Clinical trials: Surgical Blood Loss
Blood Loss
Tranexamic Acid for Unilateral Total Knee Arthroplasty
Total knee arthroplasty is often associated with excessive postoperative bleeding due to increased fibrinolysis. Hence, the objective of the proposed of this multicentre study is to determine the peri-operative bleeding comparing…
- Trial name
- TRANEXTOP (NCT01594671)
- Testing
- Tranexamic Acid, haemostasia
- Where
- 2 sites in Spain
- Volunteers
- 150 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Cesarean Section Complications, Blood Loss, Surgical
Tranexamic Acid Versus Misoprostol in Reducing Blood Loss in Cesarean Section in Primigravida
The aim of the work is to compare the efficacy of preoperative IV tranexamic acid and rectal misoprostol in reducing blood loss in the elective cesarean section.
- Conditions
- Cesarean Section Complications, Blood Loss, Surgical, Misoprostol, Tranexamic Acid
- Trial name
- NCT04635007
- Testing
- Tranexamic acid, Misoprostol 200mcg Tab
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Cairo University
Blood Loss, Postoperative, Blood Loss, Surgical
EFFECT OF TRANEXAMIC ACID ON PERIOPERATIVE BLOOD LOSS IN REAMED INTRAMEDULLARY NAILING OF DIAPHYSEAL FEMORAL AND TIBIAL FRACTURES: A PROSPECTIVE COMPARATIVE STUDY
Perioperative blood loss is one of the most frequently encountered and significant complications of spine surgery. Intraoperative and post-operative bleeding cause various complications and negatively affect patient outcomes.
- Conditions
- Blood Loss, Postoperative, Blood Loss, Surgical, Femoral Fracture, Tibial Fracture
- Trial name
- NCT07625709
- Testing
- Intervention with Tranexamic Acid, Control group (Normal Saline)
- Where
- Nepal
- Volunteers
- 54 people
- Sponsor
- Kathmandu University School of Medical Sciences
Dexmedetomidine, Bleeding
Dexmedetomidine Improves the Surgical Field and Postoperative Recovery of Nasal Endoscopic Surgery
Studies showed dexmedetomidine (DEX) could improve surgical field, but the effect for functional nasal endoscopic surgery (FESS) was unclear.
- Conditions
- Dexmedetomidine, Bleeding, Surgical Field
- Trial name
- NCT04276545
- Testing
- IV administration of DEX to investigate the effects for functional nasal endoscopic surgery, IV administration of Midazolam to investigate the effects for functional nasal endoscopic surgery
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Infection of Total Knee Joint Prosthesis, Aseptic Loosening of Prosthetic Joint
Surgical / Economic Effect of the Aquamantys System in Blood Management for Aseptic and Septic Revision TKA
To assess the surgical and economic effectiveness of the Aquamantys System in managing intra- and post-operative blood loss, and reducing transfusion needs in patients undergoing both aseptic and septic revision total knee…
- Trial name
- NCT02266407
- Testing
- Aquamantys System
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medtronic Surgical Technologies
Cardiopulmonary Bypass, Hemorrhage
Dose-ranging Study of Two Doses of Tranexamic Acid During Cardiac Surgery
Cardiac surgery with CardioPulmonary Bypass (CPB) exposes to per and postoperative bleeding, and may lead to allogenic blood transfusion re-intervention and many adverse outcomes.
- Trial name
- Exacylcardio (NCT00809393)
- Testing
- tranexamic acid
- Where
- 4 sites in France
- Volunteers
- 600 people
- Sponsor
- Hopital Foch
Surgical Site Infection, Bleeding
Mild Hypothermia Influence on Patient Outcome in Major Abdominal Surgery
This study investigate associations between mild hypothermia (patients' core temperature ≤ 36.0 degrees Celsius) and intra-operative blood loss and surgical site infections (SSI) in patients undergoing major abdominal surgery.
- Trial name
- NCT03112317
- Testing
- Prevention of hypothermia
- Where
- 2 sites in Norway
- Volunteers
- 3,059 people
- Sponsor
- Haukeland University Hospital
Orthopaedic Surgery
The Influence of Perioperative Strategies on the Extent of in Orthopaedic Prosthetic Surgery
To assess the extent of blood loss in prosthetic surgery, considering whether possible variables may influence, either positively or negatively, the extent of such loss.
- Trial name
- IPECO (NCT07500350)
- Where
- Italy
- Volunteers
- 1,683 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Surgical Site Infection, Length of Stay
Prevena to Prevent Surgical Site Infection After Emergency Abdominal Laparotomy
Post-operative wound complications in abdominal surgery have a major impact on patient outcomes and the real impact of Closed incision negative pressure therapy (CINVt) is not clear in the literature moreover concerning its…
- Conditions
- Surgical Site Infection, Length of Stay, Seroma, Hematoma
- Trial name
- CiPNT/SSI (NCT04496180)
- Testing
- Closed incision negative pressure therapy versus standard dressing after emergency abdominal laparotomies
- Volunteers
- 334 people
- Sponsor
- University Hospital, Geneva
The Primary Study Objective is to Assess the Efficacy and, Safety of Extended 4-week Heparin Prophylaxis Compared to
ONE WEEK VERSUS FOUR WEEK HEPARIN PROPHYLAXIS AFTER LAPAROSCOPIC SURGERY FOR COLORECTAL CANCER.
Overall, only limited evidence exists regarding the clinical benefit of antithrombotic prophylaxis after laparoscopic surgery for cancer.
- Conditions
- The Primary Study Objective is to Assess the Efficacy and, Safety of Extended 4-week Heparin Prophylaxis Compared to, Prophylaxis Given for 8±2 Days After Planned Laparoscopic, Surgery for Colorectal Cancer.
- Trial name
- PRO-LAPS I (NCT01589146)
- Testing
- Heparin, Low-Molecular-Weight
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- University Of Perugia
Hypothermia
Study to Determine the Effects of Pre-warming on OR Patient Temperatures and Surgical Outcomes
The application of active warming to patients whether awake or under general anesthesia has been proven safe in numerous studies and it is common practice to use warmers.
- Trial name
- NCT02177903
- Testing
- Bair Paws Patient Adjustable Warming System
- Where
- Canada
- Volunteers
- 220 people
- Sponsor
- Solventum US LLC
Hematoma
Strategy of Continued Versus Interrupted Novel Oral Anti-coagulant at Time of Device Surgery in Patients With Moderate to High Risk of Arterial Thromboembolic Events
The purpose of this study is to determine the best strategy to manage novel oral anti-coagulants (NOACs) at the time of pacemaker or defibrillator surgery.
- Trial name
- BRUISECONTROL2 (NCT01675076)
- Testing
- Dabigatran, Rivaroxaban, Apixaban
- Where
- 15 sites in Canada, Israel
- Volunteers
- 663 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Surgical Blood Loss, Total Knee Arthroplasty
Topical Tranexamic Acid for Total Knee Arthroplasty
Total knee arthroplasty (TKA), the definitive treatment of osteoarthritis, is often associated with excessive postoperative bleeding due to increased fibrinolysis.
- Trial name
- NCT00985920
- Testing
- tranexamic acid
- Where
- Canada
- Volunteers
- 125 people
- Sponsor
- University Health Network, Toronto
Chronic Subdural Hematoma
Puerto Rico Embolization of the Middle Meningeal Artery for the Treatment of Chronic Subdural Hematoma Trial (PREMMA)
Puerto Rico Embolization of the Middle Meningeal Artery (PREMMA) trial is a multi-center, parallel, prospective, superiority, randomized controlled trial with concealed allocation comparing reoperation rates and neurological…
- Trial name
- PREMMA (NCT06466733)
- Testing
- Embolization of the middle meningeal artery, Surgical Evacuation via burr hole or craniotomy
- Volunteers
- 658 people
- Sponsor
- Juan M. Ramos Acevedo
Obesity, Bariatric Surgery
Impact of Weight Loss After a Bypass Surgery on Renal Hemodynamic Under Stress Conditions
The sympathetic nervous (SNS) and the renin angiotensin aldosterone system (RAS) have a direct impact on renal hemodynamic, hormonal secretion and vasoactive peptide.
- Conditions
- Obesity, Bariatric Surgery, Blood Pressure
- Trial name
- OBBYSS (NCT02218112)
- Testing
- bariatric surgery (gastric bypass)
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Bleeding, Surgery
How to Predict Post-Surgical Bleeding and Hemoglobin in Liposuction?
To evaluate the effect of using a mathematical model developed through pre- and post-surgical hemoglobins to predict the volume to aspirate in patients undergoing primary body liposuction.
- Trial name
- NCT06453772
- Testing
- Liposuction
- Where
- 2 sites in Mexico
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
ENT Disease, Tonsil Disease
Bizact Tonsillectomy: Postoperative Pain, Bleeding and Cost-effectiveness (Randomized Study)
Randomized trial assessing Bizact-instrument in tonsillectomy and it's impact on postoperative recovery (pain, hemorrhage)
- Conditions
- ENT Disease, Tonsil Disease, Surgery
- Trial name
- NCT07842419
- Testing
- Tonsillectomy
- Where
- Finland
- Volunteers
- 224 people
- Sponsor
- Helsinki University Central Hospital
Bariatric Surgery Candidate, Obesity, Morbid
Suture Reinforcement to Reduce the Leak Rate After Sleeve Gastrectomy
Staple line reinforcement (SLR) has been suggested as a mean of reducing the risk of sleeve leakage or bleeding. The aim of this study is to analyze if the suture reinforcement can be used to reduce the leakage rate after sleeve…
- Conditions
- Bariatric Surgery Candidate, Obesity, Morbid, Leak, Anastomotic, Bleeding
- Trial name
- NCT05987787
- Testing
- laparoscopic sleeve gastrectomy without suture reinforcement, laparoscopic sleeve gastrectomy with suture reinforcement
- Where
- Italy
- Volunteers
- 33 people
- Sponsor
- University of Foggia
Intraoperative Bleeding
Tranexamic Acid Versus Epinephrine During Exploratory Tympanotomy
Exploratory tympanotomy is surgical access to the middle ear, made for diagnosis and management of unexplained conductive hearing loss, performed under an oto-microscope across the external auditory canal after tympanic membrane…
- Trial name
- NCT04188184
- Testing
- Tranexamic Acid, Epinephrine
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Congenital Heart Defect, Surgery-Induced Tissue Adhesions
Effects of CoSeal on Bleeding & Adhesions in Pediatric Heart Surgery
This is a prospective, randomized, open-label, blinded-evaluator study that will evaluate the effectiveness of a surgical sealant (CoSeal) composed of biocompatible polyethylene glycol on the formation of mediastinal and…
- Conditions
- Congenital Heart Defect, Surgery-Induced Tissue Adhesions, Hemorrhage
- Trial name
- NCT01330433
- Testing
- CoSeal Surgical Spray Group
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Loma Linda University
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