Clinical trials: Sympathetic Activity
Diabetes Mellitus, Type 2, Metabolic Associated Fatty Liver Disease
Correlation Between Serum Nociceptin and Sympathetic Nerve Activity in Diabetic Patients With MAFLD
This observational study aims to investigate the relationship between serum nociceptin levels and sympathetic nervous system activity in patients with both type 2 diabetes mellitus (T2DM) and metabolic associated fatty liver…
- Trial name
- NCT07663682
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Hospital of Shanxi Medical University
Vasodilation, Vasoconstriction
Sex Differences in Sympathetic Activity and Vascular Reactivity During Acute and Chronic Hypoxia.
This study aims to investigate sex differences in blood pressure control associated with exposure to acute hypoxia (low oxygen), and short term acclimatization to hypoxia at high altitude.
- Trial name
- NCT05001048
- Testing
- Phenylephrine Hydrochloride, Cold Pressor Test, Isocapnic Acute Hypoxia
- Where
- 2 sites in Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Respiratory Muscle, Blood Pressure
Respiratory Muscle Contribution to Blood Pressure During Exercise
The investigators seek to understand how reflexes from the breathing muscles influence blood pressure during exercise. Furthermore, the investigators are determining if increasing breathing muscle strength (via inspiratory muscle…
- Conditions
- Respiratory Muscle, Blood Pressure, Exercise Capacity, Sympathetic Nerve Activity
- Trial name
- NCT03514823
- Testing
- Inspiratory Muscle Training (IMT), No Inspiratory Muscle Training (IMT)
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Heart Failure
Inspiratory Muscle Training Effectiveness in Sympathetic Activity and Functional Capacity in Patients With Heart Failure
Heart failure (HF) is configured major problem for public health in the country. Affected individuals may experience fatigue, dyspnea, respiratory muscle weakness, overstimulation of the sympathetic myocardial activity, among…
- Trial name
- NCT02600000
- Testing
- Myocardial scintigraphy, Cardiopulmonary test, AVD-Glittre Test
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade Federal de Pernambuco
Spinal Cord Injury
Sympathetic-Somatomotor Coupling in Human Spinal Cord Injury
Significance: The long term objective of this study is to improve physical therapy and fitness programs in people with spinal cord injury.
- Trial name
- NCT02115685
- Testing
- Treadmill Training
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Chronic Insomnia
Impact of Suvorexant on Sympathetic Nerve Activity and Baroreflex Function in Chronic Insomnia
This study aims to evaluate the effect of Suvorexant on sympathetic nerve activity and baroreflex function in subject with chronic insomnia.
- Trial name
- NCT03768713
- Testing
- Suvorexant
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Montana State University
Obesity
Transduction of Sympathetic Neural Activity in Human Obesity Without Hypertension
In addition to chronically elevated MSNA, there is a growing recognition that hypertension in states of insulin resistance and obesity may also be attributed to an increased vascular sensitivity to MSNA (1, 2, 13, 36-38).
- Trial name
- NCT06626113
- Testing
- ascorbic acid
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Kansas Medical Center
Hypertension
Renal Denervation for Uncontrolled Hypertension
This is a study investigating the safety and usefulness of the Renal Denervation Procedure in reducing high blood pressure in people whose blood pressure is not adequately controlled despite already being treated with 2 blood…
- Trial name
- RDNP-2012-02 (NCT02016573)
- Testing
- Renal Denervation
- Sponsor
- Baker Heart and Diabetes Institute
Blood Pressure, Neurovascular Control
Meal Timing and Blood Pressure
Brain blood flow, blood pressure, and neurovascular control mechanisms will be measured in middle-aged adults before and after a brief intervention period.
- Trial name
- NCT04133701
- Testing
- Time-Restricted Feeding
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Atrial Fibrillation
Moxonidine for Prevention of Post-ablation AFib Recurrences
Hypothesis: Modulation of central nervous sympathetic activation by administration of moxonidine, a centrally acting medication which decreases the sympathetic nervous system activity, can lead to a decrease in atrial…
- Trial name
- NCT01791699
- Testing
- Moxonidine
- Where
- 3 sites in Greece
- Volunteers
- 150 people
- Sponsor
- Spyridon Deftereos
Healthy Volunteers, Sympathetic Activity
SPARK Study - Sympathetic Periarterial Radial Block in Healthy Volunteers
The SPARK Study evaluates changes in peripheral sympathetic vasomotor activity following a targeted, ultrasound-guided periarterial sympathetic block of the distal radial artery in healthy volunteers.
