Clinical trials: Sympathetic Disorder
Uncontrolled Hypertension
Impact of Renal SympAthetic DenerVation on Chronic HypErtension
Despite the development of many drug therapies designed to treat high blood pressure (hypertension), it remains a considerable and poorly managed health, social and economic burden.
- Trial name
- SAVE (NCT01628198)
- Testing
- Celcius Thermacool Catheter or Chilli II Cooled Ablation Catheter
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Vivek Reddy
Type 2 Diabetes, Insulin Resistance
Effect of Neuromuscular Electrostimulation on Sympathetic Nerve Activity in Patients With Type 2 Diabetes (ELECTROSYMP2)
Physical activity (PA) is recommended for the treatment of subjects with type 2 diabetes to increase insulin sensitivity and improve metabolic control.
- Trial name
- ELECTROSYMP2 (NCT02171351)
- Testing
- effect of neuromuscular electrostimulation (NMES), effect of neuro electrostimulation (NES), effect of voluntary contractions (VC)
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Breast Cancer, Chemotherapeutic Toxicity
Neurovascular Changes Induced by Chemotherapy
The purpose of the present study was to test the hypothesis that doxorubicin and cyclophosphamide adjuvant chemotherapy (CHT) acutely induces neurovascular and hemodynamic changes in patients with breast cancer.
- Trial name
- NCT03339804
- Testing
- Chemotherapy
- Where
- Brazil
- Volunteers
- 16 people
- Sponsor
- University of Sao Paulo General Hospital
Parkinson
Evaluation of Myocardial Sympathetic Denervation in Parkinson's Disease Using [18F]FDOPA
The purpose of this study is to evaluate the added value of PET-CT with [18F]FDOPA tracer for Assessment of the Myocardial Sympathetic Denervation in patients with or suspected with Parkinson's disease.
- Trial name
- NCT02495649
- Testing
- [18F]-DOPA, PET-CT
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Spinal Cord Injury, Autonomic Dysreflexia
Treatment of Post-SCI Hypotension
While treatment strategies for OH have been identified for use in persons with acute SCI, the field of SCI medicine lacks a gold standard for treatment thresholds and well-defined outcome parameters.
- Conditions
- Spinal Cord Injury, Autonomic Dysreflexia, Orthostatic Hypotension, Baroreceptor Integrity
- Trial name
- NCT02919917
- Testing
- Midodrine Hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Temporal Lobe Epilepsy
Autonomic Dysfunction in Temporal Lobe Epilepsy and SUDEP
The study aimed at detection of autonomic dysfunction among cases with temporal lobe epilepsy; using different electrophysiological techniques.
- Trial name
- NCT06269822
- Testing
- Sympathetic skin response, heart rate variability test, quantitative EEG
- Where
- Egypt
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hypertension
High-Dose Quinapril Versus Low-Dose Quinapril Plus Amlodipine in the Treatment of High-Risk Hypertensive Patients
The purpose of this study is to compare the impact of two blood pressure lowering treatments (high dose quinapril versus low dose quinapril plus amlodipine) on variations in heart rate over 24 hours.
- Trial name
- NCT00313547
- Testing
- Quinapril 40 mg, Quinapril 10 mg and amlodipine 5 mg
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Montreal Heart Institute
Heart Failure, Obstructive Sleep Apnea
CPAP Therapy in Patients With Heart Failure and Obstructive Sleep Apnea.
Heart failure affects approximately 5-6 million North Americans and is increasing in prevalence. Sleep-related disorders, such as obstructive sleep apnea (OSA) often coexist (11-37% incidence) with heart failure.
- Trial name
- PET-OSA (NCT00756366)
- Testing
- Positron Emission Tomography
- Where
- Canada
- Volunteers
- 67 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Refractory Hypertension
Renal Sympathetic Denervation in Mild Refractory Hypertension
The purpose of this study is to examine the benefit of renal sympathetic denervation in patients with mild refractory hypertension
- Trial name
- NCT01656096
- Testing
- Renal sympathetic denervation (Symplicity ablation catheter, Medtronic Inc. Minneapolis, Minnesota, USA)
- Where
- Germany
- Volunteers
- 71 people
- Sponsor
- University of Leipzig
Cardiac Resynchronization Therapy, Heart Failure
Optimal Cardiac Resynchronization Therapy Pacing Rate
The optimal pacing rate during cardiac resynchronization therapy (CRT) is not known. Investigators investigate the impact of changing basal pacing frequencies on autonomic nerve function, cardiopulmonary exercise capacity and…
- Conditions
- Cardiac Resynchronization Therapy, Heart Failure, Bi-ventricular Pacing, Sympathetic Activity
- Trial name
- NCT02258061
- Testing
- DDD-80, DDD-60
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Shoulder-hand Syndrome
The Treatment of Shoulder-hand Syndrome in Hemiplegia Patients
The purpose of this clinical study is to investigate effects of Kinesio taping (KT) combined with dry needling (DN) on myofascial trigger points (MTrPs) in post-stroke hemiplegic shoulder-hand syndrome (SHS).
- Trial name
- NCT07245472
- Testing
- Dry Needling, Kinesio Taping
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Handan Central Hospital
Healthy, Vasodilation
Impact of Intranasal Insulin on Sympathetic Activity and Cerebral Vasodilation
The purpose of this project is to examine the impact of increases in brain insulin on sympathetic nervous system activity, as well as peripheral and cerebral blood flow in humans.
- Conditions
- Healthy, Vasodilation, Insulin Resistance, Autonomic Dysfunction
- Trial name
- NCT05153395
- Testing
- Carbon dioxide breathing, Neurovascular Coupling, Human insulin
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Spinal Cord Injury
Sympathetic-Somatomotor Coupling in Human Spinal Cord Injury
Significance: The long term objective of this study is to improve physical therapy and fitness programs in people with spinal cord injury.
- Trial name
- NCT02115685
- Testing
- Treadmill Training
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Heart Failure
Targeting Sympathetic Overactivity in Heart Failure Patients With Statins
Heart failure (HF) is a leading cause of morbidity and mortality in the United States with the incidence and prevalence of the disease on a continual rise.
- Trial name
- NCT01097785
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Hypertension, Type 2 Diabetes
Multi-Organ Denervation With the iRF System to RedUce Sympathetic Drive
The objective of the study is to evaluate the safety of multi-organ denervation using the Integrated Radio Frequency (iRF) Denervation System. and to understand any potential improvement in hypertension and glycemic control.
- Conditions
- Hypertension, Type 2 Diabetes, Metabolic Syndrome
- Trial name
- MODUS (NCT04917393)
- Testing
- iRF System Multi-organ Denervation, Control Procedure
- Where
- 2 sites in Georgia
- Volunteers
- 45 people
- Sponsor
- Metavention
Hypertension, Proteinuria
Sympathetic Overactivity in Essential Hypertension
The primary objective of the study is whether subjects with hypertension and proteinuria display increased sympathetic nerve activity compared to hypertensive subjects without proteinuria and normotensive controls.
- Trial name
- NCT00541619
- Where
- Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Type 2 Diabetes, Diabetic Nephropathy
Role of Sleep Apnea and Sympathetic Activity in Resistant Hypertensive Patients.
Hypertension is highly prevalent in type 2 diabetic patients (NIDDM) with nephropathy, and is the single most important determinant of the rate of renal function loss.
- Conditions
- Type 2 Diabetes, Diabetic Nephropathy, Hypertension, Sleep Apnea
- Trial name
- SAS (NCT01875341)
- Testing
- NCPAP; Nasal continuous positive airway pressure., NCPAP Nasal Continuous Positive Airway Pressure-sub-therapeutic treatment group
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Ottawa Hospital Research Institute
Nerve; Disorder, Sympathetic
Changes in Skin Conductance Measurement as an Endpoint Monitor for Sympathetic Blocks
This study is intended to evaluate a monitor that will facilitate ascertainment of an effective sympathetic blockade following Lumbar Sympathetic blocks.
- Trial name
- NCT02390323
- Testing
- Lumbar Sympathetic Block, Skin conductance algesimeter
- Volunteers
- 13 people
- Sponsor
- Hospital for Special Surgery, New York
End-stage Renal Disease (ESRD), Kidney Disease
Sympathetic Activity in Patients With End-stage Renal Disease on Peritoneal Dialysis
Hypothesis: Patients starting peritoneal dialysis with a glucose-based regimen have high sympathetic activity in response to an increase in leptin and insulin.
- Trial name
- SAPD (NCT01228279)
- Testing
- DIANEAL, EXTRANEAL
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Ottawa Hospital Research Institute
Coronary Artery Disease (CAD), Obstructive Sleep Apnea (OSA)
Chemoreflex Control of Sympathetic Activity in Patients With Coronary Artery Disease
The investigators hypothesize that chemoreflex response of muscle sympathetic nerve activity (MSNA) during hypoxia and hypercapnia will be increased in coronary artery disease (CAD) patients and that the presence of obstructive…
- Trial name
- NCT02624297
- Testing
- Aerobic exercise training
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital