Clinical trials: Synbiotics
PCOS- Polycystic Ovary Syndrome
The Synbiotics Effects in Polycystic Ovary Syndrome: A Randomized Controlled Trial
The goal of this clinical trial is to compare the effect of synbiotics and placebo in Thai women with polycystic ovary syndrome.
- Trial name
- PCOS (NCT06169566)
- Testing
- synbiotics
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maharaj Nakorn Chiang Mai Hospital
Atopic Dermatitis (Eczema)
The Effects of an Oral Prebiotic and an Oral Synbiotic Supplement in Combination With a Topical Lotion and Soap On Eczema
The purpose of this study is to examine the effects of 2 dietary supplements (an oral prebiotic and an oral synbiotic) in combination with a topical lotion, and an unscented soap on eczema severity, various skin measures (such as…
- Trial name
- NCT07041892
- Testing
- Prebiotic Supplement + Synbiotic Supplement + Topical Lotion + Unscented Soap
- Where
- Poland
- Volunteers
- 34 people
- Sponsor
- Codex Labs Corporation
Cirrhosis With Ascites
Evaluation of Safety & Efficacy of Synbiotic on the Incidence and Recurrence of Spontaneous Bacterial Peritonitis (SBP) in Cirrhotics
Background: Spontaneous bacterial peritonitis (SBP) is a serious complication in patients of cirrhosis with ascites and may occur despite antibiotic prophylaxis.
- Trial name
- NCT00947336
- Testing
- Norfloxacin + Synbiotic
- Where
- India
- Volunteers
- 110 people
- Sponsor
- Govind Ballabh Pant Hospital
Anxiety Generalized, Breast Cancer Female
Anti-anxiety Biotics for Breast Cancer Survivors
Cancer survivors experience more rapid declines in health-related quality of life which include physical and psychological comorbidities, the latter of which may be subclinical and often overlooked by primary care providers.
- Trial name
- ABBCS (NCT04784182)
- Testing
- probiotic plus prebiotic supplement
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Auburn University
Ulcerative Colitis
Synbiotic Treatment of Ulcerative Colitis Patients
Ulcerative colitis (UC) is one of the two main forms of inflammatory bowel disease. UC is associated with high morbidity and incurs significant social, commercial and NHS costs.
- Trial name
- NCT00803829
- Testing
- Synbiotic (Synergy1/B. longum)
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of Dundee
Obese Patients (BMI ≥ 30 kg/m²), Anxiety
Therapeutic Potential of a Synbiotic to Improve Mental Health in Subjects With Obesity.
Obese individuals are a particularly vulnerable population for mental health problems, especially depression and anxiety. The aim of this study is to evaluate whether the intake of a synbiotic, composed of prebiotics and…
- Conditions
- Obese Patients (BMI ≥ 30 kg/m²), Anxiety, Depressive Disorder
- Trial name
- NCT06901739
- Testing
- Synbiotic
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Celia Bañuls
Periodontal Disease
Effects of Adjunctive Synbiotic Supplementation to Non-Surgical Periodontal Therapy in Smokers With Periodontitis
The aim of this study is to evaluate the effects of adjunctive synbiotic supplementation combined with non-surgical periodontal therapy in smokers with periodontitis.
- Trial name
- NCT07672379
- Testing
- Synbiotic supplementation
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people
- Sponsor
- Biruni University
Nephrolithiasis, Hyperoxaluria
Use of Oral Probiotics to Reduce Urinary Oxalate Excretion
The purpose of this study was to determine the effect of two probiotic preparations (Agri-King Synbiotic and Oxadrop) on urinary oxalate excretion in patients with mild hyperoxaluria.
- Conditions
- Nephrolithiasis, Hyperoxaluria, Crohn's Disease
- Trial name
- NCT00587041
- Testing
- Oxadrop, Agri-King Synbiotic (AKSB)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Healthy Volunteers
Human Milk Oligosaccharide-Based Synbiotic Supplement for Intestinal Microbiota Dysbiosis
Background: Human intestines are home to a complex gut flora, also called microbiome; this is a natural occurring community of bacteria, fungi, yeast, and viruses.
- Trial name
- NCT06615986
- Testing
- Cardiosyn
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Non Alcoholic Steatohepatitis, Non-Alcoholic Fatty Liver Disease
Synbiotics and Fecal Microbiota Transplantation to Treat Non-Alcoholic Steatohepatitis
The goal of this clinical trial is to investigate the therapeutic potential of A. soehngenii and pasteurized A. muciniphila combined with B. animalis subsp.
