Clinical trials: Synthetic Mesh
Stress Urinary Incontinence
Autologous Versus Synthetic Versus Biological Sling for Trans-obturator Correction of Urinary Stress Incontinence
The treatment of urinary stress incontinence with trans-obturator approach, know as transobturatory tape (TOT), is a largely used sling-adopting procedures.
- Trial name
- NCT00744198
- Testing
- Autologous transobturator tape procedure, Synthetic transobturator tape procedure, Biological transobturator tape procedure
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- University Magna Graecia
Abdominal Wall Defect, Abdominal Wall Infection
The Use of Synthetic Mesh in Contaminated and Infected Abdominal Wall Repairs. A Long-term Prospective Clinical Trial
Background: Abdominal wall reconstruction in patients presenting with enteric fistulas and mesh infection is challenging. There is a consensus that synthetic mesh must be avoided in infected operations.
- Conditions
- Abdominal Wall Defect, Abdominal Wall Infection, Abdominal Wall Fistula, Infection
- Trial name
- NCT03702153
- Testing
- Abdominal wall reconstruction
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- University of Sao Paulo General Hospital
Pelvic Organ Prolapse, Stage III and IV High Grade Pelvic Organ Prolapse
Efficacy/Safety of Urogynecology Synthetic Mesh Surgery
This is a retrospective cohort study, aiming at analyzing the efficacy and safety of mesh surgery in pelvic organ prolapse. The synthetic mesh for pelvic organ prolapse include transvaginal mesh or laparotomy, laparoscope, or…
- Trial name
- NCT05682989
- Testing
- Urodynamic investigations before and after a mesh surgery protocol., Urodynamic investigations before and after a robotic-assisted sacrocolpopexy protocol., Urodynamic investigations before and after a hysterectomy with trans-vaginal mesh repair
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Mackay Medical College
Incontinence
Synthetic Mesh Materials In Sling Surgery
The purpose of this study is to determine the clinical results contributions to surgical success,and complications of mixed type of mesh materials as well as prolen mesh materials in sling surgery in a 3 year follow-up the first…
- Trial name
- NCT01348334
- Testing
- Synthetic sling surgery
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Ataturk Training and Research Hospital
Pelvic Organ Prolapse (POP), Synthetic Mesh
Safety and Performance of a Pelvic Floor Mesh Implant for Laparoscopic Sacrocolpopexy (ProGYNious)
The purpose of this clinical investigation is to collect clinical data about the ProGYNious Mesh based on a prospective clinical investigation.
- Conditions
- Pelvic Organ Prolapse (POP), Synthetic Mesh, Laparoscopic Surgery, Gynecologic Laparoscopic Surgery
- Trial name
- ProGYNious (NCT07497321)
- Testing
- Surgical mesh for pelvic organ prolapse repair (ProGYNious)
- Where
- 5 sites in Austria, Germany
- Volunteers
- 100 people
- Sponsor
- A.M.I. Agency for Medical Innovations GmbH
Hernia Inguinal, Biologic Mesh
Effect of Biologic vs Synthetic Mesh on Chronic Pain After Laparoscopic Repair of Contralateral Asymptomatic Hernia in Patients With Unilateral Symptomatic Inguinal Hernia
Inguinal hernia is one of the most common conditions in general surgery. In clinical practice, surgeons frequently face a dilemma: during the evaluation of a patient with unilateral symptomatic inguinal hernia, a contralateral…
- Trial name
- BiSAH (NCT07649434)
- Testing
- Biologic Mesh, Synthetic Mesh
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Xiangya Hospital of Central South University
Pelvic Organ Prolapse
Evaluation of the Avaulta Procedure for the Correction of Pelvic Organ Prolapse - Results at 1 Year
This study is a 1 year review of all patients who had surgery to correct pelvic organ prolapse (i.e. cystocele, rectocele, enterocele) using the Avaulta synthetic mesh kit.
- Trial name
- NCT00774215
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Atlantic Health System
Breast Cancer
Biological Matrices Versus Synthetic Meshes
In this feasibility study, 60 women undergoing reconstruction will be randomly allocated to receive biological or synthetic mesh and followed for 6 months.
- Trial name
- BIOSYM (NCT05449691)
- Testing
- One-stage immediate breast reconstruction
- Where
- 5 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Ventral Hernia
The Use of Biologic Mesh vs Bioabsorbable Mesh During Ventral Hernia Repair in At-risk Patients
This study evaluates the outcomes of patients who have been treated with Strattice or Gore Bio-A mesh for the repair of complicated abdominal wall hernias.
- Trial name
- NCT01794338
- Testing
- Strattice Arm, Bio-A Arm
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Wake Forest University Health Sciences
Intestinal Obstruction, Pelvic Organ Prolapse
Biological Mesh Versus Synthetic Mesh in Interdisciplinary RRP With SCP
The purpose of the pilot study is to demonstrate the safety and efficacy of a biological mesh compared to a standard synthetic mesh for the planned procedure in the above-mentioned clinical picture.
