Clinical trials: Sympathetic Activity
Diabetes Mellitus, Type 2, Metabolic Associated Fatty Liver Disease
Correlation Between Serum Nociceptin and Sympathetic Nerve Activity in Diabetic Patients With MAFLD
This observational study aims to investigate the relationship between serum nociceptin levels and sympathetic nervous system activity in patients with both type 2 diabetes mellitus (T2DM) and metabolic associated fatty liver…
- Trial name
- NCT07663682
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Hospital of Shanxi Medical University
Vasodilation, Vasoconstriction
Sex Differences in Sympathetic Activity and Vascular Reactivity During Acute and Chronic Hypoxia.
This study aims to investigate sex differences in blood pressure control associated with exposure to acute hypoxia (low oxygen), and short term acclimatization to hypoxia at high altitude.
- Trial name
- NCT05001048
- Testing
- Phenylephrine Hydrochloride, Cold Pressor Test, Isocapnic Acute Hypoxia
- Where
- 2 sites in Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Respiratory Muscle, Blood Pressure
Respiratory Muscle Contribution to Blood Pressure During Exercise
The investigators seek to understand how reflexes from the breathing muscles influence blood pressure during exercise. Furthermore, the investigators are determining if increasing breathing muscle strength (via inspiratory muscle…
- Conditions
- Respiratory Muscle, Blood Pressure, Exercise Capacity, Sympathetic Nerve Activity
- Trial name
- NCT03514823
- Testing
- Inspiratory Muscle Training (IMT), No Inspiratory Muscle Training (IMT)
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Spinal Cord Injury
Sympathetic-Somatomotor Coupling in Human Spinal Cord Injury
Significance: The long term objective of this study is to improve physical therapy and fitness programs in people with spinal cord injury.
- Trial name
- NCT02115685
- Testing
- Treadmill Training
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Blood Pressure, Neurovascular Control
Meal Timing and Blood Pressure
Brain blood flow, blood pressure, and neurovascular control mechanisms will be measured in middle-aged adults before and after a brief intervention period.
- Trial name
- NCT04133701
- Testing
- Time-Restricted Feeding
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Healthy Volunteers, Sympathetic Activity
SPARK Study - Sympathetic Periarterial Radial Block in Healthy Volunteers
The SPARK Study evaluates changes in peripheral sympathetic vasomotor activity following a targeted, ultrasound-guided periarterial sympathetic block of the distal radial artery in healthy volunteers.
- Trial name
- SPARK (NCT07429292)
- Testing
- Lidocaine 2%
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Duke University
Obesity, Metabolic Syndrome X
The Potential Role for Adenosine in the Haemodynamic Effects of Free Fatty Acids
The metabolic syndrome is associated with hyperdynamic circulation and sympathetic activation. Recently, Bakker et al. (Atherosclerosis 2002) described the hypothesis that free fatty acids are responsible for this association.
- Trial name
- NCT00184899
- Testing
- Intravenous infusion of Intralipid/heparin, Intravenous infusion of Glycerol/heparin
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Hypercapnia
End Tidal CO2 and Masks: Is There a Correlation?
In light of the ongoing COVID-19 pandemic, wearing a mask has become a universal standard as an attempt to reduce the spread of COVID-19. As of 2020, more than half of all U.S.
- Trial name
- NCT06437301
- Testing
- Baseline measure of ETCO2 without mask, Baseline ETCO2 with mask, ETCO2 after 200 meter walk with mask
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- CHRISTUS Health
Menopause, Hot Flashes
Time-Efficient Inspiratory Muscle Strength Training for Reducing Sympathetic Activity and Improving Sleep in Midlife Women
The purpose of this research is to understand how training the muscles used for breathing (inhalation) affects menopausal hot flashes, sympathetic nerve activity and sleep.
- Conditions
- Menopause, Hot Flashes, Blood Pressure Regulation
- Trial name
- NCT06743269
- Testing
- High-Resistance Inspiratory Muscle Strength Training, Low-Resistance Inspiratory Muscle Strength Training, POWERbreathe K3 device
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Vasoconstriction, Vasodilation
Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences
The main purpose of this interventional study is to examine differences in resting blood pressure control between healthy males and females. The main questions it aims to answer are: 1.
