488 people
- Sponsor
- Massachusetts General Hospital
Sepsis
Prevention of Infection in Indian Neonates - Phase I Observational Study
India, with one of the world's largest populations, continues to struggle with extremely high infant and neonatal mortality rates.
- Trial name
- NCT00518609
- Where
- 3 sites in India
- Volunteers
- 1,326 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Sepsis, Critical Illness
Indirect Calorimetry Usage and Effect in Ventilator-free Days and Muscle Thickness in Septic Ventilated Patients
Patients admitted to the ICU with diagnosis of sepsis and requiring mechanical ventilation for at least 24-hours and receiving enteral or parenteral nutrition will be prospectively randomized to one of two arms.
- Conditions
- Sepsis, Critical Illness, Respiratory Failure, Nutrition Disorders
- Trial name
- NCT03440593
- Testing
- Caloric delivery will target results of IC measurement.
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Baylor Research Institute
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