- Conditions
- Non Alcoholic Steatohepatitis, Non-Alcoholic Fatty Liver Disease, Fecal Microbiota Transplantation, FMT
- Trial name
- SYNCH (NCT05821010)
- Testing
- Lyophilized fecal microbiota transplantation capsules, A. soehngenii, Pasteurized A. muciniphila
- Where
- Netherlands
- Volunteers
- 48 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Cirrhosis, Liver, Metagonimiasis
Synbiotics Interventions for Managing Cirrhosis and Its Complications
Background Liver cirrhosis is commonly accompanied by intestinal dysbiosis and metabolic defects. Many clinical trials have shown microbiota-targeting strategies represent promising interventions for managing cirrhosis and its…
- Trial name
- NCT05687409
- Testing
- Entecavir 0.5 mg, A 10-g packet of lactulose oral solution and three capsules of probiotics, A 10-g packet of glucose oral solution and three capsules of starch
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Immunity
A Clinical Study to Investigate the Effect of a Partially Hydrolysed Infant Formula With Added Synbiotics on Gut Microbiota Composition and Clinical Effectiveness in Infants at High Risk of Developing Allergy
With the rising prevalence of allergic diseases and the subsequent risk of developing other immune-related disorders, primary prevention of allergy has become a major priority.
- Trial name
- TEMPO (NCT03067714)
- Testing
- Infant formula with added synbiotics, Standard infant formula
- Where
- 59 sites in Belgium, Czechia and 11 more
- Volunteers
- 855 people, healthy volunteers welcome
- Sponsor
- Nutricia Research
Infant Nutrition
Effects of a Synbiotics-containing Starter Formula on Infant Growth
In this study the investigators want to evaluate the satiety of two infant formulas, one containing prebiotics and the other containing synbiotics.
- Trial name
- NCT01010113
- Testing
- Standard infant formula with prebiotics, Infant formula with synbiotics
- Where
- Singapore
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Constipation, End Stage Renal Disease on Dialysis
Effects of Synbiotics Supplementation on the Uremic Toxin Indoxyl Sulfate Level and Constipation in End-stage Renal Disease Patients Undergoing Hemodialysis
This is a double-blind, placebo-controlled, randomized clinical trial conducted to evaluate the effects of synbiotics supplementation on the level of the uremic toxin indoxyl sulfate, symptoms of constipation, and…
- Trial name
- NCT04527640
- Testing
- Synbiotics containing Lactobacillus acidophilus & Bifidobacterium longum 5x10^9 CFU and FOS 60 mg
- Volunteers
- 60 people
- Sponsor
- Universitas Indonesia
Rheumatoid Arthritis
SBD121, a Synbiotic Medical Food for RA Management
The aim of this randomised, double-blind, placebo controlled clinical food trial is to determine if the medical food SBD121 Synbiotic (prebiotic and probiotic) will aid in the dietary management of symptoms of early rheumatoid…
- Trial name
- NCT06005220
- Testing
- SBD121
- Where
- 22 sites in Australia, Bulgaria and 2 more
- Volunteers
- 143 people
- Sponsor
- Solarea Bio, Inc
Aging
The Effects of a High Protein Diet on Microbiota, Gastrointestinal Function and Wellness in Older Women
The purpose of the proposed study is to determine the effects of consuming a high protein diet on fecal microbial communities, gastrointestinal function and symptoms, and general wellness in older adults.
- Trial name
- NCT02445560
- Testing
- Probiotic capsule and Fiber Sachet
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- University of Florida
Obesity, Metabolic Syndrome
Role of Colonic Events on Metabolism and Appetite Control: A Synbiotic Approach
The purpose of the study is to evaluate food factors related to colonically derived regulation of glucose metabolism (and related parameters) and satiety using a semi-acute meal study in healthy subjects as experimental model.
- Trial name
- NCT01718418
- Testing
- test meal, reference
- Where
- Sweden
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Lund University
Healthy
Synbiotic Approach to Immunity and Metabolism in the Elderly Study
The aging process leads to a marked decline in immune function (immunosenescence), causing a significant reduction in immune response after vaccination or infections.
- Trial name
- SAIMES (NCT03168503)
- Testing
- LGG+Promitor™, Promitor™, LGG-PB12+Promitor™
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Roehampton
Hypertension, Gut Dysbiosis
The Effects of a Commercially Available Synbiotic on the Gut Microbiome and Cardiometabolic Health
The purpose of this study is to see the effect of 30 days of synbiotic vs. probiotic supplementation (usingJuice+ nutrition products) on body weight, metabolism, cardiovascular health, and gut health.
- Conditions
- Hypertension, Gut Dysbiosis, Overweight , Obesity
- Trial name
- NCT07515443
- Testing
- Synbiotic
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Southern Utah University
Morbid Obesity
Effect of Prebiotic or Synbiotic on Inflammatory Response and Indicators of Nutritional Status in Obesity
The purpose of this study is to evaluate the effect of prebiotic or synbiotic supplementation on inflammatory response and indicators of nutritional status in patients with morbid obesity.
- Trial name
- NCT02660333
- Testing
- Prebiotic, Synbiotic
- Where
- Brazil
- Volunteers
- 22 people
- Sponsor
- Universidade Federal de Santa Catarina