Clinical trials: Synaptic Plasticity
Traumatic Brain Injury
Neurofeedback Technology (GZNT) for Persistent Post-Concussive Symptoms in Soldiers
A new technology called Global Z-Score Neurofeedback Technology (GZNT) has been identified that can overcome an existing barrier to the use of neurofeedback as a treatment technique in a military setting.
- Trial name
- GZNT (NCT02509689)
- Testing
- Global Z-Score Neurofeedback Training
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- The Defense and Veterans Brain Injury Center
Cerebral Palsy, Walking, Difficulty
A Motor Learning Intervention to Target Walking Performance in Ambulant Children With Cerebral Palsy
The goal of this clinical trial is to learn if a new therapy approach to improve walking ability in children with Cerebral Palsy is acceptable to the children and the families in a community setting.
- Conditions
- Cerebral Palsy, Walking, Difficulty, Spastic Diplegia, Hemiplegic Cerebral Palsy
- Trial name
- MOBILE (NCT06454656)
- Testing
- MOBILE
- Where
- Ireland
- Volunteers
- 14 people
- Sponsor
- Royal College of Surgeons, Ireland
Post-Traumatic Stress Disorder
Intra-Sessional Autonomic Arc Detection in Ketamine-Assisted Therapy for PTSD: A Signal Characterisation Pilot Study
This study examines whether a continuous wearable biosensor and a proprietary signal detection algorithm (JungleCODE, Open Medicine Studio) can detect and characterise the autonomic nervous system arc - a trajectory from a state…
- Trial name
- OMS-KAT (NCT07614581)
- Testing
- Continuous wearable physiological monitoring (EmbracePlus, Empatica), Ketamine-assisted therapy (independently arranged), Structured pre- and post-session interviews
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Adriaan Dirk van der Wart
Motor Neuropathy
Stroke Recovery Research Based on EEG-fMRI
This study is aimed to investigate the post-stroke motor recovery of patients with ischemic stroke based on their neural features extracted from EEG-fMRI data.
- Trial name
- EEG-fMRI (NCT05427422)
- Testing
- MRI recording, EEG recording
- Where
- China
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Xi'an Jiaotong University
Atomoxetine Hydrochloride, Placebos
Post-stroke Neural Plasticity With Atomoxetine
This proposal evaluates the safety and effectiveness of a noradrenergic drug named atomoxetine combined with motor training to enhance cortical plasticity and improve hand function after stroke.
- Trial name
- NCT02788357
- Testing
- Atomoxetine
- Volunteers
- 12 people
- Sponsor
- Lumy Sawaki
Trichotillomania
Cognitive Training in Patients With Trichotillomania (Hair-pulling Disorder)
The principal aim of this study is to establish the impact of Cognitive Training in patients with primary Hair-pulling Disorder.
- Trial name
- CTTTM (NCT02794753)
- Testing
- Working memory training, Game
- Where
- South Africa
- Volunteers
- 40 people
- Sponsor
- University of Stellenbosch
Multiple Sclerosis, Parkinson Disease
Biomarkers of Synaptic Damage in Multiple Sclerosis
A prospective and retrospective cohort study of about five years will be performed on blood and cerebrospinal fluid samples taken for diagnostic reasons from recruited patients within the Neuromed Neurology Unit.
- Conditions
- Multiple Sclerosis, Parkinson Disease, Amyotrophic Lateral Sclerosis, Alzheimer Disease
- Trial name
- NCT03217396
- Testing
- lumbar puncture
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Neuromed IRCCS
Aphasia, Apraxia of Speech
MIRAA - Implementation of Intensive Rehabilitation of Aphasia and/or Apraxia of Speech in Swedish Healthcare
Positive outcomes have been shown following intensive treatment of speech and/or language impairment post stroke, but how to design intensive treatment programs to achieve optimal recovery and neuroplasticity changes needs to be…
- Conditions
- Aphasia, Apraxia of Speech, Stroke
- Trial name
- MIRAA (NCT04957225)
- Testing
- MIRAA (Multimodal Intensive Rehabilitation of Aphasia and Apraxia of speech)
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Karolinska Institutet
Stroke
Effectiveness of Robot-assisted Rehabilitation in Persons With Stroke
This study is to investigate the effects of robot-assisted hand with visual feedback intervention on cortical excitability, brain structure, spasiticity, gross and fine motor of upper limb and hand in individuals with stroke.
- Trial name
- NCT04002076
- Testing
- Robot-assisted hand combined with occupational therapy, Traditional occupational therapy
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Taipei Medical University Hospital
Microgravity, Neuroplasticity
Neuroimage Genome Study of Neuroplasticity Associated With Microgravity
This clinical trial investigates the neuroplasticity and cognitive status changes of the human brain in microgravity. To explore the relationship between cognitive status changes and brain functional activities, gray matter and…
- Conditions
- Microgravity, Neuroplasticity, MRI, Repeatable Battery for the Assessment of Neuropsychological Status
- Trial name
- NCT06350422
- Testing
- Head-Down tilt Bed Rest test
- Where
- China
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Multiple Sclerosis, Mobility Limitation
Innovative Approaches to Enhance Balance and Neuroplasticity in Multiple Sclerosis
This study will evaluate the effects of combining balance training with electrical stimulation techniques in individuals with Multiple Sclerosis (MS).
- Conditions
- Multiple Sclerosis, Mobility Limitation, Balance; Distorted, Gait
- Trial name
- NCT07174973
- Testing
- Balance training with FES, Balance training wiith combined neuromodulation (TSCS+FES), Balance training only
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University Health Network, Toronto
Cerebral Palsy, Spastic
Effect of the Nutritional Support System on Neuromotor Alterations in Patients With Cerebral Palsy
Study to determine the impact of a nutritional support system (NSS) on neuromotor alterations in patients with cerebral palsy.
- Conditions
- Cerebral Palsy, Spastic, Malnutrition
- Trial name
- NSS-PC (NCT05648422)
- Testing
- Probiotics, NSS Nutritional Support System, Deworming
- Where
- Mexico
- Volunteers
- 144 people
- Sponsor
- Anahuac University
Neurological Diseases or Conditions, Cardiovascular Diseases
New Technological Pathway for Gait Rehabilitation
Brief Summary The study aims to explore how the integration of visual and motor systems can be trained and enhanced to improve gait rehabilitation in patients with various neurological and cardiovascular conditions.
- Conditions
- Neurological Diseases or Conditions, Cardiovascular Diseases, Neuromuscular Disease
- Trial name
- LABODIMOTO (NCT06859229)
- Testing
- Innovative technology pathway for gait neurorehabilitation, Conventional gait rehabilitation strategy
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Bruxism
Somatosensory Training Versus Exercise Therapy in Awake Bruxism
Awake bruxism (daytime teeth clenching or jaw tension) is a common condition that can cause jaw pain, facial pain, muscle fatigue, and reduced quality of life.
- Trial name
- NCT07336082
- Testing
- Jaw exercise therapy, Somatosensory Awareness-Based Training, Wait-List Control
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Aydin Adnan Menderes University
Depression
(GluEsk) Glutamate and Esketamine
Esketamine is the S-enantiomer of racemic ketamine, a N-methyl-D-aspartate (NMDA) receptor antagonist. Esketamine and other antidepressant NMDA receptor antagonists are hypothesised to act by producing a rapid increase in brain…
- Trial name
- GluEsk (NCT06432322)
- Testing
- Esketamine nasal spray
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Parkinson Disease
The Learning Effects of Attentional Strategy on Dual-task Walking in Patients With Parkinson's Disease: Behavioral Performance and Neural Plasticity
[year1] 1. To compare the effects of dual-task training with two different task priority instruction in people with Parkinson's disease and healthy controls on dual-task weight shifting performances. 2.
- Trial name
- NCT03895125
- Testing
- [year1] dual-task training with task priority strategy, [year2-3] dual-task training with internal and external focus
- Where
- Taiwan
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Stroke
Exercise the Mind and Brain. A Multimodal Intervention in Stroke
The main objective of MindFit Project is to develop an evidence-based multimodal investigation of combined non-pharmacological strategies in chronic stroke patients and clarify the neuroplasticity mechanisms underlying the…
- Trial name
- Mindfit (NCT04759950)
- Testing
- Multicomponent Physical Activity Program, Mindfulness-Based Stress Reduction Program, Computerized Cognitive Training
- Where
- Spain
- Volunteers
- 141 people
- Sponsor
- University of Barcelona
Aging Well
Assessing Causality of the Association Between Exercise and Neurocognitive Gains
Brief Summary: The aim of this project is to examine: 1. The effects of a community based square stepping exercise programme on cognitive and physical functions in older adults. 2.
- Trial name
- NCT05511259
- Testing
- exercise
- Where
- Singapore
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Nanyang Technological University
Cognitive Change
Brain Exercises for Synaptic Plasticity
The BEST study will investigate the feasibility of cognitive interventions in a randomized, placebo-controlled, clinical trial. The investigators will recruit 45 cognitively normal subjects and engage them in one of three cohorts…
- Trial name
- BEST (NCT03058055)
- Testing
- Origami, Reading
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Major Depressive Disorder, Psychedelic Experiences
Antidepressant Response of DMT Masked With Propofol
The aim of this study is to elucidate if the anti-depressive effect of N,N-dimethyltryptamine (DMT) is based on a biological mechanisms including neuroplasticity and anti-inflammatory effect or due to the subjective psychedelic…
- Trial name
- DMT4D (NCT06927076)
- Testing
- N,N-Dimethyltryptamine, Propofol, no sedation
- Where
- Switzerland
- Volunteers
- 112 people
- Sponsor
- University Hospital, Basel, Switzerland