- Conditions
- Intestinal Obstruction, Pelvic Organ Prolapse, Rectal Prolapse
- Trial name
- BioSynIRS (NCT06245577)
- Testing
- Laparoscopic mesh sacropexy (vagina, cervix) combined with resection rectopexy
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Evangelisches Klinikum Köln Weyertal gGmbH
Pelvic Organ Prolapse
Comparison of Vaginal and Laparoscopic Apical Fixation Techniques for Pelvic Organ Prolapse Treatment
This is a prospective randomized controlled study, designed to compare efficacy and safety of two methods of apical fixation in patients with pelvic organ prolapse (POP) - sacrospinous hysteropexy (SSHP) with synthetic mesh and…
- Trial name
- NCT05420831
- Testing
- Vaginal, Laparoscopic
- Where
- Russia
- Volunteers
- 110 people
- Sponsor
- Saint Petersburg State University, Russia
Abdominal Donor-site
Reinforcement of the Abdominal Wall After Breast Reconstruction With the Pedicled TRAM-flap
The purpose of this study is to compare two methods for reinforcement of the abdominal donor-site after breast reconstruction with the pedicled TRAM-flap.
- Trial name
- NCT02076724
- Testing
- Biological mesh, Synthetic mesh
- Where
- Denmark
- Volunteers
- 29 people
- Sponsor
- Aarhus University Hospital
Hiatal Hernia, Paraesophageal Hernia
Study of Paraesophageal Hernia Repair With Small Intestine Submucosa
In 2006 this research group reported their initial findings of a multi-center prospective trial comparing primary repair and primary repair buttressed with a biologic mesh made from porcine small intestinal submucosa (SIS).
- Trial name
- PEH (NCT00786084)
- Where
- 4 sites in United States
- Volunteers
- 108 people
- Sponsor
- University of Washington
Incisional Hernia After Diverting Stoma Closure
Mesh Reinforcement During Temporary Stoma Closure After Sphincter-Saving Rectal Cancer Surgery
This study aim to assess long-term results of an incisional hernia-prophylactic mesh placement during stoma reversal after total mesorectal excision (TME) for rectal cancer
- Trial name
- MEMBO (NCT02576184)
- Testing
- Biologic Mesh, Synthetic Mesh
- Where
- France
- Volunteers
- 381 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Herniorrhaphy, Humans
Synthetic Mesh Explant Study
The purpose of this study is to determine whether synthetic hernia mesh materials undergo physical and/or chemical changes while in the body.
- Conditions
- Herniorrhaphy, Humans, Polypropylene, Polytetrafluoroethylene
- Trial name
- NCT01880021
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Washington University School of Medicine
Breast Cancer, Radiation
Breast Mesh Used in Two-staged Breast Reconstruction
This is the first prospective randomized and controlled study on the efficacy and safety of TiLOOP® Bra mesh in patients with expander-implant breast reconstruction.
- Conditions
- Breast Cancer, Radiation, Breast Reconstruction, Synthetic Mesh
- Trial name
- NCT04967976
- Testing
- TiLoop Bra mesh in expander-implant breast reconstrution, sub-pectoral expander-implant breast reconstruction
- Where
- 6 sites in United States, China and 1 more
- Volunteers
- 300 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Ventral Hernia
Biologic Mesh Versus Synthetic Mesh in Repair of Ventral Hernias
This study will compare the safety, efficacy and cost effectiveness of a permanent synthetic mesh versus a biologic prosthesis for the repair of ventral hernias in the setting of clean-contaminated (Class 2) or contaminated…
- Trial name
- NCT02451176
- Testing
- Davol Bard Soft Mesh synthetic, LifeCell Strattice Reconstructive Tissue Biologic
- Where
- 4 sites in United States
- Volunteers
- 253 people
- Sponsor
- Michael Rosen
Primary and Secondary Ventral Hernia
Primary and Secondary Ventral Hernia Repair Using Long-term Resorbable Versus Non-resorbable Large Pore Synthetic Mesh.
Since abdominal wall hernia repair is currently performed with the use of a mesh, side effects associated with the mesh are frequently reported during long term follow-up.
- Trial name
- TIGR (NCT01622725)
- Testing
- Placing the resorbable mesh, Non-resorbable synthetic mesh.
- Where
- 6 sites in Belgium, Denmark and 3 more
- Volunteers
- 95 people
- Sponsor
- University Hospital, Ghent
Breast Cancer
Pre-pectoral Breast Reconstruction PART 2
The rationale for present trial conception and design moves forward from the assumption that a subcutaneous, pre-pectoral reconstruction by means of soft tissue replacement devices is feasible, safe and giving rewarding results…
- Trial name
- PreBRec (NCT02831426)
- Testing
- Two-stage with Acellular Dermal Matrix (CELLIS® Breast), Two-stage with Titanium Coated Polypropylene Mesh (TiLOOOP® Bra)
- Where
- United Kingdom
- Volunteers
- 86 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Hernia, Ventral
Complex Ventral Hernia Repair Using Biologic or Synthetic Mesh
Hernias are often treated using a prosthetic mesh to add support to the healing wound. Prosthetic meshes have been used for decades to repair ventral hernias, level 1 data regarding which type of mesh to use is limited.
- Trial name
- CVHR (NCT02041494)
- Testing
- Ventralight, Strattice
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- Hobart Harris