- Trial name
- SPARK (NCT07429292)
- Testing
- Lidocaine 2%
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Duke University
Takotsubo Syndrome
Stress-induced Vascular Dysfunction: Evaluation of Endothelial Function in a Cohort of Patients With Takotsubo Syndrome
The aim of this prospective single-center study is to evaluate endothelial function, arterial compliance, sympathetic nervous activity at rest and after mental and physical stress, carotid atherosclerosis, oxidative stress…
- Trial name
- NCT01249599
- Testing
- blood sample analysis
- Where
- Switzerland
- Volunteers
- 44 people
- Sponsor
- University of Zurich
Obesity, Metabolic Syndrome X
The Potential Role for Adenosine in the Haemodynamic Effects of Free Fatty Acids
The metabolic syndrome is associated with hyperdynamic circulation and sympathetic activation. Recently, Bakker et al. (Atherosclerosis 2002) described the hypothesis that free fatty acids are responsible for this association.
- Trial name
- NCT00184899
- Testing
- Intravenous infusion of Intralipid/heparin, Intravenous infusion of Glycerol/heparin
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Hypercapnia
End Tidal CO2 and Masks: Is There a Correlation?
In light of the ongoing COVID-19 pandemic, wearing a mask has become a universal standard as an attempt to reduce the spread of COVID-19. As of 2020, more than half of all U.S.
- Trial name
- NCT06437301
- Testing
- Baseline measure of ETCO2 without mask, Baseline ETCO2 with mask, ETCO2 after 200 meter walk with mask
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- CHRISTUS Health
Sepsis, Septic Shock
Early Dexmedetomidine and Sympathetic Regulation in Sepsis
The goal of this clinical trial is to learn whether early administration of dexmedetomidine can improve autonomic nervous system regulation and clinical outcomes in adult patients with septic shock.
- Trial name
- DEX-SNS-SEPSIS (NCT07470775)
- Testing
- Dexmedetomidine (DEX)
- Volunteers
- 168 people
- Sponsor
- Sichuan Academy of Medical Sciences
Menopause, Hot Flashes
Time-Efficient Inspiratory Muscle Strength Training for Reducing Sympathetic Activity and Improving Sleep in Midlife Women
The purpose of this research is to understand how training the muscles used for breathing (inhalation) affects menopausal hot flashes, sympathetic nerve activity and sleep.
- Conditions
- Menopause, Hot Flashes, Blood Pressure Regulation
- Trial name
- NCT06743269
- Testing
- High-Resistance Inspiratory Muscle Strength Training, Low-Resistance Inspiratory Muscle Strength Training, POWERbreathe K3 device
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Stable Chronic Kidney Disease, Hypertension
Atorvastatin and Sympathetic Activity in Chronic Kidney Disease
Hypertensive chronic kidney disease (CKD) patients often have sympathetic hyperactivity which appears to contribute to the pathogenesis of hypertension and cardiovascular organ damage.
- Trial name
- NCT01257009
- Testing
- Atorvastatin
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- UMC Utrecht
Vasoconstriction, Vasodilation
Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences
The main purpose of this interventional study is to examine differences in resting blood pressure control between healthy males and females. The main questions it aims to answer are: 1.
- Trial name
- STARS (NCT05997732)
- Testing
- Phenylephrine Hydrochloride, Isoproterenol Hydrochloride, Norepinephrine Bitartrate
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Brain Injuries, Craniocerebral Trauma
DASH After TBI Study: Decreasing Adrenergic or Sympathetic Hyperactivity After Traumatic Brain Injury
The investigators intend to determine the effect of adrenergic blockade on 1) short-term physiology, behavior, and cognition and 2) long-term neuropsychological outcomes after severe Traumatic Brain Injury (TBI).
- Conditions
- Brain Injuries, Craniocerebral Trauma, Trauma, Nervous System, Traumatic Brain Injury
- Trial name
- NCT01322048
- Testing
- IV Propranolol and Per Tube Clonidine
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Vanderbilt University
Heart Failure
Effects of Exercise Training on Mechanoreflex and Metaboreflex Control in Heart Failure Patients
The investigators hypothesize that exercise training would improve the mechanoreflex and metaboreflex control in heart failure patients.
- Trial name
- NCT01884142
- Testing
- Aerobic Exercise Training
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- University of Sao Paulo General Hospital