Clinical trials: Synucleinopathies
Parkinson
Clinical Investigation of NMS Assist
Parkinson's can cause a wide range of non-motor symptoms (NMS), including pain and problems with mental health, memory and sleep. These affect the quality of life of people with Parkinson's (PwP) and their care partners (CP).
- Trial name
- NCT05414071
- Testing
- NMS Assist
- Sponsor
- University of Plymouth
Parkinson Disease
Impact of Exercise in Parkinson's Disease
The goal of this research is to identify an intervention that will improve cognition and sleep in persons with PD.
- Trial name
- NCT03495193
- Testing
- Exercise training, Sleep hygiene
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Alabama at Birmingham
Parkinson Disease
CANadian Adaptive DBS TriAl
Parkinsonian symptoms, such as freezing of gait (FOG) or hypophonia, play a significant role in reducing quality of life for Parkinson disease (PD) patients, and are poorly responsive or can worsen with deep brain stimulation…
- Trial name
- CANADA (NCT05402163)
- Testing
- Adaptive DBS, Continuous DBS
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Toronto
Parkinson Disease
Internet-CBT for Parkinsons Disease
The aim of the study is to investigate if an Internet-based psychological treatment based on principles from Cognitive Behavioral Therapy can increase function and quality of life for patients with Parkinson disease.
- Trial name
- Patrik (NCT02627885)
- Testing
- Internet-based CBT, SMT
- Where
- Sweden
- Volunteers
- 77 people
- Sponsor
- Karolinska Institutet
Parkinson's, Alzheimer Disease
Sound Estimation and Accuracy Task
Participants will be assigned to complete computerized estimation tasks for which there is a component of accuracy, such as estimating the duration of sounds.
- Trial name
- NCT02271685
- Testing
- Instructions about Overestimates, Instructions about Parkinson's, Instructions about Underestimates
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Carnegie Mellon University
Parkinson Disease
Pedunculo-Pontin Nucleus (PPN) - Deep Brain Stimulation (DBS) in Gait and Balance Disturbance in Parkinson's Disease (PPN-GAB-PARK Study)
Disturbance of posture, gait and balance usually appear several years after Parkinson's disease (PD) onset. These axial signs, generally resistant to conventional drug and non-drug treatment, can generate a loss of autonomy and…
- Trial name
- NCT00821743
- Testing
- Deep brain stimulation electrode
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Parkinson Disease, Parkinson's Disease
A Long-Term Follow-up Study of the Severe Parkinson's Disease Patients Administered the IPS101A Gene Therapy Product.
The purpose of this study is to evaluate the long-term safety of IPS101A and to assess the durability of efficacy in subjects who received IPS101A.
- Trial name
- NCT07629115
- Where
- South Korea
- Volunteers
- 6 people
- Sponsor
- Innopeutics Corporation
Parkinson Disease, Early Parkinson's Disease
A Phase 3 Study With P2B001 in Subjects With Early Parkinson's
P2B001 is an investigational drug that comprised of low doses of two drugs, pramipexole and rasagiline, which are both approved drugs and routinely used in standard therapy for Parkinson's disease.
- Trial name
- NCT03329508
- Testing
- P2B001 0.6/0.75 mg, Rasagiline 0.75 mg, Pramipexole 0.6 mg
- Where
- 72 sites in United States, Canada and 2 more
- Volunteers
- 544 people
- Sponsor
- Pharma Two B Ltd.
Parkinson's Disease
Glucose Tolerance in Patients With an Idiopathic Parkinson's Disease
Dysfunction of autonomic nervous system is an important non motor feature of Parkinson' disease (PD). Lewy body formation is widely distributed in hypothalamus and in sympathetic and parasympathetic systems.
- Trial name
- NCT01114321
- Testing
- Protein and calorie controlled diet
- Where
- 2 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Parkinson Disease
A Study to Assess the Safety of BMS-984923 Compared to Placebo, in People With Parkinson's
A Phase 1, randomized, double-blind, placebo-controlled study of BMS-984923 administered orally twice daily (BID) for 28 days in participants with Parkinson's disease.
- Trial name
- NCT06309147
- Testing
- BMS-9894923
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Allyx Therapeutics
Parkinson Disease
Fox BioNet Project: ECV-003
The goal of this study is to optimize pre-analytical cerebrospinal fluid (CSF) extracellular vesicle isolation protocols for increasing the detection of LRRK2 activity in human CSF
- Trial name
- NCT03775447
- Testing
- Lumbar Puncture
- Where
- 3 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Michael J. Fox Foundation for Parkinson's Research
Mild Cognitive Impairment
Mild Cognitive Impairment, Use of qEEG as a Prognostic Marker
Multi center study of six Memory Clinics in four Nordic countries in validating a prognostic diagnostic investigation of qEEG in Mild Cognitive Impairment (MCI).
- Trial name
- NCT03659643
- Testing
- EEG with SPR analysis
- Where
- Iceland
- Volunteers
- 300 people
- Sponsor
- Jon Snaedal
Parkinson Disease
A Novel Virtual Reality Task in Parkinson's Disease
The purpose of this study is to compare experiences and effects of a virtual reality physical program to an in-person Rock Steady Boxing Program.
- Trial name
- NCT05859308
- Testing
- Virtual Reality Pixel Plucker, Rock Steady Boxing
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- New York Institute of Technology
Alzheimer's Disease, Parkinson's Disease
Social Cognition and Personality Changes in Alzheimer's & Parkinson's Disease & Frontotemporal Lobar Degeneration
The aim of this study is to compare personality and social cognition changes, including emotion detection and self-awareness, and neuroanatomical correlates in patients, and how that affects the caregiver-patient relationship.
- Conditions
- Alzheimer's Disease, Parkinson's Disease, Frontotemporal Lobar Degeneration
- Trial name
- NCT02964611
- Testing
- Observational Study
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Parkinson Disease
Analysis of Postural Transitions in Subjects Affected by Parkinson Disease
This observational trial aims to evaluate the effect of Rehabilitation on Postural Transfers (PTs) in subjects affected by Parkinson Disease.
- Trial name
- NCT05329987
- Testing
- Rehabilitation
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Multiple System Atrophy
Progression Rate of MSA Under EGCG Supplementation as Anti-Aggregation-Approach
MSA is a rapidly progressive disorder with an average survival time of about 7 years after the first clinical manifestation. No potent symptomatic treatment is currently available.
- Trial name
- PROMESA (NCT02008721)
- Testing
- EGCG as putative neuroprotective agent
- Where
- 12 sites in Germany
- Volunteers
- 92 people
- Sponsor
- Dr. Johannes Levin
PARKINSON DISEASE (Disorder), Parkinson's Disease (PD)
Effects of Vagal Nerve Stimulation on Leg Muscle Activity and Posture in Parkinson's Disease
This study is designed to better understand the mechanisms contributing to impaired activation of leg muscles in people with Parkinson's disease (PD) and to test if stimulation of a nerve at the neck can improve muscle…
- Trial name
- NCT07226284
- Testing
- Vagal nerve stimulation, No intervention
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Parkinson Disease
Individualized Precise Localization of rTMS on Primary Motor Area
Parkinson's disease (PD) patients have some problem with self-initiated movement task. Compared with health controls, task meta-analysis found that PD patients showed abnormal activation in pre-supplementary motor area (pre-SMA)…
- Trial name
- NCT03497884
- Testing
- rTMS
- Where
- 2 sites in China
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Hangzhou Normal University
Parkinson's Disease, Cognitive Impairment
Study of the Effect of the Cognitive Orientation to Daily Occupational Performance (CO-OP) on Cognitive Impairment in Parkinson's Disease
The purpose of the study will be to determine the effects of the Cognitive Orientation to daily Occupational Performance (CO-OP) as a treatment program for individuals with Parkinson's disease-related cognitive impairment.
- Trial name
- NCT02007785
- Testing
- CO-OP treatment protocol
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- University of Manitoba
Parkinson's Disease
Long-term Follow-up of Glutamic Acid Decarboxylase (GAD) Gene Transfer in Parkinson's Disease
The objective of this study is to evaluate the long-term safety of AAV-GAD delivered bilaterally to the subthalamic nuclei (STN) in participants with Parkinson's disease.
- Trial name
- NCT05894343
- Testing
- AAV-GAD
- Where
- 6 sites in United States
- Volunteers
- 13 people
- Sponsor
- MeiraGTx, LLC