- Trial name
- STARS (NCT05997732)
- Testing
- Phenylephrine Hydrochloride, Isoproterenol Hydrochloride, Norepinephrine Bitartrate
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Rosacea
Role of the Sympathetic Nervous System in Rosacea
Rosacea is a common skin disorder which causes facial redness and inflammation in about 16 million Americans, from an unknown cause.
- Trial name
- NCT03989492
- Testing
- systemic and local stressors
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kristen Metzler-Wilson
Electronic Cigarette Use
Vaporized Nicotine and Autonomic Control
E-cigarettes are marketed as an alternative to smoking for those who want to decrease the health risks of tobacco. Tobacco cigarettes increase heart rate (HR) and arterial pressure, while reducing muscle sympathetic nerve…
- Trial name
- NCT04613609
- Testing
- Electronic Cigarette containing nicotine, Electronic Cigarette without nicotine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Michigan Technological University
Fibromyalgia
The Effect of Sympathetic Dysfunction on Muscle Spindle in Fibromyalgia
This study aims to reveal whether there is an impairment in the sympathetic regulation of muscle spindle sensitivity in patients with fibromyalgia syndrome (FMS).
- Trial name
- NCT05704374
- Testing
- sympathetic stimulation maneuver (mental arithmetic test, cold pressure test), Pregabalin 150mg
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Cardiovascular Morbidity
Experimental Exposure to Air Pollutants and Sympathetic Nerve Activity in Human Subjects
The primary hypothesis of the study is that in healthy elderly subjects experimental exposure to air pollutants increases sympathetic nervous system activity compared with sham (clean air) exposure.
- Trial name
- Particles (NCT01914783)
- Testing
- ultrafine particles, ultrafine particles and ozone, clean air
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Cardiomyopathy
Characterization of Sympathetic Nerve Activity in Stress Cardiomyopathy
Stress (Takotsubo) cardiomyopathy (SC) is a peculiar form of acute, reversible myocardial dysfunction predominantly affecting the apical and mid left ventricular segments.
- Trial name
- NCT01048125
- Testing
- Sympathetic Nerve Activity, Mental Stress Test (Color Word Test), The Modified Oxford Technique for Baroreflex Sensitivity
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Hypertension
Sympathetic Transduction in Obesity
Central (abdominal) obesity is associated with elevated adrenergic activity and arterial blood pressure (BP). Therefore, we tested the hypothesis that transduction of spontaneous muscle sympathetic nerve activity (MSNA) to BP…
- Trial name
- NCT05590546
- Testing
- No intervention
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Gestational Diabetes
Autonomic Nervous Activity in Women With Gestational Diabetes
Through complex hormonal pathways, insulin resistance can lead to the activation of the sympathetic nervous system, and vice versa. Schobel et al.
- Trial name
- NCT00867022
- Where
- Finland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Caffeine, Control
Caffeinated Chewing Gum & Wrestling Performance
The purpose of this study was to investigate the effect of caffeinated chewing gum on sympathetic nerve activity on wrestling simulation match.
- Trial name
- NCT06758336
- Testing
- caffeine
- Where
- Taiwan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Taiwan Sport University
Primary Dysmenorrhea
Heart Rate Variability as an Indicator Associated With the Improvement of Dysmenorrhea After the Warm-water Footbath
The effect of warm-water footbath in improving primary dysmenorrhea (PD) was rarely investigated previously. We aimed to exam the hypothesis that warm-water footbath is effective to reduce the pain of PD, and the effect is…
- Trial name
- NCT04071028
- Testing
- warm-water footbath
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Camillians Saint Mary's Hospital Luodong
Nicotine Dependence
E-Cigarettes and SNA
Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on sympathetic nerve activity and markers of oxidative stress.
- Trial name
- NCT02724241
- Testing
- one time exposure to e-cig with nicotine, One time exposure to e-cigarette without nicotine, one time exposure to empty e-cigarette
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles