Clinical trials: Swallowing
Sensory Disorders, Sensory Processing Disorder
Online Parent-Report Evaluation of the Effects of Processed Music
The study aims to examine effectiveness of the Safe and Sound Protocol (SSP) on sensory, digestive, and eating behaviors in children currently receiving therapy.
- Conditions
- Sensory Disorders, Sensory Processing Disorder, Autism Spectrum Disorder, Eating Disorders
- Trial name
- NCT05249270
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Indiana University
Swallowing Function
Detecting the Changes of Swallowing Function in Oral Cancer Patients
The evidence of swallowing changes in oral cancer patients is still limited. This study aimed to investigated the swallowing changes in these patients by using the videofluoroscopy (VFSS) and high resolution impedance manometry…
- Trial name
- NCT04862637
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- National Taiwan University Hospital
Achalasia Cardia, Achalasia
Full-thickness Versus Progressive Myotomy in Peroral Endoscopic Esophageal Myotomy in Achalasia: A Randomized Controlled Trial
Peroral endoscopic esophageal myotomy (POEM) has been established as an effective therapy for Achalasia. It is still not known how deep the myotomy should be and if it should include the circular and longitudinal muscles or not.
- Trial name
- NCT07875686
- Testing
- Full thickness myotomy, Progressive thickness myotomy
- Where
- 2 sites in Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Achalasia Cardia, Esophageal Cancer (EsC)
INCIDENCE, PREVALENCE AND OVERALL RISK OF ESOPHAGEAL CANCER IN ACHALASIA: A PROPENSITY-MATCHED POPULATION-BASED STUDY FROM A LARGE MULTICENTER DATABASE
Esophageal Achalasia has been investigated as a potential risk factor for esophageal cancer (EC). Longstanding disease, repeated treatment, age and male sex seem the most relevant risk factors, but no clear effect size estimation…
- Trial name
- RECAP (NCT07022886)
- Testing
- achalasia treatments
- Where
- Italy
- Volunteers
- 47,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Healthy
Tongue Motor Recruitment During Exercise
The prevalence of dysphagia may be as high as 22% in individuals over 50 years of age. There are few therapeutic options offered to these individuals.
- Trial name
- NCT02687737
- Testing
- Electromyography, Maximum expiratory pressure, Videofluoroscopy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Dysphagia, Cardiovascular Diseases
Dysphagia and Vocal Cord Injury Following Cardiac Surgery
Aiming to determine the incidence and contributing risk factors of vocal fold mobility impairment (VFMI) and dysphagia in postoperative cardiovascular patients and evaluate the impact of VFMI on health-related outcomes.
- Trial name
- NCT04464317
- Sponsor
- University of Florida
Parkinson's Disease (PD), Dysphagia
Biomechanical Effects of EMST® on Swallowing Function in Parkinson's Disease
The aim of this non-randomized intervention study is to investigate the detailed effects of a structured four-week EMST® training program on the biomechanics of swallowing function in dysphagic Parkinson's patients.
- Trial name
- NCT07606547
- Testing
- exspiratory muscle strength training
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Muenster
Gastroesophageal Reflux Disease
A Prospective Randomized Trial Comparing Laparoscopic Nissen Against Anterior Partial Fundoplication in Treating Gastroesophageal Reflux Disease Among Chinese Patients
The aim of this study is to compare the effectiveness of laparoscopic Nissen against anterior partial fundoplication in the control of gastroesophageal reflux disease among Chinese patients Study hypothesis Laparoscopic Nissen is…
- Trial name
- NCT00480285
- Testing
- Laparoscopic Nissen Fundoplication, Laparoscopic anterior partial fundoplication
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Achalasia
A Clinical Study of Per Oral Endoscopic Myotomy (POEM) in Patients Suffering From Achalasia
This study evaluates the feasibility of endoscopic myotomy for achalasia. In achalasia, there is loss of relaxation of the lower esophageal sphincter (LES), as well as a higher baseline pressure in the LES.
- Trial name
- POEM (NCT01692106)
- Testing
- Procedure: Per Oral Endoscopic Myotomy (POEM)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- McMaster University
Swallowing Disorder.Other Specified
Electromagnetic Therapy for Cervicogenic Dysphagia
Cervicogenic dysphagia (CD) is a swallowing disorder in patients with cervicogenic pathology. Pulsed electromagnetic therapy (PEMT) is a widely utilized therapeutic modality.
- Trial name
- NCT07765043
- Testing
- The pulsed electromagnetic field treatment program plus the swallowing resistance training program
- Where
- Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- Umm Al-Qura University
Oropharyngeal Dysphagia, Deglutition Disorders
Effect of Sub-mental Sensitive Transcutaneous Electrical Stimulation on Pharyngeal Muscles Control : TENSVIRT Study
Swallowing is a complex phenomenon that allows oral feeding while protecting the airway. It involves many brain areas, including primary motor and sensory areas.
- Trial name
- TENSVIRT (NCT02170506)
- Testing
- Urostim 2 stimulation
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Swallowing Disorder
Oral Food Processing for Digitally Constructed Complete Dentures Versus Conventional Complete Dentures.
The study aimed to compare the effects of fully digital versus conventional complete denture fabrication on oral food processing (mastication and swallowing of solids) in edentulous patients, using the Test of Mastication and…
- Trial name
- NCT07290933
- Testing
- Procedure for construction of complete denture either conventional or fully digital fabrication
- Where
- Egypt
- Volunteers
- 14 people
- Sponsor
- Mansoura University
Oral Festination, Lingual Pumping
The Effect of an Auditory Rhythmic Cue on the Frequency of Rolling in Patients with Dysphagia and Parkinson's Disease
The main objective of this clinical study is to measure the effect of rhythmic auditory cueing, introduced in rehabilitation with three weekly sessions over a period of 7 weeks, on the frequency of rolling in idiopathic…
- Conditions
- Oral Festination, Lingual Pumping, Dysphagia, Swallowing Disorder
- Trial name
- Rhythm'nRoll (NCT06695455)
- Testing
- Swallowing rehabilitation by rhythmic auditory cue
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Hopital La Musse
Barrett's Esophagus, Gastroesophageal Reflux Disease
Reflux-Induced Oxidative Stress in Barrett's Esophagus: Response, Repair, and Epithelial-Mesenchymal-Transition
The purpose of this study is to elucidate mechanisms whereby oxidative stress induced by acute reflux esophagitis: 1) activates p38 to regulate proteins that control the G1/S cell cycle checkpoint, and 2) activates HIFs (hypoxia…
- Trial name
- NCT02579460
- Testing
- Cessation of Acid Suppressing Medications
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Dallas VA Medical Center
Gastroesophageal Reflux Disease (GERD)
A Trial of IW-3718 for 8 Weeks in Patients With Persistent Gastroesophageal Reflux Disease (GERD) Receiving Proton Pump Inhibitors (PPIs)
The objective of this study is to evaluate the safety and efficacy of IW-3718 administered to patients with GERD who continue to have persistent symptoms, such as heartburn and regurgitation, while receiving once-daily (QD)…
- Trial name
- NCT03561090
- Testing
- IW-3718, Standard-dose PPIs QD
- Where
- 99 sites in United States, Canada
- Volunteers
- 495 people
- Sponsor
- Ironwood Pharmaceuticals, Inc.
Gastroesophageal Reflux Disease
A Study to Compare PK, PD and Safety of the AD-214 and AD-2141
A study to compare safety, pharmacokinetics and pharmacodynamics of AD-214 to AD-2141 in healthy volunteers.
- Trial name
- NCT05062876
- Testing
- AD-214, AD-2141
- Where
- South Korea
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Addpharma Inc.
Dysphagia
Madrid - Tolerance and Acceptability Study
Tolerance and Acceptability of a gum based thickener.
- Trial name
- NCT03834896
- Testing
- AYMES MADRID
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Aymes International Limited
Not Determined
Pill Swallow Study
A prospective, single-center, open-label, single-arm, observational study assessing participant experience with swallowing the Mock-RP
- Trial name
- NCT04911296
- Testing
- Mock-RP
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- RANI Therapeutics
Erosive Esophagitis
Endoscopic Evidence of Maintenance of Healing With Oral NEXIUM in Patients 1 to 11 Years Old With Erosive Esophagitis.
The aim of the study is to compare the safety and efficacy of two doses of Nexium in maintaining healing of erosive esophagitis in patients 1 to 11 years of age.
- Trial name
- EE (NCT05267613)
- Testing
- Nexium 20mg, Nexium 10mg
- Where
- 41 sites in United States, Argentina and 8 more
- Volunteers
- 53 people
- Sponsor
- AstraZeneca
Parkinson Disease, Dysphagia
Prevalence of Subclinical and Clinical Dysphagia in Parkinson's Disease
Background: In idiopathic Parkinson's disease, 50% of patients develop in the course of the disease a dysphagia and aspiration pneumonia is the leading cause of death in all parkinsonian syndromes .
- Trial name
- NCT04889170
- Testing
- Intervention
- Where
- Austria
- Volunteers
- 180 people
- Sponsor
- Neurological Rehabilitation Hospital Rosenhügel